278 results about "Therapeutic embolization" patented technology

The invention discloses a sugar chain marker combination for predicting prognosis of liver cancer transarterial chemoembolization and application of the sugar chain marker combination. The invention discovers and verifies that the combination composed of NA3Fb, NA4Fb and NA4F2b can be used as a novel marker for evaluating TACE treatment reaction and prognosis by analyzing a serum sugar chain map of a liver cancer patient for the first time. Based on the marker combination, a TACE-GT prognosis scoring model and system are established, and the progression risk of a patient within 12 months after a TACE operation can be effectively distinguished by noninvasively detecting the expression levels of three carbohydrate chains in serum of the patient and calculating a specific score. The detection method provided by the invention is based on a blood sample, and has the advantages of noninvasiveness and convenience, and a risk assessment system can provide individualized curative effect prediction and decision support for clinicians before and after TACE treatment, and has important values for realizing precise treatment of liver cancer and improving prognosis of patients.

The invention relates to a double-framework self-developing embolism system based on iodine modified PNIPAM gel and cross-linked albumin microspheres, which simulates a brick wall-concrete effect through a microsphere-gel composite structure and synergistically improves the embolism strength. A novel TACE treatment system is designed and constructed, multiple effects of tracing, embolism, hypoxia enhanced chemotherapy and tumor microenvironment improvement are achieved through the self-developing temperature-sensitive gel-drug carrying microspheres, and the anti-tumor effect is cooperatively improved.

The invention provides an implant release system and an embolism interventional therapy device, and relates to the field of medical instruments.The implant release system comprises a push rod and a control line, the far end of the push rod is provided with a limiting block, and the limiting block is provided with a first containing cavity and a containing groove used for containing a connecting rod; the pushing rod is further provided with a second containing cavity used for containing the release head, the second containing cavity is located on the near end side of the limiting block, an opening allowing the release head to be disengaged is formed in the radial direction of the second containing cavity, and the orientation of the opening is consistent with the orientation of the containing groove. The control line is located in the hollow cavity of the push rod, and a cushion block is arranged at the far end of the control line. The implant can be smoothly released, the structure is simple, and the release operation is convenient.

The invention discloses an embolism microsphere and a preparation method thereof.The embolism microsphere is prepared through the following steps that a polycarboxylate microsphere is prepared by combining a free radical polymerization method and an emulsion polymerization method, and the polycarboxylate microsphere is obtained; and saponifying and hydrolyzing the polycarboxylate microspheres to hydrolyze the polycarboxylate microspheres to obtain hydroxyl polymer microspheres, and introducing an acidic group onto the hydroxyl polymer microspheres to obtain the embolism microspheres containing both the hydroxyl group and the acidic group. The embolism microsphere disclosed by the invention realizes high loading capacity and controllable release of the anti-tumor drug, realizes accurate embolism in blood flow, and improves the treatment effect of the drug.

The invention relates to the technical field of medical image processing and interventional therapy assistance, and discloses an intubation fluorescent image feature learning system for hepatic artery chemoembolization. Comprising an image acquisition module which is configured to acquire a distortionless two-dimensional fluorescent blood vessel image in a hepatic artery chemoembolization super-selective intubation process; the control module is used for extracting surface geometric features of the blood vessel from the two-dimensional fluorescent blood vessel image; inputting the surface geometric features to a preset spatial reasoning model, and outputting a spatial distribution probability matrix of each blood vessel part; capturing a difference signal between the spatial distribution probability matrix and angiography feedback data in an actual intubation process in real time, and forming an iterative training data set to optimize the spatial reasoning model; and identifying a potential complex blood vessel region according to the spatial distribution probability matrix, generating an intubation path early warning signal, and generating guide parameters of X-ray release opportunity and dose based on the early warning signal so as to reduce radiation exposure.

The invention relates to the technical field of traditional Chinese medicine health-care products, and particularly discloses an earthworm protein peptide composition for improving vascular embolism and a preparation method thereof.The earthworm protein peptide composition is prepared from, by weight, 28-34 parts of earthworm protein peptide, 20-26 parts of active pharmaceutical ingredients, 1-5 parts of ginkgo biloba extract, 12-15 parts of corn oligopeptide powder and 4-8 parts of auxiliary materials; lumbricus protein peptide, active pharmaceutical ingredients, ginkgo biloba extract and corn oligopeptide powder are used as raw materials, a solubilizing component is added in the preparation process, the solubilizing component is prepared by mixing functional extract, nattokinase and tween-80 according to a certain proportion, the functional extract is prepared by coating grape seed extract with hydroxypropyl-beta-cyclodextrin, and the solubilizing component is prepared by mixing the functional extract, the nattokinase and the tween-80 according to a certain proportion. Through the synergistic effect of the components, the antithrombotic effect of the earthworm protein peptide composition is synergistically enhanced.

Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and / or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.

The invention relates to an embolism microsphere, a preparation method thereof and a drug-loaded embolism microsphere, and belongs to the technical field of embolism microspheres. The embolization microsphere comprises a three-dimensional network structure formed by cross-linking polymerization of a polyhydroxy water-soluble high-molecular polymer, a water-soluble cross-linking agent, a first water-soluble monomer and a second water-soluble monomer, wherein the first water-soluble monomer comprises a sulfonic acid group or a carboxylic acid group and at least one polymerizable double bond, and the second water-soluble monomer comprises a cis vicinal diol group and at least one polymerizable double bond. The embolism microsphere contains a sulfonic acid group or a carboxylic acid group and a cis vicinal diol group, so that the embolism microsphere can simultaneously load a positively charged drug and a drug containing a boric acid structure, the problem of drug resistance caused by long-time application of a single type of drug can be solved, and the tumor treatment effect is effectively improved.

The invention belongs to the technical field of medical instruments. In order to solve the problem that an existing device is tedious in operation, the multifunctional automatic injection system is designed and comprises an injector, an automatic injection device and an auxiliary Y valve, and the auxiliary Y valve is connected with a catheter, a guide wire and the automatic injection device. Therefore, the automatic injection device can inject the contrast agent, the medicine or the embolic agent in the injector, the contrast or treatment efficiency is improved, meanwhile, the guide wire can be rapidly fixed, the guide wire does not need to be completely withdrawn out of the catheter, the surgical operation difficulty is reduced, and the surgical time is shortened.

The present application relates to the technical field of medical devices, and provides a system with a spiral structure for cavity embolization and a delivery method, the system comprising: an embolization device which is in a spiral structure in a natural state and can be freely stretched and contracted under stress; the embolization device comprises an inner mesh layer and an outer mesh layer which are concentrically arranged, and the sparseness of the outer mesh layer is greater than that of the inner mesh layer; the embolization device is used for sleeving the embolization stent and the inner circle of the spiral structure is tightly attached to the outer wall of the embolization stent. The system, after the release of the embolization device with a spiral structure, can tightly adhere to the periphery of the embolization stent, increase the diameter of the cavity part of the embolization stent, fill the entire cavity or cyst in a physical occupation manner, improve the occlusion effect, avoid the occurrence of internal leakage, and thus avoid secondary surgery. Moreover, since the sparseness of the outer mesh layer is greater than that of the inner mesh layer, the blood flow direction can be better changed, the blood flow speed is reduced, the endothelial material in the blood is quickly deposited in the embolization, the endothelialization is completed, and the tumor cyst is atrophied.

The application discloses a master-slave separated embolism agent mixed injection device, which solves the liquid layering phenomenon in the operation process, and comprises an execution end arranged in an operating room and a control end arranged in a control room and capable of controlling the execution end. The control end comprises an embedded controller, a signal collector and an injection handle, the control end and the execution end are in wireless communication, the execution end comprises a drug carrying module, a shaking module and an injection module; the drug carrying module is used for carrying a needle cylinder carrying a drug; the injection module is used for pushing the needle cylinder on the drug carrying module in an injection direction to perform injection; and the shaking module is used for reciprocating the needle cylinder in the drug carrying module in a direction perpendicular to the injection direction. In the application, the shaking module realizes reciprocating operation by cooperation of a rack and a non-complete gear, the needle cylinder can realize small-range shaking in a horizontal plane, and finally the purpose of mixing the drug liquid is achieved, which is close to the artificial mixing process.

The present application relates to the technical field of hydrogel, in particular to an injectable temperature-responsive enhanced composite double-network magnetic particle gel, a preparation method and application thereof, the hydrogel is composed of a particle gel network formed by gelatin nanoparticles and Fe3O4 nanoparticles through electrostatic interaction and a poly-N-isopropyl acrylamide (PNIPAM) based temperature-sensitive polymer gel network. At room temperature, the hydrogel has excellent shear thinning and self-healing properties, and can be easily injected through a needle and a microcatheter. When the temperature rises to human body temperature (37 DEG C), the temperature-sensitive polymer phase transition crosslinking enhances the mechanical properties of the gel network. The hydrogel is injectable in vitro, temperature-responsive in vivo, meets the requirements of vascular interventional embolization materials, and can be magnetically heated under an alternating magnetic field, and is used for liver cancer embolization combined with magnetic heating treatment. The preparation method is simple, has high biocompatibility, and has great clinical application potential.

The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.

Liquid embolic compositions, systems, and methods for occluding a treatment site are provided. In some embodiments, a system for occluding a treatment site includes a first precursor composition (Part A) including a first polymer (Polymer A) having a first reactive group (Reactive Group A), and a second precursor composition (Part B) including a second polymer (Part B) having a second reactive group (Reactive Group B). Mixing of Part A and B can cause a covalent crosslinking reaction between the Reactive Group A and Reactive Group B to form an embolic composition. The embolic composition is solvent free, hydrophobic, and immiscible with blood. The embolic composition has an initial viscosity that permits hand injection via a microcatheter to a treatment site and cures to an occlusive, soft solid.

The invention belongs to the technical field of medical instruments, and particularly relates to an embolism protection device. The embolism protection device comprises an embolism protection net, and the embolism protection net sequentially comprises an initial section, a middle section and a final section in the direction from the far end to the near end; the main body of the embolism protection net is composed of a plurality of cells; the initial section is provided with a first cell; the middle section and / or the final section are / is provided with a second cell, the second cell is provided with an extension rod, one end of the extension rod is connected with the cell at the near end of the extension rod, and the other end of the extension rod is slidably assembled with the cell at the far end of the extension rod; and the extension rods are used for adjusting the mesh size of at least part of the cells. The embolism protection device is helpful to be placed at a farther-end position through the blocking section, and is also helpful to reduce the occurrence of missed capture of fine particles.

A kit is provided for delivering local radiation to a tumor while also causing tumor devascularization. The kit includes a first liquid radioembolic agent for treatment of at least a first region of the tumor and a second liquid radioembolic agent for treatment of at least a second region of the tumor. The first liquid radioembolic agent includes: a biocompatible polymer or prepolymer and a first radioisotope having a first type of ionizing radiation for treatment of the first region of the tumor. The second liquid radioembolic agent includes: a biocompatible polymer or prepolymer and a second radioisotope having a second type of ionizing radiation for treatment of the second region of the tumor. The second type of ionizing radiation is different than the first type of ionizing radiation. Each of the first type of ionizing radiation and the second type of ionizing radiation is selected from the group consisting of: alpha type ionizing radiation, beta type ionizing radiation; gamma type ionizing radiation; and combinations thereof.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The invention provides a developing embolism microsphere, a preparation method thereof and a drug-loaded developing embolism microsphere, and relates to the technical field of embolism microspheres. The developing embolism microsphere comprises a polymer network structure formed by cross-linking polymerization of an iodine-substituted tyrosine derivative and a cross-linking agent with an epoxypropane end group; the iodine-substituted tyrosine derivative comprises at least two active groups capable of reacting with an end group of epoxypropane. The preparation method of the developing embolism microspheres comprises the following steps: adding an alkaline catalyst into water to prepare an alkaline aqueous solution, sequentially adding an iodine-substituted tyrosine derivative and a crosslinking agent with an epoxypropane end group, and pre-crosslinking for a period of time to obtain an aqueous phase solution; mixing an oil-phase solvent and a dispersing agent to obtain an oil-phase solution; and adding the oil-phase solution into the water-phase solution to obtain a water-in-oil reversed-phase suspension system, and heating for reaction to obtain the developing embolism microspheres. The developing embolism microsphere provided by the invention is more uniform in developing, can load more types of medicines, and has a better slow release effect.

This application provides a premix, kit, and application of a premix for preparing an embolic agent. The premix uses a poloxamer to sodium alginate mass ratio of 9:1 to 20:1, which enables the formation of an injectable solution while maintaining good gel properties, and offers ease of preparation and use.

The invention relates to the technical field of drugs for neutron capture therapy and medical contrast agents, in particular to 157Gd neutron embolism microspheres as well as a preparation method and application thereof. According to the technical scheme, the 157Gd neutron embolization microsphere comprises an amidoxime-based porous microsphere and 157Gd loaded on the amidoxime-based porous microsphere. The preparation method comprises the following steps: grafting and polymerizing a functional monomer containing a nitrile group onto a porous substrate microsphere to obtain a porous microsphere containing a polyacrylonitrile group; carrying out ammoximation reaction on the porous microspheres containing the polyacrylonitrile groups, and converting nitrile groups into amidoxime groups to obtain amidoxime-based porous microspheres; and carrying out coordination chelation on the amidoxime-based porous microspheres and 157Gd, so as to obtain the 157Gd neutron embolization microspheres. The medicine is mainly used for neutron capture therapy of tumor local embolism.

The invention provides an injection hydrogel for vascular embolism treatment and a preparation and formula optimization method thereof. The hydrogel formula comprises two or more 2-arm or multi-arm polyethylene glycol polymers containing functional groups which can be cross-linked with each other, lithium magnesium silicate and a contrast agent. The formula optimization method comprises the following steps: designing an orthogonal experiment, systematically investigating the influence of raw material factors (such as polyethylene glycol molecular weight, functional groups, concentration and the like) on product performances of shear viscosity eta, compression strength sigma c and tensile strength sigma t, and obtaining basic experiment data; establishing a chemical reaction kinetic model and a product performance prediction model based on machine learning based on the data; determining a multi-objective optimization objective function according to product performance requirements; establishing a non-linear multi-objective equation set for formula optimization in combination with a material proportioning relationship; solving the optimization model by adopting an intelligent optimization algorithm to obtain a preliminary optimization formula; carrying out an optimization experiment under a small-scale test condition to obtain new experiment data, and updating model parameters; and the optimization iteration is repeated until convergence.

The present invention provides an embolization device and embolization system. The embolization device includes a spring coil having a storage configuration, an application configuration, and a memory configuration. The memory configuration of the spring coil allows the spring coil to be in the application configuration after being constrained in the fallopian tube. The embolization device of the present invention, with the spring coil as the main structure, is provided with a multi-stage smooth configuration within different length ranges. This ensures that the embolization device can be configured into a supporting segment and a stacking segment after being implanted in the fallopian tube. The multiple supporting segments cooperate to extend deep into the fallopian tube distally, preventing the spring coil from becoming stuck in the fallopian tube, thereby anchoring it in the fallopian tube. The multiple stacking segments collapse and stack into a ball at the proximal end, thereby achieving localized and dense packing of the fallopian tube.

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more compounds of Formula I compounds, and methods for using the compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

An embolic coil implant system is provided that includes a microcoil having a portion that includes one or more sets of rings. The rings of each of the one or more groups continuously intersect one another in one cycle, collectively forming a three-dimensional shape. A shape setting device includes a three-dimensional (3D) body having a curved surface and a plurality of winding members extending from the curved surface of the 3D body and arranged in a plurality of groups. The winding members of each of the plurality of groups are configured to allow the microcoils to be wound to form loops, and adjacent groups of the winding members share the winding members to allow the loops formed by the adjacent groups to cross each other. A method of manufacturing an embolic device is also provided.

The invention discloses a high-drug-loading tumor liquid embolism system and application thereof, and belongs to the technical field of medical instruments. The system comprises an embolism polymer solution and a solvent used for dissolving a drug, the polymer can be dissolved at a high concentration by regulating the molecular weight of the block polymer, the solvent used for dissolving the drug can dissolve the high-concentration drug, and high-concentration drug loading is achieved after the solvent used for dissolving the drug is mixed with the embolism polymer solution. The requirements of some disease treatment on high-dose medicines are met.

An embolic hydrogel for a patient comprises an aqueous buffer and at least one functionalized polymer, each having at least one polymer backbone chemically modified with one or more functional groups. The functional groups facilitate the formation of a primary reversible cross-link on the polymer backbone such that the embolic hydrogel transitions from a gel state to a viscous liquid state in response to shear forces applied to the embolic hydrogel and transitions from the viscous liquid state to the gel state in response to the absence of shear forces applied to the embolic hydrogel. The embolic hydrogel also includes at least one phase change polymer that produces secondary crosslinking therein in response to a physiological environment such that the embolic hydrogel transitions from a gel state to a solid state.

The invention discloses a preparation method of yttrium-90 (90Y)-loaded magnesium lithium silicate and a hydrogel radiotherapy embolism agent, relates to the technical field of medical materials, and comprises the preparation method of yttrium-90-loaded magnesium lithium silicate and the hydrogel radiotherapy embolism agent. Lithium magnesium silicate is modified and treated by phosphate, and citric acid is complexed with < 90 > Y < 3 + >, so that interlayer cations of the lithium magnesium silicate are replaced, and < 90 > Y < 3 + > is stably loaded on the lithium magnesium silicate to prepare the < 90 > Y-lithium magnesium silicate compound. Yttrium-90 is a therapeutic nuclide, and a 90Y-magnesium lithium silicate loaded compound can be added into an embolism agent as a thixotropic agent to prepare a hydrogel radiotherapy embolism agent, so that dual effects of internal radiation and vascular embolism are realized.

The invention provides an embolism microsphere with antibody drug loading capacity as well as a preparation method and application thereof, and belongs to the technical field of medicines. A layer of hydroxyapatite particles is uniformly deposited on the surface of the polyvinyl alcohol embolization microsphere in situ, and the high-efficiency adsorption capacity of hydroxyapatite and drug protein is utilized to realize the loading of an antibody drug. According to the embolism microsphere with the antibody drug loading capacity, the antibody drug can be efficiently adsorbed on the surface of the embolism microsphere and is slowly released after reaching a target blood vessel. The microsphere preparation process is simple, large-scale production is easy, and clinical use requirements can be better met.

The present application relates to a drug-loaded implant medical device and a preparation method thereof, the drug-loaded implant medical device comprising a device body, a microporous membrane fixed on the device body, and nanocrystal drugs loaded on the microporous membrane. The drug-loaded implant medical device has long-term sustained-release effect and high safety without causing embolism and toxic side effects.