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Application of ginkgo terpene lactones in preparation of medicines for preventing and/or treating polycythemia vera

A technology for polycythemia and ginkgo terpene lactone is applied in the field of preparation of ginkgolide for preventing and/or treating polycythemia vera, and can solve the problems of adverse reaction treatment effect, difficulty in persistence, inconvenience in treatment and the like, and achieves Ease of treatment, high patient tolerance, and proven efficacy

Active Publication Date: 2019-10-18
CHENGDU BAIYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently commonly used treatment methods and means are: phlebotomy and myelosuppressive drug therapy such as radionuclide (32P), hydroxyurea, interferon, etc., but it may be difficult to persist due to inconvenience of treatment (phlebotomy, interferon), or Adverse reactions or treatment effects affect continuous and standardized treatment
At present, there is a lack of a convenient and effective drug choice in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Ginkgo terpene lactone mixed dropping pills

[0017] Bilobalide 1000g (1 part) Ginkgolide B 1000g

[0018] Preparation Process

[0019] Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropyl methylcellulose, etc. to the above raw materials, mix well, and add the dripping pill with water-soluble device In the machine, heat evenly and stir at the right time. After melting, drop it into the immiscible condensate. After condensation, take out the dropping pills, wipe off the condensate adhering to the surface, and dry at low temperature.

Embodiment 2

[0020] Example 2 Ginkgolide mixed emulsion

[0021] Bilobalide 1000g (1 part) Ginkgolide B 1000g

[0022] Preparation Process

[0023] Add 1 part of soybean oil, 1 part of glycerin, 1 part of hydroxypropyl methylcellulose, 1 part of lecithin, 1 part of sodium citrate, 1 part of sodium oleate, etc. to the above raw materials, mix well, sterilize under high pressure, and fill Instantly.

Embodiment 3

[0024] Example 3 Ginkgolide B Dropping Pills

[0025] Ginkgolide B 1000g (1 serving)

[0026] Preparation Process

[0027] Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropyl methylcellulose, etc. to the above raw materials, mix well, and add the dripping pill with water-soluble device In the machine, heat evenly and stir at the right time. After melting, drop it into the immiscible condensate. After condensation, take out the dropping pills, wipe off the condensate adhering to the surface, and dry at low temperature.

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PUM

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Abstract

The invention discloses application of ginkgo terpene lactones in preparation of medicines for preventing and / or treating polycythemia vera, and further relates to application of a medicinal preparation containing the ginkgo terpene lactones in preparation of medicines for preventing and / or treating polycythemia vera. The medicinal preparation can be used together with pharmaceutically acceptableauxiliaries or auxiliary ingredients. The ginkgo terpene lactones or medicinal preparation can be used for effectively preventing or treating the polycythemia vera, is convenient to use, has high patient tolerance, and provides a new choice with exact curative effect, safety, reliability and easy treatment to clinical treatment.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of ginkgolides in the preparation of medicines for preventing and / or treating polycythemia vera. Background technique [0002] Polycythemia vera (PV) is a hematopoietic stem cell clonal disease of unknown cause, which belongs to the category of myeloproliferative diseases. According to relevant literature reports, the incidence rate of the disease is 1.9 / 100,000 to 2.6 / 100,000, and the incidence is mostly among middle-aged and elderly people, among which the most common age group is 50-60 years old, and the incidence rate of women is slightly lower than that of men. Clinically, it is characterized by a significant increase in the number and volume of red blood cells, with manifestations caused by plethora and hyperviscosity, often accompanied by splenomegaly. The onset of PV is insidious, the progression is slow, and various transformations may occur in the late stage. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P7/00C07D493/22
CPCA61K31/365A61P7/00C07D493/22
Inventor 李慧琴
Owner CHENGDU BAIYU PHARMA CO LTD
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