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38 results about "Urinary output" patented technology

Traditional Chinese medicine composition for treating liver ascites symptoms and preparation method thereof

The invention discloses a new traditional Chinese medicine composition for treating liver ascites symptoms and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following medicine components: cassia twig, tuckahoe, rhizoma alismatis, Plantain seed, fiveleaf akebia, Lobelia, mulberry bark, climbing fern spore, broom cypress fruit, lysimachia, talcum, notopterygium root, ledebouriella root, acanthopanax bark, orientvine, cinnamon, clove, pangolin, dried orange peer, immature bitter orange, nut grass, rhubarb, hemlock parsley, magnolia bark, Chinese yam, white atractylodes rhizome, semen raphani, japanese sweetflag, bush-cherry seed, angelica glabra, Evodia rutaecarpa, galangal, allium macrostemon, Semen Euryales, pyrrosia lingua, ricepaperplant and oriental wormwood. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of abdominal distention, ascites, difficulty in walking, and probable obvious diaphragm elevation with expiratory dyspnea and exomphalocele before the ocurrence of ascites. Some patients possibly have the symptoms of hydrothorax, increased portal venous pressure, increased hydrostatic pressure abdominal visceral vessel beds, hypoalbuminemia diseases, excessive lymphogenesis, secondary hyperaldosteronism, reduction of renal blood flow, sodium output and urinary output and the like. The traditional Chinese medicine composition has exact and obvious clinical curative effect and high efficiency. By basically combining edible and pharmaceutical products specified in the national pharmacopoeia, the traditional Chinese medicine composition has the advantages of low cost, no toxic or side effects and the like.
Owner:TAIYI HEPU BEIJING RES INST OF TCM

Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release

InactiveCN101998989ASenses disorderPeptide/protein ingredientsSalty taste perceptionDisease
The present invention relates to high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. The inventors have identified TRPML3 as encoding a salty taste receptor in primates and humans (and likely other mammals) based on gene expression assays which have determined that TRPML3 is expressed specifically in taste bud cells and not in lingual epithelial cells, similar assays that have determined that TRPML3 is specifically expressed or enriched in the top half of taste bud cells in a subset of taste cells which do not express TRPM5 or PKD2L1, prior reports that document the expression of TRPML3 in other sensory organs such as the ear (therefore further substantiating the role of TRPML3 as a 'professional' sensory gene).
Owner:SENOMYX INC

Postoperative patient condition early-warning and monitoring method and system

InactiveCN111248875AIntelligent confirmation of guardianship levelEasy to monitorDiagnostic recording/measuringSensorsPhysical medicine and rehabilitationSystolic arterial pressure
The invention discloses a postoperative patient condition early-warning and monitoring method and system. The method comprises the following steps: S1, acquiring seven physiological parameters of a postoperative patient, wherein the seven physiological parameters comprise pulse, systolic arterial pressure, respiratory rates, body temperatures, consciousness, oxygen saturation and urine volumes; S2, analyzing scores corresponding to ranges of every physiological parameters; S3, adding the scores corresponding to the physiological parameters of the seven physiological parameters so as to obtaina total score value; and S4, judging whether the total score value meets an early-warning triggering value of a corresponding monitoring grade or not, if the total score value meets the early-warningtriggering value, triggering and outputting a corresponding monitoring grade of the postoperative patient, and recommending corresponding nursing and interference measure contents. By adopting the method and system, after the score value of the physiological parameters of the postoperative patient meets a triggering standard, corresponding monitoring grades are displayed, and corresponding nursingand interference measure contents are recommended, so that the monitoring grade of the postoperative patient can be intelligently confirmed, and the postoperative patient can be well monitored.
Owner:SHANGHAI CITY PUDONG NEW AREA GONGLI HOSPITAL

Death prediction method and system for sepsis-related acute kidney injury patient, equipment and medium

The embodiment of the invention provides a death prediction method and system for a sepsis-related acute kidney injury patient, equipment and a medium, and belongs to the technical field of medical care information. The method specifically comprises the steps of training an XGBOOST algorithm through a sample data set, and establishing a prediction model; collecting the urine volume, the maximum value of urea nitrogen, the noradrenaline injection rate, the maximum value of anion gap, the maximum value of creatinine, the maximum value of red blood cell distribution width, the minimum value of international standardization ratio, the maximum value of heart rate, the maximum value of body temperature, the minimum value of oxygen uptake fraction, the stroke state, the minimum value of creatinine, the minimum Glasgow coma scale and a diabetes state of a target person; and inputting the key information data set into a prediction model to obtain a prediction result. According to the scheme, the machine learning algorithm is used for learning, the prediction model is established, then the collected key information data set is input into the prediction model, the prediction result is obtained, and the prediction efficiency and accuracy are improved.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV

Traditional Chinese medicine composition for treating liver ascites symptoms and preparation method thereof

The invention discloses a new traditional Chinese medicine composition for treating liver ascites symptoms and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following medicine components: cassia twig, tuckahoe, rhizoma alismatis, Plantain seed, fiveleaf akebia, Lobelia, mulberry bark, climbing fern spore, broom cypress fruit, lysimachia, talcum, notopterygium root, ledebouriella root, acanthopanax bark, orientvine, cinnamon, clove, pangolin, dried orange peer, immature bitter orange, nut grass, rhubarb, hemlock parsley, magnolia bark, Chinese yam, white atractylodes rhizome, semen raphani, japanese sweetflag, bush-cherry seed, angelica glabra, Evodia rutaecarpa, galangal, allium macrostemon, Semen Euryales, pyrrosia lingua, ricepaperplant and oriental wormwood. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of abdominal distention, ascites, difficulty in walking, and probable obvious diaphragm elevation with expiratory dyspnea and exomphalocele before the ocurrence of ascites. Some patients possibly have the symptoms of hydrothorax, increased portal venous pressure, increased hydrostatic pressure abdominal visceral vessel beds, hypoalbuminemia diseases, excessive lymphogenesis, secondary hyperaldosteronism, reduction of renal blood flow, sodium output and urinary output and the like. The traditional Chinese medicine composition has exact and obvious clinical curative effect and high efficiency. By basically combining edible and pharmaceutical products specified in the national pharmacopoeia, the traditional Chinese medicine composition has the advantages of low cost, no toxic or side effects and the like.
Owner:TAIYI HEPU BEIJING RES INST OF TCM
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