Drug combination and new application of preparation thereof

A composition and drug technology, applied in the field of pharmaceutical preparations, can solve the problems of delayed patient treatment timing, inconvenient treatment of patients, and inability to exert drug efficacy well.

Active Publication Date: 2015-11-11
陕西郝其军制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because chronic myelogenous leukemia, polycythemia vera and essential thrombocythemia all belong to myeloproliferative disease, can transform each other, and above-mentioned disclosed Chinese medicine composition can only treat chronic myelogenous leukemia alone, and ignores There is a possibility of mutual transformation of the disease conditions. Once chronic myelogenous leukemia transforms into polycythemia vera or essential thrombocythemia, the above-mentioned pharmaceutical composition will not be able to exert its efficacy well, which will bring inconvenience to the treatment of patients, and even delay Optimal timing of treatment for patients, resulting in adverse outcomes

Method used

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  • Drug combination and new application of preparation thereof
  • Drug combination and new application of preparation thereof
  • Drug combination and new application of preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] [Prescription] Qingdai 20g, Cortex Moutan 1200g, Forsythia 200g, Agrimony 800g and Licorice 50g.

[0038] [Preparation method] Weigh the Qingdai, Cortex Moutan, Forsythia, Agrimony and Licorice according to the above prescription, then selectively add conventional excipients, and make clinically acceptable tablets, capsules, granules, Syrup, powder, pill, tincture, liquor, decoction, lozenge or mixture.

Embodiment 2

[0040] [Prescription] Qingdai 300g, Cortex Moutan 300g, Forsythia 800g, Agrimony 200g and Licorice 600g.

[0041] [Preparation method] Weigh the Qingdai, Cortex Moutan, Forsythia, Agrimony and Licorice according to the above prescription, then selectively add conventional excipients, and make clinically acceptable tablets, capsules, granules, Syrup, powder, pill, tincture, liquor, decoction, lozenge or mixture.

Embodiment 3

[0043] [Prescription] Qingdai 20g, Cortex Moutan 1200g, Forsythia 200g, Agrimony 800g and Licorice 50g.

[0044] [Preparation method] (1) Take the Qingdai, Cortex Moutan, Forsythia, Agrimony and Licorice according to the above prescription, and set aside;

[0045] (2) Mix the Agrimony and Cortex Moutan, then add 2 times the volume concentration of the drug weight and extract 4 times with 95% ethanol aqueous solution, each time for 4 hours, combine the ethanol extracts, filter, reclaim ethanol and concentrate under reduced pressure Prepare the extract I with a relative density of 1.15 at 60°C for subsequent use;

[0046] (3) soak the forsythia for 2 hours, then extract the volatile oil with steam distillation, extract for 9 hours, collect the volatile oil, remaining residue and water decoction, and set aside;

[0047] (4) Mix the residue in step (3) with the licorice, add water to decoct 4 times, and decoct for 4 hours each time, and combine the obtained decoction with the dec...

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Abstract

The invention discloses a drug combination and application of a preparation of the drug combination to the fields of preparing drugs for treating chronic granulocytic leukemia, polycythemia vera and primary thrombocytosis. The drug combination is formed through compatibility of natural indigo, tree peony bark, fructus forsythiae, hairyvein agrimony and liquorice, and has remarkable effects of treating the chronic granulocytic leukemia, the polycythemia vera and the primary thrombocytosis.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to the application of a pharmaceutical composition and its preparation in the field of preparing medicines for treating chronic myeloid leukemia, polycythemia vera and essential thrombocythemia. Background technique [0002] Chronic myelogenous leukemia, referred to as CML for short, is a cell line disease caused by malignant lesions at the level of pluripotent stem cells with acquired chromosomal abnormalities. Mature white blood cells gather in the bone marrow, inhibit the normal hematopoiesis of the bone marrow, and can spread throughout the body through the blood, leading to anemia, easy bleeding, infection, and organ infiltration in patients. The cause of the disease is still unclear, but it is believed that the Philadelphia chromosome is closely related to the disease, and about 90 to 95% of patients have the Philadelphia chromosome. Chronic myelogenous ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P35/02A61P7/00
Inventor 郝其军郝彬
Owner 陕西郝其军制药股份有限公司
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