7 results about "Synthetic protein" patented technology

The disclosure relates to methods for treating cancer. More particularly, the disclosure relates to use of chimeric non-natural synthetic proteins, in combination with non-tyrosine targeting kinase inhibitors (NTKIs), in treating cancer and preventing intrinsic and / or acquired resistance to NTKIs.

The disclosed methods relate to a strategy for producing ground truth quantification ratios (both synthetic knockouts and simulated dose response gradients) using synthetic peptides mixed with a human proteome background. These, synthetic, bespoke proteins serve as a built in quality control for sample preparation for proteomics workflows. Additionally, mixtures of synthetic peptides are combined to form assembled synthetic proteins that can be spiked into samples at the start of processing (e.g., trypsin digesting, purification, etc.). In this way, problems in processing methods can be discovered. Sequences can be engineered to inform how well samples are being processed.

The application discloses a synthetic protein design method based on protein feature engineering and diffusion model. First, a P-BLAST tool is used to search for homologous sequences of a query sequence in a non-redundant NR database by taking a target protein sequence as the query sequence; feature engineering is performed on the screened homologous sequences by using ProtParam-7 and ProtFactor-5; data represented by the ProtParam-7 and ProtFactor-5 features are taken as original protein input diffusion model; multidimensional screening is performed on the generated candidate proteins; wet experiments are adopted to evaluate the functional activity and structural stability of the candidate proteins, and proteins meeting the conditions are taken as the final generated results. The method combines protein sequence feature extraction and diffusion model generation, and through multidimensional screening and experimental verification, it is ensured that the generated protein is close to the target protein in structure and function.

A system is disclosed for de novo protein generation. The system receives a set of design condition(s) that specify target characteristics of a synthetic protein. The system defines a modular energy function as a composition of a diffusion energy component and one or more conditioner energy components. The system applies a diffusion model to determine a denoised protein backbone. In applying the diffusion model, in each sampling step: the system transforms one prior sampled state of the synthetic protein from unconstrained space into constrained space based on the one or more design conditions, denoises the prior sampled state in the constrained space, and samples a subsequent sampled stated by applying a gradient of the modular energy function to the denoised prior sampled state in the constrained space. The final sampled state is a denoised protein backbone for the synthetic protein that satisfies the set of design condition(s).

A system is disclosed for de novo protein generation. The system receives a set of design condition(s) that specify target characteristics of a synthetic protein. The system defines a modular energy function as a composition of a diffusion energy component and one or more conditioner energy components. The system applies a diffusion model to determine a denoised protein backbone. In applying the diffusion model, in each sampling step: the system transforms one prior sampled state of the synthetic protein from unconstrained space into constrained space based on the one or more design conditions, denoises the prior sampled state in the constrained space, and samples a subsequent sampled stated by applying a gradient of the modular energy function to the denoised prior sampled state in the constrained space. The final sampled state is a denoised protein backbone for the synthetic protein that satisfies the set of design condition(s).

The present invention relates to a synthetic protein comprising at least one synthetic amino acid bearing a diene group and at least one thioether bond, to a method for preparing said synthetic protein and to the use of said synthetic protein for the preparation of a pharmaceutical composition.

A synthetic protein molecule comprises a scaffold and at least one ligand bound to the scaffold. The scaffold is selected to mimic a conformation of a naturally occurring monomeric protein. A variety of such naturally occurring monomeric proteins exhibit a tendency to aggregate to form a variety of oligomers. The at least one ligand is selected for its affinity for the variety of oligomers in order to inhibit their aggregation. An associated method for synthesizing a synthetic protein molecule is also disclosed. The synthetic protein molecule may be a foldamer.