Preparation method of ginkgo dipyridolum injection with high content of ginkgo terpene lactones

A technology of Damo injection and terpene lactone, which is applied in the field of preparation of Ginkgo Damo injection, can solve the problems affecting the content of terpene lactone, safety risk, and effect on product efficacy, so as to improve the extraction rate and avoid The effect of destruction

Active Publication Date: 2012-09-19
SHANXI PUDE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, multiple factors and indicators affect the content of terpene lactones in Ginkgo Damole Injection. If not paid attention to, it will seriously affect the efficacy of the product, and ultimately bring safety risks to clinical medication.

Method used

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  • Preparation method of ginkgo dipyridolum injection with high content of ginkgo terpene lactones
  • Preparation method of ginkgo dipyridolum injection with high content of ginkgo terpene lactones
  • Preparation method of ginkgo dipyridolum injection with high content of ginkgo terpene lactones

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]1. Raw material of Ginkgo biloba: Ginkgo biloba leaves are collected from the artificially planted leaves of Ginkgo biloba. The age of the tree is generally 6-15 years. The water content is controlled below 6%, and it is packaged and stored in a ventilated and dry place. The total content of ginkgolide A, ginkgolide B, ginkgolide C and bilobalide in ginkgo leaves is determined to be 0.361%, and the content of total flavonoids is determined. The content is 0.897%.

[0032] 2. Ginkgo biloba terpenoid lactone extract: put Ginkgo biloba leaves into the extraction device, add 70% ethanol solution with a concentration of 10 times the weight of the medicinal materials, heat and reflux for extraction, extract for 2 hours, and extract twice. The extracts are combined, the solvent is recovered under reduced pressure at low temperature, concentrated and dried, and the organic solvent crude extract of ginkgo leaves is obtained, leaving the extracted ginkgo leaf medicinal residues. ...

Embodiment 2

[0044] 1, Ginkgo biloba raw material: with embodiment 1.

[0045] 2. Ginkgo biloba terpenoid lactone extract: put the ginkgo leaves into the extraction device, add 80% methanol solution according to 7 times the weight of the medicinal materials, heat and reflux for extraction, extract for 3 hours, and extract 3 times in total. The extracts are combined, the solvent is recovered under reduced pressure at low temperature, concentrated and dried, and the organic solvent crude extract of ginkgo leaves is obtained, leaving the extracted ginkgo leaf medicinal residues. The crude extract was added with 4 times the amount of ethyl acetate of the crude extract, extracted and then filtered to obtain the filtrate and the crude extract 2 after extraction with ethyl acetate. Combine the filtrates, reclaim ethyl acetate from the filtrate under reduced pressure, add 90% ethanol solution to fully dissolve, filter, put the filtrate on the treated polyamide chromatographic column, elute with 90...

Embodiment 3

[0056] 1, Ginkgo biloba raw material: with embodiment 1.

[0057] 2. Ginkgo biloba terpenoid lactone extract: put the ginkgo leaves into the extraction device, add 15 times the weight of the medicinal material, add acetone solution with a concentration of 40%, heat and reflux for extraction, extract for 2 hours, and extract twice. The extracts are combined, the solvent is recovered under reduced pressure at low temperature, concentrated and dried, and the organic solvent crude extract of ginkgo leaves is obtained, leaving the extracted ginkgo leaf medicinal residues. Add 3 times the amount of ethyl acetate to the crude extract, extract and filter to obtain the filtrate and the crude extract 2 after extraction with ethyl acetate. Combine the filtrates, recover ethyl acetate from the filtrate under reduced pressure, add 100% ethanol solution to fully dissolve, filter, and put the filtrate on the treated polyamide chromatographic column, elute with the same (specifically what?) s...

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Abstract

The invention provides a preparation method of ginkgo dipyridolum injection with high content of ginkgo terpene lactones. The preparation method comprises the following steps: 1), collecting, processing, detecting and classifying ginkgo leaves; 2), extracting and preparing ginkgo terpene lactones extract from ginkgo leaves; 3), extracting ginkgo leaf flavonoid extract; 4), reflowing ginkgo leaf flavonoid extract and partial dipyridamole by adding water, and then filtering so as to be prepared into mixed liquor; 5), mixing the mixed liquor, ginkgo terpene lactones extract, the rest dipyridamole and auxiliary material to be prepared into ginkgo dipyridolum injection as per conventional preparation method; and in the ginkgo dipyridolum injection, the content of the total ginkgo leaf flavonoid and that of the dipyridamole conform to the conventional requirements, and the content of the ginkgo terpene lactones ranges from 0.5 to 1.2 mg/mL.

Description

technical field [0001] The invention relates to a method for preparing an injection, in particular to a method for preparing ginkgolide A, ginkgolide B, ginkgolide C and ginkgo-damole injection with relatively high content of bilobalide. Background technique [0002] Ginkgo biloba and dipyridamole are the main starting materials for the production of Ginkgo biloba injection. Among them, Ginkgo biloba is the dried leaf of Ginkgo biloba L., a plant of the family Ginkgoceae. It has the functions of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, astringing the lungs and relieving asthma, reducing turbidity and reducing fat. Stroke hemiplegia, lung deficiency cough and asthma and hyperlipidemia embolism. The chemical composition of Ginkgo biloba is complex, mainly including flavonoids, lactones, terpenoids, phenolic acids, macromolecules, alkaloids, polysaccharides, amino acids, trace elements, etc. The chemical name of dipyridam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K31/519A61K9/08A61P3/06A61P9/10A61K31/365
Inventor 何正有金英华刘婧武世明余辉王勇苏志强李润宝李立忠胡成伟
Owner SHANXI PUDE PHARMA CO LTD
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