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38 results about "Urinary output" patented technology

Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release

The present invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals and based thereon high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels and TRPML3 related functions.
Owner:SENOMYX INC

Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids

Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids are described which are capable of sensing physiologic data based on sensors incorporated into a catheter adapted to reside in any of a urinary tract, gastrointestinal tract, rectal location, pre-peritoneal, pleural space or other body cavity. The devices aid emptying of the bladder, measure urine output and various urine parameters such as oxygen tension, urine conductance and urine specific gravity, monitor renal function, analyze urine parameters, including urine content, including the presence of infection, and track and / or control fluid administration.
Owner:POTRERO MEDICAL

Fluid management measurement module

A system and method for monitoring and analyzing patient urinary output and a plurality of additional patient physiological parameters. The system comprises a plurality of patient connections and monitoring apparatus for monitoring a plurality of patient physiological parameters. The system further comprises a processor programmed to apply at least one analysis criterion to at least a signal indicative of patient urinary output. The processor further applies additionally more complex analysis criterion to a combination of patient urinary output data and at least one additional patient physiological parameter to provide an automated diagnosis of patient condition.
Owner:GENERAL ELECTRIC CO

Traditional Chinese medicine composition for treating liver ascites symptoms and preparation method thereof

The invention discloses a new traditional Chinese medicine composition for treating liver ascites symptoms and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following medicine components: cassia twig, tuckahoe, rhizoma alismatis, Plantain seed, fiveleaf akebia, Lobelia, mulberry bark, climbing fern spore, broom cypress fruit, lysimachia, talcum, notopterygium root, ledebouriella root, acanthopanax bark, orientvine, cinnamon, clove, pangolin, dried orange peer, immature bitter orange, nut grass, rhubarb, hemlock parsley, magnolia bark, Chinese yam, white atractylodes rhizome, semen raphani, japanese sweetflag, bush-cherry seed, angelica glabra, Evodia rutaecarpa, galangal, allium macrostemon, Semen Euryales, pyrrosia lingua, ricepaperplant and oriental wormwood. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of abdominal distention, ascites, difficulty in walking, and probable obvious diaphragm elevation with expiratory dyspnea and exomphalocele before the ocurrence of ascites. Some patients possibly have the symptoms of hydrothorax, increased portal venous pressure, increased hydrostatic pressure abdominal visceral vessel beds, hypoalbuminemia diseases, excessive lymphogenesis, secondary hyperaldosteronism, reduction of renal blood flow, sodium output and urinary output and the like. The traditional Chinese medicine composition has exact and obvious clinical curative effect and high efficiency. By basically combining edible and pharmaceutical products specified in the national pharmacopoeia, the traditional Chinese medicine composition has the advantages of low cost, no toxic or side effects and the like.
Owner:TAIYI HEPU BEIJING RES INST OF TCM

Methods and compositions for diagnosis and prognosis of renal injury and renal failure

InactiveUS20160146832A1Improve assessmentIncrease urine flowOrganic active ingredientsLibrary screeningRenal tubular functionRenal Failures
It is an object of the present invention to provide a combination of a functional assessment of renal function together with biomarker results in order to improve assessment of patient at risk of or having, an acute kidney injury. A loop diuretic such as furosemide inhibits luminal active chloride transport throughout the thick ascending limb of Henle, thereby preventing sodium reabsorption and resulting in natriuresis and increased urine flow. Loop diuretic-induced increases in urine output might be a method to assess the integrity of the renal tubular function in the setting of early AKI, and so a kidney's response, or lack thereof, to a diuretic challenge as a clinical assessment of tubular function can identify patients with severe tubular injury before it is clinically apparent (e.g. a rise in creatinine).
Owner:ASTUTE MEDICAL

Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release

InactiveCN101998989ASenses disorderPeptide/protein ingredientsSalty taste perceptionDisease
The present invention relates to high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. The inventors have identified TRPML3 as encoding a salty taste receptor in primates and humans (and likely other mammals) based on gene expression assays which have determined that TRPML3 is expressed specifically in taste bud cells and not in lingual epithelial cells, similar assays that have determined that TRPML3 is specifically expressed or enriched in the top half of taste bud cells in a subset of taste cells which do not express TRPM5 or PKD2L1, prior reports that document the expression of TRPML3 in other sensory organs such as the ear (therefore further substantiating the role of TRPML3 as a 'professional' sensory gene).
Owner:SENOMYX INC

Systems, devices and methods for draining and analyzing bodily fluids and assessing health

Systems, devices and methods for draining and analyzing bodily fluids and assessing health are described and generally comprise a drainage tube in fluid communication with at least one opening near or at a distal end of a catheter, a pump in fluid communication with the drainage tube and configured to apply a negative pressure to the drainage tube, and a valve configured for unidirectional flow and in fluid communication with the drainage tube. A controller is configured to actuate the pump to apply the negative pressure for clearing an airlock and to monitor a urine output from the patient over a first predetermined period of time above a urine output threshold and over a second predetermined period of time below the urine output threshold. The controller may determine a risk of acute kidney injury if the urine output below the urine output threshold exceeds the second predetermined period of time.
Owner:POTRERO MEDICAL

Sizing Wheel for Medical Undergarments

A device (100) for determining an appropriately sized medical undergarment for a wearer includes a housing (101) and a wheel (102). A first body mass index factor alignment indicator (108) can be aligned with a first body mass index factor, such as weight of a wearer, thereby revealing color coded symbols (109) aligned with a plurality of second body mass factor alignment indicators (110). A user selects the appropriate size by determining which color is aligned with a second body mass factor alignment indicator of the wearer. An optional second side (205) of the device (100) can be used to determine an appropriate type of medical undergarment based upon urinary output, wearer mobility, or combinations thereof.
Owner:MEDLINE IND LP

Medicament composition and preparation method for treating chronic glomerulonephritis

The invention discloses a medicament composition and a preparation method for treating chronic glomerulonephritis. The medicament composition comprises the components of raw material medicament based on portions by weight: 450 to 550 portions of milk veteh, 200 to 300 portions of angelica, 330 to 430 portions of yam, 200 to 300 portions of bupleurum, 250 to 350 portions of pyrrosia lingua, 250 to 350 portions of umbellate pore furgus and 50 to 100 portions of leech. The medicament composition has obvious effect on treating chronic glomerulonephritis, raises high cutting and low cutting of whole blood viscosity, blood plasma and red cell accumulation, reduces the levels of the total protein and the albumin of blood, raises the levels of the nitrogen and the creatinine of blood urea, improves blood haemorheology and raises urinary output by 3h and total urinary output.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

Deuterated caffeine and uses thereof

Provided herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions, foods, beverages, cosmetic compositions, diet supplements) comprising deuterated caffeine. The provided compositions may be useful for treating and / or preventing various diseases and conditions, such as obesity, causing weight loss, increasing metabolic rate, reducing appetite, increasing energy expenditure, increasing urine output, increasing sodium excretion, reducing edema, a pain disorder, apnea, hypotension, an encephalopathy, a neurological or psychiatric disorder, and an inflammatory disorder.
Owner:LENNHAM PHARMA INC

Fluid therapy method

ActiveUS20190046723A1Increase chanceWork lessMedical devicesSensorsTotal fluid lossFluids therapy
A fluid therapy method for an ADHF patient includes setting a urine output rate desired threshold, setting one or more desired negative net gain rates, and optionally setting a total fluid loss goal. The urine output of the patient is monitored and fluid is automatically administered to the patient at increasing rates to equal to or approximately match the patient's increasing urine output rates until the patient's urine output rate reaches the set urine output rate desired threshold. Thereafter, fluid is administered to the patient at rates to achieve the set desired negative net gain rate until the fluid loss goal is reached. Thereafter, until the end of therapy, fluid is administered to the patient at rates equal to or approximately equal to the monitored urine output rates.
Owner:REPRIEVE CARDIOVASCULAR INC

Apparatus and method of monitoring intra-abdominal pressure and urine output

A device for measuring a rate of production of urine in a patient comprising a catheter; a pressure transducer; and a means for measuring the amount of urine produced. Urine flow from the bladder is prevented until a predetermined pressure is reached in the bladder. Urine flow is then allowed; the bladder pressure and the volume of urine exiting the bladder are measured. When the bladder pressure reaches a second, lower predetermined pressure, urine flow is again prevented. From the measured pressure during urine flow and from the volume of urine exiting the bladder, the intra-abdominal pressure and the urine production rate can be determined.
Owner:SERENNO MEDICAL

Postoperative patient condition early-warning and monitoring method and system

InactiveCN111248875AIntelligent confirmation of guardianship levelEasy to monitorDiagnostic recording/measuringSensorsPhysical medicine and rehabilitationSystolic arterial pressure
The invention discloses a postoperative patient condition early-warning and monitoring method and system. The method comprises the following steps: S1, acquiring seven physiological parameters of a postoperative patient, wherein the seven physiological parameters comprise pulse, systolic arterial pressure, respiratory rates, body temperatures, consciousness, oxygen saturation and urine volumes; S2, analyzing scores corresponding to ranges of every physiological parameters; S3, adding the scores corresponding to the physiological parameters of the seven physiological parameters so as to obtaina total score value; and S4, judging whether the total score value meets an early-warning triggering value of a corresponding monitoring grade or not, if the total score value meets the early-warningtriggering value, triggering and outputting a corresponding monitoring grade of the postoperative patient, and recommending corresponding nursing and interference measure contents. By adopting the method and system, after the score value of the physiological parameters of the postoperative patient meets a triggering standard, corresponding monitoring grades are displayed, and corresponding nursingand interference measure contents are recommended, so that the monitoring grade of the postoperative patient can be intelligently confirmed, and the postoperative patient can be well monitored.
Owner:SHANGHAI CITY PUDONG NEW AREA GONGLI HOSPITAL

Method and system to treat acute decompensated heart failure

A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.
Owner:REPRIEVE CARDIOVASCULAR INC

Application of traditional Chinese indian lettuce in preparation of diabetes drugs

The invention relates to a new application of traditional Chinese indian lettuce in the pharmaceutical field, in particular to the application of drugs for curing or preventing diabetes. Experiments prove that rats suffering from diabetes due to streptozotocin significantly decrease urinary output, put on weight gradually and significantly decrease blood sugar level after being fed with the aqueous extract of traditional Chinese indian lettuce. Experiments also prove that no evident toxic side effect produces after rats are fed with the traditional Chinese indian lettuce by 200 times more thanan adult equivalent dose by the maximum gavage amount to the rat (0.4 ml / 10g).
Owner:SHANXI UNIV OF CHINESE MEDICINE

Deuterated caffeine and uses thereof

Provided herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions, foods, beverages, cosmetic compositions, diet supplements) comprising deuterated caffeine. The provided compositions may be useful for treating and / or preventing various diseases and conditions, such as obesity, causing weight loss, increasing metabolic rate, reducing appetite, increasing energy expenditure, increasing urine output, increasing sodium excretion, reducing edema, a pain disorder, apnea, hypotension, an encephalopathy, a neurological or psychiatric disorder, and an inflammatory disorder.
Owner:LENNHAM PHARMA INC

Death prediction method and system for sepsis-related acute kidney injury patient, equipment and medium

The embodiment of the invention provides a death prediction method and system for a sepsis-related acute kidney injury patient, equipment and a medium, and belongs to the technical field of medical care information. The method specifically comprises the steps of training an XGBOOST algorithm through a sample data set, and establishing a prediction model; collecting the urine volume, the maximum value of urea nitrogen, the noradrenaline injection rate, the maximum value of anion gap, the maximum value of creatinine, the maximum value of red blood cell distribution width, the minimum value of international standardization ratio, the maximum value of heart rate, the maximum value of body temperature, the minimum value of oxygen uptake fraction, the stroke state, the minimum value of creatinine, the minimum Glasgow coma scale and a diabetes state of a target person; and inputting the key information data set into a prediction model to obtain a prediction result. According to the scheme, the machine learning algorithm is used for learning, the prediction model is established, then the collected key information data set is input into the prediction model, the prediction result is obtained, and the prediction efficiency and accuracy are improved.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV

Urinary catheter

The invention discloses a urinary catheter, and relates to the technical field of medical instruments. The urinary catheter comprises a catheter body and a front blind end; the center of the catheter body is a urine discharge channel, and a plurality of garlic clove-shaped balloons used for preventing dropping are arranged between the inner end of the catheter body and the front blind end; a urine guide opening communicating with the urine discharge channel is formed between every two adjacent garlic-clove-shaped balloons; and an inflation connector arranged on the catheter body communicates with the multiple garlic-clove-shaped balloons through a balloon inflation channel. The effective area of a urine outlet is increased, blockage is prevented, meanwhile, part of blood clots, small stones and the like can be drained, the urine guide opening and the garlic-clove-shaped balloons are integrated, the position of the urine guide opening in the bladder opening is lowered, drainage is sufficient, the residual urine amount is reduced, and the urine leakage probability is reduced.
Owner:THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV

Special urinal for women

The invention relates to the technical field of medical apparatus and instruments, and discloses a special urinal for women, which comprises a urine receiver for receiving urine when women urinate, the urine receiver comprises a urine receiver handle and an arc urine receiving port, and through the arc urine receiving port, the urinal better fits the human body structure and prevents the urine from scattering to other places, the urine receiver far away from one side of the arc urine receiving opening is connected with a pot body for containing urine through a catheter and a pot body joint; the kettle body comprises a kettle body handle and scales; when a patient needs to urinate, the family member of the patient attaches the urine collector to the urination opening of a woman, and then urine enters the pot body through the urine collector and the catheter. According to the invention, the pot body does not need to be cleaned after urination is completed, the pot body can store and take the urine with a certain period of time according to the requirements of a doctor, and the pot body with the urine does not need to be held to directly receive the urine.
Owner:周新欢

Formula of instant coffee capable of slimming and expelling toxins

The invention discloses an instant coffee formula capable of slimming and detoxifying, and relates to the field of health drinks. The instant coffee formula capable of slimming and detoxifying uses Brazilian black coffee powder, L-carnitine, dietary fiber, xylooligosaccharide, vitamins, and compound enzyme powder For the raw material. The instant coffee can promote kidney function, excrete excess sodium ions in the body, increase urine output, improve abdominal distension and edema, and help lose weight. It has a protective effect on gastric ulcer, can promote the synthesis of DNA and protein, prolong the life of red blood cells, enhance the immunity of disease, and delay the aging of blood vessels and tissues. The instant coffee that can slim down and detoxify is used for socializing, people with irregular diet, obese people, and fatigued people, and long-term consumption can improve the situation.
Owner:夏慧

Traditional Chinese medicine composition for treating liver ascites symptoms and preparation method thereof

The invention discloses a new traditional Chinese medicine composition for treating liver ascites symptoms and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following medicine components: cassia twig, tuckahoe, rhizoma alismatis, Plantain seed, fiveleaf akebia, Lobelia, mulberry bark, climbing fern spore, broom cypress fruit, lysimachia, talcum, notopterygium root, ledebouriella root, acanthopanax bark, orientvine, cinnamon, clove, pangolin, dried orange peer, immature bitter orange, nut grass, rhubarb, hemlock parsley, magnolia bark, Chinese yam, white atractylodes rhizome, semen raphani, japanese sweetflag, bush-cherry seed, angelica glabra, Evodia rutaecarpa, galangal, allium macrostemon, Semen Euryales, pyrrosia lingua, ricepaperplant and oriental wormwood. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of abdominal distention, ascites, difficulty in walking, and probable obvious diaphragm elevation with expiratory dyspnea and exomphalocele before the ocurrence of ascites. Some patients possibly have the symptoms of hydrothorax, increased portal venous pressure, increased hydrostatic pressure abdominal visceral vessel beds, hypoalbuminemia diseases, excessive lymphogenesis, secondary hyperaldosteronism, reduction of renal blood flow, sodium output and urinary output and the like. The traditional Chinese medicine composition has exact and obvious clinical curative effect and high efficiency. By basically combining edible and pharmaceutical products specified in the national pharmacopoeia, the traditional Chinese medicine composition has the advantages of low cost, no toxic or side effects and the like.
Owner:TAIYI HEPU BEIJING RES INST OF TCM

D9-caffeine compositions and uses thereof

Provided herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions, foods, beverages, cosmetic compositions, nutritional supplements) comprising d9-caffeine. The provided compositions may be useful for treating and / or preventing various diseases and conditions, such as obesity, causing weight loss, increasing metabolic rate, reducing appetite, increasing energy expenditure, decreasing daytime sleepiness, increasing urine output, increasing sodium excretion, reducing edema, a pain disorder, apnea, hypotension, an encephalopathy, a neurological or psychiatric disorder, and an inflammatory disorder.
Owner:LENNHAM PHARMA INC

Urethral catheterization metering device

PendingCN112451768ADestroy surface tensionPrevents the problem of not being able to drip from the drip meterMedical devicesSensorsUrethral catheterizationEngineering
The invention provides a urethral catheterization metering device. A urine inlet is formed in a catheter metering device and communicates with a distribution chamber through a urine channel; a stop valve is arranged on the urine channel; a distribution chamber inlet and a distribution chamber outlet are formed in the distribution chamber; the distribution chamber inlet is connected with the urinechannel; a metering branch outlet and a urethral catheterization outlet are formed in the distribution chamber outlet; the metering branch outlet communicates with a metering pipeline; the urethral catheterization outlet is connected with a urine outlet pipe; and a liquid drop sensor is arranged on the metering pipeline. The urethral catheterization metering device can effectively meter the urinevolume for reference of medical staff.
Owner:汤阴恒润昌医疗器材有限公司
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