16 results about "Terpene lactones" patented technology

The invention relates to the technical field of medicines, in particular to application of ginkgo terpene lactones in preparation of medicines for preventing and / or treating Parkinson's disease. The bilobalide and the composition or extract thereof can improve the motion coordination of Parkinson's disease model mice, have a treatment effect on Parkinson's disease, and can be used for preparing drugs for treating Parkinson's disease.

The application provides a light irradiation method for improving the quality of Andrographis paniculata, and belongs to the technical field of agricultural planting. The method for improving the quality of Andrographis paniculata provided by the application comprises the following steps: starting to irradiate Andrographis paniculata with blue light when the Andrographis paniculata sprouts for 15 days. The method for improving the quality of Andrographis paniculata provided by the application is simple and easy to implement, has low cost, can promote the growth and development of Andrographis paniculata plants, can effectively improve the accumulation of terpene lactone components of Andrographis paniculata, and further improves the quality of Andrographis paniculata, thereby providing strong technical support for the high-quality development of the Andrographis paniculata industry.

The invention provides application of ginkgo terpene lactones, bilobalide or stereoisomers thereof in preparation of drugs for preventing or treating hyperlipidemia and hyperlipidemia complications.

The invention discloses a gene GbCYP701A6 for promoting synthesis of ginkgo terpene lactones and application of the gene GbCYP701A6. The nucleotide sequence of the gene GbCYP701A6 is shown as SEQ ID NO.1, and the amino acid sequence of protein expressed by the gene GbCYP701A6 is shown as SEQ ID NO.2. The invention further discloses a preparation method of the gene GbCYP701A6. According to the invention, a brand new gene GbCYP701A6 is cloned from gingko for the first time. The GbCYP701A6 gene is transferred into a ginkgo biloba body, the GbCYP701A6 gene is over-expressed, the contents of terpene lactones including ginkgolide A, ginkgolide B, ginkgolide C and bilobalide in ginkgo biloba are remarkably increased, and the contents of the ginkgolide A, ginkgolide B, ginkgolide C and bilobalide are remarkably reduced when the gene is silently expressed, so that the gene is a key gene for promoting synthesis of the ginkgo terpene lactones, and the GbCYP701A6 gene can be used for preparing the ginkgo biloba terpene lactones. Therefore, the regulation and control of the expression of the GbCYP701A6 has important application value in the aspects of improving the medicinal quality of the ginkgo leaves and the like.

This invention provides a composition of Ginkgo biloba extract and its preparation method. The composition consists of Ginkgo biloba extract (calculated as total flavonol glycosides) and dipyridamole in a dosage ratio of 10:4. The preparation method can significantly improve product yield, reduce production costs, and significantly increase the content of the main components of the produced Ginkgo biloba extract, namely total flavonol glycosides and terpene lactones. It can also reduce the content of poorly water-soluble ginkgolides and harmful impurities such as ginkgolic acid, control its microbial level, and improve the stability and safety of the Ginkgo biloba extract preparation product of this invention.

The invention provides a composition of ginkgo biloba extract and a preparation method thereof, the composition is composed of ginkgo biloba extract (based on total flavonol glycosides) and dipyridamole according to a dosage ratio of 10: 4, and the preparation method can significantly improve the product yield, reduce the production cost and improve the product quality. The ginkgo biloba extract prepared by the method has the advantages that the content of main components, namely total flavonol glycosides and terpene lactones, of the ginkgo biloba extract is obviously increased, the content of bilobalide with poor water solubility and the content of a harmful impurity, namely ginkgolic acid can be reduced, the microbial level of the ginkgo biloba extract is controlled, and the stability and safety of the ginkgo biloba extract preparation product are improved.

The invention belongs to the technical field of dietary therapy health-care products, and particularly relates to a formula of a dietary therapy composition capable of reducing blood fat, reducing blood pressure and resisting aging and a food prepared from the dietary therapy composition, and the dietary therapy composition comprises the following components in parts by weight: 8-12 parts of ginkgo leaves, 15-20 parts of haws, 10-15 parts of kudzuvine roots, 6-10 parts of astragalus membranaceus, 12-15 parts of cassia seeds and 10-18 parts of Chinese wolfberry fruits. The raw materials are made into powder to serve as auxiliary materials to be made into various foods such as health preserving porridge material bags, flour products, nutritional meal replacement powder, solid beverages, tablet candies, oral liquid, capsules and seasonings which are beneficial to lowering lipid and blood pressure and resisting aging. All the components in the formula are derived from natural food materials, effective substances of all the components have a synergistic effect, flavonoid compounds and terpene lactones in the ginkgo leaves, flavones and organic acids in the hawthorn fruits, puerarin and isoflavones in the radix puerariae, astragalus polysaccharide and flavones in the astragalus membranaceus and other components are matched with one another, and the effects of improving the immunity of the human body are achieved. And multiple effects of reducing blood fat, reducing blood pressure and resisting aging can be realized at the same time.

The invention discloses a method for rapidly detecting the content of terpene lactones in a ginkgo biloba extract, which comprises the following steps: directly carrying out reflux extraction on an extract sample by using a 90% methanol solution, and analyzing and detecting by using an ultra-high performance liquid chromatography-evaporative light detector combined technology. The method can remarkably shorten the sample pretreatment time and the instrument analysis time, improve the detection efficiency and improve the detection sensitivity, is suitable for industrial production, and plays an important role in guaranteeing the product quality of the ginkgo biloba extract.

The present application relates to a terpene lactone derivative and its application in the preparation of tranquilizers, in particular to a terpene lactone derivative as shown in general formula (I), or its stereoisomer, solvate, metabolite, prodrug, pharmaceutically acceptable salt or co-crystal, wherein the definitions of the substituents in general formula (I) are the same as those in the specification

The invention provides an illumination method for improving the quality of andrographis paniculata, and belongs to the technical field of agricultural planting. The method for improving the quality of the andrographis paniculata comprises the following step of irradiating the andrographis paniculata with blue light 15 days after seedling emergence of the andrographis paniculata. The method for improving the quality of the andrographis paniculata is simple, easy to implement and low in required cost, growth and development of andrographis paniculata plants can be promoted, accumulation of andrographis paniculata terpene lactone components can be effectively improved, the quality of the andrographis paniculata is improved, and powerful technical support is provided for high-quality development of the andrographis paniculata industry.

The invention discloses application of a DNA methylation inhibitor in regulation and control of synthesis of ginkgo terpene lactones in the technical field of plant cultivation, and the epigenetic regulation and control effect of 5-azacytidine on leaf growth and terpene lactones synthesis is researched by taking ginkgo as a material. 5-AzaC with different concentrations is set for treatment, and the dynamic change of leaf growth traits and terpene lactone accumulation is systematically analyzed. Researches show that treatment of 5-AzaC shows a significant dose effect: low concentration (50 [mu] mol / L) promotes increase of fresh weight and increase of terpene lactone content, and high concentration (greater than or equal to 150 [mu] mol / L) inhibits growth but significantly increases accumulation of bilobalide and ginkgolide C. Correlation analysis shows that biomass and terpene lactone content are in significant negative correlation, a growth and defense balance phenomenon is proved, the invention reveals that 5-AzaC affects synthesis and accumulation of different terpene lactones by regulating DNA methylation level difference, and a theoretical basis and a technical path are provided for accurate regulation of ginkgo medicinal components.

The invention discloses a gene GbSAUR48 for promoting synthesis and biomass of bilobalide as well as a carrier, a protein and application of the gene GbSAUR48. The nucleotide sequence of the gene GbSAUR48 is shown as SEQ ID NO. 1. According to the invention, the GbSAUR48 gene specifically and highly expressed in the ginkgo biloba root reveals dual functions of the GbSAUR48 gene in promoting lateral root generation, improving overground and underground biomass and promoting bilobalide synthesis for the first time. The number of fibrous roots / lateral roots and the overall overground / underground biomass of the plant over-expressed with GbSAUR48 are remarkably increased, and meanwhile the content of active terpene lactones (GA and GB) is synchronously increased. The invention not only shows that the GbSAUR48 is a key gene for regulating and controlling the quality (medicinal quality) and yield (biomass) of the gingko, but also provides a new theoretical basis and a practical path for realizing double improvement of the medicinal value and the yield of the gingko through a molecular breeding means.

This invention belongs to the field of pharmaceutical technology, specifically relating to a ginkgo leaf extract for improving cognitive impairment, its preparation method, and its application. The method includes the following steps: (1) first, pulverizing and sieving ginkgo leaves to obtain ginkgo leaf powder; (2) then mixing the ginkgo leaf powder with a eutectic solvent and extracting to obtain an extract; (3) finally, passing the extract sequentially through a macroporous resin and a polyamide column for adsorption, collecting the eluent, and obtaining the final product. The eutectic solvent is a mixture of L-carnitine, urea, and trifluoromethanesulfonic acid in a molar ratio of 1.5-2:1:0.2-0.4. This invention uses a specific eutectic solvent in the preparation of the ginkgo leaf extract. Through the synergistic effect of L-carnitine, urea, and trifluoromethanesulfonic acid, the pharmacological activity and the content of the effective components—total flavonol glycosides, total terpene lactones, and proanthocyanidins—are preserved to the greatest extent possible. Furthermore, it requires less equipment and has lower costs.

The invention provides a planting method for increasing the content of flavone and terpene lactones in ginkgo leaves, which is characterized by comprising the following steps: S1, in a ginkgo seedling field which grows well and is free from plant diseases and insect pests, applying a mixed fertilizer in each hole in a seedling germination stage, namely March of the current year, and then applying a bacterial solution to promote accumulation of flavonoid glycoside; s2, in the seedling leaf fast-growing period, namely May to June of the current year, the mixed fertilizer in the step S1 is applied to each ditch, then the bacterial liquid is applied, and accumulation of flavonoid glycoside is promoted; s3, in the growth period of the seedlings, namely September to October of the current year, a mixed fertilizer which is dissolved with water and diluted into 500 times is sprayed to the leaf surfaces of the seedlings, lactone cyclase is induced, and terpene lactone synthesis is promoted. The ginkgo leaf flavone content is greater than or equal to 26%, the terpene lactone content is greater than or equal to 6.5%, the utilization value of ginkgo leaves is improved, the market demand is met, and greater economic benefits are obtained for the planting industry.

A neuroprotective composition for the therapeutic and prophylactic treatment of Parkinson's disease, consisting of: (a) Curcuminoids in an amount of 45% to 65% by weight, the curcuminoids being curcumin, demethoxycurcumin and bisdemethoxycurcumin in the ratio 70:20:10; b) a standardized extract of Withania somnifera in an amount of 15 to 25 wt. %, wherein the extract contains at least 5 wt. %, withanolides; c) a standardized extract of Bacopa monnieri in an amount of 10 to 20 wt.%, wherein the extract contains at least 25 wt.% bacosides; and d) a standardized extract of Ginkgo biloba in an amount of 5 to 10 wt.%, wherein this extract contains at least 24 wt.% flavone glycosides and 6 wt.% terpene lactones.