The invention discloses a traditional Chinese medicine ultrasonic atomization agent for treating xerophthalmia and a preparation method thereof. The traditional Chinese medicine ultrasonic atomization agent is prepared from the Chinese medicine raw materials in percentage by weight: 8 to 25 percent of Chinese medicine raw materials and 75 to 92 percent of water, wherein the Chinese medicine raw materials comprise the following components in percentage by weight: 5 to 15 percent of radix ophiopogonis, 5 to 15 percent of the root of straight ladybell, 5 to 15 percent of radix bupleuri, 5 to 15 percent of angelica root, 5 to 15 percent of chrysanthemum, 5 to 15 percent of barbary wolfberry fruit, 5 to 15 percent of dendrobe, 5 to 15 percent of mulberry leaf, 5 to 15 percent of divaricate saposhnikovia root, 5 to 15 percent of fructus viticis and 2 to 12 percent of mint. The traditional Chinese medicine combination is dialectically screened, and the traditional Chinese medicine ultrasonic atomization agent is high in preparation purity, high in clarity and suitable for an ultrasonic atomization instrument for xerophthalmia, the liquid medicine reaches the eye conjunctiva and surrounding skin of the eyes to realize blood circulation, the absorption and availability is high, and the liquid medicine is easily accepted by a patient. Compared with the methods for treating xerophthalmia, such as single eye drops for dropping the eyes, traditional Chinese medicine for oral administration and traditional Chinese medicinal fuming and washing external treatment, the ultrasonic atomization agent has the advantages of accurate curative effect and no toxic or side effect, and a novel effective and non-toxic treatment medicine and method can be increased for the common diseases and frequently-occurring diseases in ophthalmology. The ultrasonic atomization agent has the advantages of simple manufacture, convenience, safety, good curative effect, low cost and no toxic and side effect.