The invention relates to a method for refining
fasudil hydrochloride. The method comprises the following steps: 1, discoloring, namely adding
active carbon into
fasudil after resin adsorption, fully mixing the
active carbon and the
fasudil, filtering the mixture, removing the
active carbon, and collecting the filtered solution for later use; 2, washing, namely adding
purified water into the discolored solution, fully mixing the solution, separating the solution to remove water phase, and collecting the
oil phase for later use; 3, acidifying and salifying, namely adding the
purified water intothe
oil phase, adjusting pH value of the solution by
hydrochloric acid to fully acidify and salify the
oil phase, and collecting the water phase for later use; and 4,
crystallization, namely, adding n-butyl
alcohol into the water phase, fully mixing the solution, then decompressing and azeotropic-crystallizing the solution, duly replenishing the n-butyl
alcohol to keep the consistency of the solution, stopping
crystallization till the
moisture content in the mother solution is reduced to a certain value, and filtering and
drying the crystals to obtain a refined fasudil
hydrochloride product.