Process for preparing water-soluble ginkgo biloba extract used for injection

A preparation process and extract technology, which is applied in the field of preparation process of water-soluble ginkgo biloba extract, can solve problems such as tannin residue, affecting the curative effect and safety of ginkgo injection preparations, and internal quality differences of ginkgo leaf extract, so as to achieve product quality stable effect

Active Publication Date: 2009-12-09
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the different extraction processes of Ginkgo biloba extracts, there are obvious differences in the internal quality of Ginkgo biloba extracts, mainly in: the solubility of Ginkgo biloba extracts in water, the content of terpene lactone components, The content ratio between total flavonoids and total ginkgo terpene lactones, tannin residues, resin residues, etc.
Seriously affect the efficacy and safety of various ginkgo injection preparations developed with ginkgo leaf extract
Therefore, the ginkgo leaf extract with the above-mentioned quality defects cannot be directly used in ginkgo injection preparations, and must be processed to make it meet the requirements for use of injections before it can be used in ginkgo injection preparations

Method used

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  • Process for preparing water-soluble ginkgo biloba extract used for injection
  • Process for preparing water-soluble ginkgo biloba extract used for injection
  • Process for preparing water-soluble ginkgo biloba extract used for injection

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Weigh 7.2g of medicinal gelatin (bone glue) and add slowly to 4800ml of purified water heated to about 40°C in advance under stirring. Insulate and stir until the medicinal gelatin is completely dissolved into a uniform solution to obtain a 0.15% medicinal gelatin aqueous solution (g / v), which is set aside.

[0027] Weigh 80g Ginkgo biloba extract (Ginkgo biloba extract is produced by our company, production batch number 0691013, total flavonol glycoside content is 24.4%, terpene lactone content is 8.5%, moisture content is 3.4%, flavonoid aglycone peak area ratio is 0.9) Pour into the above-mentioned concentration of medicinal gelatin aqueous solution, heat up to 100° C., keep warm and stir for extraction for 30 minutes. After the extraction is completed, the extract is cooled to 10° C., allowed to stand and settle for 24 hours, the solution is filtered, the solids are discarded, and the filtrate is used for later use.

[0028] The above-mentioned filtrate is ultrafil...

Embodiment 2

[0033] Weigh 14.4g of medicinal gelatin (bone glue) and add slowly to 4800ml of purified water heated to about 40°C in advance under stirring. Insulate and stir until the medicinal gelatin is completely dissolved into a uniform solution to obtain a 0.30% medicinal gelatin aqueous solution (g / v), which is set aside.

[0034] Weigh 80g Ginkgo biloba extract (Ginkgo biloba extract is produced by our company, production batch number 0691013, total flavonol glycoside content is 24.4%, terpene lactone content is 8.5%, moisture content is 3.4%, flavonoid aglycone peak area ratio is 0.9) Pour into the above-mentioned concentration of medicinal gelatin aqueous solution, heat up to 100° C., keep warm and stir for extraction for 30 minutes. After the extraction is completed, the extract is cooled to 10° C., allowed to stand and settle for 24 hours, the solution is filtered, the solids are discarded, and the filtrate is used for later use.

[0035] The above-mentioned filtrate is ultrafi...

Embodiment 3

[0040] Weigh 4.8g of medicinal gelatin (bone glue) and add slowly to 4800ml of purified water heated to about 40°C in advance under stirring. Keeping warm and stirring until the medicinal gelatin is completely dissolved into a uniform solution to obtain a 0.10% medicinal gelatin aqueous solution (g / v), which is set aside.

[0041] Weigh 80g Ginkgo biloba extract (Ginkgo biloba extract is produced by our company, production batch number 0691013, total flavonol glycoside content is 24.4%, terpene lactone content is 8.5%, moisture content is 3.4%, flavonoid aglycone peak area ratio is 0.9) Pour into the above-mentioned concentration of medicinal gelatin aqueous solution, heat up to 100° C., keep warm and stir for extraction for 30 minutes. After the extraction is completed, the extract is cooled to 10° C., allowed to stand and settle for 24 hours, the solution is filtered, the solids are discarded, and the filtrate is used for later use.

[0042] The above-mentioned filtrate is ...

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Abstract

The invention discloses a process for preparing a water-soluble ginkgo biloba extract used for injection, which comprises the following steps: preparing a medicinal gelatin aqueous solution of 0.1-0.3 percent; dissolving the water-soluble ginkgo biloba extract by the gelatin aqueous solution; ultrafiltering and drying the dissolved ginkgo biloba extract in vacuum to prepare total ginkgo terpene lactones and a total ginkgo flavone-glycoides extract; and generally mixing the components according to respective contents so as to prepare a finished product. In the water-soluble ginkgo biloba extract, the content ratio of total flavonol glycosides to the total ginkgo terpene lactones is 4:1, thus the water-soluble ginkgo biloba extract can be used as a water-soluble ginkgo injection raw material, thereby enlarging the range of application and ensuring the safety, the effectiveness, the stability and the controllability of product quality.

Description

Technical field: [0001] The invention relates to a preparation process of traditional Chinese medicine, in particular to a preparation process of water-soluble ginkgo leaf extract for injection preparations. Background technique: [0002] Ginkgo biloba extract is a traditional Chinese medicine extract extracted from Ginkgo biloba with unique pharmacological activity. Due to its unique pharmacological activity and huge and extensive clinical application value, it has become a hot spot and focus in the research and development of herbal medicines. . There are two major types of substances that play a major therapeutic role in Ginkgo biloba extract, one is ginkgo flavonoids, and the other is ginkgolides. Studies have shown that: Ginkgo flavonoids can expand blood vessels, improve blood vessel endings and cerebrovascular circulation, lower cholesterol, relieve smooth muscle spasm, relax bronchus, etc., and are often used to treat and prevent cardiovascular diseases and dizzines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P9/10A61P9/00A61P7/00A61P29/00A61P37/08A61K127/00
Inventor 胡林森
Owner SHANGHAI SINE PROMOD PHARMA
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