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Detachable tip microcatheter

A catheter and miniature technology, applied in the field of catheters, can solve the problems that the risk of nerve microcatheters cannot be completely eliminated, and the treatment effect is small, so as to prevent separation or bursting, minimize potential harmful effects, and high bursting strength Effect

Active Publication Date: 2011-09-14
TYCO HEALTHCARE GRP LP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alternatively, the clinician will try to minimize reflux by underfilling the cavity, which would result in less than the desired therapeutic effect and would not completely eliminate the risk of nerve microcatheter entrapment

Method used

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  • Detachable tip microcatheter

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0133] Example 1: Use of detachable biodegradable tips

[0134] This example shows how one can embolize a blood vessel with a catheter. The term "embolization" refers to the process by which a substance is injected into a blood vessel, typically blocking the blood vessel to stop unwanted blood flow. Methods of materials for embolization are set forth in US Patent No. 5,695,480, which is hereby incorporated by reference in its entirety and which forms a part of this specification. Alternatively, materials for embolization are commercially available from ev3 Neurovascular, Irvine, California, USA. Examples include Onyx Onyx sold in 18, 20, 34 and 500 HD embolic compounds Embolic compounds. For example, in the case of a patient having an aneurysm in the brain, the embolic material proposed in US 6,454,738 may be delivered to the site of the aneurysm through a catheter.

[0135] As mentioned above, one commercially available embolic agent is Onyx and related kits, Onyx...

example 2

[0140] Example 2: Use of detachable biodegradable ends

[0141] The catheter of Example 1 may be used, wherein the predetermined tip separation region is a separate tip that is sleeved on the distal end of the catheter, such as Figure 12 shown in . The separate ends may be constructed of a biocompatible, biodegradable polymer. Biodegradable polymers may contain enzymatic degradation sites which, in the presence of suitable enzymes, degrade the termini into bioabsorbable components.

example 3

[0142] Example 3: Use of a detachable tip with a grip for mechanical extraction

[0143] Such as Figure 14 The tip shown with the grippable element can be removed from the catheter. A guidewire or other mechanical element can be used to stabilize or extract the tip with the grippable element. The tip can then be prevented from migrating into the systemic circulation or embedded in the vasculature. Such a stabilized end can retain the end in situ for localized deployment of any other component (eg, imaging agent or bioactive agent) provided the end has suitable delivery properties as described herein or well known in the art. For example, an active agent (eg, a bioactive agent) can be non-covalently attached to the termini for release in an aqueous environment under suitable applicable conditions.

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Abstract

A microcatheter for delivering embolic agent to a vascular site is provided. The microcatheter has a biocompatible or biocompatible and biodegradable tip which can be detachably engaged to the microcatheter body by a thermoplastic sleeve. Once the embolic agent is delivered to the desired vascular site, the tip of the microcatheter is often entrapped within the mass of the liquid embolic fluid. Using the microcatheter, the clinician can retract the microcatheter at a predetermined retraction force thereby disengaging the tip from the microcatheter body allowing for easier removal of the microcatheter.

Description

[0001] priority claim [0002] This application claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 61 / 090,185, filed August 19, 2008, and U.S. Provisional Patent Application No. 61 / 090,188, filed August 19, 2008 , the entire contents of each of these two US Provisional Patent Applications are hereby incorporated by reference. technical field [0003] This application relates to detachable-tipped catheters, including detachable, biocompatible-tipped microcatheters with thermoplastic sleeves. Background technique [0004] Microcatheters, including neuromicrocatheters, are typically tiny tubes that are inserted into the body through blood vessels such as the femoral artery and have a variety of uses (see, eg, US Patent Nos. 6,306,124 and 6,454,738). The microcatheter has a distal end and a proximal end, wherein, typically, at or near the distal-most end, a marking band is employed to allow a clinician to view the microcatheter as it is posi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00
CPCA61M25/0069A61M2025/0042A61L29/16A61M25/0043A61M25/0067A61M25/01A61B17/12109A61B17/12113A61B17/12186A61B2017/00955A61B2017/1205A61M25/0021A61M25/005A61M25/0108A61M25/09
Inventor 卡尔·萨瑟兰厄尔·霍华德·斯利维塔斯·乔纳·斯伯利斯马克·安东尼·斯米努克布赖恩·迈克尔·施特劳斯
Owner TYCO HEALTHCARE GRP LP
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