33 results about "Joint arthralgia" patented technology

The invention relates to the technical field of biomedicine, in particular to a novel target spot for resisting chikungunya virus infection and application. According to the invention, human colon cancer cells (HCT116) are taken as target cells, and retinoic acid-induced protein expression of the target cells is reduced by adopting a gene knockout technology, so that host factors capable of effectively inhibiting CHIKV infection of the human colon cancer cells are found, and the purpose of blocking CHIKV infection from the source is achieved. It is found that retinoic acid induced protein 16 (RAI16) plays an important role in CHIKV infected HCT116 cells, and CHIKV infection can be obviously promoted by down-regulating expression of RAI16. The invention provides an application of RAI16 in preparation of a medicine for preventing or treating chikungunya virus infection, and provides a new target spot and a treatment scheme for clinically preventing and treating fever, arthralgia, arthrocele, muscular pain, headache, nausea, fatigue, rash and other diseases caused by CHIKV infection.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The application discloses a triple fluorescent quantitative PCR detection kit for simultaneously detecting CHIKV, BFV and RRV, which contains a specific primer probe composition for simultaneously detecting chikungunya virus, Barmah Forest virus and Ross River virus, can simultaneously detect three viruses which are transmitted by insect vectors and cause acute fever with arthralgia symptoms in human beings in one PCR reaction tube, and has excellent specificity and repeatability, and is suitable for routine laboratory diagnosis of suspected samples of alphavirus infection, and provides a rapid and accurate detection method for the epidemiological study of CHIKV, BFV and RRV.

This invention discloses an environmental parameter sensing and adaptive adjustment system and method based on a photoconductive film. It integrates six-dimensional environmental sensors—light intensity, ultraviolet radiation, temperature, humidity, air pressure, and air quality—at the edge of the photoconductive film, and utilizes the film's directional light guidance and stray light filtering mechanisms to reduce environmental interference. The system includes an environmental sensing module, an environmental parameter processing module, a health data interface module, a correlation analysis module, an adaptive adjustment module, and an environmental early warning module. The correlation analysis module has preset environmental-health correlation patterns such as low temperature-increased blood pressure, high humidity-decreased blood oxygen, high ultraviolet radiation-skin health, poor air quality-respiratory diseases, and sudden changes in air pressure-headaches and joint pain, set based on clinical research data. The adaptive adjustment module pairs with smart home devices through a unified identity authentication center, sending control commands via Wi-Fi / Bluetooth / infrared to automatically adjust air conditioners, humidifiers, dehumidifiers, air purifiers, and lighting according to environmental parameters. The environmental early warning module supports single-indicator early warning, correlation early warning, trend early warning, and seasonal disease early warning, with customizable thresholds. The multi-environmental data fusion module uses weighted averaging and the 3σ principle for anomaly removal, integrating data from multiple devices such as mobile phones, watches, vehicles, and smart home devices. The sensors are automatically calibrated daily using meteorological bureau data, with the calibration process simultaneously linked to health data. This invention solves the problems of scattered environmental sensing devices, disconnect from health data, and inability to proactively adjust, serving as the infrastructure for intelligent health management.

The invention relates to the technical field of medicinal liquor, in particular to medicinal liquor and a preparation method thereof.The preparation method comprises the steps that main medicinal liquor raw materials are crushed, and medicinal powder is obtained; pouring the medicinal powder into Baijiu for mixed extraction, filtering after extraction, heating and concentrating, and cooling to obtain main medicinal liquor; preparing auxiliary medicinal liquor; and adding the auxiliary medicinal liquor into the main medicinal liquor to obtain the medicinal liquor. The premna microphylla is used as a main raw material and has the effects of diminishing inflammation, sterilizing, relieving pain, promoting blood circulation to remove blood stasis, removing necrotic tissue and promoting granulation, and the honeysuckle, the dandelion, the ganoderma lucidum and the like are used as auxiliary materials, so that the prepared main medicinal liquor is relatively good in overall functionality; in order to meet the treatment requirements of different kinds of diseases, different kinds of auxiliary medicinal liquor are compounded on the basis of the main medicinal liquor, part of diseases can be specifically treated, for example, gastrodia elata / polygonum multiflorum is used as an auxiliary material, and the obtained medicinal liquor has excellent performance in the aspect of treating arthralgia; corn cervi pantotrichum / ginseng / American ginseng are used as auxiliary materials, and the obtained medicinal liquor can better improve acne skin problems.

The invention discloses a rodent arthralgia threshold value measuring device and method, and relates to the field of pain sense measurement, the rodent arthralgia threshold value measuring device is characterized in that a pressure sensor is movably connected to a shell, and an automatic telescopic device is arranged in the shell; a pressure sensing probe is arranged on the pressure sensor; the automatic telescopic device is connected with the pressure sensor; the pressure sensor is connected with the display screen through a signal converter in the shell; a camera is arranged on the shell; the camera is connected with the display screen through a signal converter; the display screen is used for displaying a time-pressure change curve and animal behavior information; and based on the time-pressure change curve and the animal behavior information, taking the pressure value of the pressure sensing probe corresponding to the time point when the rodent has the effective withdrawal behavior as the pain threshold of the rodent joint, so that the requirement of simply, conveniently, quickly and continuously measuring the pain threshold is met, and the efficiency of measuring the pain threshold of the joint is improved.

A method of forming a suspension of an undenatured type II collagen is provided, wherein the method comprises the steps of: (a) combining a natural flavouring and / or preserve and water, and heating in a first heating stage; (b) adding a gum; (c) adding a hydrated pectin mixture, and heating to a temperature higher than the temperature of the first heating stage; (d) adding an undenatured type II collagen powder; and (e) cooling to form a suspension. The method may further comprise added an acidifying agent, such as citric acid, after adding the undenatured type II collagen. The gum may be selected from xanthan gum and / or lecithin sunflower gum. A suspension of an undenatured type II collagen prepared by the method is provided. An exemplary suspension for dogs comprises 40 wt% chicory root fibre, 4 wt% undenatured type II collagen, 1.2 wt% pectin, 0.55 wt% citric acid, 0.4 wt% xanthan gum, 0.3 wt% natural flavouring, 0.05 wt% potassium sorbate, and 53.5 wt% water. The suspension is preferably a gel that can be orally administered to a pet or animal with joint pain / arthritis.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The invention discloses a massage composition for relieving muscle and neck, shoulder, waist and leg joint pain and a preparation method. The composition is prepared from pallas pit viper oil, a snow lotus herb extract, a pilose antler extract, a dragon's blood extract, garden balsam stem oil, a myrrh extract, saffron crocus oil, vanillyl butyl ether, ginger root oil, tortoise shells, menthol, frankincense oil, cetostearyl alcohol, a stearyl trimethyl ammonium chloride mixture, 2-bromine-2-nitropropane-1, 3-diol, methylparaben and water. The invention further provides a preparation method of the massage composition for relieving muscle and neck-shoulder-waist-leg joint pain and application of the composition. The massage composition for relieving the pain of the muscles, the neck, the shoulders, the waist and the legs shows remarkable effects in the aspects of relieving the pain of the muscles, the neck, the shoulders, the waist and the legs and relieving fatigue, the pain degree of a patient can be effectively relieved, and the life quality of the patient is improved.

The invention discloses a triple fluorescent quantitative PCR detection kit for simultaneously detecting CHIKV, BFV and RRV, and the kit comprises a specific primer probe composition for simultaneously detecting chikungunya virus, Bama forest virus and Rosc river virus, three viruses which are transmitted through entomophilous and cause human acute fever with arthralgia symptoms can be simultaneously detected in one PCR reaction tube, the lowest detection concentration of CHIKV plasmid samples is 20 copies / microliter, the lowest detection concentration of RRV and BFV positive samples is 10 copies / microliter, and the kit has excellent specificity and repeatability, and can be used for detecting the acute fever with arthralgia symptoms of the human acute fever with the arthralgia symptoms of the human acute fever with the arthralgia symptoms of the human acute fever with the arthralgia symptoms. The kit is suitable for conventional laboratory diagnosis of suspected alphavirus infection samples, and a rapid and accurate detection method is provided for epidemiological research of CHIKV, BFV and RRV.

The invention relates to the technical field of biomedicine, in particular to a novel target spot for resisting chikungunya virus infection and application. According to the invention, human neuroblastoma cells (SH-SY5Y) and human brain astroblastoma cells (U87) are taken as target cells, and the expression of the target cell part capable of exerting receptor action membrane protein is down-regulated by adopting an RNA interference technology, so that a host factor capable of effectively inhibiting CHIKV infection of human nerve cells is found, and the purpose of blocking CHIKV infection from the source is achieved. It is found that platelet membrane glycoprotein VI (GP6) plays an important role in CHIKV infection SH-SY5Y and U87 cells, expression of GP6 is reduced, and CHIKV infection can be obviously inhibited. The invention provides an application of GP6 in preparation of a medicine for preventing or treating chikungunya virus infection, and provides a new target spot and a treatment scheme for clinically preventing and treating fever, arthralgia, joint swelling, muscle pain, headache, nausea, fatigue, rash and other diseases caused by CHIKV infection.

The invention discloses a traditional Chinese medicine composition for soothing channels and activating collaterals. The traditional Chinese medicine composition comprises the following components: 2-4 parts of asiatic toddalia root, 1-3 parts of raw pinellia ternate, 1-3 parts of monkshood, 1-3 parts of radix aconiti agrestis, 1-3 parts of radix aconiti carmichaeli, 3-5 parts of safflower, 3-5 parts of asarum, 3-5 parts of angelica sinensis, 3-5 parts of ligusticum wallichii, 1-3 parts of croton root, 3-5 parts of pepper, 3-5 parts of ground beeltle, 5-7 parts of pseudo-ginseng root, 3-5 parts of radix clematidis, 3-5 parts of sappan wood, 2-4 parts of cortex dictamni, 2-4 parts of radix angelicae pubescentis, 2-4 parts of honeycomb and 2-4 parts of frankincense. , 3-5 parts of pomegranate rind, 1-3 parts of hippocampus, 1-3 parts of centipede and 1-3 parts of dragon's blood. The traditional Chinese medicine composition for relaxing the channels and activating the collaterals has the effects of relaxing the channels and activating the collaterals, dispelling wind and eliminating dampness, and relieving swelling and pain, can effectively relieve swelling and pain caused by traumatic injury, blood stasis, joint dysfunction and the like, can be used for treating diseases such as traumatic injury, rheumatic arthralgia and the like after a fracture operation, also has a certain curative effect on stroke, is sprayed or smeared on an affected part, and has no toxic or side effect. A preservative film can be used for covering, so that the pesticide effect is greatly improved.

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

The invention relates to the technical field of body conditioning medicines, in particular to a medicine formula for conditioning a body movement system and a preparation process of the medicine formula. Comprising a main material and an auxiliary material, the main material is prepared by mixing the following raw materials by weight: 15-24 g of white peony root, 2-8 g of licorice, 4-12 g of achyranthes bidentata, 2-8 g of safflower, 5-15 g of dogwood, 5-12 g of prepared rehmannia root, 5-15 g of eucommia ulmoides, 2-10 g of fennel, 4-15 g of fructus aurantii and 15-25 g of folium artemisiae argyi; the auxiliary material is prepared by mixing the following raw materials by weight: 3-7 g of coix seed powder, 1-3 g of small red bean powder, 1-3 g of pea powder, 1-3 g of buckwheat powder, 1-3 g of Chinese yam powder, 1-3 g of soybean powder, 1-3 g of hyacinth bean powder, 8-12 g of Chinese wolfberry and 8-12 g of red dates. The formula has the beneficial effects that the formula is scientifically prepared, the nutrition is balanced, and diseases such as cervical spondylosis, chest, neck, waist and leg pains (chest, neck, waist and legs), protrusion of intervertebral disc, ankylosing spondylitis, arthritis, tennis elbow, rheumatic arthritis, femoral head necrosis, numbness of limbs, arthralgia, synovitis, knee effusion, meniscus injury, hyperostosis, sciatica and varicosity can be conditioned.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving muscles and penetrating rashes, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-30 parts of pachouli, 10-40 parts of kudzu vine, 5-30 parts of notopterygium, 10-40 parts of talc, 5-30 parts of red peony root, 5-30 parts of thin soja bean, 5-30 parts of lophatherum gracile, 5-30 parts of raw rehmannia, and 10-30 parts of forsythia. The traditional Chinese medicine composition has the effects of dispelling dampness and relieving muscles, clearing heat and penetrating rashes, and can effectively improve the symptoms of fever, arthralgia, rash, fatigue, dry mouth and bitter taste, thick and greasy tongue fur and the like of patients with chikungunya fever caused by dampness stagnation in muscles and joints and heat entering the interior.

Uses are described for hemolymph, contents of hemolymph, fragments or components of the contents found within hemolymph, including hemocyanin, any of which may be derived from crustaceans, as functional agents to treat diseases, provide symptomatic relief, provide a beautifying or relieving effect to the intended organ or site-of-intended-use, or be used as an ingredient in formulations designed to aid in the relief of pathologies or states commonly associated with inflammation and dry skin, including, but not limited to eczema, dermatitis, psoriasis, cystitis, asthma, sinusitis, joint pain, as well as other instances of acute and chronic inflammation, and for relief of general symptoms that may be associated with inflammation and dry skin but not linked directly in the intended use, including, but not limited to, redness, itchiness, irritation, muscle or joint fatigue, swelling, hydrating the skin, and reducing transepidermal water loss (TEWL).

The invention discloses a traditional Chinese medicine composition which comprises the following medicinal materials in terms of 50 preparation units: 60-100 parts of pseudo-ginseng, 60-100 parts of vinegar-processed rhizoma corydalis, 20-60 parts of starfish, 20-60 parts of ground beeltle, 5-15 parts of processed semen strychni, 10-30 parts of safflower, 1-20 parts of vinegar-processed frankincense, 1-20 parts of vinegar-processed myrrh, 1-10 parts of borneol and 0.1-1 part of artificial musk. The invention further discloses a preparation method of a tincture of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating acute and chronic falling trauma, neck, shoulder, waist and knee pain or arthralgia. The traditional Chinese medicine composition disclosed by the invention has the effects of relaxing muscles and tendons, promoting blood circulation, dredging collaterals, dissipating blood stasis, diminishing swelling and relieving pain. Pharmacodynamic studies show that the traditional Chinese medicine composition disclosed by the invention takes effect quickly and has a good curative effect when being used for treating symptoms such as traumatic injuries, blood stasis swelling and swelling and red and swollen injuries. The traditional Chinese medicine composition disclosed by the invention effectively relieves the injury condition of a tested animal, and is free of irritation and sensitization to the tested animal in a skin medication toxicity test.

A nanoemulsion for topical drug delivery, comprising diclofenac alkali metal salt, diclofenac free acid, a solvent of the glycol, or glycol ether or glycol ether ester family, a nonionic surfactant with a hydrophilic lipophilic balance (HLB) value of about 14-16, caprylic capric triglyceride, and water. The nanoemulsion is useful in the treatment of joint pain, osteoarthritis, muscle pain, back pain and / or inflammation.

To provide a dosage regimen for safely and effectively treating androgen-dependent prostate cancer without causing testosterone surge and / or other side effects of GnRH agonist therapy such as urinary tract infection or joint pain-related or cardiovascular side effects.SOLUTION: A relatively low dose of degarelix GnRH antagonist is provided about once every 28 days (e.g. once a month).SELECTED DRAWING: Figure 2

The invention discloses a traditional Chinese medicine extract composition for assisting in reducing uric acid and a preparation method, and relates to the technical field of traditional Chinese medicine compositions, the traditional Chinese medicine extract composition comprises poria cocos, cichorium intybus, radix puerariae, gentiana macrophylla, rhizoma smilacis glabrae, Tibetan capillary, emblic leafflower fruit, glabrous sarcandra herb, Chinese starjasmine stem, wild buckwheat rhizome and white gourd. The traditional Chinese medicine extract composition breaks through the limitation of single existing uric acid reducing mechanism, plays a role in uric acid generation and excretion links, regulates a key pathway of uric acid metabolism through traditional Chinese medicine components to reduce uric acid generation, promotes urination to promote uric acid excretion, inhibits inflammatory mediator release and relieves oxidative damage by means of glabrous sarcandra herb and wild buckwheat rhizome components, and has a good application prospect. According to the traditional Chinese medicine preparation, the effect of multi-link synergistic effect of reducing uric acid, resisting inflammation and resisting oxidation is achieved, meanwhile, the blood uric acid level is reduced, the gout arthralgia symptom is relieved, the problem that an existing traditional Chinese medicine preparation cannot give consideration to comprehensive curative effect is solved, the requirement of a patient for comprehensive improvement of the illness state is met, and the overall effectiveness of treatment is improved.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating gouty arthritis and a preparation method and application of the traditional Chinese medicine composition and the traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from, by mass, 2.5-5% of herba ephedrae, 7-8% of cassia twig, 7-8% of radix aconiti carmichaeli, 7-8% of radix saposhnikoviae, 7-8% of radix stephaniae tetrandrae, 9-9.8% of radix clematidis, 7-8% of scorpio, 7-8% of pawpaw, 11.5-14.8% of radix cyathulae and 7-8% of nidus vespae. 14.5-15.8% of rhizoma dioscoreae septemlobae and 4-5% of radix glycyrrhizae; the traditional Chinese medicine components are used for rapidly relieving red, swollen and hot pain of joints and improving intractable joint pain, stiffness and unfavorable flexion and extension. The traditional Chinese medicine composition has the advantages that the effect of reducing the serum inflammatory factor level of a gouty arthritis patient is obvious, the pain symptom can be effectively relieved, the red, swollen and heat pain of joints can be quickly relieved, and the intractable joint pain, stiffness and unfavorable flexion and extension are improved.

The invention discloses a traditional Chinese medicine formula of cold-dispelling dampness-eliminating anti-epidemic medicinal liquor and a preparation method of the traditional Chinese medicine formula. The formula comprises 22 traditional Chinese medicines such as 400-500g of Japanese peristrophe (or lycopodium clavatum), 300-450g of glossy privet fruit and the like and 40-60kg of Baijiu of 50 degrees or more. The preparation method comprises the following steps: pretreating the medicinal materials, sealing and soaking for 3 months (keeping out of light at room temperature and regularly stirring), and filtering to remove residues. Through the synergistic effect of the medicinal materials, the wine has the effects of dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, promoting blood circulation to remove meridian obstruction and assisting in lowering'three highs', can improve soreness and weakness of waist and knees, arthralgia and the like, is suitable for sub-health people, and is clear in taboo and controllable in safety.

The invention relates to the technical field of biomedicine, in particular to a novel target spot for resisting chikungunya virus infection and application. According to the invention, human neuroblastoma cells (SH-SY5Y) and human brain astroblastoma cells (U87) are taken as target cells, and the expression of the target cell part capable of exerting receptor action membrane protein is down-regulated by adopting an RNA interference technology, so that a host factor capable of effectively inhibiting CHIKV infection of human nerve cells is found, and the purpose of blocking CHIKV infection from the source is achieved. The invention discovers that the nerve cilia protein 2 (NRP2) plays an important role in CHIKV infection SH-SY5Y and U87 cells, and the CHIKV infection can be obviously inhibited by down-regulating the expression of the NRP2. The invention provides an application of NRP2 in preparation of a medicine for preventing or treating chikungunya virus infection, and provides a new target spot and a treatment scheme for clinically preventing and treating fever, arthralgia, arthrocele, muscular pain, headache, nausea, fatigue, rash and other diseases caused by CHIKV infection.

The control method of the shaking bed described in the present application realizes the equipment and standardization of the traditional shaking health preservation method through precise control of the bed plate swing, walking assembly swing and heating assembly heating, breaks through the technical limitations of the existing conditioning equipment, solves the problem that the shaking method needs to be learned and cannot be quickly popularized. The control method simulates the whole body resonance effect of the shaking method, combines passive walking and heating to raise yang, and realizes whole body systemic deep conditioning in a lying state, which can dredge the meridians, regulate the viscera, promote blood circulation, relieve muscle tension, improve digestion, and has auxiliary conditioning effect on rheumatism and joint pain, lumbar problems, etc.

Disclosed is a method of treating or preventing skeletal sequelae of coronavirus infection in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an endothelin receptor antagonist, with the proviso that the endothelin receptor antagonist is not co-administered with dapagliflozin or niclosamide. The skeletal sequelae may include one or more of arthralgia, viral arthritis, osteopenia, osteochondral injury, and osteoporosis.

The invention provides an acetaminophen ointment and a preparation method thereof. According to the ointment composition disclosed by the invention, the medicine can better play a role in local positioning treatment of arthralgia and neuralgia diseases, and meanwhile, the side effect of liver injury caused by oral medicine can be avoided. The ointment composition is good in spreadability, basically free of granular sensation, resistant to heat and stable, the preparation method is simple, the production cost is low, and the ointment composition is especially suitable for large-scale industrial production.

Cannabinoid compositions formulated for use in the treatment of Aromatase Inhibitor- Induced Arthralgia (AHA) are disclosed. The compositions include cannabidiol (CBD), cannabigerol (CBG), and tetrahydrocannabinol (THC) as the major components therein, which may be isolated, purified or extracted from cultivars and blended together. The compositions include CBD, CBG and THC in certain ratios, formulated for the use in the treatment of AHA.

A therapeutic treatment for the treatment of COVID-19 disease, the treatment to be initiated soon after and preferably within approximately twenty four hours after a patient develops the first signs of symptoms comprising but not limited to individually or in combination thereof fever, headache, sore joints, cough, fatigue, chills. The treatment consists of the oral administration of an herb thyme also know as common thyme (Thymus Vulgaris). The treatment is thought to inhibit the replication and activity of the virus allowing the patient to regain normal health and assist in developing immunity to the virus. The treatment is not known to completely eliminate the virus from the patient therefore resulting in the patient possibly developing the same or different symptoms of the disease a second, or more times requiring additional treatments of the disclosed thyme therapeutic treatment.

The invention discloses a medicine bag and medicinal liquor for treating rheumatism ostalgia and a preparation method thereof, and belongs to the technical field of medicine bags and medicinal liquor for treating rheumatism ostalgia, the medicine bag and medicinal liquor are prepared from the following raw materials in parts by weight: 1 part of red clam flower, 1 part of adhatoda vasica, 1 part of alpinia japonica and 1 part of artemisia biloba. The preparation method of the rheumatism bag comprises the following steps: grinding fresh leaf branches or dry leaf branches of the red clam flower, the adhatoda vasica, the alpinia japonica and the artemisia biloba into coarse powder, and then fumigating the medicinal materials at 105 DEG C for 10-20 minutes to obtain the rheumatism bag. The preparation method of the wine for treating rheumatism comprises the following steps: cutting fresh leaf branches or dry leaf branches of the red clathraea, the adhatoda vasica, the alpinia japonica and the artemisia biloba into sections, and then soaking the medicinal materials in 10 parts of white spirit with the alcohol content of 50 degrees or above for three months to obtain the wine for treating rheumatism. The formula can be used for treating the rheumatism ostalgia disease, and the external medicine bag and medicinal liquor for treating the rheumatism ostalgia disease have the effects of clearing away heat and toxic materials, promoting blood circulation to subdue swelling, dispelling wind and relieving pain, promoting reunion of fractured tendons and bones, treating rheumatism arthralgia, tonifying fire, strengthening the body, eliminating swelling and dissipating blood stasis, treating rheumatism limb joint swelling and pain and the like through external application.