Chitosan microspheres and preparation method thereof

A technology of chitosan microspheres and chitosan, which is applied in the field of medical devices, can solve the problems of uneven particle size, lack of chitosan microspheres, material waste, etc., and achieve moderate density and stable and uniform product quality , good fluid stability
CN104208757AInactive Publication Date: 2014-12-17SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
Publication Date
2014-12-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to chitosan microspheres. The microspheres are solid spheres which have smooth surface and uniform granularity and are formed by crosslinking of chitosan and a crosslinking agent, wherein the grain diameter of each microsphere is 50-1200 mu m, preferably 50-600mu m, and further preferably 150-300mu m; and the grain diameter difference is not more than 20 percent, and preferably not more than 10 percent. The microspheres provided by the invention have the characteristics of small grain diameters and high uniformity, and are capable of improving the safety effectiveness of embolism in interventional therapy, reinforcing the clinical operability, reducing the clinical safety accident rate and reducing the production cost.
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Description

technical field

[0001] The invention belongs to the technical field of medical devices, and in particular relates to a chitosan microsphere and a preparation method thereof. Background technique

[0002] With the rapid development of modern medicine, in addition to conventional drug therapy and surgical treatment, a new treatment method, that is, interventional therapy is becoming more and more mature. The key to interventional therapy is to use microspheres of appropriate particle size to embolize blood vessels in the lesion, cut off the blood supply to the diseased tissue, and achieve the purpose of inhibiting the development of the disease. effect.

[0003] Chitosan is a natural polysaccharide, and its derivatives such as carboxymethyl chitosan also show excellent effects such as low toxicity, high degradability, and high biocompatibility. Recently, chitosan and its derivatives have been It is widely used in the research of microsphere preparation.

[0004] The purpose...

Claims

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