22 results about "Joint arthralgia" patented technology

The invention relates to the technical field of biomedicine, in particular to a novel target spot for resisting chikungunya virus infection and application. According to the invention, human colon cancer cells (HCT116) are taken as target cells, and retinoic acid-induced protein expression of the target cells is reduced by adopting a gene knockout technology, so that host factors capable of effectively inhibiting CHIKV infection of the human colon cancer cells are found, and the purpose of blocking CHIKV infection from the source is achieved. It is found that retinoic acid induced protein 16 (RAI16) plays an important role in CHIKV infected HCT116 cells, and CHIKV infection can be obviously promoted by down-regulating expression of RAI16. The invention provides an application of RAI16 in preparation of a medicine for preventing or treating chikungunya virus infection, and provides a new target spot and a treatment scheme for clinically preventing and treating fever, arthralgia, arthrocele, muscular pain, headache, nausea, fatigue, rash and other diseases caused by CHIKV infection.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The application discloses a triple fluorescent quantitative PCR detection kit for simultaneously detecting CHIKV, BFV and RRV, which contains a specific primer probe composition for simultaneously detecting chikungunya virus, Barmah Forest virus and Ross River virus, can simultaneously detect three viruses which are transmitted by insect vectors and cause acute fever with arthralgia symptoms in human beings in one PCR reaction tube, and has excellent specificity and repeatability, and is suitable for routine laboratory diagnosis of suspected samples of alphavirus infection, and provides a rapid and accurate detection method for the epidemiological study of CHIKV, BFV and RRV.

This invention discloses an environmental parameter sensing and adaptive adjustment system and method based on a photoconductive film. It integrates six-dimensional environmental sensors—light intensity, ultraviolet radiation, temperature, humidity, air pressure, and air quality—at the edge of the photoconductive film, and utilizes the film's directional light guidance and stray light filtering mechanisms to reduce environmental interference. The system includes an environmental sensing module, an environmental parameter processing module, a health data interface module, a correlation analysis module, an adaptive adjustment module, and an environmental early warning module. The correlation analysis module has preset environmental-health correlation patterns such as low temperature-increased blood pressure, high humidity-decreased blood oxygen, high ultraviolet radiation-skin health, poor air quality-respiratory diseases, and sudden changes in air pressure-headaches and joint pain, set based on clinical research data. The adaptive adjustment module pairs with smart home devices through a unified identity authentication center, sending control commands via Wi-Fi / Bluetooth / infrared to automatically adjust air conditioners, humidifiers, dehumidifiers, air purifiers, and lighting according to environmental parameters. The environmental early warning module supports single-indicator early warning, correlation early warning, trend early warning, and seasonal disease early warning, with customizable thresholds. The multi-environmental data fusion module uses weighted averaging and the 3σ principle for anomaly removal, integrating data from multiple devices such as mobile phones, watches, vehicles, and smart home devices. The sensors are automatically calibrated daily using meteorological bureau data, with the calibration process simultaneously linked to health data. This invention solves the problems of scattered environmental sensing devices, disconnect from health data, and inability to proactively adjust, serving as the infrastructure for intelligent health management.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The invention discloses a massage composition for relieving muscle and neck, shoulder, waist and leg joint pain and a preparation method. The composition is prepared from pallas pit viper oil, a snow lotus herb extract, a pilose antler extract, a dragon's blood extract, garden balsam stem oil, a myrrh extract, saffron crocus oil, vanillyl butyl ether, ginger root oil, tortoise shells, menthol, frankincense oil, cetostearyl alcohol, a stearyl trimethyl ammonium chloride mixture, 2-bromine-2-nitropropane-1, 3-diol, methylparaben and water. The invention further provides a preparation method of the massage composition for relieving muscle and neck-shoulder-waist-leg joint pain and application of the composition. The massage composition for relieving the pain of the muscles, the neck, the shoulders, the waist and the legs shows remarkable effects in the aspects of relieving the pain of the muscles, the neck, the shoulders, the waist and the legs and relieving fatigue, the pain degree of a patient can be effectively relieved, and the life quality of the patient is improved.

The invention relates to the technical field of biomedicine, in particular to a novel target spot for resisting chikungunya virus infection and application. According to the invention, human neuroblastoma cells (SH-SY5Y) and human brain astroblastoma cells (U87) are taken as target cells, and the expression of the target cell part capable of exerting receptor action membrane protein is down-regulated by adopting an RNA interference technology, so that a host factor capable of effectively inhibiting CHIKV infection of human nerve cells is found, and the purpose of blocking CHIKV infection from the source is achieved. It is found that platelet membrane glycoprotein VI (GP6) plays an important role in CHIKV infection SH-SY5Y and U87 cells, expression of GP6 is reduced, and CHIKV infection can be obviously inhibited. The invention provides an application of GP6 in preparation of a medicine for preventing or treating chikungunya virus infection, and provides a new target spot and a treatment scheme for clinically preventing and treating fever, arthralgia, joint swelling, muscle pain, headache, nausea, fatigue, rash and other diseases caused by CHIKV infection.

The invention discloses a traditional Chinese medicine composition for soothing channels and activating collaterals. The traditional Chinese medicine composition comprises the following components: 2-4 parts of asiatic toddalia root, 1-3 parts of raw pinellia ternate, 1-3 parts of monkshood, 1-3 parts of radix aconiti agrestis, 1-3 parts of radix aconiti carmichaeli, 3-5 parts of safflower, 3-5 parts of asarum, 3-5 parts of angelica sinensis, 3-5 parts of ligusticum wallichii, 1-3 parts of croton root, 3-5 parts of pepper, 3-5 parts of ground beeltle, 5-7 parts of pseudo-ginseng root, 3-5 parts of radix clematidis, 3-5 parts of sappan wood, 2-4 parts of cortex dictamni, 2-4 parts of radix angelicae pubescentis, 2-4 parts of honeycomb and 2-4 parts of frankincense. , 3-5 parts of pomegranate rind, 1-3 parts of hippocampus, 1-3 parts of centipede and 1-3 parts of dragon's blood. The traditional Chinese medicine composition for relaxing the channels and activating the collaterals has the effects of relaxing the channels and activating the collaterals, dispelling wind and eliminating dampness, and relieving swelling and pain, can effectively relieve swelling and pain caused by traumatic injury, blood stasis, joint dysfunction and the like, can be used for treating diseases such as traumatic injury, rheumatic arthralgia and the like after a fracture operation, also has a certain curative effect on stroke, is sprayed or smeared on an affected part, and has no toxic or side effect. A preservative film can be used for covering, so that the pesticide effect is greatly improved.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving muscles and penetrating rashes, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-30 parts of pachouli, 10-40 parts of kudzu vine, 5-30 parts of notopterygium, 10-40 parts of talc, 5-30 parts of red peony root, 5-30 parts of thin soja bean, 5-30 parts of lophatherum gracile, 5-30 parts of raw rehmannia, and 10-30 parts of forsythia. The traditional Chinese medicine composition has the effects of dispelling dampness and relieving muscles, clearing heat and penetrating rashes, and can effectively improve the symptoms of fever, arthralgia, rash, fatigue, dry mouth and bitter taste, thick and greasy tongue fur and the like of patients with chikungunya fever caused by dampness stagnation in muscles and joints and heat entering the interior.

The invention discloses a traditional Chinese medicine composition which comprises the following medicinal materials in terms of 50 preparation units: 60-100 parts of pseudo-ginseng, 60-100 parts of vinegar-processed rhizoma corydalis, 20-60 parts of starfish, 20-60 parts of ground beeltle, 5-15 parts of processed semen strychni, 10-30 parts of safflower, 1-20 parts of vinegar-processed frankincense, 1-20 parts of vinegar-processed myrrh, 1-10 parts of borneol and 0.1-1 part of artificial musk. The invention further discloses a preparation method of a tincture of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating acute and chronic falling trauma, neck, shoulder, waist and knee pain or arthralgia. The traditional Chinese medicine composition disclosed by the invention has the effects of relaxing muscles and tendons, promoting blood circulation, dredging collaterals, dissipating blood stasis, diminishing swelling and relieving pain. Pharmacodynamic studies show that the traditional Chinese medicine composition disclosed by the invention takes effect quickly and has a good curative effect when being used for treating symptoms such as traumatic injuries, blood stasis swelling and swelling and red and swollen injuries. The traditional Chinese medicine composition disclosed by the invention effectively relieves the injury condition of a tested animal, and is free of irritation and sensitization to the tested animal in a skin medication toxicity test.

To provide a dosage regimen for safely and effectively treating androgen-dependent prostate cancer without causing testosterone surge and / or other side effects of GnRH agonist therapy such as urinary tract infection or joint pain-related or cardiovascular side effects.SOLUTION: A relatively low dose of degarelix GnRH antagonist is provided about once every 28 days (e.g. once a month).SELECTED DRAWING: Figure 2

The invention discloses a traditional Chinese medicine extract composition for assisting in reducing uric acid and a preparation method, and relates to the technical field of traditional Chinese medicine compositions, the traditional Chinese medicine extract composition comprises poria cocos, cichorium intybus, radix puerariae, gentiana macrophylla, rhizoma smilacis glabrae, Tibetan capillary, emblic leafflower fruit, glabrous sarcandra herb, Chinese starjasmine stem, wild buckwheat rhizome and white gourd. The traditional Chinese medicine extract composition breaks through the limitation of single existing uric acid reducing mechanism, plays a role in uric acid generation and excretion links, regulates a key pathway of uric acid metabolism through traditional Chinese medicine components to reduce uric acid generation, promotes urination to promote uric acid excretion, inhibits inflammatory mediator release and relieves oxidative damage by means of glabrous sarcandra herb and wild buckwheat rhizome components, and has a good application prospect. According to the traditional Chinese medicine preparation, the effect of multi-link synergistic effect of reducing uric acid, resisting inflammation and resisting oxidation is achieved, meanwhile, the blood uric acid level is reduced, the gout arthralgia symptom is relieved, the problem that an existing traditional Chinese medicine preparation cannot give consideration to comprehensive curative effect is solved, the requirement of a patient for comprehensive improvement of the illness state is met, and the overall effectiveness of treatment is improved.

The invention discloses a traditional Chinese medicine formula of cold-dispelling dampness-eliminating anti-epidemic medicinal liquor and a preparation method of the traditional Chinese medicine formula. The formula comprises 22 traditional Chinese medicines such as 400-500g of Japanese peristrophe (or lycopodium clavatum), 300-450g of glossy privet fruit and the like and 40-60kg of Baijiu of 50 degrees or more. The preparation method comprises the following steps: pretreating the medicinal materials, sealing and soaking for 3 months (keeping out of light at room temperature and regularly stirring), and filtering to remove residues. Through the synergistic effect of the medicinal materials, the wine has the effects of dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, promoting blood circulation to remove meridian obstruction and assisting in lowering'three highs', can improve soreness and weakness of waist and knees, arthralgia and the like, is suitable for sub-health people, and is clear in taboo and controllable in safety.

The invention relates to the technical field of biomedicine, in particular to a novel target spot for resisting chikungunya virus infection and application. According to the invention, human neuroblastoma cells (SH-SY5Y) and human brain astroblastoma cells (U87) are taken as target cells, and the expression of the target cell part capable of exerting receptor action membrane protein is down-regulated by adopting an RNA interference technology, so that a host factor capable of effectively inhibiting CHIKV infection of human nerve cells is found, and the purpose of blocking CHIKV infection from the source is achieved. The invention discovers that the nerve cilia protein 2 (NRP2) plays an important role in CHIKV infection SH-SY5Y and U87 cells, and the CHIKV infection can be obviously inhibited by down-regulating the expression of the NRP2. The invention provides an application of NRP2 in preparation of a medicine for preventing or treating chikungunya virus infection, and provides a new target spot and a treatment scheme for clinically preventing and treating fever, arthralgia, arthrocele, muscular pain, headache, nausea, fatigue, rash and other diseases caused by CHIKV infection.

The control method of the shaking bed described in the present application realizes the equipment and standardization of the traditional shaking health preservation method through precise control of the bed plate swing, walking assembly swing and heating assembly heating, breaks through the technical limitations of the existing conditioning equipment, solves the problem that the shaking method needs to be learned and cannot be quickly popularized. The control method simulates the whole body resonance effect of the shaking method, combines passive walking and heating to raise yang, and realizes whole body systemic deep conditioning in a lying state, which can dredge the meridians, regulate the viscera, promote blood circulation, relieve muscle tension, improve digestion, and has auxiliary conditioning effect on rheumatism and joint pain, lumbar problems, etc.

Disclosed is a method of treating or preventing skeletal sequelae of coronavirus infection in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an endothelin receptor antagonist, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide. The skeletal sequelae may include one or more of arthralgia, viral arthritis, osteopenia, osteochondral injury, and osteoporosis.

The invention provides an acetaminophen ointment and a preparation method thereof. According to the ointment composition disclosed by the invention, the medicine can better play a role in local positioning treatment of arthralgia and neuralgia diseases, and meanwhile, the side effect of liver injury caused by oral medicine can be avoided. The ointment composition is good in spreadability, basically free of granular sensation, resistant to heat and stable, the preparation method is simple, the production cost is low, and the ointment composition is especially suitable for large-scale industrial production.

The invention discloses a medicine bag and medicinal liquor for treating rheumatism ostalgia and a preparation method thereof, and belongs to the technical field of medicine bags and medicinal liquor for treating rheumatism ostalgia, the medicine bag and medicinal liquor are prepared from the following raw materials in parts by weight: 1 part of red clam flower, 1 part of adhatoda vasica, 1 part of alpinia japonica and 1 part of artemisia biloba. The preparation method of the rheumatism bag comprises the following steps: grinding fresh leaf branches or dry leaf branches of the red clam flower, the adhatoda vasica, the alpinia japonica and the artemisia biloba into coarse powder, and then fumigating the medicinal materials at 105 DEG C for 10-20 minutes to obtain the rheumatism bag. The preparation method of the wine for treating rheumatism comprises the following steps: cutting fresh leaf branches or dry leaf branches of the red clathraea, the adhatoda vasica, the alpinia japonica and the artemisia biloba into sections, and then soaking the medicinal materials in 10 parts of white spirit with the alcohol content of 50 degrees or above for three months to obtain the wine for treating rheumatism. The formula can be used for treating the rheumatism ostalgia disease, and the external medicine bag and medicinal liquor for treating the rheumatism ostalgia disease have the effects of clearing away heat and toxic materials, promoting blood circulation to subdue swelling, dispelling wind and relieving pain, promoting reunion of fractured tendons and bones, treating rheumatism arthralgia, tonifying fire, strengthening the body, eliminating swelling and dissipating blood stasis, treating rheumatism limb joint swelling and pain and the like through external application.

The invention discloses an ephedra decoction formula which comprises the following raw materials by mass: 10 g of ephedra, 10 g of cassia twig, 10 g of apricot kernel, 6 g of licorice and 8 g of root of kudzu vine. Compared with the prior art, the traditional Chinese medicine composition has the advantages that the radix puerariae is added in the formula, so that the traditional Chinese medicine composition has a remarkable effect on forehead fever, eyebrow and ridge pain and afterbrain pain, has the major functions of fever, body temperature rise, cough and phlegm, aversion to cold, arthralgia of the whole body, chest distress and shortness of breath, unsmooth breath and throat disadvantage, has a good treatment effect on symptoms caused by pneumovirus, and is good in applicability and free of toxic and side effects. The popularization is convenient.

The invention provides a collateral-dredging and pain-relieving liquid for treating osteoarthralgia, and relates to the technical field of traditional Chinese medicines. The collateral-dredging and pain-relieving liquid for treating bone and joint pain is prepared from asarum, cinnamon, raw radix aconiti agrestis, raw radix aconiti kusnezoffii, raw semen strychni, ephedra, rhizoma zingiberis, rosin, camphor and borneol. The liquid for dredging collaterals and relieving pain has the effects of clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, diminishing inflammation and relieving pain and smoothening joints, and can effectively treat neck, shoulder, waist and leg pain and bone and joint pain caused by rheumatism, rheumatoid, synovitis, soft tissue injury and the like.

The invention relates to a traditional Chinese medicine composition for removing fatigue and treating osteoarthralgia as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in parts by weight of dry substances in the raw materials: 20-60 parts of fig, 20-60 parts of cistanche, 0-10 parts of peach kernel and 0-20 parts of lalang grass rhizome. The preparation method comprises the step of mixing the components of the traditional Chinese medicine composition. The traditional Chinese medicine has the advantages of being good in qi and blood supplementing effect, capable of eliminating fatigue, quick in treatment effect on waist, shoulder, neck and knee joint pain, capable of quickly relieving the pain and good in treatment and healing effect.