474 results about "Therapeutic embolization" patented technology

The invention provides an embolism microsphere capable of slowly releasing drugs and controlling degradation speed and a preparation method thereof, the method comprises the following steps: dissolving a dispersant in an oil phase liquid, and stirring at a first preset temperature to obtain a dispersion liquid; dissolving gelatin in water at a second preset temperature to obtain a gelatin solution; the preparation method comprises the following steps: dissolving a compound with negative electricity groups in water, and adding alkali liquor and an initiator in an ice bath to obtain a modified solution; adding the modified solution into a gelatin solution, stirring to obtain a water-phase pre-polymerized solution, dropwise adding the water-phase pre-polymerized solution into the dispersion solution, premixing, adding a cross-linking agent and a catalyst, and directly grafting negative electricity groups onto gelatin molecules in a low-temperature free radical polymerization manner to obtain an intermediate product; and performing post-treatment to obtain the embolism microspheres. According to the preparation method disclosed by the invention, a non-degradable material is not needed, negative electricity groups can be directly grafted on the surface of gelatin, so that the embolism microspheres have efficient drug loading performance and good long-period drug sustained release, and the degradation speed of the embolism microspheres is controlled.

The invention discloses a sugar chain marker combination for predicting prognosis of liver cancer transarterial chemoembolization and application of the sugar chain marker combination. The invention discovers and verifies that the combination composed of NA3Fb, NA4Fb and NA4F2b can be used as a novel marker for evaluating TACE treatment reaction and prognosis by analyzing a serum sugar chain map of a liver cancer patient for the first time. Based on the marker combination, a TACE-GT prognosis scoring model and system are established, and the progression risk of a patient within 12 months after a TACE operation can be effectively distinguished by noninvasively detecting the expression levels of three carbohydrate chains in serum of the patient and calculating a specific score. The detection method provided by the invention is based on a blood sample, and has the advantages of noninvasiveness and convenience, and a risk assessment system can provide individualized curative effect prediction and decision support for clinicians before and after TACE treatment, and has important values for realizing precise treatment of liver cancer and improving prognosis of patients.

The invention provides a bending-adjustable balloon micro-catheter, and belongs to the technical field of balloon micro-catheters.The bending-adjustable balloon micro-catheter comprises a catheter body, a balloon, a bending mechanism and a feedback mechanism, the catheter body is of a slender tubular structure, and an inner cavity of the catheter body is used for conveying therapeutic drugs or embolism materials or other media; the balloon is located at the far end of the catheter body, is in an ellipsoidal shape and is used for blocking blood flow or expanding blood vessels. The multiple bending mechanisms are sequentially located at the middle section position of the catheter body and are composed of shape memory alloy wires, and the shape memory alloy wires are spirally wound around the outer wall of the catheter body, connected to the catheter body and used for adjusting the bending angle and direction of the catheter body; the feedback mechanisms are pressure sensor arrays, and the number of the feedback mechanisms is eight. The problems that an existing balloon micro-catheter is difficult to accurately reach a target position in a complex blood vessel or cavity, and the blood vessel is prone to being damaged can be solved.

The invention relates to the technical field of medical interventional therapy materials, and particularly discloses a preparation method of sodium hyaluronate embolism microspheres and the prepared embolism microspheres. The preparation method of the sodium hyaluronate embolization microspheres comprises the following steps: S1, adding methacrylic anhydride, N, N-dimethylformamide and sodium hydroxide into a sodium hyaluronate aqueous solution, reacting, adding sodium chloride, reacting, adding absolute ethyl alcohol, precipitating, filtering to remove filtrate, cleaning and drying; s2, preparing a mixture of methacrylated sodium hyaluronate, a monomer with negative charges, an initiator and water into a water phase; a mixture of oil soluble liquid and a dispersing agent is used as an oil phase; and under the protection of nitrogen, carrying out reverse suspension polymerization. According to the preparation method of the sodium hyaluronate embolization microspheres, the methylacryloylated sodium hyaluronate and the negatively charged monomer are copolymerized to introduce the negatively charged group, so that the microspheres can effectively load chemotherapeutic drugs, and the compression elasticity is high.

The invention relates to a double-framework self-developing embolism system based on iodine modified PNIPAM gel and cross-linked albumin microspheres, which simulates a brick wall-concrete effect through a microsphere-gel composite structure and synergistically improves the embolism strength. A novel TACE treatment system is designed and constructed, multiple effects of tracing, embolism, hypoxia enhanced chemotherapy and tumor microenvironment improvement are achieved through the self-developing temperature-sensitive gel-drug carrying microspheres, and the anti-tumor effect is cooperatively improved.

The invention provides an implant release system and an embolism interventional therapy device, and relates to the field of medical instruments.The implant release system comprises a push rod and a control line, the far end of the push rod is provided with a limiting block, and the limiting block is provided with a first containing cavity and a containing groove used for containing a connecting rod; the pushing rod is further provided with a second containing cavity used for containing the release head, the second containing cavity is located on the near end side of the limiting block, an opening allowing the release head to be disengaged is formed in the radial direction of the second containing cavity, and the orientation of the opening is consistent with the orientation of the containing groove. The control line is located in the hollow cavity of the push rod, and a cushion block is arranged at the far end of the control line. The implant can be smoothly released, the structure is simple, and the release operation is convenient.

The invention belongs to the field of medical embolism agents, and particularly relates to embolism hydrogel which can be used for radiography and drug loading and is moderate in degradation and a preparation method of the embolism hydrogel. The embolism hydrogel provided by the invention comprises two powders and two solutions, and the powders and the solutions are matched and combined with corresponding tools during use. The powder I is a multi-arm polyethylene glycol derivative with a double-bond group, the powder II is an iodine-containing contrast agent, the solution I comprises a reducing agent and an acidity regulator, and the solution II is an initiator. According to the prepared embolism agent, the problem of secondary embolism caused by the fact that the degradation time is short and the embolism effect of the embolism agent is not enough is solved, and targeted step-by-step embolism is achieved; and the double requirements of radiography and drug loading can be met at the same time.

The invention provides an embolism device and a conveying system thereof, and belongs to the technical field of interventional surgical instruments. The embolism device comprises embolism components, a connecting unit, a pushing component and a connection guaranteeing component, and the multiple embolism components are connected end to end; each connecting unit comprises a first buckle fixedly arranged at the near end of the corresponding embolism component and a second buckle fixedly arranged at the far end of the corresponding embolism component, and the first buckle on each embolism component can be buckled with the second buckle on the adjacent embolism component; the far end of the pushing part is detachably arranged at the near end of the embolism part, and the pushing part is used for pushing the embolism part to a target position; the connection guarantee component is used for simultaneously penetrating through the overlapped part formed after the first buckle and the second buckle are buckled so as to limit the radial displacement of the buckled first buckle and second buckle, and after the first buckle and second buckle move out of the connection guarantee component, the first buckle and second buckle are not buckled; by means of the design, the connection stability of the embolism component in the conveying process is improved, and therefore the success rate and safety of an interventional operation are remarkably improved.

The invention discloses an embolism microsphere and a preparation method thereof.The embolism microsphere is prepared through the following steps that a polycarboxylate microsphere is prepared by combining a free radical polymerization method and an emulsion polymerization method, and the polycarboxylate microsphere is obtained; and saponifying and hydrolyzing the polycarboxylate microspheres to hydrolyze the polycarboxylate microspheres to obtain hydroxyl polymer microspheres, and introducing an acidic group onto the hydroxyl polymer microspheres to obtain the embolism microspheres containing both the hydroxyl group and the acidic group. The embolism microsphere disclosed by the invention realizes high loading capacity and controllable release of the anti-tumor drug, realizes accurate embolism in blood flow, and improves the treatment effect of the drug.

The invention relates to an aneurysm embolism device, which comprises an embolism main body, which comprises a near-side net body, a middle net body and a far-side net body which are sequentially connected along the axial direction of the embolism main body, and the diameter of the middle net body is smaller than the diameter of the near-side net body and the diameter of the far-side net body; the aneurysm embolism device has a compressed state and an unfolded state, in the compressed state, the near-side net body and the far-side net body are oppositely folded, the near-side net body is folded and wraps the middle net body, and the far-side net body is folded and wraps the near-side net body; therefore, the pushing resistance of the device in the conveying catheter can be reduced, and the operation difficulty is reduced.

The invention relates to the technical field of medical image processing and interventional therapy assistance, and discloses an intubation fluorescent image feature learning system for hepatic artery chemoembolization. Comprising an image acquisition module which is configured to acquire a distortionless two-dimensional fluorescent blood vessel image in a hepatic artery chemoembolization super-selective intubation process; the control module is used for extracting surface geometric features of the blood vessel from the two-dimensional fluorescent blood vessel image; inputting the surface geometric features to a preset spatial reasoning model, and outputting a spatial distribution probability matrix of each blood vessel part; capturing a difference signal between the spatial distribution probability matrix and angiography feedback data in an actual intubation process in real time, and forming an iterative training data set to optimize the spatial reasoning model; and identifying a potential complex blood vessel region according to the spatial distribution probability matrix, generating an intubation path early warning signal, and generating guide parameters of X-ray release opportunity and dose based on the early warning signal so as to reduce radiation exposure.

The invention relates to a developing embolism microsphere as well as a preparation method and application thereof, and belongs to the technical field of embolism microspheres. The developing embolism microsphere comprises a polymer network structure formed by cross-linking polymerization of an iodine-substituted aminobenzoic acid monomer and a glycidyl ether cross-linking agent with an epoxypropane end group. The developing embolism microsphere provided by the invention has good X-ray developing capability, relatively low density, excellent suspension performance and moderate hardness and elasticity, and can be effectively applied to preparation of tumor radiotherapy, chemotherapy and embolism combined treatment medicines and developing diagnostic reagents.

The invention belongs to the technical field of medical infusion, and particularly relates to a neurosurgical nursing infusion device which comprises a base, a supporting rod and a supporting plate, the base is fixedly arranged at the lower end of the supporting rod, the supporting plate is fixedly arranged at the upper end of the supporting rod, and the neurosurgical nursing infusion device further comprises a weighing hook which is arranged below the supporting plate and connected with the weighing hook. The weighing hook is used for lifting the medicine bottle; and the electromagnetic lifting mechanism is arranged at the upper end of the weighing hook. According to the invention, the RFID tag reader and the PLC are used for checking the information of medicines and patients, so that the risk of medicine use errors is reduced; a weighing sensor and an electromagnetic lifting mechanism are used for automatically adjusting the height of a medicine bottle according to liquid level changes in the medicine bottle, the infusion speed is stabilized, and the treatment effect is guaranteed; by means of the automatic speed reduction mechanism, the infusion speed is automatically reduced when liquid medicine in a medicine bottle is almost emptied, risks such as air embolism are avoided, meanwhile, an infusion tube can be heated, the infusion comfort of a patient is improved, and adverse reactions caused by low-temperature infusion are avoided.

A developing embolic microsphere and a preparation method thereof, belonging to the field of medical device technology. The developing embolic microsphere comprises a fluorine-containing compound, a hydroxyl-containing acrylamide monomer, a cross-linking agent containing an epoxy end group, and an ionic monomer containing a double bond, and a network structure formed by cross-linking polymerization. Among them, the fluorine-containing compound contains a silicon-oxygen bond and / or an end group with an epoxy group. The fluorine-containing compound is introduced into the embolic microsphere by chemical reaction. The fluorine-containing compound is not easy to seep out of the embolic microsphere. The fluorine-containing compound can be used as a nuclear magnetic resonance contrast agent, and has the characteristics of low toxicity and high contrast, which can make the embolic microsphere have good developing signal intensity. In addition, the fluorine-containing compound is also hydrophobic. The introduction of the fluorine-containing compound enables the embolic microsphere to have good drug loading and release properties for hydrophobic drugs.

The invention relates to the technical field of traditional Chinese medicine health-care products, and particularly discloses an earthworm protein peptide composition for improving vascular embolism and a preparation method thereof.The earthworm protein peptide composition is prepared from, by weight, 28-34 parts of earthworm protein peptide, 20-26 parts of active pharmaceutical ingredients, 1-5 parts of ginkgo biloba extract, 12-15 parts of corn oligopeptide powder and 4-8 parts of auxiliary materials; lumbricus protein peptide, active pharmaceutical ingredients, ginkgo biloba extract and corn oligopeptide powder are used as raw materials, a solubilizing component is added in the preparation process, the solubilizing component is prepared by mixing functional extract, nattokinase and tween-80 according to a certain proportion, the functional extract is prepared by coating grape seed extract with hydroxypropyl-beta-cyclodextrin, and the solubilizing component is prepared by mixing the functional extract, the nattokinase and the tween-80 according to a certain proportion. Through the synergistic effect of the components, the antithrombotic effect of the earthworm protein peptide composition is synergistically enhanced.

A preparation system and method for gelatin embolization microspheres. The preparation system comprises a feed device, a microfluidic device, a cross-linking curing device, and a cleaning device. The feed device, the microfluidic device, the cross-linking curing device, and the cleaning device form a continuous pathway for the preparation of gelatin embolization microspheres. The preparation method comprises: formulation, feeding, microfluidic reaction, low-temperature cross-linking curing, isopropanol washing, water washing, and freeze drying. By means of said method, uniform and large-scale gelatin embolization microspheres with stable performance are obtained, thereby achieving large-scale, batch, controlled, and standardized preparation of gelatin embolization microspheres.

The invention provides an intracavity implant, a suturing method and a blood vessel plug system. The intracavitary implant comprises a supporting framework, the supporting framework is of a tubular structure with an inner cavity, and the supporting framework is of a latticed structure which is formed by weaving a plurality of strands of weaving wires in a staggered mode and provided with a plurality of meshes. The inner membrane is fixed in the inner cavity of the supporting framework, the inner membrane is of a tubular structure with an inner cavity, and at least one hole is formed in the inner membrane. By means of at least one intracavity implant, plugging and treatment of a cavity can be achieved, and the intracavity implant can adapt to the form of a false cavity; the intracavitary implant provided by the invention can be expanded and formed at one time, and compared with a spring coil embolism technology, the artificial cavity can be blocked by using less materials, so that the cost is relatively low; and in addition, the forming mode is low in requirement for an operator, operation is more convenient and faster, and efficiency is higher.

Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and / or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.

The present application relates to an embolic microsphere and a preparation method thereof and a drug-loaded embolic microsphere, belonging to the technical field of embolic microspheres. The embolic microspheres include a three-dimensional network structure formed by cross-linking polymerization of a polyhydroxy water-soluble polymer modified mainly by a photodegradation agent and a photosensitizer, a water-soluble monomer with a polymerizable double bond, and a water-soluble cross-linking agent, wherein the photosensitizer is covalently coupled to the photodegradation agent, and the photodegradation agent is covalently coupled to the polyhydroxy water-soluble polymer. The embolic microspheres can have the therapeutic effects of embolization and photodynamic therapy, and embolization therapy and photodynamic therapy can be synergistically treated to improve the therapeutic efficiency of tumors.

The present application provides a compound for preparing an embolization bead, a hydrogel bead, a preparation method therefor and a use thereof, the compound having a structure as shown in formula I. A hydrogel bead capable of carrying a chemical drug has a core-shell structure, comprising a shell formed from the compound, and a core formed from an ionic monomer polymeric segment. A hydrogel bead capable of carrying a protein has a core-shell structure, comprising a shell formed from the compound, and a core formed from a zwitterionic polymeric segment. The compound of the present application has good stability, which makes it possible to improve the stability of a hydrogel bead when the compound is used to prepare the hydrogel bead. The hydrogel beads of the present application have a super-hydrophilic core-shell structure, and the dense shell layer and high hydrophilicity cause the beads to have strong toughness, and not break when swelling. Dry beads of the hydrogel beads can quickly adsorb a drug solution, achieving high-efficiency, rapid and high-load drug loading, with significant sustained release effects for drugs or proteins, which can effectively regulate drug release.

The present invention belongs to the field of biological technology, and specifically relates to a method for predicting the risk of tumor re-progression after hepatic artery embolization chemotherapy. The method comprises determining core characteristic variables in collected data, and using a 0-8 week data set, an 8-12 week data set, a 12-16 week data set, and a >16 week data set as training sets, performing data enhancement processing, and respectively training neural networks to obtain a first cycle prediction network, a second cycle prediction network, a third cycle prediction network, and a fourth cycle prediction network; inputting the data to be tested into four prediction networks respectively to obtain corresponding probabilities, selecting the maximum value among the four probability values ​​as a prediction result, and the corresponding time period as a prediction period of tumor re-progression; thereby realizing individualized risk prediction of tumor re-progression, so as to facilitate the formulation of an individualized plan.

The invention discloses an embolism protection structure, a shaping tool and a preparation method, and relates to the technical field of interventional medical instruments.The embolism protection structure is optimized, a straight third weaving section is arranged between a second weaving section and a tow for connection, the straight third weaving section can provide better supporting force, and the stability of the second weaving section is improved. The embolism protection structure is prevented from displacing in the blood vessel in the use process, and the embolism protection structure can generate a better thrombus fishing effect; and the woven wires are equally divided and shaped to form tows, so that the pushing force for pushing in the operation process and the withdrawing force for withdrawing from the blood vessel after the operation can be reduced. Besides, according to the optimized embolism protection structure, the second frustum-shaped weaving section and the third straight weaving section enable weaving preparation to be more convenient, and the arrangement of the tows and the fishing holes enable the embolism protection structure to be more convenient in the heat setting process. And the preparation difficulty is reduced, and meanwhile, the formed embolism protection structure has a more stable structure.

Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.

The invention relates to a developing embolism microsphere as well as a preparation method and application thereof, and belongs to the technical field of embolism microspheres. The developing embolism microsphere comprises a polymer network structure formed by cross-linking polymerization of a modified iodine-containing compound with a sulfonic acid group and polyhydroxy and a cross-linking agent, wherein the cross-linking agent comprises a glycidyl ether compound with an epoxypropane end group; the modified iodine-containing compound is obtained by modifying a polyhydroxy iodine-containing compound with a modifier with a sulfonic acid group, the chemical structure of the iodine-containing compound is as shown in formula (I): # imgabs0 #, R1, R2 and R3 are hydroxyl-containing alkyl or derivatives thereof, and R4 is-H, alkyl or derivatives thereof. The developing embolism microsphere has good developing property and mechanical property, has broad-spectrum drug loading capacity for various types of drugs, and is beneficial to delivery and clinical use of the embolism microsphere and enlargement of the application range of the embolism microsphere.

The invention relates to an embolism microsphere, a preparation method thereof and a drug-loaded embolism microsphere, and belongs to the technical field of embolism microspheres. The embolization microsphere comprises a three-dimensional network structure formed by cross-linking polymerization of a polyhydroxy water-soluble high-molecular polymer, a water-soluble cross-linking agent, a first water-soluble monomer and a second water-soluble monomer, wherein the first water-soluble monomer comprises a sulfonic acid group or a carboxylic acid group and at least one polymerizable double bond, and the second water-soluble monomer comprises a cis vicinal diol group and at least one polymerizable double bond. The embolism microsphere contains a sulfonic acid group or a carboxylic acid group and a cis vicinal diol group, so that the embolism microsphere can simultaneously load a positively charged drug and a drug containing a boric acid structure, the problem of drug resistance caused by long-time application of a single type of drug can be solved, and the tumor treatment effect is effectively improved.

The invention belongs to the technical field of medical instruments. In order to solve the problem that an existing device is tedious in operation, the multifunctional automatic injection system is designed and comprises an injector, an automatic injection device and an auxiliary Y valve, and the auxiliary Y valve is connected with a catheter, a guide wire and the automatic injection device. Therefore, the automatic injection device can inject the contrast agent, the medicine or the embolic agent in the injector, the contrast or treatment efficiency is improved, meanwhile, the guide wire can be rapidly fixed, the guide wire does not need to be completely withdrawn out of the catheter, the surgical operation difficulty is reduced, and the surgical time is shortened.

One embodiment includes a system comprising: a trunk; a first polyurethane shape memory polymer (SMP) foam on the trunk; a second polyurethane SMP foam on the trunk; and a third polyurethane SMP foam on the trunk and between the first SMP foam and the second SMP foam. Other embodiments are described herein.

The present application relates to the technical field of medical devices, and provides a system with a spiral structure for cavity embolization and a delivery method, the system comprising: an embolization device which is in a spiral structure in a natural state and can be freely stretched and contracted under stress; the embolization device comprises an inner mesh layer and an outer mesh layer which are concentrically arranged, and the sparseness of the outer mesh layer is greater than that of the inner mesh layer; the embolization device is used for sleeving the embolization stent and the inner circle of the spiral structure is tightly attached to the outer wall of the embolization stent. The system, after the release of the embolization device with a spiral structure, can tightly adhere to the periphery of the embolization stent, increase the diameter of the cavity part of the embolization stent, fill the entire cavity or cyst in a physical occupation manner, improve the occlusion effect, avoid the occurrence of internal leakage, and thus avoid secondary surgery. Moreover, since the sparseness of the outer mesh layer is greater than that of the inner mesh layer, the blood flow direction can be better changed, the blood flow speed is reduced, the endothelial material in the blood is quickly deposited in the embolization, the endothelialization is completed, and the tumor cyst is atrophied.

The application discloses a master-slave separated embolism agent mixed injection device, which solves the liquid layering phenomenon in the operation process, and comprises an execution end arranged in an operating room and a control end arranged in a control room and capable of controlling the execution end. The control end comprises an embedded controller, a signal collector and an injection handle, the control end and the execution end are in wireless communication, the execution end comprises a drug carrying module, a shaking module and an injection module; the drug carrying module is used for carrying a needle cylinder carrying a drug; the injection module is used for pushing the needle cylinder on the drug carrying module in an injection direction to perform injection; and the shaking module is used for reciprocating the needle cylinder in the drug carrying module in a direction perpendicular to the injection direction. In the application, the shaking module realizes reciprocating operation by cooperation of a rack and a non-complete gear, the needle cylinder can realize small-range shaking in a horizontal plane, and finally the purpose of mixing the drug liquid is achieved, which is close to the artificial mixing process.