25 results about "VASCULAR EMBOLISM" patented technology

The invention relates to the technical field of traditional Chinese medicine health-care products, and particularly discloses an earthworm protein peptide composition for improving vascular embolism and a preparation method thereof.The earthworm protein peptide composition is prepared from, by weight, 28-34 parts of earthworm protein peptide, 20-26 parts of active pharmaceutical ingredients, 1-5 parts of ginkgo biloba extract, 12-15 parts of corn oligopeptide powder and 4-8 parts of auxiliary materials; lumbricus protein peptide, active pharmaceutical ingredients, ginkgo biloba extract and corn oligopeptide powder are used as raw materials, a solubilizing component is added in the preparation process, the solubilizing component is prepared by mixing functional extract, nattokinase and tween-80 according to a certain proportion, the functional extract is prepared by coating grape seed extract with hydroxypropyl-beta-cyclodextrin, and the solubilizing component is prepared by mixing the functional extract, the nattokinase and the tween-80 according to a certain proportion. Through the synergistic effect of the components, the antithrombotic effect of the earthworm protein peptide composition is synergistically enhanced.

The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.

The application discloses a four-stage paddle thrombus-removing micro robot, a preparation method and a magnetic field driving thrombus-removing micro robot system, relates to the technical field of micro robots, and comprises a conical drill bit, a main straight rod and a four-stage paddle group, wherein the conical drill bit is made of a biodegradable material; the bottom of the conical drill bit is connected with the main straight rod; the main straight rod is internally provided with a thrombolytic drug; the four-stage paddle group is arranged on the outer circumferential surface of the main straight rod in an axial direction; the paddle group comprises three paddle blades which are centrally symmetrical to the axis of the main straight rod; the paddle blades in the adjacent two-stage paddle groups are arranged in a staggered manner; the paddle blades are of a round head structure; the thickness of the paddle blades gradually increases from outside to inside; and the surface of the micro robot is coated with a magnetic film and is subjected to directional magnetization treatment. The application can obtain strong movement ability and stable movement state under the accurate control of a movement system, realizes intravascular drilling and crushing of a thrombus, and can biodegrade and release the thrombolytic drug after surgery, so as to solve the problem of downstream vascular embolism after drilling.

The invention discloses a locally degradable vascular embolism spring ring. The spring ring comprises an inner core shaft; the degradable spring is sleeved on the inner core shaft; the macromolecular binding wire harness is used for binding and fixing the inner core shaft and the degradable spring; wherein a plurality of binding position points are arranged on the spring rings, the macromolecule binding wire harnesses are arranged at the binding position points, the macromolecule binding wire harnesses are wound on the spring rings by at least one circle to form binding winding lantern rings, and the wire harnesses of the binding winding lantern rings are locally embedded into gaps between the degradable spring rings. And the wire harness embedded in the gap between the degradable spring rings is also partially wound on the inner core shaft. The invention further discloses a manufacturing method of the locally degradable vascular embolism spring ring. Compared with the prior art, the problem that the inner core shaft and the outer-layer degradable spring displace and slide beyond the allowable range in the pushing process when the spring ring is placed into a blood vessel is solved.

The present application relates to a kind of hemangioma occlusion device, hemangioma occlusion treatment device and hemangioma occlusion system, hemangioma occlusion device includes mesh expansion structure and guide structure, the mesh expansion structure has from the unwinding state of spiral shape around from distal end to proximal end and the compressed state for being delivered from inside blood vessel to hemangioma;At least a part of the guide structure is arranged in the lumen of mesh expansion structure, and when the mesh expansion structure is in spiral shape, at least a part of the guide structure is unwound in the lumen of mesh expansion structure in spiral shape.The present application has the advantages of preventing hemangioma rupture, preventing vascular embolism, improving the coverage of tumor neck, promoting the formation of intratumoral thrombus, accelerating hemangioma embolism and the like while realizing stable and compliant tamponade.

The utility model relates to the technical field of medical instruments, and provides a plugging support and a plugging balloon catheter, and the plugging support comprises a supporting part and an intercepting part; the supporting part can be contracted and unfolded for supporting, one end of the intercepting part is connected with the supporting part, the other end of the intercepting part is gradually contracted and extends to form a cone shape, the supporting part and the intercepting part are both provided with hollowed-out parts, and a woven mesh is arranged in the hollowed-out part of at least one of the supporting part and the intercepting part. According to the utility model, the woven mesh is arranged in the hollow part of at least one of the supporting part and the intercepting part, so that the gap of the occlusion stent is further reduced, and the woven mesh can better leave substances in blood vessels, so that the occlusion time is shortened, and the clinical requirements of acute vascular embolism occlusion are met.

The utility model relates to the technical field of medical instruments, in particular to a vascular embolism stripping and suction catheter system. The vascular embolism stripping and suction catheter system comprises a catheter, a compressible and self-expanding thrombus cutting stripper and a traction silk thread, a traction cavity and a negative pressure cavity are formed in the catheter in the length direction of the catheter, the traction silk thread penetrates through the traction cavity, one end of the traction silk thread is connected with the thrombus cutting stripper, and the other end of the traction silk thread is connected with the negative pressure cavity. One end of the negative pressure cavity is communicated with the catheter, the other end of the negative pressure cavity penetrates out of the other end of the catheter, the thrombus cutting detacher can be compressed to be arranged in the traction cavity or can be released outside the catheter in a self-expanding mode, and the other end of the catheter is provided with a negative pressure connector communicated with the negative pressure cavity. The device has the advantages that the structural design is simple and reasonable, the wall-attached embolism can be effectively cut and crushed and then sucked out through negative pressure, and the embolism can be taken out more easily.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

The utility model discloses a tissue separation pad beneficial to microvascular anastomosis, which comprises a pad, an air cushion is arranged on the inner wall of the pad, a support is arranged in the air cushion, two suture pads are arranged above the pad, and the two suture pads can be attached to each other. The utility model relates to the technical field of vascular anastomosis, in particular to a tissue separation pad beneficial to microvascular anastomosis, which can play a role in physically separating tissues around a blood vessel from a lumen of the blood vessel through the matching of a gasket, an air cushion, a winding rope, a titanium alloy layer and a bracket, and provides a relatively pure anastomosis environment. In the process, some easily-coagulated substances, fat particles, vascular adventitia and other tissues are effectively prevented from entering a vascular lumen in the anastomosis process, vascular embolism is prevented, and the tissue separation pad beneficial to microvascular anastomosis can be expanded outwards all the time by means of the elasticity of the support, so that the tissue separation pad is more stable. And the phenomenon of vascular occlusion caused by extrusion of the tissue separation pad beneficial to microvascular anastomosis is avoided.

The invention provides a vascular embolism recurrence risk prediction method and device and electronic equipment. The vascular embolism recurrence risk prediction method comprises the steps that multi-modal data of a patient at each time point is acquired, the multi-modal data of each time point comprises at least two modal data of a vascular image, a medical text, biochemical test information and a physiological signal, and the multi-modal data of at least one time point comprises the vascular image; determining a first feature and a second feature according to the multi-modal data of each time point, the first feature being obtained by analyzing correlation between the modal data and reflecting a recurrence risk level of the patient at the current time point, and the second feature being obtained by analyzing a change rule of the multi-modal data along with time and reflecting a recurrence risk evolution trend of the patient; the vascular embolism recurrence risk of the patient in the future period is predicted according to the first feature and the second feature, and the prediction accuracy of the vascular embolism recurrence risk can be improved.

The invention provides a hydrogel material with an effect of supporting tissue cell growth as well as a preparation method and application thereof, and belongs to the technical field of medicines. The hydrogel material is prepared from the following raw materials: povidone, polyvinyl alcohol, agar, boric acid, edible tannin and polyacrylic resin II. The preparation method comprises the following steps: mixing the raw materials with water to obtain a mixed solution, and then carrying out a cross-linking reaction on the mixed solution through electron beam irradiation to obtain the hydrogel material with the function of supporting tissue cell growth. The hydrogel material is applied to preparation of vascular embolism agents. The hydrogel can enable a body to generate histological reaction on the hydrogel serving as a foreign body, fibroblasts wrap the hydrogel and then grow into the hydrogel, cells migrate and proliferate to form collagenous fiber tissue of a three-dimensional network structure, and then capillary and tissue cells grow into the hydrogel to form connective tissue; meanwhile, under the action that cells swallow foreign matters, the hydrogel is digested and degraded, and finally the diseased tissues are repaired.

The invention discloses body temperature responsive self-adhesive gel microspheres as well as a preparation method and application thereof, and relates to the technical field of medicines. The body temperature responsive self-adhesive gel microspheres comprise a photocuring structure stabilizing unit material and a body temperature responsive self-adhesive unit material; the photocuring structure stable unit material comprises at least one of a natural polymer derivative material and a synthetic polymer material; the body temperature responsive self-adhesive unit material can be subjected to chain segment migration and re-entanglement at a physiological temperature. The gel microsphere has good temperature-controlled self-adhesion capability and interface adhesion property, and can be used as an embolism agent for treating vascular embolism.

The invention belongs to the technical field of medical instruments, and provides a continuous flushing type balloon catheter device, an inner cavity is used for continuous perfusion of heparin water, an outer cavity is used for balloon dilatation to inject liquid or air, the device is stably fixed in a blood vessel through balloon dilatation, continuous perfusion of liquid in the blood vessel is achieved, and the continuous flushing type balloon catheter device is convenient to use. Therefore, the donor keeps the blood vessel (radial artery or superficial temporal artery) to keep certain tension to avoid distortion caused by collapse, continuous perfusion keeps the blood vessel cavity of the donor blood vessel clean and moist, the condition of vascular embolism blockage caused by foreign matters or thrombus in the donor blood vessel is avoided, thrombus formation is fundamentally prevented, and the donor blood vessel is protected from being damaged. Meanwhile, the continuous perfusion can enable the intracranial vascular anastomotic stoma to be in an open state, so that the smooth rate of vascular anastomosis can be kept, the operation area can be kept clean, and the situation that surrounding blood pollutes the anastomotic stoma and affects the smooth rate of the operation is avoided.

The invention relates to the field of biomedical materials, in particular to cyanoacrylate medical blood vessel blocking glue and a preparation method thereof.The cyanoacrylate medical blood vessel blocking glue is prepared from, by mass, 30-35 parts of 2-octyl cyanoacrylate, 7-8 parts of lactide modified hydroxyethyl methylacrylate, 0.02-0.03 part of polymerization inhibitor propyl gallate, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator, 0.02-0.03 part of initiator and the balance water. By innovatively adopting various functional components and carrying out synergistic compatibility and precise preparation, compared with the prior art, the comprehensive performance of the product is remarkably improved, and the plugging agent has the advantages of rapid and reliable plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect, good plugging effect and the like. Meanwhile, good biocompatibility, intraoperative developing capacity and a potential drug sustained release function are achieved, operation is easy and convenient, performance is stable, a safer and more efficient choice is provided for clinical vascular interventional therapy, and wide application prospects are achieved in the fields of cardiovascular and neurological intervention, peripheral vascular embolism and the like.

The invention discloses a cerebrovascular embolism interventional thrombectomy device, and relates to the technical field of medical instruments. The vascular embolism interventional thrombectomy device comprises a container catheter, a pushing assembly is movably connected to the interior of the container catheter, and a containing assembly is fixedly connected to the inner wall of the container catheter; the pushing assembly comprises a position control pipe, the position control pipe is arranged in the container guide pipe, and the twitching pipe is arranged in the position control pipe; the pushing air bag is movably connected to the right side of the container guide pipe. According to the vascular embolism interventional thrombus extraction device, the pushing air bag is driven to one side of a thrombus, certain gas is injected into the pushing air bag, so that the pushing air bag is expanded, and the pushing air bag is extruded to be expanded by pulling the twitching tube; the whole thrombus can be taken out from the container catheter under the condition that too large supporting force is prevented from being generated on the inner wall of the blood vessel, and then secondary far-end embolism caused by thrombus tearing is avoided.

The utility model belongs to the field of injection needles, particularly relates to a pumpable double-cavity injection needle device, and aims to solve the problems that an existing hyaluronic acid injection needle is provided with a single cavity, whether the needle is placed in a blood vessel or not cannot be clearly confirmed before injection, so that an injection object is possibly injected into the blood vessel by mistake, and adverse complications such as tissue necrosis are caused by vascular embolism. According to the scheme, the device comprises a blood return needle cylinder, a medicine injection needle cylinder is fixedly arranged in the blood return needle cylinder, the front end of the blood return needle cylinder is in threaded connection with a connector, the connector is communicated with the blood return needle cylinder, one side of the connector is fixedly communicated with a blood return needle tube, and a medicine injection channel is fixedly arranged in the blood return needle tube. Through the arrangement of the double-cavity needle cylinder and the double-cavity needle tube, whether the needle head is in a blood vessel or not can be determined before injection, so that bad complications such as tissue necrosis and the like caused by the fact that liquid medicine is injected into the blood vessel due to the improper position of the needle head are avoided.

The present application provides a silk fibroin vascular embolism agent loaded with polyhydroxy phenolic compounds, which is prepared from a silk fibroin compound loaded with polyhydroxy phenolic compounds, wherein the silk fibroin compound loaded with polyhydroxy phenolic compounds is prepared by self-assembly of polyhydroxy phenolic compounds and silk fibroin, the silk fibroin is treated by a beta-fold conformation transformation process, and the mass ratio of polyhydroxy phenolic compounds to silk fibroin is <1:1; the vascular embolism agent is prepared by one of emulsification dispersion method, phase separation coagulation method, supercritical fluid technology, electrostatic adsorption method and dry granulation method. The vascular embolism agent has good biocompatibility and degradability, can effectively block blood flow, realize rapid hemostasis, and can be used for tumor vascular embolism treatment. Through the innovative self-assembly strategy, the mechanical properties of the silk fibroin microspheres are significantly improved. Compared with traditional hemostatic materials, the vascular embolism agent exhibits faster settling speed and higher hemostatic efficiency.

The application relates to the technical field of biological medicine, in particular to a radioactive embolism gel, a preparation method thereof and a radioactive embolism agent. The radioactive embolism gel comprises the following components: a radionuclide; a skeleton material comprising polyethylene glycol dimercapto; a chelating ligand comprising 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracarboxylic acid-N-hydroxysuccinimidyl ester; wherein the chelating ligand is covalently grafted on the skeleton material, and the radionuclide is combined with the chelating ligand through chelation. The radioactive embolism gel has the characteristics of high radiochemical purity and good stability, can be made into a gel embolism agent integrating arterial tumor embolism and local radiotherapy, realizes the synergistic treatment of vascular embolism and internal irradiation, and has a good clinical application prospect.

The utility model relates to a thrombus filtration system, the thrombus filtration system comprises a delivery device and a filtration device, the delivery device comprises a connecting piece, a handle assembly and a sheathing canal, the handle assembly comprises a sliding assembly, the near end of the sheathing canal is connected with the sliding assembly, and the filtration device is connected with the connecting piece. The near end of the connecting piece penetrates through the near end of the sheathing canal and then is fixed in the handle assembly, the far end of the connecting piece is connected with the filtering device, the filtering device can be contained in the far end of the sheathing canal, and the sliding assembly can drive the sheathing canal to move relative to the connecting piece and the filtering device. The thrombus filtering system can intercept and capture fallen thrombus or calcification fragments in the operation process so as to prevent the thrombus or calcification fragments from rushing to the telecentric end along with blood flow to cause vascular embolism, and therefore the risks of local pain, tissue necrosis, hemiplegia, dementia and even death of a patient are avoided.

The invention belongs to the field of developers, and particularly relates to developable particles as well as a preparation method and application thereof. The developable particle provided by the invention is prepared by taking iodine-containing alcohol as a main body through a physical crushing or reversed-phase emulsification cross-linking process, and can be used for directly loading a medicine and developing for a long time. Compared with embolism drug-loading microspheres sold in the market, the drug adsorption capacity of the developable particles is larger than or equal to 140 mg / g within 3 min, the adsorption rate within 1 d is larger than or equal to 90%, the developable particles have the functions of developing, rapid drug loading and controllable release, and the developable particles can be used for preparing tissue gasket drugs, tissue filling drugs, tumor vascular embolism drugs and radiotherapy labeling drugs.

The invention discloses a coagulant-loaded embolism microsphere as well as a preparation method and application thereof, the embolism microsphere is prepared through microfluidic and free radical polymerization technologies, and the coagulant-loaded embolism microsphere has a wide application prospect in the fields of arterial embolism treatment, tumor vascular infarction and the like. The embolism microspheres have the characteristics of uniform size, efficient entrapment and continuous release of the coagulant, and can effectively promote fibrinogen to generate fibrin and accelerate coagulation of rabbit blood. Besides, the thrombin-loaded embolism microspheres can obviously induce tumor artery occlusion, and obvious blood clots are formed in far-end blood vessels, so that the growth of rabbit in-situ VX2 tumors is effectively inhibited. The embolism microsphere carrying the coagulant has the advantages of being high in safety, easy and convenient to prepare, good in embolism effect and the like, and efficient entrapment and controllable release of thrombin can be achieved. In the aspects of liver cancer transarterial embolism and tumor vascular infarction treatment, the technology has great transformation potential and is expected to promote the development of vascular embolism agents.

A disposable zero-exchange long sheath transradial artery access sheath assembly includes, but is not limited to, a needle and / or a skin cutter, and also a guide wire, a long sheath, and a dilator. The needle head is used for puncturing the skin, muscle and blood vessel wall close to the radial artery; the guide wire is used for entering blood vessels of a human body and abutting against an area near a focus; the long sheath is provided with a channel for an instrument to pass through, one end in the far-end direction is a head end for treatment, and one end in the near-end direction is one end for external operation; the dilator is in a catheter shape, movably connected to the outer portion of the guide wire in a sleeving mode and connected to a channel in the long sheath in a penetrating mode, and is used for providing a supporting basis for the near-end pipe section of the long sheath. The utility model is used for solving the defect that the current vascular embolism treatment lacks a catheter assembly combination, and avoiding the situation that in case of vasculopathy which needs to use a super-selection device, other medical devices need to be used for matching after unpacking. And the long sheath is directly matched to complete the operations of puncture and blood vessel super-selection. A puncture short sheath and a puncture guide wire are omitted.

The invention discloses a chemotherapeutic drug-loaded embolism microsphere as well as a preparation method and application of the chemotherapeutic drug-loaded embolism microsphere. The preparation method comprises the following steps: carrying out free radical polymerization cross-linking curing on a water-phase material containing macromolecules with cross-linking groups and an oil-phase material through a micro-channel pipeline to obtain microspheres; and mixing the microspheres with a chemotherapeutic drug to obtain the embolism microspheres carrying the chemotherapeutic drug. In transarterial chemical embolism treatment, by using the embolism microspheres loaded with the chemotherapeutic drugs, liver tumors can be effectively embolized, meanwhile, the entrapped chemotherapeutic drugs are slowly released, the growth of in-situ liver cancer is remarkably inhibited, and the occurrence of pulmonary metastasis is effectively reduced. The embolism microsphere capable of loading the chemotherapeutic drugs has the advantages of being high in safety, convenient to prepare, good in embolism effect and the like, efficient entrapment and controllable release of various chemotherapeutic drugs can be achieved, the embolism microsphere has large transformation potential in the field of transarterial chemical embolism of liver cancer, and development of vascular embolism agents is expected to be promoted.

The invention discloses degradable and elastic embolism microspheres with uniform particle size as well as a preparation method and application of the embolism microspheres, and belongs to the technical field of biomedical polymer materials. Crosslinkable micromolecules with an acrylic acid structure are connected to the macromolecules in a covalent bond mode, and the functionalized macromolecules are formed. The embolism microspheres are prepared through microfluidic and free radical polymerization technologies, and the microspheres prepared by the method have good application prospects in the field of arterial embolism treatment. According to the embolism microsphere, the embolism microsphere with the uniform particle size is prepared through the microfluidic technology, the generation operation is further simplified, the production cost is reduced, and the production process is more economical and environmentally friendly. The embolism microsphere disclosed by the invention is high in safety, convenient to prepare, good in dispersity, relatively good in elasticity and good in embolism effect, has relatively large transformation potential in the aspect of transarterial embolism treatment, and is expected to assist the development of vascular embolism agents.

The invention provides a temperature response type magnetic emulsion embolization agent containing triptolide as well as a preparation method and application of the temperature response type magnetic emulsion embolization agent, and belongs to the technical field of biological medicines. The triptolide temperature response type magnetic emulsion embolization agent comprises triptolide, a temperature-sensitive polymer, iodized oil and magnetic nanoparticles, and the temperature-sensitive polymer can be subjected to phase change at 32 DEG C or above to be gelated. The triptolide temperature response type magnetic emulsion embolism agent provided by the invention can continuously release triptolide and has excellent mechanical properties to realize long-acting tumor vascular embolism, and the magnetic nanoparticles can effectively exert magnetocaloric properties to realize an anti-tumor effect; the iodinated oil has X-ray opaqueness and can be visualized in an embolism operation, the safety in the using process is improved, and then the triple synergistic anti-tumor effect of embolism, chemotherapy and magnetic hyperthermia is achieved.