14 results about "Hemangioma" patented technology

The invention relates to a spring ring releasing structure and a spring ring system. The spring ring releasing structure comprises a pushing rod, a notch elastic piece located in the pushing rod and a traction wire connected with the notch elastic piece. The notch elastic piece is provided with a notch used for clamping a spring ring ball head, and the outer side wall of the notch elastic piece abuts against the inner wall of the pushing rod. A releasing groove is formed in the far end of the pushing rod, when the outer side wall of the notch elastic piece abuts against the groove bottom of the releasing groove, the caliber of the notch is larger than the diameter of the spring ring ball head, and when the outer side wall of the notch elastic piece abuts against the inner wall, outside the releasing groove, of the pushing rod, the caliber of the notch is smaller than the diameter of the spring ring ball head. The defects that an existing spring ring release structure limits the filling effect of a spring ring in hemangioma and the tube kicking phenomenon is likely to be caused are overcome, the embolism precision is improved in a free torsion air-finding connection mode, the fracture risk is reduced through low-pressure filling, meanwhile, the reliability of mechanical release is kept, and the safety of the embolism is improved. The method is a targeted upgrade of an interventional embolism spring ring release technology.

The invention discloses a positioning and delimiting method and system for a cortex pathological focus based on an intracranial electroencephalogram signal. The method comprises the following steps: constructing an individualized three-dimensional navigation model; obtaining an original intracranial electroencephalogram signal; generating a plurality of representative segments according to the original intracranial electroencephalogram signals; analyzing the original intracranial electroencephalogram signal and the plurality of representative segments so as to obtain a network analysis core index; generating a fusion type three-dimensional brain model according to the network analysis core index and the individualized three-dimensional navigation model; generating a space-time three-dimensional electroencephalogram model and an electrophysiology functional area distribution diagram according to the fused three-dimensional brain model and the network analysis core indexes; and according to the space-time three-dimensional electroencephalogram model and the electrophysiology functional area distribution map, generating accurate electrophysiology positioning and delimiting information of the cortical pathological focus. According to the invention, accurate electrophysiological delimitation of intra-operative cortical pathological lesions (glioma, hemangioma, focal cortical dysplasia and the like) is realized.

The utility model discloses a device for reducing hardener overflow in maxillofacial hemangioma cavity injection, and the device comprises a first clamping part which comprises a first hand-held part and an annular pressing ring arranged at the end part of the first hand-held part, and a second clamping part which comprises a second hand-held part and an annular pressing ring arranged at the end part of the second hand-held part, the second clamping part comprises a second handheld part and a matched pressing part arranged at the end part of the second handheld part; the first clamping part is connected with the second clamping part through the hinge seat; the second handheld part is provided with a tooth positioning arc-shaped plate for allowing the arc-shaped positioning plate to penetrate through, and one end of the tooth positioning arc-shaped plate is fixedly connected with the first clamping part; the elastic sheet is arranged between the first handheld part and the second handheld part, and one end of the elastic sheet is fixed on the second handheld part through a screw; and the locking plate is used for locking the annular pressing ring and the matched pressing part at a preset opening and closing angle. The medicine is effectively prevented from overflowing in the injection process, so that the treatment effect is improved, and the potential risk of the medicine to other parts of a patient is reduced.

This invention discloses a medical image processing method, device, medium, and product, relating to the field of medical image processing technology. The method includes: acquiring the segmentation results of hemangioma and tumor-bearing vessels in a scanned image of a target vessel; determining a first point set for the hemangioma based on the hemangioma segmentation results; determining a second point set for the tumor-bearing vessels based on the tumor-bearing vessel segmentation results; determining a bidirectional neighboring point set for the first and second point sets, each bidirectional neighboring point set including at least three non-collinear pixels; determining a plane equation for the tumor diameter plane based on the bidirectional neighboring point set; determining the intersection points of the plane containing the plane equation with the first and second point sets, and using the plane enclosed by all intersection points as the tumor diameter plane. The technical solution provided by this invention solves the technical problem of slow speed in existing tumor diameter plane determination methods, improving the speed of tumor diameter plane determination.

The invention discloses timolol maleate gel emplastrum and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The gel paste comprises timolol maleate, a gel skeleton, a cross-linking agent, a cross-linking regulator, a filler, a penetration enhancer, a tackifier, a humectant, a pH regulator, a preservative and purified water. The preparation method comprises the following steps: preparing an oil phase; preparing the medicine and the water-soluble auxiliary materials into a solution; the tackifier adopts methyl acrylate / acrylic acid 2-ethylhexyl copolymer resin emulsion as a single phase; mixing the oil phase with the solution and the tackifier to obtain uniform gel paste with better ductility; and uniformly coating the paste on a backing layer, covering with a protective layer, and packaging to obtain the timolol maleate gel emplastrum. Through optimized prescription composition and process, the preparation has the characteristics of stable drug content and good skin adhesion, can realize continuous transdermal release of drugs, and is especially suitable for long-term safe treatment of infantile hemangioma.

The application discloses application of coccinellin in antitumor drugs and the drugs, wherein the coccinellin has a molecular formula of C 14 H 10 N2O5, and the tumor includes at least one of colorectal cancer, pancreatic cancer, lung cancer, liver cancer, gastric cancer, thyroid cancer, kidney cancer, bladder cancer, ovarian cancer, cervical cancer, breast cancer, myeloma, hemangioma and central nervous system tumor. The antitumor mechanism of the coccinellin is to inhibit KRAS G12D mutant subtype. The coccinellin can effectively inhibit proliferation of various tumor cells, and is expected to be applied to tumor treatment as an antitumor small molecule targeted drug.

The invention relates to an embolism assembly and an embolism system for treating hemangioma, the embolism assembly is provided with a far end and a near end which are opposite, the embolism assembly comprises an embolism part, the embolism part is made of shape memory polymer foam, and a threading channel is formed in the embolism part; the near end of the delivery shaft is an operating end, the far end of the delivery shaft is provided with a connecting section, the connecting section is detachably inserted into the threading channel, the connecting section is clamped when the embolism part is intervened and delivered after being loaded, and the connecting section is clamped when the embolism part is released. The connecting section is moved out of the threading channel, and the threading channel is sealed by the plug piece; the blocking net is fixed to the delivery shaft, the blocking net has a compressed state suitable for interventional delivery and a relative unfolded state, the blocking net is located on the near end side of the connecting section in the compressed state, and the blocking net is used for blocking the embolism piece in the unfolded state. Through the structural improvement of the plug part and the mutual cooperation of the plug part and the blocking net, a better positioning effect can be achieved.

The present application relates to a kind of hemangioma occlusion device, hemangioma occlusion treatment device and hemangioma occlusion system;Hemangioma occlusion system includes hemangioma occlusion device and microcatheter;Hemangioma occlusion device includes the main occlusion structure of net tubular shape, main occlusion structure has the unwinding state of plane helix and is used for from inside the vessel delivery to aneurysm compressed state, and the net tube outer diameter of main occlusion structure is uneven, so that the outer diameter distribution of plane helix when main occlusion structure unwinds is uneven;Hemangioma occlusion device is compressed in microcatheter, and after being separated from microcatheter, it can also restore into unwinding state;Hemangioma occlusion treatment device includes hemangioma occlusion device and push rod, push rod is connected to the proximal end of main occlusion structure.The present application is suitable for irregular aneurysm, and the forming effect is good, and it is easier to realize the occlusion of tumor neck.

The invention provides a gene detection kit for molecular diagnosis of hemangioma and vascular malformation and application. Specifically, the invention provides a gene combination for determining molecular diagnosis of hemangioma and vascular malformation, and based on NGS panel + RNAseq gene sequencing, the gene combination for molecular diagnosis of hemangioma and vascular malformation provided by the invention can be applied to all molecular diagnosis and liquid biopsy related to hemangioma and vascular malformation. The correlation between mutation sites and abundance and disease phenotypes is disclosed, so that the method has a relatively great clinical popularization and application prospect.

The invention belongs to the field of biological detection, and discloses a gene detection panel for detecting hemangioma and vascular malformation and application of the gene detection panel. The invention discloses a gene detection panel for hemangioma and vascular malformation. Comprising the gene detection panel and is used for detecting hemangioma and vascular malformation; an application of the gene detection panel in preparation of a hemangioma and vascular malformation diagnostic reagent or diagnostic kit; the gene detection panel is applied to a device for auxiliary diagnosis of etiology of hemangioma and vascular malformation patients; and the device is used for auxiliary diagnosis of pathogenesis of hemangioma and vascular malformation patients. The gene detection panel disclosed by the invention can efficiently and accurately identify gene mutation related to hemangioma and vascular deformity, can cover wide genes related to hereditary and sporadic vascular deformity, and can provide accurate information for diagnosis, treatment and prognosis evaluation of diseases.

The application discloses a method and system for locating and delimiting a cortical pathological focus based on an intracranial electroencephalogram signal. The method comprises the following steps: constructing an individualized three-dimensional navigation model; obtaining an original intracranial electroencephalogram signal; generating a plurality of representative segments according to the original intracranial electroencephalogram signal; analyzing the original intracranial electroencephalogram signal and the plurality of representative segments to obtain network analysis core indexes; generating a fusion three-dimensional brain model according to the network analysis core indexes and the individualized three-dimensional navigation model; generating a space-time three-dimensional electroencephalogram model and an electrophysiological functional area distribution map according to the fusion three-dimensional brain model and the network analysis core indexes; and generating accurate electrophysiological locating and delimiting information of the cortical pathological focus according to the space-time three-dimensional electroencephalogram model and the electrophysiological functional area distribution map. The application realizes accurate electrophysiological delimiting of an intraoperative cortical pathological focus (glioma, hemangioma, focal cortical dysplasia, etc.).

The application provides a method for constructing a hemangioma animal model, and belongs to the field of animal models. The method is to inject hemangioma endothelial cells and hemangioma pericytes into subcutaneous tissues of an animal, and to obtain a hemangioma animal model after 5-30 days. The application successfully constructs a hemangioma animal model based on hemangioma endothelial cells and hemangioma pericytes, the hemangioma animal model has a short construction time, consistent pathological characteristics with those of hemangioma, and can simulate the characteristics of in-vivo hemangioma from proliferation to regression evolution, thereby providing an important animal model carrier platform for in-vitro mechanism research of hemangioma and screening of new targeted drugs.

This invention discloses the application of GLPG0187 in combination with propranolol in the preparation of drugs for the treatment or inhibition of hemangiomas. GLPG0187 is an integrin β1 inhibitor, and propranolol is a β-receptor blocker. This invention was validated through CCK8 assays, scratch assays, and tube formation assays. The results showed that, compared with propranolol monotherapy, GLPG0187 (4 nM) combined with propranolol (20-30 μM) could further inhibit the proliferation, migration, and tube formation ability of human hemangioma endothelial cells, demonstrating superior efficacy compared to propranolol monotherapy. This invention addresses the issue that approximately 2.1% of patients treated with propranolol monotherapy for infantile hemangiomas experience side effects such as sleep disturbances, bronchospasm, and hypoglycemia, providing a new combination therapy regimen and offering a new drug option for reducing the clinical dosage of propranolol and minimizing the risk of side effects. This invention identifies a new target for the treatment of hemangiomas, providing new possibilities for hemangioma treatment.

The invention belongs to the technical field of medical instruments, and particularly relates to a preparation method of a coating capable of enabling the inner surface and the outer surface of a stent to have different antithrombotic performance, which comprises the following steps: (1) preparation of a coating solution: mixing a polymer and a solvent to obtain the coating solution; (2) coating preparation: attaching the coating solution to the surface of the stent; and (3) inducing beta phase change: performing corona polarization treatment on the stent obtained in the step (2), so that the outer surface of the stent is positively charged, and the inner surface of the stent is negatively charged. According to the preparation method, a coating with a piezoelectric effect can be formed on the surface of the stent, so that negative potential can be generated on the inner surface of the stent and positive potential can be generated on the outer surface of the stent under the conditions of contact with a blood vessel wall and blood flow impact pressure, and the inner surface of the stent has anti-thrombus capability; fibrous protein deposition occurs at the position where the outer surface of the stent is in contact with a tumor neck opening, the tumor neck opening is rapidly closed, and the artery hemangioma is closed.