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835 results about "Voltage clamp" patented technology

The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level. A basic voltage clamp will iteratively measure the membrane potential, and then change the membrane potential (voltage) to a desired value by adding the necessary current. This "clamps" the cell membrane at a desired constant voltage, allowing the voltage clamp to record what currents are delivered. Because the currents applied to the cell must be equal to (and opposite in charge to) the current going across the cell membrane at the set voltage, the recorded currents indicate how the cell reacts to changes in membrane potential. Cell membranes of excitable cells contain many different kinds of ion channels, some of which are voltage-gated. The voltage clamp allows the membrane voltage to be manipulated independently of the ionic currents, allowing the current-voltage relationships of membrane channels to be studied.

Charge perturbation detection system for DNA and other molecules

Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably DNA. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal. The initial enzyme attachment to the DNA molecule can be detected prior to polymerization, with electrode capacitance measurement using the same voltage-clamp amplifier. This technique and device may be adapted to other reaction determinations, such as enzymatic reactions, other electrode configurations, and other amplifying circuits.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Reverse-connection preventing circuit, reverse-connection preventing processing method and communication equipment

The invention provides a reverse-connection preventing circuit, a reverse-connection preventing processing method and communication equipment. The circuit comprises a voltage bias resistor connected between the anode and the cathode of the power supply, a bidirectional voltage-lamping circuit and at least one field-effect tube, wherein the voltage bias resistor is connected with the grid electrode of the field-effect tube and is used for conducting and biasing the field-effect tube; the bidirectional voltage-lamping circuit is connected in parallel at two ends of the grid electrode and the source electrode of the field-effect tube and is used for taking a grid electrode and source electrode voltage clamp of the field-effect tube as a first protective voltage when inputting overvoltage in the forward direction; and the first protective voltage is the normal work voltage of the field-effect tube. The invention also provides the reverse-connection preventing processing method and the communication equipment. The invention achieves the input overvoltage protection function of the direct current input reverse-connection preventing circuit and improves the reliability of the circuit.
Owner:BEIJING XINWANG RUIJIE NETWORK TECH CO LTD

Segmented slope compensation circuit applicable to BUCK converter

A segmented slope compensation circuit applicable to a BUCK converter belongs to the technical field of an electronic circuit. An oscillator circuit is used for introducing output voltage informationof the BUCK converter, a negative input end voltage of an operational amplifier is clamped to a positive input end voltage thereof, a first capacitor is charged by a current mirror, the negative inputend voltage, namely a slop voltage signal, of the operational amplifier is obtained, the slop voltage signal is compared with a second reference voltage to obtain a periodic slope voltage signal, a slope current generation circuit is used for generating compensation slopes with different slope rates under different duty ratios, a slope voltage correlated to the duty ratios is generated on a sampling resistor after passing through a slope summing circuit, and a base current compensation circuit is used for stabilizing a system. Compared with a traditional slope compensation circuit, the segmented slope compensation circuit has the advantages that the system stability is improved by employing different slope compensation rates under different duty ratios; and with the adoption of a triode as a buffer, the segmentation accuracy is improved.
Owner:UNIV OF ELECTRONIC SCI & TECH OF CHINA

Open drain driver, and a switch comprising the open drain driver

An open drain driver (7) selectively switches a MOSFET switch (MN1) which is passively held in the conducting state into the non-conducting state. The MOSFET switch (MN1) switches an AC analogue input signal on a main input terminal (3) to a main output terminal (4) and the gate of the MOSFET switch (MN1) is AC coupled by a capacitor (C1) to the drain thereof. The open drain driver (7) comprises a first MOSFET (MN2) and a second MOSFET (MN3) through which the gate of the MOSFET switch (MN1) is pulled to ground (Vss). The gate of the first MOSFET (MN2) is coupled to the supply voltage (VDD) for maintaining the first MOSFET (MN2) in the open state. A control signal is applied to the gate of the second MOSFET (MN3) for selectively operating the open drain driver (7) in the conducting state for operating the MOSFET switch (MN1) in the non-conducting state. When the second MOSFET (MN3) is in the non-conducting state, the first MOSFET (MN2) remains in the conducting state until the voltage on a coupling node (9) between the first and second MOSFETs (MN2,MN3) equals the difference between its gate voltage and its threshold voltage, at which stage, any over-voltages applied to the gate of the MOSFET switch (MN1) are divided between the first and second MOSFETs (MN2,MN3). A coupling diode (D1) coupling the coupling node (9) to the supply voltage (VDD) clamps the voltage on the coupling node (9) at the supply voltage (VDD) plus the conducting voltage of the diode (D1), in the event of the voltage on the coupling node (9) rising after the first MOSFET (MN2) has gone into the non-conducting state. The coupling node (9) may be capacitively coupled to the supply voltage (VDD) by a coupling capacitor instead of or as well as the diode (D1) for limiting the voltage on the coupling node (9).
Owner:ANALOG DEVICES INC

Soft start circuit based on feedback voltage clamping soft start signal

The invention discloses a soft start circuit based on a feedback voltage clamping soft start signal, and mainly aims to overcome the drawback that soft start protection cannot be provided in the process that output voltage recovers from an abnormal condition in the prior art. The circuit comprises a constant current source I1 and a capacitor Cs, wherein the constant current source I1 charges the capacitor Cs to generate a soft start signal VS which climbs upward with a slope for replacing a reference voltage upon start so as to allow an output voltage to rise smoothly; the output end of the constant current source I1 and the output end of the capacitor Cs are connected with a soft start signal clamping circuit which performs clamping on the soft start signal Vs under the abnormal condition; and the control end A of the clamping circuit is connected with an output voltage monitoring circuit which is used for monitoring the output voltage and controlling the operation condition of the clamping circuit. When the method is used, the condition of the output voltage can be monitored under different conditions such as a condition that the output voltage climbs to a normal value or recovers from the abnormal condition, and the active soft start protection is provided for a voltage regulator circuit and can be used in different voltage regulator circuits.
Owner:深圳德信微电子有限公司
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