13results about How to "Suppressor mutation" patented technology

The invention discloses an application of an MDH2 gene and an inhibitor thereof in resisting ZEA toxin, and relates to the technical field of biology. An MDH2 gene deletion cell line is obtained through CRISPR gene editing, and compared with a wild type MDH2 gene expression cell, under the influence of ZEA, the cell activity of the MDH2 gene deletion cell line is remarkably improved, and the cell apoptosis rate is remarkably reduced. In addition, the LW6 inhibitor is used for inhibiting the MDH2 activity of wild type IPEC-J2 cells, and the tolerance of the cells to ZEA can also be improved. Therefore, through knockout, mutation or activity inhibition of the MDH2 gene, the ZEA resistance of people, animals and plants can be improved. The invention provides a potential solution way for solving untoward effects caused by ZEA (Zinc Ethylenediamine).

The present disclosure relates to the technical field of vehicle intelligent driving, and provides a vehicle torque control method and a vehicle. When it is detected that a gear position of a vehicle changes and an accelerator pedal opening degree changes, a first engine request torque at a current moment and a second engine request torque at a previous moment of the current moment are acquired. A remaining power of the vehicle is acquired, a target change gradient is determined according to the first engine request torque, the second engine request torque and the remaining power of the vehicle, and the engine request torque of the vehicle is controlled based on the target change gradient. When the driver performs a throttle opening or throttle closing operation during the gear shifting process, the present disclosure adjusts the change gradient of the engine request torque correspondingly, provides a buffer time for the engine response, effectively suppresses the mutation and oscillation of the driving force, guarantees the smoothness of the vehicle torque, and further improves the user's vehicle experience.

The invention discloses a driving system and a measuring method for inhibiting micro resistance measuring errors, and belongs to the field of precision measurement. The problem that a driving system for measuring the micro resistance is difficult to suppress low-frequency noise and cannot measure the micro resistance at high precision is solved. The driving system is used for converting low-frequency voltage signals of the high-voltage end and the low-voltage end of a resistor to be measured into high-frequency voltage signals, the driving system is constructed through JFET switch tubes K1 and K2, and a transient compensation circuit is used for restraining transient voltage of the JFET switch tube K1. The switching tube driving circuit is used as a feedback loop to ensure that the gate-source voltage of the JFET switching tubes K1 and K2 is zero, and mutation caused by noise is suppressed. The device and the method are mainly used for high-precision micro resistance measurement.

The invention discloses a large-size beam hoisting closed-loop control method and system for crossing an in-service multi-strand track, and relates to the technical field of bridge construction control. The method comprises the following steps: acquiring and synchronizing beam body reaction force, displacement, inclination angle and train approaching / enveloping data; calculating a barycentric coordinate G and an attitude deviation vector E; identifying a flexibility matrix H (k) on line; generating multiple constraints including counter force, deflection, synchronization error and the like, and a linkage tightening threshold value when the train approaches; robust MPC is adopted to solve the correction amount with minimization of the maximum reaction force change as a main target; synchronously executing and adopting double closed-loop control; switching and re-optimizing the active set when the soft constraint is triggered; and the stability is judged according to quantitative indexes such as G and E dual-threshold duration time. According to the method, operation scene linkage constraint, peak counter-force suppression and multi-target cooperative control are achieved, and the safety and precision of non-stop hoisting of the in-service track are improved.

The present invention relates to a method for suppressing sudden changes in the operating force of a reconfigurable manipulator. Based on the matrix perturbation theory, a space manipulator joint torque compensation is proposed to achieve the compensation torque equation and the dynamic equation containing the Jacobian matrix, thereby realizing the redistribution of the joint torque of a generalized redundant space manipulator fault. At the same time, the method of the present invention combines the advantages of the minimum norm method and the minimum torque method, and proposes a joint acceleration inverse solution method obtained by minimizing the joint torque as the optimization goal, so as to solve the instability of the joint values ​​and the joint singularity problems caused by the calculation of the minimum joint torque method.

The invention relates to the technical field of compact modeling of gallium nitride HEMT (high electron mobility transistor), and discloses a modeling method of a GaN HEMT compact model based on machine learning, and the method comprises the following steps: 1, constructing a GaN HEMT transistor model by using a simulation tool, and generating a model sample, each model sample comprises the following device parameters: the thickness of the AlGaN barrier layer, the Al component of the AlGaN barrier layer, the gate-source distance, the gate-source distance and the gate length; iV characteristic simulation is carried out on each model sample, and simulation data are extracted; 2, performing data preprocessing on the device parameters of each model sample in the step 1; step 3, constructing an EEHEMT model; 4, constructing a physical guidance mixed loss function; and step 5, carrying out EEHEMT model training. According to the method, automatic prediction and self-adaptive fitting of segmented parameters can be realized, so that simulation optimization and modeling of the device can be quickly and accurately realized.

The invention provides a clamp voltage control circuit and an integrated circuit chip. A first end of a voltage division module receives a power supply voltage; the first end of the clamping module is connected with the second end of the voltage dividing module, the second end of the clamping module is connected with the third end of the voltage dividing module, and the third end of the clamping module is grounded; the first end of the voltage regulating module is connected with the third end of the voltage dividing module, and the second end of the voltage regulating module is connected with the third end of the clamping module; the first end of the output module is connected with the first end of the voltage dividing module, the second end of the output module is connected with the first end of the voltage regulating module, and the third end of the output module is used for outputting clamping voltage. When the power supply voltage is suddenly changed, most of the generated suddenly-changed current flows to the ground from the clamping module, and a small part of the generated suddenly-changed current flows through the voltage regulating module, so that the voltage change of the voltage regulating module is small, the current change of the output module is small, the clamping voltage does not generate large change, and the suddenly-changed power supply voltage is effectively inhibited.

The utility model discloses a battery charging and discharging circuit, including main circuit and control unit, main circuit includes the first series branch that constitutes by first electronic switch, second electronic switch, inductor, first electronic switch, second electronic switch reverse series connection, still including the second series branch that constitutes by controllable switch, first electronic switch anti-parallel first diode, second electronic switch anti-parallel second diode, first series branch, second series branch parallel, main circuit is equipped with current detection unit, first electronic switch, second electronic switch, controllable switch all are controlled in control unit, and current detection unit connects control unit. The utility model discloses a battery system and control method thereof. The utility model can effectively control the charging and discharging current of battery, avoid the damage of device caused by too large current, guarantee the safety of battery and service life.

The utility model discloses a protection circuit, a flying capacitor three-level BUCK circuit and a photovoltaic hydrogen production power supply, relates to the technical field of photovoltaic hydrogen production power supply products, is used for realizing breakdown protection of an IGBT (Insulated Gate Bipolar Translator) in the flying capacitor three-level BUCK circuit, and provides the protection circuit aiming at the problem of bus voltage oscillation caused by a traditional scheme. The voltage oscillation generated when an IGBT device in the flying capacitor three-level BUCK circuit is turned off and turned on can be restrained, the high-frequency switching circuit is suitable for being applied to a high-frequency switch, the loss of the absorption circuit is small, and bus voltage oscillation is not prone to being caused. The IGBT device can be prevented from being broken down by the turn-off peak voltage, the quality of the output voltage of the flying capacitor three-level BUCK circuit can be optimized, the IGBT withstand voltage grade selection is reduced, and the product material cost is saved.

The invention discloses an intelligent control method and system for paperboard cutting for packaging box processing, and relates to the technical field of production control, and the method comprises the following steps: firstly, based on a preset classification strategy, carrying out classification processing on operation state data and transmission speed data to realize structured classification of production data; further, a target speed data set needing speed control is screened out, and an initial cutting interval reference is determined; and finally, the initial cutting interval reference is corrected based on fluctuation amplitude data in the production environment, environmental fluctuation frequency data and a tool wear degree evaluation result, a target cutting interval reference is obtained, operation of target equipment is controlled according to the target cutting interval reference, and accurate regulation and control of the cutting process are achieved. According to the design, the initial cutting interval reference is corrected through the fluctuation amplitude data, the environment fluctuation frequency data and the tool abrasion degree evaluation result, sudden change is restrained, and the cutting precision and stability are improved.

The invention relates to the technical field of hoisting equipment, and discloses a free hook falling hydraulic control method, device and system and a storage medium. Original control current converted from an output voltage signal of an electric control proportional pedal is directly input into an electric proportional pressure reducing valve, and rapid feedforward control over pressure of a brake cavity is achieved; the problem of response delay caused by reciprocating motion of a valve element of the electric proportional pressure reducing valve is solved, and brake torque regulation and control can rapidly follow pedal operation; meanwhile, the current brake cavity pressure is collected and converted into feedback current based on the first preset mapping relation, target control current is obtained by combining the original control current and the feedback current, then the electric proportional pressure reducing valve is driven, pressure closed-loop control is formed, the static hysteresis characteristic of the electric proportional pressure reducing valve is effectively compensated, and the brake efficiency is improved. The pressure of the brake cavity is accurately matched with pedal operation of a user, and the brake regulation and control accuracy in the free hook falling process is improved.

The utility model discloses a PID temperature control circuit applied to a microbial culture monitor. The PID temperature control circuit comprises a PID controller and a PID control circuit, the PID controller is used for receiving target temperature, incubation frame bias temperature and PID control parameters issued by the upper computer, receiving temperature parameters, sent by the PID control circuit, of all incubation frames in real time, conducting PID operation on the temperature parameters, outputting PWM adjusting signals to the PID control circuit according to operation results, and adjusting the temperature of the incubation frames by changing the output quantity of the PID control circuit. And the output power of the heating component or the refrigerating component is adjusted. The three-state buffer can buffer and isolate signals, prevent noise from interfering with the PID controller, protect the sensitive PID controller from being damaged by a rear-end circuit, and prevent residual output signals of the PID controller from influencing turn-off logic. In emergency, the output of the PID controller is cut off according to the emergency stop signal, so that the power switch device is quickly closed, the power output of the temperature control load is stopped, and the emergency stop function is realized.

The present invention discloses an OBVP active motion control trajectory optimization method, including: obtaining the current position of the cross slide, calculating the final position according to the patient's motion force; setting the objective function to minimize the integral of the square of the acceleration, and constructing a loss function; based on the Hamiltonian function, using the boundary conditions of fixed position and fixed speed, obtaining the co-state input matrix; solving the co-state input matrix, obtaining the optimal state input, calculating the cross slide final position force; and obtaining the optimal trajectory of the cross slide. The OBVP active motion control trajectory optimization method provided by the present invention can enable desktop rehabilitation equipment to obtain mechanical control input signals at a relatively low hardware price, and have control quality that is not inferior to high-performance force sensors.