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32 results about "Polycythemia vera" patented technology

Polycythemia vera (PV) is a bone marrow disorder in which the body produces an excessive amount of red blood cells.

Melphalan freeze-dried powder injection

The invention relates to a melphalan freeze-dried powder injection and a preparing method thereof. The prepared melphalan freeze-dried powder injection is used for treating multiple myeloma, oophoroma, polycythemia vera, local malignant melanoma and soft tissue sarcoma. The melphalan freeze-dried powder injection contains melphalan, utilizes the mixed solvent composed of the tert-butyl alcohol and the injection water in the preparation process, wherein the concentration of the melphalan in the mixed solvents is 10-25 mg / ml; and the volume ratio of the solvents is: 5-50% of tert-butyl alcohol and the balance of injection water. The preparation process comprises the following steps: measuring tert-butyl alcohol, adding injection water, mixing evenly, cooling to 2-15 DEG C, heat preserving, adding melphalan, stirring and dripping 0.5 mol hydrochloric acid to dissolve, filtering, filling, plugging, disking, freeze-drying, pressing plug, out box, tying and packing after quality test qualification.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD

Methods for treating myeloproliferative disorders

In part, the present disclosure relates methods for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or one or more complications of a myeloproliferative disorder. The present disclosure further relates methods for treating, preventing, or reducing the severity of a Janus kinase-associated disorder or one or more complications of a Janus kinase-associated disorder. In certain aspects the disclosure provides TβRII antagonists for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or a Janus kinase-associated disorder or one or more complications of a myeloproliferative disorder or a Janus kinase-associated disorder.
Owner:ACCELERON PHARMA INC

Methods and Compounds Regulating the Erythroid Response to Iron Deficiency

The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakary-ocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

Traditional Chinese medicine liquid for treating skin itch and preparation method

InactiveCN103893495AHeat-clearing and disinfectingBlood stasisDermatological disorderPlant ingredientsModern medicineSide effect
The invention discloses traditional Chinese medicine liquid for treating skin itch and a preparation method, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine liquid disclosed by the invention comprises the following effective components: white loosestrife herb, bunge corydalis herb, jasminum polyanthum, garlic, swamp violet, Indian damnacanthus herb, emblic leafflower leaf, japanese white birch bark, alate senna leaf, Chinese juniper leaf, redfruit actinodaphne root and leaf, calabash, nakedflower beautyberry branchlet and leaf, rhizoma nardostachyos, wadalee-gum-tree and arnica montana. The selected medicinal materials in the traditional Chinese medicine liquid disclosed by the invention are properly compatible and accord with the theories of traditional Chinese medicines and modern medicines; furthermore, the traditional Chinese medicine liquid disclosed by the invention has the effects of clearing heat, disinfecting, eliminating blood-heat and stasis, dispelling the wind, dehumidifying, diminishing swelling and relieving itching, has obvious curative effects on skin itch caused by the systematic diseases, such as inflammatory dermatosis, uremia, primary cholestasis, polycythemia vera and the like, and has the advantages of being short in treatment course, rapid in effect, non-recurrent after healing, safe and free from toxic and side effect; the purpose of treating both symptoms and root causes can be achieved, and therefore, the traditional Chinese medicine liquid for treating skin itch disclosed by the invention is worthy of being widely popularized and applied.
Owner:孙艳萍

Bloodletting device for polycythemia vera

The invention discloses a bloodletting device for polycythemia vera. The device is characterized by comprising a bloodletting rubber tube, a fleam, a bloodletting container and an anti-blocking component, the anti-blocking component comprises conveying belts, a drive device and elastic extrusion components, and there are two conveying belts which are respectively located at two opposite sides of the bloodletting rubber tube; the elastic extrusion components arranged on the two conveying belts respectively correspond to each other and respectively push and extrude the two opposite sides of thebloodletting rubber tube, and the drive device can drive the elastic extrusion components to move in the blood flowing direction during the process of driving the conveying belts to rotate; the elastic extrusion components comprise rotary clamping bars, conflicting idler wheels and elastic pieces used for pushing the rotary clamping bars to rotate outward around the hinged portions with the conveying belts, and during the process of the elastic pieces releasing elastic potential energy, the elastic pieces can push the rotary clamping bars to make that the conflicting idler wheels always push and extrude the bloodletting rubber tube. The device can avoid that the blood flowing speed of the vein is slow so as to cause blood coagulation, and the bloodletting device is blocked.
Owner:WENZHOU CENT HOSPITAL

JAK kinase inhibitor with 4-amino-(1H)-pyrazole structure and preparation method and application thereof

The invention discloses a JAK kinase inhibitor with 4-amino-(1H)-pyrazole structure and a preparation method and application thereof. The compound has a structure shown in general formula (I) or (II), and the invention provides a specific preparation method of the compound and application of the compound in preventing or treating inflammation, tumor and blood related diseases; the inflammation, tumor and blood related diseases include psoriasis, rheumatic arthritis, polycythemia vera, cicatricial alopecia, primary thrombocythemia, ulcerative colitis, myelofibrosis with myeloid metaplasia, severe combined immune deficiency, various leukemia, various solid tumors and the like.
Owner:SHANDONG UNIV

Traditional Chinese medicine composition for treating polycythemia vera

The invention discloses a traditional Chinese medicine composition for treating polycythemia vera. The traditional Chinese medicine composition comprises the following raw materials: felwort, chrysanthemum, scutellaria baicalensis in wine, cape jasmine, semen plantaginis, starwort root, rhizoma alismatis, rhizoma sparganii, aloes, indigo naturalis, oldenlandia diffusa, safflower carthamus, caulis spatholobi, codonopsis pilosula, agastache rugosus and cortex moutan. The traditional Chinese medicine composition adopts a principle of treatment based on syndrome differentiation, has the effects of activating blood to remove stasis, clearing the liver to discharge heat, nourishing the kidney yin and reducing the liver yang in combination with difference of extravasated blood from blood heat, and is prepared by mixing the raw materials through multi-time clinical verifications; after the traditional Chinese medicine composition is taken, the traditional Chinese medicine composition enters a human body, the effect is quickly brought into play, the stasis and heat can be removed, the concentration of red blood cells is effectively reduced, the blood viscosity and the blood resistance are reduced, and finally the effects of unblocking channels and regulating yin and yang are achieved, so that the clinical symptoms and various laboratory indicators of patients return to normal and the purpose of clinical treatment is achieved.
Owner:侯云珍

Pyrrolopyrimidine five-membered azacyclic derivative and application thereof

A pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase (Janus kinase) inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and / or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like.
Owner:HANGZHOU BANGSHUN PHARM CO LTD

Traditional Chinese medicine composition for treating polycythemia vera

The invention provides a traditional Chinese medicine composition for treating polycythemia vera. The composition is composed of lithospermum, gentian, raw rehmannia root, radix scutellariae, rhizoma alismatis, and anemarrhena, and has the functions of clearing liver heat, purging fire, cooling blood, and removing heat. The clinical effective rate is 79%.
Owner:李智

A kind of medicine for treating leukemia and preparation method thereof

The invention relates to a novel medicine for treating leukemia and a preparation method thereof and belongs to the technical field of traditional Chinese medicines. The medicine is prepared into different preparations by the conventional method in the following steps: by taking taxus chinensis, sculellaria barbata, oldenlandia diffusa, trigone, curcuma zedoary and silkworm bombycis as main materials and cleavers, American ginseng, prismatomeria tetrandra, isatis roots, tuber fleeceflower stems, Tupistra fimbriata Hand.Mazz., fructus corni, lucid ganoderma, human placenta, ligusticum wallichii and turtle shells as auxiliary materials, dosing; drying; respectively grinding fine powder; uniformly mixing; and then steaming and basking for three times. As taxus chinensis contains the No.1 anti-cancer drug in world: paclitaxel and the auxiliary materials assist, growth and development of cancer cells can be controlled, the anticancer ability of human body is boosted, and meanwhile, cyclic and metabolic functions of the human body can be further enhanced, so that viruses accumulated in the human body are eliminated outside by diuresis and defecation so as to realize the effect of treating leukemia. According to clinical trails, the total effective rate is over 90%. The medicine has the best curative effect on acute myelocytic leukemia, myelodysplastic syndromes and graft-versus-host disease, the second effect on polycythemia vera and chronic myelognous leukia, and then acute promyelocytic leukemia.
Owner:罗心刚

Methods and Compounds Regulating the Erythroid Response to Iron Deficiency

The present invention discloses the signaling pathway involved erythroid repression by iron deficiency. Further disclosed is anon-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

Drug combination and new application of preparation thereof

The invention discloses a drug combination and application of a preparation of the drug combination to the fields of preparing drugs for treating chronic granulocytic leukemia, polycythemia vera and primary thrombocytosis. The drug combination is formed through compatibility of natural indigo, tree peony bark, fructus forsythiae, hairyvein agrimony and liquorice, and has remarkable effects of treating the chronic granulocytic leukemia, the polycythemia vera and the primary thrombocytosis.
Owner:陕西郝其军制药股份有限公司

Medicine for treating polycythemia vera and preparation method thereof

The invention discloses a medicine for treating polycythemia vera and a preparation method thereof. The medicine for treating polycythemia vera is prepared by Chinese gentian, mulberry, Chinese garlic, spine date seed, cremastra, tree peony bark, red sage root, spatholobus stem, magnolia cortex, dendrobium, chrysanthemum and scorpion according to certain weight ratio. The medicine for treating polycythemia vera has the functions of clearing heat and detoxifying, and cooling the blood to resolve stagnation, and can be used for treating polycythemia vera with fast effectiveness, good curative effect and no recurrence.
Owner:卢文华

Tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera

The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′untranslated region (3′UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and / or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy.
Owner:TEMPLE UNIVERSITY

Traditional Chinese medicine decoction for treating polycythemia vera and preparation method of traditional Chinese medicine decoction

The invention relates to a traditional Chinese medicine decoction for treating polycythemia vera and a preparation method of the traditional Chinese medicine decoction. The traditional Chinese medicine decoction is mainly prepared from following raw herbal materials in parts by weight: 8-16 parts of kudzuvine roots, 5-13 parts of tree peony bark, 6-10 parts of corydalis roots, 1-5 parts of rough gentian, 11-17 parts of Chinese holly leaves, 10-20 parts of snow of June herb, 20-30 parts of barbed skullcap herbs, 10-15 parts of honeysuckle stems, 20-28 parts of lalang grass rhizomes, 4-10 parts of bunge corydalis herbs, 5-15 parts of curcuma roots, 10-16 parts of dwarf lilyturf tuber and 14-24 parts of manyprickle acanthopanax roots. The effect of the traditional Chinese medicine decoction for treating polycythemia vera is remarkable, and the traditional Chinese medicine decoction is reasonable in compatibility, adopts a unique formula, is low in in cost and has functions of removing heat from the liver, purging fire, promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, promoting qi circulation to relieve pain, cooling blood to stop bleeding and the like under the joint action of the raw herbal materials, so that the purpose of treating both symptoms and root causes of polycythemia vera is achieved.
Owner:济南超舜中药科技有限公司

Neutrophilia inhibitor

To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs. An antineutrophilia agent containing a 3(2H)-pyridazinone compound represented by the formula (I) or a pharmaceutically acceptable salt thereof [wherein each of R1, R2 and R3 is independently a hydrogen atom or a C1-6 alkyl group, X is a halogen atom, cyano or a hydrogen atom, Y is a halogen atom, trifluoromethyl or a hydrogen atom, and A is a C1-8 alkylene which may be substituted with a hydroxyl group].
Owner:NISSAN CHEM IND LTD +1

Application of ginkgo terpene lactones in preparation of medicines for preventing and/or treating polycythemia vera

The invention discloses application of ginkgo terpene lactones in preparation of medicines for preventing and / or treating polycythemia vera, and further relates to application of a medicinal preparation containing the ginkgo terpene lactones in preparation of medicines for preventing and / or treating polycythemia vera. The medicinal preparation can be used together with pharmaceutically acceptableauxiliaries or auxiliary ingredients. The ginkgo terpene lactones or medicinal preparation can be used for effectively preventing or treating the polycythemia vera, is convenient to use, has high patient tolerance, and provides a new choice with exact curative effect, safety, reliability and easy treatment to clinical treatment.
Owner:CHENGDU BAIYU PHARMA CO LTD

Traditional Chinese medicine for treating polycythemia vera

The invention discloses a traditional Chinese medicine for treating polycythemia vera, which is characterized in that the traditional Chinese medicine comprises the following ingredients: 15g radix arnebiae seu lithospermi, 15g semen persicae, 15g pinellia ternata, 15g rhizoma sparganii, 15g radix curcumae, 15g hirudo, 10g rheum officinale, 10g capillary artemisia, 10g rehmannia glutinosa, 8g oysters, 8g radix notoginseng, 8g fructus forsythiae, 8g ligusticum wallichii, 8g radix isatidis, 5g lumbricus and 3g Chinese polyphaga; and a method comprises the steps that the ingredients are decocted with water, decoration liquid is administered one dose every day, and each dose is administered by two times. The traditional Chinese medicine is adapted to polycythemia vera treatment, precludes complications of a blood vessel and a nervous system easily caused due to inappropriate use of the medicine, and solves the problems that the existing traditional Chinese medicine for treating polycythemia vera takes effect slowly, is ordinary in effect and even exerts a reverse action.
Owner:徐立江

Facile detection of polycythemia vera

A facile means of diagnosing polycythemia vera is provided by detecting expression of the DLX7 gene in a sample of a hematopoietic cell from an individual. Increased expression of DLX7 may also be used to diagnose acute myeloid leukemia. A method is provided for treating patients suffering from polycythemia vera or acute myeloid leukemia using agents that inhibit or prevent expression of the DLX7 gene or that inhibit or prevent any downstream effects of DLX7 gene expression. Examples of the agents useful in this treatment are DLX7 antisense oligonucleotides and decoy therapy directed at binding the DLX7 gene product and preventing its contribution to the pathogenesis of polycythemia vera.
Owner:NEW YORK UNIV

Composition traditional Chinese medicine for treating polycythemia vera

The invention provides a traditional Chinese medicine composition for treating polycythemia vera, which is composed of comfrey, gentian, rehmannia, scutellaria, Alisma, anemarrhena, etc. It has the effects of clearing the liver and purging fire, cooling blood and purging heat, and is clinically useful. The efficiency is 79%.
Owner:邱再生

Novel medicine for treating leukemia and preparation method thereof

The invention relates to a novel medicine for treating leukemia and a preparation method thereof and belongs to the technical field of traditional Chinese medicines. The medicine is prepared into different preparations by the conventional method in the following steps: by taking taxus chinensis, sculellaria barbata, oldenlandia diffusa, trigone, curcuma zedoary and silkworm bombycis as main materials and cleavers, American ginseng, prismatomeria tetrandra, isatis roots, tuber fleeceflower stems, Tupistra fimbriata Hand.Mazz., fructus corni, lucid ganoderma, human placenta, ligusticum wallichii and turtle shells as auxiliary materials, dosing; drying; respectively grinding fine powder; uniformly mixing; and then steaming and basking for three times. As taxus chinensis contains the No.1 anti-cancer drug in world: paclitaxel and the auxiliary materials assist, growth and development of cancer cells can be controlled, the anticancer ability of human body is boosted, and meanwhile, cyclic and metabolic functions of the human body can be further enhanced, so that viruses accumulated in the human body are eliminated outside by diuresis and defecation so as to realize the effect of treating leukemia. According to clinical trails, the total effective rate is over 90%. The medicine has the best curative effect on acute myelocytic leukemia, myelodysplastic syndromes and graft-versus-host disease, the second effect on polycythemia vera and chronic myelognous leukia, and then acute promyelocytic leukemia.
Owner:罗心刚

TCM (traditional Chinese medicine) preparation for treating polycythemia vera and preparing method thereof

The invention discloses a TCM (traditional Chinese medicine) preparation for treating polycythemia vera and a preparing method thereof. The TCM preparation comprises, according to a certain weight ratio, Chinese thorowax root, bitter orange, Turmeric root-tuber, Szechuan lovage rhizome, root of common peony, dried rehamnnia root, tree peony bark, safflower, root of red-rooted salvia, zedoary rhizome, ground beetle, cape jasmine, Chinese angelica, Chinese gentian root, natural indigo, baical skullcap root, goldthread, white peony root, hairyvein agrimonia herb and bud, mole cricket, leaf of purpleflower holly, Yerbadetajo herb and blackend swallowwort root. The TCM preparation has the effects of soothing liver-qi and reliving stagnation, regulating qi to disperse stasis, removing heat to cool blood, and nourishing yin and generating body fluid; the TCM preparation has the effect of treating polycythemia vera.
Owner:日照新睿招商发展有限公司

Neutrophilia inhibitor

To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs.An antineutrophilia agent containing a 3(2H)-pyridazinone compound represented by the formula (I) or a pharmaceutically acceptable salt thereof [wherein each of R1, R2 and R3 is independently a hydrogen atom or a C1-6 is alkyl group, X is a halogen atom, cyano or a hydrogen atom, Y is a halogen atom, trifluoromethyl or a hydrogen atom, and A is a C1-8 alkylene which may be substituted with a hydroxyl group].
Owner:NISSAN CHEM IND LTD +1
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