Microsphere type embolic agent and preparation technology thereof

A preparation process and technology of embolic agent, which is applied in the field of microsphere embolic agent and its preparation process, can solve the problems of non-biocompatibility of embolic agent, different particle sizes of embolic agent, difficulty in identification and manipulation, etc., and achieve Strong target fixation, easy manipulation, and stable positional fixation

Inactive Publication Date: 2008-02-20
SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process is relatively simple, but the prepared embolic agent has different particle sizes and is difficult to separate. At the same time, the above-mentioned embolic agent is not biocompatible and has a hard texture, which is difficult to identify and manipulate in vivo and in vitro, and may cause incomplete embolism.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh the molecular weight 2×10 4 -5×10 4 Add 100g of polyvinyl alcohol into 500g of water, heat to 90°C, and stir at a speed of 190r / min for 2 hours. After the polyvinyl alcohol is fully dissolved, cool the solution to room temperature, then add 1.2g of sodium acrylate, and stir at a speed of 190r / min. Stir at a high speed for 6 hours to fully react the above-mentioned reactants. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature.

[0036] Weigh 1.63g of 2-acrylamide-2-methylpropanesulfonic acid, 1.034g of potassium persulfate and 17.3g of water and stir and mix evenly. After the potassium persulfate is fully dissolved, add 40g of the above-mentioned functionalized macromolecular intermediate, and stir. To obtain a polymer monomer solution; take another 240mL of butyl acetate, add 4.55g of cellulose acetate, fully stir at a stirring speed of 2...

Embodiment 2

[0039] Weigh molecular weight 3×10 4 ~4×10 4 Add 200g of polyethylene glycol to 500g of water, heat to 80°C, and stir at a speed of 100r / min for 2.5h at the same time, after the polyethylene glycol is fully dissolved, cool the solution to room temperature, add 2.0g of butyl acrylate, Stir for 4 hours at a speed of 1 / min to fully react. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature.

[0040] Weigh 1.73g of 2-acrylamide-2-methylpropanesulfonic acid, 1.044g of potassium persulfate and 18.8g of water and stir and mix evenly. After the potassium persulfate is fully dissolved, add 45g of the above-mentioned functionalized polyvinyl alcohol intermediate, and stir , to obtain a polymer monomer solution; take another 270mL butyl acetate, add 4.60g cellulose acetate, fully stir at a stirring speed of 300r / min for 10min, and then pass N 2 10min, heat at th...

Embodiment 3

[0043] Weigh the molecular weight 4×10 4 ~5×10 4 Add 100g of amylose to 500g of water, heat to 90°C, and stir at a speed of 190r / min for 3 hours. After the amylose is fully dissolved, cool the solution to room temperature, add 1.2g of sodium acrylate, and stir at a speed of 190r / min. Stir for 6 hours to make it fully react. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature;

[0044] Weigh 1.83g of 2-acrylamide-2-methylpropanesulfonic acid, 1.054g of potassium persulfate and 20.3g of water and stir and mix evenly. After the potassium persulfate is fully dissolved, add 40g of the above-mentioned functionalized polyvinyl alcohol intermediate, and stir Mix well to obtain a polymer monomer solution; take another 300mL of butyl acetate, add 4.65g of cellulose acetate, fully stir at a stirring speed of 360r / min for 10min, and then pass N 2 10min, heat at t...

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Abstract

The invention provides a microsphere embolic agent, which is an elastic microsphere formed by the crosslink polymer of the functionalized macromolecules with the biocompatibility, and the particle size of the microsphere ranges from 1 Mum to 1500 Mum. The preparing technology includes the steps as follows: in a covalent link, linking a crosslinkable micromolecules with an acrylic acid structure on the polyvinyl alcohol, polyethylene glycol or polysaccharide macromolecules, forming the functionalized macromolecules; after that, the functionalized macromolecules and the monomer of the 2- acrylamide-2-methyl propanesulfonic acid undertakes opposite suspension polymerization, obtaining the crosslink polymeric microsphere embolic agent. The embolic agent has comparatively large retractility and elasticity, whose particle size is controllable and has perfect dispersiveness; moreover, the raw material is non-toxic and at the same time has good biocompatibility and stability. The preparing technology is a real chemosynthesis technology, whose material and preparing process does not produce any virus pollution, according with various requirements of the international embolic agent, which can replace various import and domestic expensive embolic agent products and is extensively applicable to various surgeries in the interventional radiology field.

Description

technical field [0001] The invention relates to an embolic agent and a preparation process thereof in the technical field of medical materials, in particular to a microsphere embolic agent for interventional therapy for tumor diseases and a preparation process thereof. Background technique [0002] With the maturity of interventional therapy, it is being more and more widely used in the field of medical technology. The principle of interventional therapy is to use a high-definition medical imaging device to guide a catheter into the tumor site in the human body through a small incision, and then infuse anti-tumor drugs through the blood supply artery or block the blood supply of the tumor tissue, so that the tumor can be cured in a short time. Necrosis, atrophy, to achieve the purpose of treatment. The key technology of interventional therapy is to choose the appropriate particle embolization agent for blocking the blood supply of tumor tissue. Mixed particles of paraffin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10
Inventor 姚飞孙小薇杨吉
Owner SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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