The invention discloses a production process of high-strength and high-toughness as-cast ductile cast iron. Raw materials including pig iron, low-carbon steel and ductile cast iron foundry returns are added to a medium-frequency melting furnace and heated to be molten, an efficient carburant, a manganese-iron alloy and a silicon-iron alloy are added to the medium-frequency melting furnace, and the mixture is molten into molten iron; firstly, a spheroidizing ladle is preheated, a spheroidizing agent is added to one side, close to a furnace body, of a dam of the spheroidizing ladle, an inoculant is taken and applied to the surface of the spheroidizing agent in a covering manner, metal nickel and metal titanium are added to the other side, close to the furnace body, of the dam of the spheroidizing ladle, the surface of the spheroidizing agent is covered with a perlite covering agent, part of molten iron is poured into the spheroidizing agent for a reaction, the remaining molten iron is poured into the spheroidizing agent after the reaction is stable, the remaining inoculant is added along with the flow for inoculation, the mixture is stirred sufficiently, a molten iron deslagging agent is added after slagging off, slag is rammed, silicon granules are added, the mixture is covered with the perlite covering agent after inoculation of unstable silicon, and a product is obtained after pouring and air cooling. The production process has the advantages that the process is simple, reasonable and low in production cost, heat treatment is not required, the product elongation is increased, and the mechanical performance of the product is good.