The invention relates to obstinate arthralgia wine used for treating rheumatic and rheumatoid arthritis arthralgia and a preparation method thereof and belongs to the field of medicine. The obstinate arthralgia wine is prepared with, by weight, nidus vespae, bee larva, eel blood, garter snake, long-noded pit viper, little multibanded krait, earthworm, centipede, Chinese azalea flower, red fennel root, four-leaf clover, prepared aconite root, prepared kusnezoff monkshood root, siegesbeckia herb, obscured homalomena rhizome, pepper stem, Chinese starjasmine stem, himalayan coralbean bark, scarlet kadsura root, clematis root, pawpaw, Wu Chia Pee, teasel root, cibotii rhizome, mulberry twig, pine node, wooly datchmanspipe herb, cassia twig, notopterygium root, pubescent angelica root, white peony root, geranium herb, silkworm excrement, beautiful sweetgum fruit, Chinese taxillus twig, drynaria rhizome, red-rooted salvia root, common peony root, logwood, ground beeltle, peach kernel, safflower, myrrh, zedoary, bidentate achyranthes root, frankincense, suberect spathololus stem, hirudo, Szechuan lovage rhizome, Chinese angelica root, hairy asiabell root, astragalus, glossy privet fruit, prepared rehmannia rhizome, sealwort, Chinese wolfberry, licorice and encommia bark. The obstinate arthralgia wine is rich in nutrition and excellent in taste, has efficacy of reinforcing qi and blood, tonifying liver and kidney, strengthening tendons and bones, dispelling wind and cold and removing dampness, meets drinking habits of people and can treat rheumatic arthralgia.