160 results about "Therapeutic embolization" patented technology

The invention discloses a sugar chain marker combination for predicting prognosis of liver cancer transarterial chemoembolization and application of the sugar chain marker combination. The invention discovers and verifies that the combination composed of NA3Fb, NA4Fb and NA4F2b can be used as a novel marker for evaluating TACE treatment reaction and prognosis by analyzing a serum sugar chain map of a liver cancer patient for the first time. Based on the marker combination, a TACE-GT prognosis scoring model and system are established, and the progression risk of a patient within 12 months after a TACE operation can be effectively distinguished by noninvasively detecting the expression levels of three carbohydrate chains in serum of the patient and calculating a specific score. The detection method provided by the invention is based on a blood sample, and has the advantages of noninvasiveness and convenience, and a risk assessment system can provide individualized curative effect prediction and decision support for clinicians before and after TACE treatment, and has important values for realizing precise treatment of liver cancer and improving prognosis of patients.

The invention discloses an embolism microsphere and a preparation method thereof.The embolism microsphere is prepared through the following steps that a polycarboxylate microsphere is prepared by combining a free radical polymerization method and an emulsion polymerization method, and the polycarboxylate microsphere is obtained; and saponifying and hydrolyzing the polycarboxylate microspheres to hydrolyze the polycarboxylate microspheres to obtain hydroxyl polymer microspheres, and introducing an acidic group onto the hydroxyl polymer microspheres to obtain the embolism microspheres containing both the hydroxyl group and the acidic group. The embolism microsphere disclosed by the invention realizes high loading capacity and controllable release of the anti-tumor drug, realizes accurate embolism in blood flow, and improves the treatment effect of the drug.

The invention relates to an embolism microsphere, a preparation method thereof and a drug-loaded embolism microsphere, and belongs to the technical field of embolism microspheres. The embolization microsphere comprises a three-dimensional network structure formed by cross-linking polymerization of a polyhydroxy water-soluble high-molecular polymer, a water-soluble cross-linking agent, a first water-soluble monomer and a second water-soluble monomer, wherein the first water-soluble monomer comprises a sulfonic acid group or a carboxylic acid group and at least one polymerizable double bond, and the second water-soluble monomer comprises a cis vicinal diol group and at least one polymerizable double bond. The embolism microsphere contains a sulfonic acid group or a carboxylic acid group and a cis vicinal diol group, so that the embolism microsphere can simultaneously load a positively charged drug and a drug containing a boric acid structure, the problem of drug resistance caused by long-time application of a single type of drug can be solved, and the tumor treatment effect is effectively improved.

The invention belongs to the technical field of medical instruments. In order to solve the problem that an existing device is tedious in operation, the multifunctional automatic injection system is designed and comprises an injector, an automatic injection device and an auxiliary Y valve, and the auxiliary Y valve is connected with a catheter, a guide wire and the automatic injection device. Therefore, the automatic injection device can inject the contrast agent, the medicine or the embolic agent in the injector, the contrast or treatment efficiency is improved, meanwhile, the guide wire can be rapidly fixed, the guide wire does not need to be completely withdrawn out of the catheter, the surgical operation difficulty is reduced, and the surgical time is shortened.

The present application relates to the technical field of medical devices, and provides a system with a spiral structure for cavity embolization and a delivery method, the system comprising: an embolization device which is in a spiral structure in a natural state and can be freely stretched and contracted under stress; the embolization device comprises an inner mesh layer and an outer mesh layer which are concentrically arranged, and the sparseness of the outer mesh layer is greater than that of the inner mesh layer; the embolization device is used for sleeving the embolization stent and the inner circle of the spiral structure is tightly attached to the outer wall of the embolization stent. The system, after the release of the embolization device with a spiral structure, can tightly adhere to the periphery of the embolization stent, increase the diameter of the cavity part of the embolization stent, fill the entire cavity or cyst in a physical occupation manner, improve the occlusion effect, avoid the occurrence of internal leakage, and thus avoid secondary surgery. Moreover, since the sparseness of the outer mesh layer is greater than that of the inner mesh layer, the blood flow direction can be better changed, the blood flow speed is reduced, the endothelial material in the blood is quickly deposited in the embolization, the endothelialization is completed, and the tumor cyst is atrophied.

The application discloses a master-slave separated embolism agent mixed injection device, which solves the liquid layering phenomenon in the operation process, and comprises an execution end arranged in an operating room and a control end arranged in a control room and capable of controlling the execution end. The control end comprises an embedded controller, a signal collector and an injection handle, the control end and the execution end are in wireless communication, the execution end comprises a drug carrying module, a shaking module and an injection module; the drug carrying module is used for carrying a needle cylinder carrying a drug; the injection module is used for pushing the needle cylinder on the drug carrying module in an injection direction to perform injection; and the shaking module is used for reciprocating the needle cylinder in the drug carrying module in a direction perpendicular to the injection direction. In the application, the shaking module realizes reciprocating operation by cooperation of a rack and a non-complete gear, the needle cylinder can realize small-range shaking in a horizontal plane, and finally the purpose of mixing the drug liquid is achieved, which is close to the artificial mixing process.

The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.

Liquid embolic compositions, systems, and methods for occluding a treatment site are provided. In some embodiments, a system for occluding a treatment site includes a first precursor composition (Part A) including a first polymer (Polymer A) having a first reactive group (Reactive Group A), and a second precursor composition (Part B) including a second polymer (Part B) having a second reactive group (Reactive Group B). Mixing of Part A and B can cause a covalent crosslinking reaction between the Reactive Group A and Reactive Group B to form an embolic composition. The embolic composition is solvent free, hydrophobic, and immiscible with blood. The embolic composition has an initial viscosity that permits hand injection via a microcatheter to a treatment site and cures to an occlusive, soft solid.

A kit is provided for delivering local radiation to a tumor while also causing tumor devascularization. The kit includes a first liquid radioembolic agent for treatment of at least a first region of the tumor and a second liquid radioembolic agent for treatment of at least a second region of the tumor. The first liquid radioembolic agent includes: a biocompatible polymer or prepolymer and a first radioisotope having a first type of ionizing radiation for treatment of the first region of the tumor. The second liquid radioembolic agent includes: a biocompatible polymer or prepolymer and a second radioisotope having a second type of ionizing radiation for treatment of the second region of the tumor. The second type of ionizing radiation is different than the first type of ionizing radiation. Each of the first type of ionizing radiation and the second type of ionizing radiation is selected from the group consisting of: alpha type ionizing radiation, beta type ionizing radiation; gamma type ionizing radiation; and combinations thereof.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The invention provides a developing embolism microsphere, a preparation method thereof and a drug-loaded developing embolism microsphere, and relates to the technical field of embolism microspheres. The developing embolism microsphere comprises a polymer network structure formed by cross-linking polymerization of an iodine-substituted tyrosine derivative and a cross-linking agent with an epoxypropane end group; the iodine-substituted tyrosine derivative comprises at least two active groups capable of reacting with an end group of epoxypropane. The preparation method of the developing embolism microspheres comprises the following steps: adding an alkaline catalyst into water to prepare an alkaline aqueous solution, sequentially adding an iodine-substituted tyrosine derivative and a crosslinking agent with an epoxypropane end group, and pre-crosslinking for a period of time to obtain an aqueous phase solution; mixing an oil-phase solvent and a dispersing agent to obtain an oil-phase solution; and adding the oil-phase solution into the water-phase solution to obtain a water-in-oil reversed-phase suspension system, and heating for reaction to obtain the developing embolism microspheres. The developing embolism microsphere provided by the invention is more uniform in developing, can load more types of medicines, and has a better slow release effect.

This application provides a premix, kit, and application of a premix for preparing an embolic agent. The premix uses a poloxamer to sodium alginate mass ratio of 9:1 to 20:1, which enables the formation of an injectable solution while maintaining good gel properties, and offers ease of preparation and use.

The invention relates to the technical field of drugs for neutron capture therapy and medical contrast agents, in particular to 157Gd neutron embolism microspheres as well as a preparation method and application thereof. According to the technical scheme, the 157Gd neutron embolization microsphere comprises an amidoxime-based porous microsphere and 157Gd loaded on the amidoxime-based porous microsphere. The preparation method comprises the following steps: grafting and polymerizing a functional monomer containing a nitrile group onto a porous substrate microsphere to obtain a porous microsphere containing a polyacrylonitrile group; carrying out ammoximation reaction on the porous microspheres containing the polyacrylonitrile groups, and converting nitrile groups into amidoxime groups to obtain amidoxime-based porous microspheres; and carrying out coordination chelation on the amidoxime-based porous microspheres and 157Gd, so as to obtain the 157Gd neutron embolization microspheres. The medicine is mainly used for neutron capture therapy of tumor local embolism.

The invention provides an injection hydrogel for vascular embolism treatment and a preparation and formula optimization method thereof. The hydrogel formula comprises two or more 2-arm or multi-arm polyethylene glycol polymers containing functional groups which can be cross-linked with each other, lithium magnesium silicate and a contrast agent. The formula optimization method comprises the following steps: designing an orthogonal experiment, systematically investigating the influence of raw material factors (such as polyethylene glycol molecular weight, functional groups, concentration and the like) on product performances of shear viscosity eta, compression strength sigma c and tensile strength sigma t, and obtaining basic experiment data; establishing a chemical reaction kinetic model and a product performance prediction model based on machine learning based on the data; determining a multi-objective optimization objective function according to product performance requirements; establishing a non-linear multi-objective equation set for formula optimization in combination with a material proportioning relationship; solving the optimization model by adopting an intelligent optimization algorithm to obtain a preliminary optimization formula; carrying out an optimization experiment under a small-scale test condition to obtain new experiment data, and updating model parameters; and the optimization iteration is repeated until convergence.

An embolic coil implant system is provided that includes a microcoil having a portion that includes one or more sets of rings. The rings of each of the one or more groups continuously intersect one another in one cycle, collectively forming a three-dimensional shape. A shape setting device includes a three-dimensional (3D) body having a curved surface and a plurality of winding members extending from the curved surface of the 3D body and arranged in a plurality of groups. The winding members of each of the plurality of groups are configured to allow the microcoils to be wound to form loops, and adjacent groups of the winding members share the winding members to allow the loops formed by the adjacent groups to cross each other. A method of manufacturing an embolic device is also provided.

An embolic hydrogel for a patient comprises an aqueous buffer and at least one functionalized polymer, each having at least one polymer backbone chemically modified with one or more functional groups. The functional groups facilitate the formation of a primary reversible cross-link on the polymer backbone such that the embolic hydrogel transitions from a gel state to a viscous liquid state in response to shear forces applied to the embolic hydrogel and transitions from the viscous liquid state to the gel state in response to the absence of shear forces applied to the embolic hydrogel. The embolic hydrogel also includes at least one phase change polymer that produces secondary crosslinking therein in response to a physiological environment such that the embolic hydrogel transitions from a gel state to a solid state.

The invention provides an embolism microsphere with antibody drug loading capacity as well as a preparation method and application thereof, and belongs to the technical field of medicines. A layer of hydroxyapatite particles is uniformly deposited on the surface of the polyvinyl alcohol embolization microsphere in situ, and the high-efficiency adsorption capacity of hydroxyapatite and drug protein is utilized to realize the loading of an antibody drug. According to the embolism microsphere with the antibody drug loading capacity, the antibody drug can be efficiently adsorbed on the surface of the embolism microsphere and is slowly released after reaching a target blood vessel. The microsphere preparation process is simple, large-scale production is easy, and clinical use requirements can be better met.

The present application relates to a drug-loaded implant medical device and a preparation method thereof, the drug-loaded implant medical device comprising a device body, a microporous membrane fixed on the device body, and nanocrystal drugs loaded on the microporous membrane. The drug-loaded implant medical device has long-term sustained-release effect and high safety without causing embolism and toxic side effects.

Systems and methods for performing embolization to treat various medical indications and targets (e.g., bleeding, tumors) utilize a mixture of embolization particles and delivery media at very low concentrations of embolization material while intermittently injecting contrast agent boluses for visualizing progression of embolization. The systems and methods are also automated to minimize user interaction, and may also incorporate sensor and feedback control processes to control the systems and methods when performing embolization.

Embodiments of the invention relate to embolic compositions having immunomodulating components therein and methods for using the embolic compositions to treat cancer. The embolic compositions include a hydrogel embolic with the immunomodulator(s) therein.

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

The invention discloses hydrogel microspheres capable of loading radioactive isotopes and a preparation method of the hydrogel microspheres. The microsphere is formed by copolymerizing a macrocyclic ligand structure, a hydrophilic monomer and a cross-linking agent, and a macrocyclic ligand is connected with a polymer main chain through a bridging structure containing p-aminobenzoic acid and aliphatic diamine and can efficiently and stably complex various radioactive isotopes. The microspheres have the characteristics of being close to water in density, good in suspension property, smooth in surface and rich in elasticity, and are easily and uniformly distributed in tumor peripheral blood vessels. The preparation method comprises the following two routes: firstly synthesizing the functional monomer and then copolymerizing, or firstly preparing the microspheres and then gradually grafting. The problems that existing microsphere nuclides are prone to falling off, high in density and poor in suspension property are effectively solved, and the microsphere is suitable for interventional radioactive embolism treatment.

Techniques for detecting embolic information for a patient. The techniques may include obtaining data identifying an ultrasound signal associated with the patient, identifying a set of candidate embolic regions in the data, identifying a set of embolic regions from among the set of candidate embolic regions, and outputting embolic information corresponding to the set of embolic regions.

The invention discloses a natural polymer polyelectrolyte microsphere as well as a preparation method and application thereof, the microsphere is of a covalent and non-covalent double-crosslinking network structure formed by crosslinking natural polymer and polyelectrolyte, and the modification degree of the crosslinked natural polymer is 1.0-50.0%; the natural polymer is a compound containing more than two carboxyl groups or amino groups or a combination of the carboxyl groups and the amino groups; and the polyelectrolyte is a compound containing more than two carboxyl groups or amino groups or a combination of the carboxyl groups and the amino groups. The preparation method comprises the following steps: S1, dissolving a natural polymer and a polyelectrolyte in a water phase to generate an electrostatic complex; s2, adding enzyme into the electrostatic complex and incubating to form microspheres; and S3, adding a condensing agent and / or a cross-linking agent, removing the unreacted condensing agent and / or cross-linking agent, and sterilizing to obtain the natural polymer polyelectrolyte microspheres. The microsphere can be used as an embolism agent in an interventional technology or a separation and purification medium of protein, antibodies and drugs or a cell and drug carrier system, or as an implant material for orthopedics, surgery, ophthalmology and medical beauty.

The present invention relates to polymer radiotherapy particles, compositions and methods of production thereof, wherein the radionuclides are alpha and / or beta-emitting radionuclides. The invention also relates to the use of said particles and compositions in the treatment of cancer and their use in localized region radiation therapy, brachytherapy and transarterial radioembolism.

This invention proposes an embolic microsphere capable of sustained drug release and controlled degradation rate, and its preparation method. The method includes: dissolving a dispersant in an oil phase liquid and stirring at a first preset temperature to obtain a dispersion; dissolving gelatin in water at a second preset temperature to obtain a gelatin solution; dissolving a compound with negatively charged groups in water, adding an alkali solution and an initiator under ice bath conditions to obtain a modified solution; adding the modified solution to the gelatin solution and stirring to obtain an aqueous prepolymer solution, which is then added dropwise to the dispersion for premixing; adding a crosslinking agent and a catalyst; and directly grafting the negatively charged groups onto the gelatin molecules via low-temperature free radical polymerization to obtain an intermediate product; and then performing post-treatment to obtain embolic microspheres. This invention eliminates the need for non-degradable materials, enabling the direct grafting of negatively charged groups onto the gelatin surface, resulting in embolic microspheres with highly efficient drug loading capacity, excellent long-term sustained drug release, and controlled degradation rate.

The invention discloses a balloon micro-catheter and belongs to the technical field of medical instruments. The balloon micro-catheter comprises a catheter body and a balloon. The tube body has a proximal end and a distal end in an axial direction thereof. The pipe body comprises an inner pipe and an outer pipe arranged outside the inner pipe in a sleeving mode, and a gap between the inner pipe and the outer pipe forms a filling cavity. A control cavity extending in the axial direction is formed in the tube wall of the outer tube, a control wire is arranged in the control cavity in a penetrating mode, the far end of the control wire is connected with the far end of the outer tube, and the near end of the control wire penetrates out of the control cavity. A first pin of the balloon is connected with the far end of the outer tube, and a second pin of the balloon is connected with the far end of the inner tube, so that the filling cavity is communicated with the balloon. When the balloon micro-catheter is used, the inner tube and the outer tube can be bent through the control wire, liquid is filled into the balloon through the filling cavity to enable the balloon to be filled and expanded, an embolism agent or an instrument is conveyed through the infusion cavity of the inner tube, and the balloon micro-catheter and an embolism micro-catheter which are independent do not need to penetrate into the balloon micro-catheter and the embolism micro-catheter respectively. The catheter operation process can be simplified, and the treatment safety can be improved.

The application discloses a polymer vesicle-stabilized drug-iodized oil emulsion and a preparation method and application thereof, to realize safe and efficient transarterial chemoembolization (TACE) treatment of hepatocellular carcinoma in situ. The drug-iodized oil emulsion system has the following advantages: simple preparation, convenient size adjustment, excellent stability, near-zero order and sustained controllable drug release rate, low blood drug concentration after transarterial embolization, and the retention time and retention amount of the drug in the liver are superior to those of free drug-iodized oil emulsion used in clinical treatment, the tumor can be completely eradicated, angiogenesis can be effectively inhibited, and adverse reactions can be reduced. In general, the polymer vesicle-stabilized drug-iodized oil emulsion has the advantages of high stability and sustained controllable drug release, and can greatly improve the embolization chemotherapy effect of hepatocellular carcinoma, and provide a safe and efficient TACE strategy.

A system or device for injecting a therapeutic agent into a patient's blood vessel, comprising a catheter structure and a turbulence-inducing structure. The catheter structure extends from a distal end to a proximal end, having an outer surface and an inner surface. The catheter structure includes an opening at its distal end, which forms a continuous flow path with a lumen extending through the catheter structure, defined by the inner surface. The turbulence-inducing structure is formed from or attached to the outer surface or distal end of the catheter structure. The turbulence-inducing structure is configured to induce turbulence in the blood flowing through a local region of the blood vessel. The turbulence-inducing structure is of a suitable size and shape so as not to completely occlude the blood vessel, allowing blood to flow through the turbulence-inducing structure.