57 results about "VASCULAR EMBOLISM" patented technology

A snare for capture and removal of arterial emboli is disclosed. The snare is formed from a basket of interlaced filamentary members or a skeleton of interconnected flexible members. The basket has an opening at one end. A tongue extends from the basket adjacent to the opening, the tongue being offset from the basket centerline. A tether is attached to the tongue. The basket is collapsible into a collapsed configuration for delivery within an artery via a catheter. The basket is resiliently biased to expand into an open configuration upon release from the catheter. The tongue has a leading edge that engages the embolus and separates it from the artery when the snare is drawn toward it using the tether.

The invention relates to a mechanical embolism conveying instrument and a mechanical embolism conveying method. A vascular embolism spring ring system comprises an implantation object constituted by an embolism spring ring; a releasing lining assembly connected with the embolism spring ring; and a releasing conveying conductor (DDW) assembly. The releasing conveying conductor (DDW) assembly comprises an external pushing assembly and an internal traction conductor. The internal traction conductor comprises a far-end area having an increased diameter. The external pushing assembly also comprises a far-end spring tube provided with a flexible far-end area and a near-end micro-internal diameter tube. The object of the invention to release the spring ring by using the instrument releasing system is achieved, and complete releasing is guaranteed. Both of the reliability and the firmness of the mechanical instrument in an operation process are considered.

Disclosed is a microvascular anastomat. The microvascular anastomat is characterized in that the microvascular anastomat comprises two cannulas same in diameter, a sliding rod, an anastomosis nail anda nail base; each cannula is a tubular member formed by splicing two arc tube sheets in a hinged mode, a flanging arranged at the periphery of a tube opening in one end of each cannula, and a plurality of negative pressure holes are formed in the flangings around the tube opening; the sliding rod is a rod-shaped member, and the outer walls of the two cannulas are both connected with the sliding rod in a symmetrical and sliding mode, wherein the flangings of the two cannulas are opposite to each other; the nail base is a semi-annular member and is fixedly arranged on the sliding rod and located between the two cannulas; the main body of the anastomosis nail is an annular member, the annular member is fixedly provided with a plurality of pins parallel to the central axes of the cannulas, the middle of each pin is fixed to the annular member, and the whole anastomosis nail on the annular member is fixed on the nail base. The microvascular anastomat is simple in structure, the inner membrane eversion of microvessel is maintained after anastomosis, the contact area between the anastomosis nail and the micorvessel after an operation is small, and the risk of postoperative vascular embolism is greatly reduced.

The present invention belongs to the field of Chinese medicine, and is especially the purified product of notoginseng as one kind of Chinese medicinal materials and its preparation process and pharmaceutical use. The notoginseng triol-saponin composition obtained through purifying notoginseng consists of ginsenoside Rg1, ginsenoside Re and saponin R1 as main components, and contains ginsenoside Rg1 30-70 wt%, ginsenoside Re 4-15 wt% and saponin R1 7-25 wt%, with the total content of ginsenoside Rg1, ginsenoside Re and saponin R1 being up to 98 wt%. The notoginseng triol-saponin composition has obvious treating effect on vascular embolism diseases, and is used in preparing medicine for treating vascular embolism diseases.

The invention discloses an antibacterial chitosan-based hemostatic patch, which comprises a back lining layer, a hemostatic layer and a protective layer which are sequentially arranged from bottom to top; the back lining layer is a base material prepared from polypropylene or polyethylene terephthalate, and an adhesive is coated on the back lining layer; the hemostatic layer comprises a non-woven fabric on the lower side and a composite hemostatic material on the upper side, and the composite hemostatic material is composite hydrogel prepared from modified chitosan, polyethylene glycol 2000, gelatin, xanthan gum, a tea polysaccharide-nano-selenium compound, dopamine modified nano-silica and oleamide; and the protective layer is a PET (Polyethylene Terephthalate) film. The antibacterial chitosan-based hemostatic patch provided by the invention is convenient to store, carry and use, does not stimulate wounds, has good antibacterial and anti-infection effects, can realize rapid blood coagulation through adhesion sealing and activation of a blood coagulation system, and can avoid the occurrence of side effects of vascular embolism.

The invention belongs to the field of traditional Chinese medicines, and relates to an anti-tumor vascular embolism agent containing asparagus deproteinized polysaccharide and a preparation method thereof. According to the invention, the asparagus deproteinized polysaccharide is obtained from asparagus, i.e., a Chinese medicinal crop, through preparation processes such as extraction, deproteinization, purification and drying; and the asparagus deproteinized polysaccharide is added into iodine-containing solution to be prepared into a refined asparagus colloidal preparation of which every 100 ml contains 2.0-50.0 g of asparagus deproteinized polysaccharide. Experiments prove that the embolism agent has low toxicity, high compatibility with a water-soluble anti-tumor medicament and a medicament slow release effect; after the embolism agent is injected into hepatic artery, obstruction of local blood vessel can be caused to result in necrosis of tumor tissues; and the embolism agent also has a direct tumor suppression pharmaceutical effect and functions of straightening the body resistance and improving immunity and is an ending anti-tumor embolism agent with a good effect. According to the preparation method provided by the invention, the active ingredients in the medicinal crop can be efficiently reserved, the preparation of a Chinese medicinal preparation is simplified, the environment is protected, and the operation of batch production is facilitated.

The invention discloses an injection type facial filler composition gel for cosmetic and plastic surgery, and belongs to the technical field of medical treatment. The injection type facial filler composition gel is prepared from the following components in parts by weight: 10-20 parts of sodium hyaluronate, 90-100 parts of an aqueous solution for injection, 2-5 parts of collagen powder, 5-8 parts of modified particles, 0.1-0.2 part of an extraction agent, and 0.4-0.7 part of multivitamins. The injection type facial filler composition gel is safe to use, the problems of redness, swelling, vascular embolism and the like are solved, and the treated skin is attractive and natural.

The present invention relates to a method for generating a non-human model animal of an arterial occlusive disease, wherein the method is characterized in that an artery is occluded at a specific site by ligating it or with an autologous blood clot. In particular, the present invention relates to a method and a kit for generating a cardiac infarction model, as well as a cardiac infarction animal model obtained by employing the method or kit, characterized in that in a non-human experimental animal, a blood vessel is ligated downstream of an arterial site of the heart to be occluded, followed by occluding the artery at said site. In addition, the present invention also relates to a method and a system for generating a non-human animal model of arterial embolus, as well as an arterial embolus animal model obtained by employing the method or system, characterized by adding an coagulating agent to autologous blood to form an autologous blood clot and subsequently employing an angiographic apparatus in delivering the autologous blood clot into an artery.

The invention provides a vascular embolism spring ring system. The system comprises a pushing rod with an inner cavity, a releasing wire, a releasing ball and an embolism spring ring connected with the releasing ball; the releasing wire and the releasing ball are arranged in the inner cavity; and a limiting notch is formed in the side wall, close to the far end, of the inner cavity of the pushing rod. The releasing ball is matched with the limiting notch under the action of the releasing wire so as to be limited in the inner cavity of the pushing rod; the releasing ball is connected with a connecting wire; a near-end connecting piece is arranged at the near end of the pushing rod; and the releasing ball is matched with the limiting notch under the action of the releasing wire to be limited in the inner cavity of the pushing rod, so that the embolism spring ring is limited, a limiting step or an end cover for limiting the releasing ball does not need to be arranged at the far-end port of the pushing rod, the problem that the releasing ball is blocked by the limiting step or the end cover and cannot be released when being released from the far-end port is solved, and the releasing ball can be conveniently, rapidly and accurately released from the pushing rod when the releasing wire is pulled out.

The invention relates to a hemangioma plugging device, a hemangioma plugging treatment device and a hemangioma plugging system.The hemangioma plugging device comprises a net-shaped expansion structure and a guiding structure, and the net-shaped expansion structure has an unfolded state in which the net-shaped expansion structure is wound into a spiral shape from the far end to the near end and a compressed state in which the net-shaped expansion structure is delivered to hemangioma from the inside of a blood vessel; at least one part of the guide structure is arranged in an inner cavity of the net-shaped expansion structure, and when the net-shaped expansion structure is in a spiral shape, at least one part of the guide structure is unfolded in the inner cavity of the net-shaped expansion structure to be in a spiral shape. According to the invention, stable and compliant filling is realized, and the method also has the advantages of preventing hemangioma rupture, preventing vascular embolism, improving the coverage rate of a tumor neck opening, promoting the formation of thrombus in a tumor, accelerating hemangioma embolism and the like.

The invention discloses an application of a recombinant human hyaluronidase preparation. The recombinant human hyaluronidase preparation is prepared from recombinant human hyaluronidase, a buffering agent, a stabilizing agent and a nonionic surfactant, wherein the enzyme activity of the recombinant human hyaluronidase is 45 to 450,000 units/ml; the concentration of the buffering agent is 5-50 mM; the concentration of the stabilizer is 1-500mM, and the stabilizer is selected from one or more of trehalose, cane sugar, mannitol, sodium chloride and methionine; the concentration of the nonionic surfactant is 0.01%-0.1% (w/v); the pH value of the recombinant human hyaluronidase preparation is 5.0 to 8.0. The problems that when an existing clinically-used hyaluronidase extraction product is used for treating, correcting or preventing side reactions such as vascular embolism, excessive filling or uneven filling caused by hyaluronic acid filling, the intravenous administration dosage is too large, the effect is poor, and subcutaneous local treatment is poor in safety and curative effect can be solved.

The invention provides preparation and application of chitosan and propylene glycol alginate blended microcapsules, and relates to the field of microcapsule preparation and application. Chitosan is dissolved by an acetum solution with the mass percent concentration of 0.5-5%, propylene glycol alginate is dissolved by water, then the two solutions are blended, under a high-voltage static field, theblended solution is extruded into a 2-8% NaOH aqueous solution to form wet blended microcapsules, and after washing and drying, the dried blended microcapsules are obtained. The prepared chitosan andpropylene glycol alginate blended microcapsules can be taken as embolism substances for vascular embolism, the embolism substances are injected or conveyed into the target blood vessel through a catheter, so that the blood vessel at the target position is blocked, good expansibility can avoid that the microcapsules move in the blood vessel, the structures of the microcapsules are stable, and embolism can be more stable; the microcapsules can be applied to slow-release medicine and taken as a carrier of the slow-release medicine, the blended microcapsules are combined with the medicine to achieve the slow releasing effect of the medicine, and good slow releasing performance is achieved.

The invention relates to a hemangioma plugging device, a hemangioma plugging treatment device and a hemangioma plugging system. The hemangioma plugging device comprises a net-shaped expansion structure and a positioning guide structure, wherein the net-shaped expansion structure has a plane vortex-shaped expansion state; the positioning guide structure has a three-dimensional spiral expansion state, after the hemangioma plugging device is expanded, one part of the positioning guide structure is spirally arranged in a central cavity of the plane vortex, and the other part of the positioning guide structure is located outside the plane vortex, so that positioning and guiding are carried out through the positioning guide structure, the whole device is stable, the device can be stably positioned in a tumor for a long time and is not easy to move, and a tumor cavity can be filled and stably supported through the net-shaped expansion structure. While realizing stable filling, the hemangioma plugging device also has the advantages of preventing the rupture of hemangioma, preventing vascular embolism, improving the coverage rate of the neck of the tumor, promoting the formation of thrombus in the tumor, accelerating the embolism of the hemangioma and the like.

The invention discloses a medicament for preventing or treating cardiovascular and cerebrovascular diseases. The medicament comprises the following natural bulk pharmaceutical chemicals in parts by weight: 3-5 parts of gambir plant, 3-5 parts of red paeony root, 3-5 parts of oriental waterplantain rhizome, 5-8 parts of Spanishneedles herb, 3-5 parts of rehmannia root, 2-3 parts of photinia stem, 15-30 parts of chrysanthemum, 5-10 parts of barbary wolfberry fruit, 10-15 parts of green forsythia and 10-20 parts of shanzhi. The medicament has functions of inhibiting thrombosis, obviously increasing cerebral blood flow, dissolving thrombus, inhibiting platelet aggregation, reducing miocardial infarction area, reducing the total peripheral resistance of blood vessel and increasing cardiac coronary artery flow, can prevent or treat the diseases such as chest distress, angina, insomnia, headache, hemiplegia caused by cardio-cerebral vascular embolism, limbs stalemate, dribbling, local numbness, skin blood capillary burst and sciatica, and has specific curative effect on the cardiovascular and cerebrovascular diseases such as apoplexy, coronary heart disease, cerebral hemorrhage, cerebral thrombosis and other symptoms; and moreover, the medicament is a pure traditional Chinese medicine preparation, which has the advantages of reasonable formula, low cost, simple processing and obvious clinical effects and is highly praised by the patients and family members of the patients.

The invention discloses injectable hydrogel for vascular embolism, which is formed by in-situ crosslinking of aldehyde-terminated star-shaped multi-arm polyethylene glycol, polyethyleneimine and polylysine, the molar ratio of aldehyde to amino in polyethyleneimine is 1: (0.6-5), and the molar ratio of aldehyde to amino in polylysine is 1: (0-5). The in-vitro gelling time of the hydrogel is equal to or less than 8 seconds, namely 8 seconds, and the hydrogel can quickly embolize blood vessels to cause necrosis of target organs or tissues.