Method for preparing iodic liquid embolic agent capable of long-time self-developing

A liquid embolic agent and organic solvent technology, which is applied in the preparation of X-ray contrast agents, medical science, surgery, etc., can solve the problems of increasing the workload and cost of postoperative review, and achieve reduced treatment costs, stable performance, and simple preparation Effect

Active Publication Date: 2009-08-26
山东大正医疗器械股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Temporary development will increase the workload and cost of postoperative reexamin...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1), first synthesize iodine-containing product polyvinyl alcohol iodine (I-PVA): reactant polyvinyl alcohol (PVA) powder 6.0g is put into 250ml round bottom flask, add the dry pyridine of 30ml, stir and make it mix 2 Then remove pyridine with a rotary evaporator, dissolve the remaining substance in 100ml of dry dimethyl sulfoxide (DMSO), remove moisture, slowly heat up to 60°C, stir with a magnetic stirrer until the PVA is completely dissolved, and then After cooling to 45°C, a solution of 3.00 g of triiodobenzoyl chloride and 6 ml of dichloromethane was added dropwise, and then excess triethylamine (about 6 ml) was added. The mixture was cooled to room temperature, continued to stir for 24 hours, then poured the mixture in the flask into about 1 g of butyl ether and acetone mixture (the mixture ratio was butyl ether / acetone=80 / 20), collected the precipitate, washed with water, and dried in vacuo , the iodine-containing product (I-PVA) was 4.5 g.

[0020] (2), above-m...

Embodiment 2

[0022] (1), first synthesize iodine-containing product polyvinyl alcohol iodine (I-PVA): put 6.0g of PVA powder into a 250ml round bottom flask, add 30ml of dry pyridine, stir and make it mix for 2 hours, then use a rotary evaporator Remove pyridine, dissolve the remaining substance in 100ml of dry dimethyl sulfoxide (DMSO), remove moisture, slowly raise the temperature to 60°C, stir with a magnetic stirrer until the PVA is completely dissolved, then cool to 45°C, add dropwise A solution of 3.00 g of N-(2.6-diiodocarboxyphenyl)-3.4.5-triiodobenzamide acid chloride and 6 ml of dichloromethane was added with excess triethylamine (about 6 ml). The mixture was cooled to room temperature, continued to stir for 24 hours, then poured the mixture in the flask into about 1 g of butyl ether and acetone mixture (the mixture ratio was butyl ether / acetone=80 / 20), collected the precipitate, washed with water, and dried in vacuo , The iodine-containing reaction product was 4.5 g.

[0023] (...

Embodiment 3

[0025] Dissolve 35 g of the iodine-containing product (I-PVA) obtained in Example 1 in 65 g of N-methyl-pyrrolidone, mix well, and sterilize to obtain an iodine-containing long-term self-developing liquid embolism.

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Abstract

The invention provides a method for preparing an iodic liquid embolic agent capable of long-time self-developing. Water-soluble polyvinyl alcohol (PVA) is added with pyridine to be stirred and evaporated for removing the pyridine. Residual reactant is dehumidified and dissolved in dimethyl sulphoxide (DMSO) organic solvent and then is added with solution of iodic compound and dichloromethane and added with triethylamine; and an obtained iodic product (I-PVA) is poured into a mixture of butyl ether and acetone to be deposited and separated. The iodic product is washed in water, is dried and then is confected into the liquid embolic agent by the dimethyl sulphoxide or N-methyl-ketopyrrolidine organic solvent. The liquid embolic agent prepared by the invention is injectable and can develop under X-ray for a long time. When contacting with blood, the organic solvent diffuses fast for depositing and separating solid to take embolic effect. The embolic agent can be used for embolotherapy of cerebral arteriovenous malformation, tumour and other vascular disease.

Description

technical field [0001] The invention relates to a medical liquid embolic agent, in particular to a preparation method of an iodine-containing liquid embolic agent capable of long-term self-development. Background technique [0002] We know that embolic agents play an important role in interventional embolization operations. Currently, liquid embolic agents widely used in clinics are made by mixing X-ray-opaque substances, such as tantalum powder and iodine-containing compounds, into polymers. [0003] Invention patent ZL021344116 discloses a new type of peripheral blood vessel embolic agent, the metal core of the embolic agent is connected by a binder to form a granular structure. The development effect is produced by metal, which has good visibility under X-ray; the specific gravity is moderate, which facilitates the formation of thrombus in blood vessels, and is not easy to reflux, effectively avoiding accidental thrombus. Invention patent ZL 2006101456411 discloses a non...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/18A61K49/04
Inventor 刘江州衣瑛李秀英闫芳芳
Owner 山东大正医疗器械股份有限公司
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