7 results about "Nanoconjugates" patented technology

Novel nanoconjugate compositions, such as nanoparticle-oligomer arrays (NOAs), and related methods for precision therapeutics and molecular diagnostics. These compositions comprise a core, optionally a nanoparticle core, and a plurality of oligomeric strands forming a dense, highly oriented three-dimensional scaffold. This scaffold architecture is engineered to position functional molecules precisely at desired distances from the core and / or the external surface, thereby controlling their physical and chemical interactions with the core and / or microenvironment, enabling distinct functionalities not observed with the functional molecules in an unstructured formulation.

The present invention relates to proteins suitable for being used as scaffolds to which a peptide of interest is bound, or which are comprised within a conjugate to which an agent of interest is attached. It also relates to said conjugates suitable for the selective delivery of their conjugated agents of interest to specific cell and tissue types, wherein said agent can be a therapeutic agent or an imaging agent. It also relates to nanoparticles comprising such conjugates and the therapeutic uses thereof.

The present invention relates to nanostructured conjugates, more specifically to nanostructured fusion proteins suitable for the selective delivery of their conjugated therapeutic agents to specific cell and tissue types. It also relates to nanoparticles comprising such nanostructured proteins and the therapeutic uses thereof.

Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and / or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.

The invention is applicable to the technical field of biological medicine, and provides a preparation method and application of a uracil modified gold nano conjugate, the method comprises the following steps: in the presence of a reducing agent, slowly adding a uracil ligand solution into a gold precursor solution for controlled reduction reaction to form a gold nano conjugate with the average particle size less than or equal to 2 nm; and adding a sulfhydrylation uracil derivative into the obtained dispersion liquid of the gold nano conjugate, adjusting the pH value of a reaction system to be alkaline, and enabling the sulfhydrylation uracil derivative to be combined with the surface of the gold nano conjugate through an Au-S bond to obtain the uracil modified gold nano conjugate. The material has the characteristics of ultra-small size, pH-responsive surface and selective uptake of pathogenic bacteria, can efficiently penetrate through a periodontal biological membrane, and realizes efficient removal and toxicity blocking of periodontal pathogenic bacteria by interfering bacterial proton dynamic potential and inhibiting toxicity factor secretion.

This invention relates to the field of biomedical technology and provides a method for preparing uracil-modified gold nanoconjugated materials and their applications. The method includes the following steps: in the presence of a reducing agent, a uracil ligand solution is slowly added to a gold precursor solution for a controlled reduction reaction to form gold nanoconjugated materials with an average particle size ≤2 nm; a thiolated uracil derivative is added to the dispersion of the obtained gold nanoconjugated materials, and the pH of the reaction system is adjusted to alkaline, so that the thiolated uracil derivative is bound to the surface of the gold nanoconjugated materials through Au-S bonds, thereby obtaining uracil-modified gold nanoconjugated materials. This material possesses ultra-small size, pH-responsive surface, and selective uptake characteristics by pathogens, enabling it to efficiently penetrate periodontal biofilms and achieve efficient clearance and virulence blocking against periodontal pathogens by interfering with bacterial proton kinetic potential and inhibiting the secretion of virulence factors.

The present invention relates to proteins suitable for being used as scaffolds to which a peptide of interest is bound, or which are comprised within a conjugate to which an agent of interest is attached. It also relates to said conjugates suitable for the selective delivery of their conjugated agents of interest to specific cell and tissue types, wherein said agent 5 can be a therapeutic agent or an imaging agent. It also relates to nanoparticles comprising such conjugates and the therapeutic uses thereof.