Methods and compositions for diagnosis and prognosis of renal injury and renal failure
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example 1
[0110]The following study was performed on two separate cohorts of critically ill patients with either stage I or II Acute Kidney Injury Network (AKIN) criteria (Table A) who were given a standardized dose of furosemide and assessed their response and outcomes.
[0111]Cohort 1 (Test)
[0112]The Southern Acute Kidney Injury Network (SAKInet) was formed in 2007 to collect samples from patients who developed AKI with the goal of testing the diagnostic and prognostic accuracy of previously described and novel AKI biomarkers. We identified a subset of patients from the SAKInet cohort at the George Washington University who fulfilled the study criteria.
[0113]Cohort 2 (Validation)
[0114]The protocol for cohort 2 was registered in clinicaltrials.gov. The study was carried out at the George Washington University (NCT00673244) and at the University of Chicago (NCT01275729). The respective university IRBs approved the identical protocol. Patients or their surrogates were required to sign informed c...
example 2
[0141]Patients with acute decompensated (ADHF) heart failure typically have oliguria and reduced renal blood flow (RBF). As a consequence, these patients can have concomitant AKI. In order to determine the severity of tubular damage from AKI, the FST can be used (with biomarkers of course). Patients with severe ADHF who have diminished RBF will have a poor response to an FST (not much urine output). The FST can be used specifically to assess early in the course of ADHF to assess the degree of diuretic resistance to loop diuretic. Instead of stepping up the dose of diuretic, then realizing the patient us resistant, the FST enables the use of substantial amounts of loop diuretic, and if the urine output response is very brisk, intravenous fluid replacement can be done to prevent excessive volume depletion. As an example, if a patient has a response to 600 cc per hour of UO as a response to the dose of furosemide, 400 cc / hr of intravenous fluid can be returned per hour to allow a nice ...
example 3
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