Chitosan microspheres and preparation method thereof

Abstract

The invention relates to chitosan microspheres. The microspheres are solid spheres which have smooth surface and uniform granularity and are formed by crosslinking of chitosan and a crosslinking agent, wherein the grain diameter of each microsphere is 50-1200 mu m, preferably 50-600mu m, and further preferably 150-300mu m; and the grain diameter difference is not more than 20 percent, and preferably not more than 10 percent. The microspheres provided by the invention have the characteristics of small grain diameters and high uniformity, and are capable of improving the safety effectiveness of embolism in interventional therapy, reinforcing the clinical operability, reducing the clinical safety accident rate and reducing the production cost.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a chitosan microsphere and a preparation method thereof. Background technique [0002] With the rapid development of modern medicine, in addition to conventional drug therapy and surgical treatment, a new treatment method, that is, interventional therapy is becoming more and more mature. The key to interventional therapy is to use microspheres of appropriate particle size to embolize blood vessels in the lesion, cut off the blood supply to the diseased tissue, and achieve the purpose of inhibiting the development of the disease. effect. [0003] Chitosan is a natural polysaccharide, and its derivatives such as carboxymethyl chitosan also show excellent effects such as low toxicity, high degradability, and high biocompatibility. Recently, chitosan and its derivatives have been It is widely used in the research of microsphere preparation. [0004] The purpose...

AI Technical Summary

Problems solved by technology

However, the problem that currently plagues those in the field of medical technology is that the particle size of microspheres produced by traditional microsphere preparation processes such as emulsification-crosslinking method and emulsification-solvent evaporation method is not uniform, especially for small particle size microspheres. The particle size of microspheres required for interventional embolization therapy is generally 50-500 μm, which belongs to small particle size microspheres. Within this particle size range, the particle size difference will further increase under the same process, and the deviation is often more than 50%. In order to control the particle size deviation within 15%, the finished product needs to be screened by particle size, resulting in a lot of waste of materials. Therefore, the microspheres prepared by ordinary technology are used for interventional therapy with poor curative effect, easy to cause ectopic embolism, high fatality rate, and poor safety. , in order to make up for the defect of uneven particle size, precision screening is required, which is not only time-consuming and laborious, but also causes material loss and high cost

[0005] Therefore, there is a lack of chitosan microspheres and a preparation method thereof in the prior art, which can meet the requirements of small particle size and high uniformity for microspheres in interventional therapy embolization technology, improve the safety and effectiveness of interventional therapy, reduce the Cost of production

Images