The invention discloses chicken hot and spicy sauce and a preparation method thereof, and the chicken hot and spicy sauce is characterized by being prepared from the following raw materials by weight: 3-4 parts of semen cassiae, 4-5 parts of raisin tree seed, 2-3 parts of raspberry, 2.5-3.5 parts of loquat leaf, 4-4.5 parts of cucumber leaf, 1-1.5 parts of campanula, 1-2 parts of achyranthes aspera, 200-210 parts of red pepper, 8-10 parts of grape seed oil, 20-23 parts of bamboo salt, 20-25 parts of fresh ginger, 15-18 parts of biscuits, 14-15 parts of chicken bone, 40-45 parts of chicken, 10-11 parts of egg liquid, 10-11 parts of cherry, 10-12 parts of pitaya, 15-17 parts of papaya, 12-15 parts of beer, 20-22 parts of rice vinegar and 8-9 parts of a nutritional additive. The chicken hot and spicy sauce is hot, spicy, tasty and refreshing, unique in flavor, and reasonable in formula, the added chicken bone increases the calcium content of the chicken hot and spicy sauce, and the added fried chicken tastes good and tastes delicious, and by cooperation of the egg liquid, the chicken hot and spicy sauce is rich in proteins; in addition, the chicken hot and spicy sauce also contains a variety of herbal ingredients, and has the effects of tonifying liver, benefitting kidney, nourishing and activating blood, nourishing yin and clearing heat, tonifying spleen and harmonizing stomach.