57 results about "Embolic Agent" patented technology

A system for transvascular delivery to an aortic arch of a patient includes an embolic protection device, a connector mechanism, and a catheter or sheath for delivering the embolic protection device to a working zone. The embolic protection device includes a support frame having a distal portion and a proximal portion, and a filter member attached to the support frame and configured for preventing embolic materials from passing there through. At least one of the distal portion and the proximal portion includes a spring section configured for providing a radial force between the support frame and a wall of the aortic arch when in an expanded state. The embolic protection device is pivotable axially but not radially relative to the connector mechanism.

A method and a system for thermally or hyperthermally treating an object. A precipitating hydrophobic injectable liquid (PHIL) embolic agent is prepared and enhanced with a magnetic nanoparticle (NP). A delivery device is advanced to a target area and the PHIL−IONP embolic agent is injected directly at the target area. The PHIL and IONPS are observed in-situ using complementary imaging and an impulse is applied to the target area to generate heat sufficient to thermally ablate or induce hyperthymia at the target area. Additional impulses applied to the target areas at later times generate heat sufficient to ablate or induce hyperthymia at the target.

The invention provides a nano embolism microsphere based on a magnetocaloric effect and a preparation method and application thereof, and relates to the field of medicines. According to the nano embolization microsphere, mesoporous ferroferric oxide is used as a carrier, and rificiguat and bevacizumab are loaded at the same time. The preparation method has the beneficial effects that the magnetic nano embolism microsphere system is constructed for the first time and is combined with the magnetocaloric effect; according to the invention, the embolism system of the magnetic nano-microsphere loaded rificiguat and bevacizumab is constructed for the first time; compared with an embolism agent for independently embolizing the blood vessel, the nano embolism microsphere disclosed by the invention also plays a role in killing residual tumor cells; compared with an uncontrollable embolism agent, the nano embolism microsphere disclosed by the invention can be used for accelerating drug release in an alternating magnetic field and a slightly acidic environment.

This application provides a premix, kit, and application of a premix for preparing an embolic agent. The premix uses a poloxamer to sodium alginate mass ratio of 9:1 to 20:1, which enables the formation of an injectable solution while maintaining good gel properties, and offers ease of preparation and use.

Optical transmission microcatheter devices and methods of endovascular embolization are described herein. A microcatheter device is provided that includes a working lumen and a mechanical protection waveguide. The working lumen has at least one outlet port at a distal end of the working lumen and is configured to provide an intravascular injection of a photoactivated embolic agent (PEA) to a target vessel via the at least one outlet port. The mechanical protection waveguide (MPW) is operatively connected to the working lumen and configured to emit at least one electromagnetic wave via the at least one outlet port for delivery to the target blood vessel.

The invention provides a premixing agent for preparing an embolic agent, a kit and application of the premixing agent. The premix adopts poloxamer and sodium alginate in a mass ratio of 9: 1-20: 1, can form a solution with good injectability in use, keeps good gel performance, and is good in preparation and use convenience.

The present invention relates to the field of medical technology, and discloses an injection device for a protective embolic agent through a blood vessel cavity, comprising a first injection syringe and a second injection syringe, wherein the first injection syringe and the second injection syringe are externally detachably connected to a three-way joint, the interior of the three-way joint is fixedly connected to a connecting ring, the exterior of the connecting ring is detachably connected to a locking ring, the interior of the locking ring is threadedly connected to a connector first, the interior of the connector first is slidably connected to a connector first, the interior of the connector first is detachably connected to a connector second, and the interior of the connecting ring is slidably connected to multiple push rods. In the present invention, the difficulty of maintenance is reduced, and the elastic card plate, sealing ring, and connecting tube in the receiving groove cooperate with each other to form an excellent sealing barrier, effectively preventing leakage of the embolic agent, reducing irritation and adverse reactions to human tissue, and further improving the safety and reliability of treatment.

The invention provides a developing agent which is modified iopamidol, a clinically safe nonionic hydrophilic developing agent iopamidol is subjected to structural modification, a hydrophilic side chain and a connecting arm are introduced, and the iopamidol is introduced into a gelatin degradable microsphere matrix with good biocompatibility in a covalent bonding manner; the degradable non-ionic X-ray developing microsphere with good biocompatibility is formed. Developing microspheres prepared by adopting the developing agent provided by the invention not only keep excellent X-ray developing performance, solve the problems of aggregation tendency and biocompatibility of traditional developing microspheres and realize real-time visual monitoring of an embolism process, but also have degradability and good biological safety, and are not only suitable for permanent embolism treatment, but also suitable for treatment of embolism. The solid developing embolism agent can also be expanded to the fields of temporary embolism, tissue engineering and the like, and the solid developing embolism agent with precise developing and safe degradation performance is provided for minimally invasive interventional therapy of diseases such as tumor intervention and vascular malformation.

The application relates to a composite nanogel and a preparation method and application thereof, in particular to the technical field of biomedical materials. The composite nanogel comprises a nanogel framework and tirapazamine and folic acid loaded on the nanogel framework, wherein raw material components of the nanogel framework comprise a temperature-sensitive monomer and a monomer containing a catechol group. The composite nanogel provided by the application can solve the problems that poor blood vessel adhesion of traditional embolic agents easily leads to embolism recanalization, simple physical embolism is difficult to completely remove hypoxic tumor cells, and existing treatment strategies cannot effectively reverse the immune suppression microenvironment after embolism and activate the systemic anti-tumor immune response.

The present disclosure provides compositions including alginate microspheres capable of self-degradation upon rehydration, the alginate microspheres comprising alginate, alginate lyase, and divalent metal ions. The present disclosure also provides methods of making compositions including alginate microspheres capable of self-degradation upon rehydration, comprising alginate, alginate lyase, and divalent metal ions. The present disclosure also provides methods of inducing an embolism in a subject in thereof, and syringes containing the compositions of the present disclosure for use in the methods thereof.

A detachable tip sheathed balloon microcatheter is provided for delivering an embolic agent to a target location for the embolization of an arteriovenous malformation (AVM). The detachable tip sheathed balloon microcatheter including a balloon microcatheter including a first shaft and an inflatable balloon that is coupled to a distal end portion of the first shaft; and a detachable tip assembly that is configured to be detachably coupled to the first shaft of the balloon microcatheter. The detachable tip assembly includes a protective balloon sheath that is coupled to a proximal end portion of the second shaft, wherein when the detachable tip assembly is coupled to the balloon microcatheter, the protective balloon sheath surrounds at least a portion of the inflatable balloon.

A nanocarbon-iodine calcium alginate microspheres and a preparation method thereof are provided, the nanocarbon is added to the microspheres to enhance an imaging capability of iodine under X-ray, which is a good way to solve a problem that an embolic agent in clinical application cannot be imaged under X-ray. In addition, the preparation method is simple with good stability and safety. It is proved through experiments that the microspheres can be imaged under conventional interventional X-ray examination devices in CT and DSA, it is proved through animal experiments that the microspheres have good X-ray imaging performance and embolization effect.

The present invention belongs to the technical field of medical devices, and specifically relates to an occluder and an occlusion system. The occluder includes a fixing portion, a sealing portion, and a connecting portion connected between the fixing portion and the sealing portion. The occluder also includes a plurality of hollow ablation parts, which are arranged on the fixing portion. The occlusion system includes a medium conveying device that can be detachably connected to the connecting portion. By arranging the ablation part on the fixing portion, while the occluder blocks the mouth of the left atrial appendage, the ablation part cooperates with the refrigerant to freeze the left atrial appendage, so that an isolation zone is formed on the inner wall of the left atrial appendage, thereby blocking the conduction of electrical signals between the left atrial appendage and the left atrium, and realizing electrical isolation between the left atrial appendage and the left atrium. In addition, the ablation part located at the fixing portion can also cooperate with the embolic agent to increase the anchoring ability of the fixing portion. After the embolic agent is injected and expanded, the ablation part presses against the inner wall of the left atrial appendage, further reducing the possibility of the occluder falling off from the anchoring position.

The present invention discloses the use of a short-term embolic agent in reducing drug accumulation in the liver, hepatic clearance and / or liver toxicity. The present invention provides the use of a short-term embolic agent in the manufacture of a medical composition for: (a) temporarily embolizing blood vessels supplying the liver; and (b) reducing the accumulation of a drug subsequently or concurrently administered intravenously in the liver. The strategy aims to minimize the exposure of a drug (such as LNP) to the liver by temporarily blocking the blood supply to the liver via the portal vein and / or arteries. The present invention significantly reduces the non-specific accumulation of a drug in the liver by temporarily blocking the portal vein, arterial and / or their branch blood flow, thereby greatly reducing the opportunity for the drug to enter the liver from a hemodynamic root.

The invention provides a medicine injection tool and a medicine injection module, which can reduce the burden of an operator and inhibit the adhesion of a medicine such as a liquid embolic substance to a joint inner cavity. A drug injection tool (1) in which a catheter (2) is connected to the tip side (A) and a drug accommodated in a syringe (31) is supplied from the base end side (B), said catheter (2) being provided with a catheter body (21) having a catheter lumen (21a) and a joint (22) that is joined to the base end side (B) of the catheter body (21) and has a joint lumen (224) that communicates with the catheter lumen (21a), the drug supplied from the syringe (31) is injected into the living body through the catheter lumen (21a) without passing through the adapter lumen (224).

A temperature-stable double-emulsion droplet drug-loaded microsphere, and its preparation method and application. The present invention belongs to the field of biomedicine technology. The purpose of the present invention is to solve the technical problem that current drug-loaded microspheres are difficult to store for a long time and have poor temperature stability. The method of the present invention comprises: dissolving the drug in deionized water to obtain an inner phase, adding PDMS and its curing agent to white oil to obtain an intermediate phase; dissolving Tween 80 in deionized water to obtain an outer phase; then generating double-emulsion droplets using microfluidics technology; and reintroducing the double-emulsion droplets into the outer phase and curing at room temperature to obtain drug-loaded microspheres. The drug-loaded microspheres of the present invention are mixed with a storage solution composed of propylene glycol, gum arabic, and deionized water and then used as an embolic agent. The embolic agent of the present invention has excellent temperature stability, fluidity, embolic properties, and long-term stable storage. It is also highly versatile, and the effective active ingredients can be replaced and adjusted as needed.

The invention relates to the technical field of new material detection, in particular to a medical device for intravascular embolism treatment and a control system thereof.The medical device comprises a miniature pressure sensor, a temperature sensor, a magnetic sensor, an LED lamp, a resistance-type heating piece, a catheter, a display screen, an embolism agent storage tank, an embolism agent conveying pipeline, a carrier, a magnetic field generator, the control system and a spiral CT scanner; the high-precision blood vessel 3D model is constructed through the medical image data, the injection speed and the injection amount of the embolic agent are planned, a reasonable injection scheme of the embolic agent and the complete patient blood vessel 3D model are obtained, embolic agent injection can be conveniently conducted on a patient subsequently, and by accurately controlling the intensity and the direction of the magnetic field, the blood vessel 3D model can be obtained. Real-time and accurate positioning of the position and direction of the catheter in a blood vessel is achieved, and accurate release of an embolic agent is achieved through an embolic agent release system integrating temperature control and light curing functions.

The invention relates to composite nanogel as well as a preparation method and application thereof, in particular to the technical field of biomedical materials. The composite nanogel comprises a nanogel skeleton, tirapazamine and folic acid, the tirapazamine and the folic acid are loaded on the nanogel skeleton, and raw material components of the nanogel skeleton comprise a temperature-sensitive monomer and a monomer containing a catechol group. The composite nanogel provided by the invention can solve the problems that a traditional embolism agent is poor in blood vessel adhesion and easy to cause embolism recovery, hypoxia tumor cells are difficult to thoroughly remove by pure physical embolism, and an immunosuppressive microenvironment after embolism cannot be effectively reversed and systemic anti-tumor immune response cannot be activated by an existing treatment strategy.

[0003] A light-transmitting microcatheter device and method for intravascular embolization are described herein. A microcatheter device is provided, comprising a working lumen and a mechanically protected waveguide. The working lumen has at least one exit port at a distal end of the working lumen and is configured for intravascular injection of a photoactivated embolic agent (PEA) into a target vessel through the at least one exit port. A mechanically protected waveguide (MPW) is operably connected to the working lumen and configured to emit at least one electromagnetic wave through the at least one exit port for delivery to the target vessel.

A system or device for infusing a therapeutic agent to a blood vessel of a patient includes a catheter arrangement and a turbulence inducing structure. The catheter arrangement extends from a distal end to a proximal end, having an outer surface and an inner surface. The catheter arrangement includes an opening at a distal tip of the catheter arrangement in a continuous fluid passage having a lumen extending through the catheter arrangement defined by the inner surface. The turbulence inducing structure is formed by or attached to the outer surface of the catheter arrangement or the distal tip of the catheter arrangement. The turbulence inducing structure is configured to induce turbulence on blood flowing through a localized region of the blood vessel. The turbulence inducing structure is dimensioned and shaped appropriately to incompletely occlude the blood vessel such that the blood can flow through the turbulence inducing structure.

The invention discloses body temperature responsive self-adhesive gel microspheres as well as a preparation method and application thereof, and relates to the technical field of medicines. The body temperature responsive self-adhesive gel microspheres comprise a photocuring structure stabilizing unit material and a body temperature responsive self-adhesive unit material; the photocuring structure stable unit material comprises at least one of a natural polymer derivative material and a synthetic polymer material; the body temperature responsive self-adhesive unit material can be subjected to chain segment migration and re-entanglement at a physiological temperature. The gel microsphere has good temperature-controlled self-adhesion capability and interface adhesion property, and can be used as an embolism agent for treating vascular embolism.

Provided in the present application are the use of zein as an embolic agent, a zein embolization system and a zein-drug composite embolization system, and the use in the preparation of a drug for transcatheter arterial chemoembolization. The present application belongs to the technical field of medicine. In the present application, zein is used as an embolic agent in the preparation of a drug for transcatheter arterial chemoembolization, which has an excellent therapeutic effect. Specifically, in the present application, zein is used as an embolic agent to facilitate the starvation therapy of TACE. In addition, zein also has high tissue adhesion, so that a zein-based embolization system has a high mechanical strength, and can resist deformation caused by the blood pressure and detachment caused by blood flow flushing. In addition, in the present application, zein is used as an embolic agent to restrict the site of drug action and facilitate the extension of the therapeutic approaches of a drug in chemotherapy. On this basis, zein is integrated with TACE-supported starvation therapy, can be used for TACE treatment of liver cancer, and is beneficial to improving the therapeutic effect.

This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas. The disclosure also relates to shear-thinning compositions comprising silicate nanoparticles, gelatin or a derivative thereof, and a contrast agent. In some examples, the shear-thinning compositions comprise about 1.5% to about 10% by weight of silicate nanoparticles and about 0.5% to about 6.75% by weight of gelatin or a derivative thereof.

A nanocarbon-iodine calcium alginate microspheres and a preparation method thereof are provided, the nanocarbon is added to the microspheres to enhance an imaging capability of iodine under X-ray, which is a good way to solve a problem that an embolic agent in clinical application cannot be imaged under X-ray. In addition, the preparation method is simple with good stability and safety. It is proved through experiments that the microspheres can be imaged under conventional interventional X-ray examination devices in CT and DSA, it is proved through animal experiments that the microspheres have good X-ray imaging performance and embolization effect.

The invention discloses a developing plasticizer, a preparation method and a liquid embolism agent, and relates to the field of medical materials. According to the invention, citric acid, an epoxy compound and hydrogen iodide are taken as raw materials to synthesize the citric acid iodo-ester compound connected with the iodine atoms through covalent bonds, so that the iodine atoms are uniformly arranged on the molecules of the citric acid iodo-ester compound, and the dispersity of the iodine atoms when the iodine atoms are applied to the liquid embolism agent is improved. By adding the citric acid iodo-ester compound, the problems that in the prior art, after an additional developing agent needs to be added, the mixing compatibility of the developing agent and cyanoacrylate is poor, and the mechanical property of the cured cyanoacrylate is reduced are solved. When the developing plasticizer is applied to a liquid embolism agent, the liquid embolism agent has developing performance, and the embolism agent can be directly observed in the embolism process.

This invention belongs to the field of biomedical technology, specifically disclosing an injectable embolic agent, its preparation method, and its application. The embolic agent is a hydrocolloid system containing core-shell structured nanoparticles: the core contains Cu... 2+ Salt and ATOX1 inhibitors, where ATOX1 inhibitors can inhibit copper ion efflux and promote intracellular copper accumulation, and interact with Cu 2+ It synergistically induces copper death in tumor cells; the shell is a thermosensitive block copolymer hydrogel that can interact with Cu. 2+ Coordination bonds are formed, enhancing the stability of nanoparticles, while a sol-gel transition occurs at physiological temperatures, enabling precise vascular embolization; the overall core-shell structure allows for the formation of Cu... 2+ The sustained-release effect of ATOX1 inhibitors was observed. In the VX2 rabbit hepatocellular carcinoma model, this embolization agent significantly improved tumor necrosis rate and reduced metastasis rate compared to traditional iodized oil embolization; it also downregulated hypoxia- and angiogenesis-related factors such as HIF-1α, VEGF, and CD31, inhibited MMP9-mediated tumor invasion and metastasis, and promoted CD8+. + T-cell infiltration effectively improves the tumor immunosuppressive microenvironment after transarterial chemoembolization.

The invention provides a duplex injection and suction device. The duplex injection and suction device comprises a shell and an injection and suction driving assembly, the shell is provided with two installation structures arranged side by side, and the two installation structures are used for installing and maintaining a first injector and a second injector correspondingly; the injection and suction driving assembly is connected with the shell and used for driving the first injector and the second injector to conduct pushing injection and suction synchronously. One injector sucks blood to block blood flow in a blood vessel, and the other injector injects embolism substances into the blood vessel, so that the embolism substances are prevented from drifting along with the blood flow, the embolism substances accurately act on a target blood vessel area, operation can be completed with one hand, and the operation difficulty is reduced.

To provide a preparation for tumors and a method for preparing the same.SOLUTION: A tumor preparation, characterized in that the tumor preparation comprises active metal microspheres, wherein the active metal microspheres are prepared from an active metal, and the active metal has a metal activity stronger than that of hydrogen and is selected from at least one of magnesium, zinc, gallium, manganese and tin. Preferably, the active metal microsphere has a particle size of 0.1 to 500 microns.SELECTED DRAWING: None