41 results about "Immunologic Competence" patented technology

The invention discloses an aptamer and a new use of derivative thereof. The new use provided by the invention is application of aptamer and the derivative thereof in preparation of target drugs. The invention further protects the target drugs obtained by coupling the drugs with the aptamer or the derivative thereof. The invention has the advantages of screening and preparing specific aptamer or derivative thereof under the condition of not knowing the molecular transformation of the target cell surface related to the disease, and can simultaneously obtain multiple aptamers or derivatives thereof of molecular related to the cell surface cell; the specificity of the obtained aptamer or derivative thereof is strongly combined with the disease cell; the aptamer or the derivative thereof can be chemically synthesized in large scale and can be easily connected with the drug molecules and has low cost; the molecular weight of the aptamer or the derivative thereof is relatively small without immunologic competence and toxicity; the aptamer or the derivative thereof has good stability; and the formed target drugs are stable. The invention has very high application value.

The invention provides a streptococcus thermophilus AR-333 strain and application thereof. The streptococcus thermophilus AR-333 strain is obtained through being separated from naturally fermented milk, and the collection number of the strain is CGMCC 10262. The streptococcus thermophilus AR-333 is fermented for 16h under the condition of 40 DEG C by skimmed milk; the yield of extracellular mucopolysaccharide reaches 256.97 mg/L; meanwhile, the streptococcus thermophilus is used as a yoghourt fermenting agent; the viscosity of yoghourt can be obviously improved; the tissue state of the yoghourt can be improved; good flavor is realized; the generated extracellular mucopolysaccharide has an immunologic competence regulating function; macrophages RAW264.7 can be simulated to release NO.

The invention relates to a method for preparing microbial feed additive used for promoting growth of goose liver. All of the microbial strain is screened out from the animal intestinal tract. The method comprises culturing all the strains on the same culture medium through combined culture, constituting powerful compound microbial community by using mixed sync solid fermentation process, and forming effective enzyme producing ability to make the product has amount of physiologic metabolite such as organized enzyme for analysing cellulose and fructose, peptide, antioxidants, free amino acid, and vitamin. The invention can promote feed digestion and absorption of animal, promote synthesize and utilization of protein, enhance immunologic competence of livestock, fowl and aquatic livestock, and improve feed conversion ratio and production capacity of breed animal. The inventive product has good practicability and pertinency.

This document relates to methods and materials involved in evaluating immune competence in a subject. For example, methods and materials for evaluating immune competence in a subject to BK virus (BKV) are provided. Also provided are isolated peptides, compositions, and methods useful for evaluating whether or not a subject is BKV immunocompetent. Also provided are methods for treating BK virus nephropathy in a subject that is BKV immune incompetent.

The invention discloses bamboo leaves teabag and a preparation process and is made of the following raw material according to the following weight percentage: tender tea leaves 60-80 percent and tender bamboo leaves 20-40 percent. Procedure is as follows: tender tea leaves is cut into fine-grained share with drying, sterilization, strip straightening out and rolling and cooling; with cleaning and drying as well as hot steaming, rolling and baking at a certain temperature and for a certain time, bamboo leaves is cut into fine-grained share; after processed with the prodecures, tender tea leaves and tender bamboo leaves is mixed together by a certain ratio and then is packaged after repeat stirring and sterilization. Bamboo leaves teabag provided by the invention is convenient and time-saving while having the good health care effect of conditioning visceral balance and strengthening immunologic competence and no preservative.

The invention relates to a vitamin premix for juvenile sea cucumbers and a preparation method thereof. The invention is characterized in that the vitamin premix per ton comprises 500 thousand IU to 1000 thousand IU of vitamin A, 100 thousand IU to 500 thousand IU of vitamin D, 5g to 10g of vitamin E, 1g to 5g of vitamin K3, 1g to 5g of vitamin B1, 1g to 5g of vitamin B2, 1g to 5g of vitamin B6, 1g to 5g of vitamin B12, 0.5g to 15g of vitamin C, 5g to 10g of nicotinic acid, 100mg to 500mg of folic acid, 5g to 10g of pantothenic acid, 10g to 15g of inositol, 1g to 5g of calcium pantothenate, 10mg to 20mg of biotin and the balanced alpha-cellulose. The preparation method comprises the following steps: firstly weighting the vitamin D, the vitamin B12, the folic acid, the biotin and 100g of alpha-cellulose and mixing the same evenly; then, adding the other weighted vitamins and 500g of alpha-cellulose and mixing evenly the mixture; and finally, adding the rest alpha-cellulose to the mixture and mixing the new mixture to be fully even. The invention has the advantages that the growth performance and the immunologic competence of the juvenile sea cucumbers in a growth period are remarkably improved, the addition effect is stable, the cost is low and the application is convenient.

The invention relates to a feed additive, in particular to a method for preparing fructo-oligosaccharide serving as a feed additive with an enzyme method, belonging to the technical field of deep processing of farm products. Fructo-oligosaccharide is a nuisanceless and functional dual-purpose feed additive which can be used for stimulating the growth of bifidobacteria, suppressing the growth of diarrhea causing pathogenic bacteria, eliminating or reducing the possibilities of specific recognition and binding of pathogenic bacteria with intestinal wall cells of a host animal by being bound with specific glycosyl binding sites of enteric pathogenic bacteria, reducing the settling and reproduction of salmonella, colon bacillus and enterococcus in intestinal tracts, inducing the production of microbial polysaccharide carbohydrate hydrolase in alimentary tracts of animals and directly or indirectly stimulating in-vivo immunologic competence of animals positively, and the like. By applying the fructo-oligosaccharide to a feed additive, the feed conversion rate and the health levels of animal organisms can be increased remarkably, a part of conventional antibiotics for feeds are replaced, the residual quantity of antibiotics in livestock products is reduced, the quality of livestock products is improved, and the growing speed of animals is increased remarkably.

The present invention relates to a method for treatment of cancer, which comprises the following steps (A) and (B): (A) applying a treatment which induces the reduction in lymphocytes to a patient; and (B), subsequent to step (A), administering lymphocytes to the patient promptly. The present invention also relates to a cancer therapeutic agent and a cancer treatment kit for use in the method. When the method is used as an immunoreconstructive therapy, the decrease in immunologic competence which may be caused by the reduction in lymphocytes can be avoided and, therefore, the risk of the occurrence of an infectious disease can be decreased.

The invention belongs to the technical field of fodder, and particularly relates to a material for preventing bovine gastrointestinal nematodiasis and a preparation method of the material. According to the material, a traditional Chinese medicine preparation, stillage, phoenix tree leaves, corn flour, wheat bran, eggshell powder and salt are taken as raw materials, and are reasonably matched to prepare the material for preventing the bovine gastrointestinal nematodiasis. The material for preventing the bovine gastrointestinal nematodiasis can promote the growth and development of cows, has an obvious weight increment effect, and can lower the morbidity of the bovine gastrointestinal nematodiasis simultaneously, so that the bovine immunologic competence is improved, and the economic loss of farmers is reduced.

The invention discloses preparation and application of a recombinant yeast preparation for co-expression of porcine interleukin 4/6 and fusion porcine antibacterial peptide. The antibacterial peptidefusion cytokine FFPIL46 is as follows A1), A2) or A3); A1) is the protein of which an amino acid sequence is the sequence 1 in a sequence listing; A2) is the protein with the same functions as the amino acid sequence shown by the sequence 1 in the sequence listing subjected to substitution and/or deletion and/or addition of one or more amino acid residues; A3) is the fusion protein obtained by connecting the N-terminal or/and C-terminal of A1) or A2) with labels. Experiments show that the FPAPL46 can promote the proliferation of lymphocytes, red blood cells and white blood cells, inhibit the growth of pathogenic microorganisms, promote the secretion of non-specific antibodies (IgG, IgG1, IgG2a) and disease-specific antibodies, and improve the immunity and survival rate of animals.

Immunocompetent animal models having immunological tolerance to a xenograft and methods of producing the same. The animal models are tolerized to the xenograft in the pre-immune, fetal or embryonic stage, followed by transplanting the xenograft into the animal in the post-natal stage, such that the post-natal animal is immunologically tolerant to the xenograft, while remaining immunocompetent.

The invention discloses preparation for a genetic modified rice formulation and usage thereof. The preparation includes steps of: A. acquiring specific promoter for rice and semaphore peptides thereof; B. obtaining human GM-CSF gene of rice's genetic codon; C. genetically transforming rice gene and highly expressing selection of genetic modified plant; D. processing seeds of genetic modified rice. An application of genetic modified rice seed as medicament for treating or preventing leucocytopenia is also disclosed. The invention is simple in process, low in cost, good in safety property and curative effect, and has no side effect. Because recombinant rhGM-CSF is stored in rice flour, and rice is main food of human, any purification steps are not needed in tablet preparation, and the tablet contains no pathogenic bacteria and virus of human, the invention is safe and reliable. The tablet has functions to stimulate proliferation of leukocyte, improve immunologic competence in vivo, recover lowered immunologic competence resulted by reduction of leucopenia induced by chemotherapy and radiotherapy of cancer.

The invention relates to a liquid dairy product containing omega-3 unsaturated fatty acid; 0.01-10 parts of omega-3 unsaturated fatty acid are contained per 100 parts by weight. Because omega-3 unsaturated fatty acid is reasonably added, the dairy product has good stability and taste while providing the immunologic competence efficacy. The invention also relates to the production method of the liquid dairy product; omega-3 unsaturated fatty acid is added in sterilized normal temperature posterior segment so that all functional components will not lose and the health-care function can be fully performed.

The invention discloses a streptococcus pyogenes HtsA protein vaccine as well as a preparation method and an application thereof. The streptococcus pyogenes vaccine is prepared by the following operations: firstly, linking an HtsA gene that a signal peptide sequence is removed to an expression vector containing a His tag; then, transferring escherichia coli, implementing induced expression, and implementing Ni-affinity chromatography purification on HtsA recombinant protein; and finally, conducting mixed emulsifying of the HtsA recombinant protein and an immunologic adjuvant, so that the streptococcus pyogenes vaccine is obtained. The vaccine is good in stability; the immunological capacity of an organism to GAS is effectively enhanced, and a survival rate is improved; titers of the HtsA protein and the immunologic adjutant to an HtsA antibody in serum undergoing immune response can reach 1/163840-1/2621440; and in a mouse bacteremia model and a skin infection model, the HtsA proteinvaccine, which shows an obvious protective effect on mice, can serve as a novel vaccine candidate of streptococcus pyogenes; therefore, the HtsA protein vaccine is relatively high in application prospect.

The invention discloses feedstuff for enhancing mating capability of rams and a preparation method thereof. The feedstuff comprises the ingredients in percentage by weight: 60% to 80% of straws, 13% to 30% of maize, 2% to 4% of soybean meal, 1.5% to 2.5% of dicalcium phosphate, 0.2% to 0.5% of common salt, 0.5% to 2% of compound additives and 0.5% to 2.5% of traditional Chinese medicine additives,wherein the traditional Chinese medicine additives comprise the ingredients in parts by weight: 15-20 parts of semen juglandis, 12-15 parts of Chinese chive seeds, 10-12 parts of cortex phellodendri,10-12 parts of tangerine seeds, 9-12 parts of rhizoma dioscoreae, 8-12 parts of prepared rehmannia roots, 9-11 parts of aconite roots, 8-10 parts of cortex cinnamomi, 6-9 parts of fructus lycii and 6-8 parts of Chinese angelica. The feedstuff is ingenious in prescription and can be used for effectively improving semen collection amount and sperm density of the rams and enhancing the mating capability of the rams; the immunologic competence of the rams can be enhanced, and the physical constitution of propagated offspring is robust.

The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.