33 results about "Painful joints" patented technology

The invention discloses a traditional Chinese medicine composition for treating arthralgia, a traditional Chinese medicine preparation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, and the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of vine of multiflower knotweed, 5-14 parts of rhizoma anemarrhenae, 10-20 parts of dandelion and 10-20 parts of bunge corydalis herb. The composition has a good treatment effect on rheumatoid arthritis, arthritis, arthralgia, muscular pain and the like caused by damp-heat, and can effectively solve the problem of limitation of existing medicines.

The invention belongs to the technical field of acupoint patches, and particularly relates to an acupoint patch acting on joints and a preparation method thereof.The acupoint patch comprises a breathable non-woven fabric, the front portion of the breathable non-woven fabric is coated with a medical adhesive layer and provided with a plurality of tearing cracks, the middle of the front side of the breathable non-woven fabric is connected with a cotton backing ring in an adhesive mode through the medical adhesive layer, and a medicine cake is arranged in the cotton backing ring; the medicine cake is prepared from the following components in parts by weight: 12 parts of notopterygium root, 12 parts of radix angelicae pubescentis, 12 parts of ramulus mori, 12 parts of pawpaw, 12 parts of rhizoma sparganii, 10 parts of ligusticum wallichii, 6 parts of cassia twig, 15 parts of angelica sinensis, 15 parts of kadsura pepper stem, 15 parts of salvia miltiorrhiza, 5 parts of frankincense, 5 parts of myrrh, 10 parts of cornu cervi pantotrichum and a proper amount of collagen peptide. By adding the cornu cervi pantotrichum and the collagen peptide, both the cornu cervi pantotrichum and the collagen peptide can effectively relieve arthralgia and improve joint flexibility, and meanwhile, the collagen peptide can maintain skin elasticity, promote wound healing and prevent skin damage to the position where a user uses the acupoint patch for a long time.

The invention provides a traditional Chinese medicine formula for treating rheumatism bone diseases. The traditional Chinese medicine formula comprises the following raw material medicines in parts by weight: 10g or 40g of pangolin, 10g or 15g of pseudo-ginseng, 10g or 15g of dragon's blood, 15g or 20g of angelica sinensis, 15g of rhizoma drynariae and 10g or 15g of teasel root. According to the principle of monarch, minister, assistant and guide, the formula is scientific, the compatibility is reasonable, all the components are synergistic, and the traditional Chinese medicine composition has the effects of treating wind-cold-dampness arthralgia, arthralgia, sore and ulcer pyogenic infections, soreness and weakness of waist and knees, falling injury and osteoarticular soreness, can safely, quickly and efficiently remove wind, cold, dampness, heat, toxicity and stasis in the body, and achieves the effects of treating and preventing diseases, and has no toxic or side effects. The effects of supporting healthy energy, promoting metabolism and enhancing the immunity of the organism are achieved.

The application discloses a massage system for relieving rheumatic joint pain and relates to the technical field of medical auxiliary equipment. The massage system for relieving rheumatic joint pain is composed of an upper shell, a lower shell and a stretching device. The upper shell is composed of two half circular plates. The lower shell is composed of two half circular plates. The stretching device comprises a first motor. Longitudinal grooves are formed in the inner walls of the upper shell. The first motor is installed in the longitudinal grooves and fixedly connected with the inner walls of the longitudinal grooves. The pressing device comprises rubber blocks installed in the inner walls of the upper shell and the lower shell. The massage system for relieving rheumatic joint pain has various massage modes, can promote blood circulation of users in multiple modes, improves flexibility, can conveniently adjust the distance of joint stretching according to needs, reduces use difficulty and can conveniently adjust the length of joint stretching in a small range.

The present application relates to a kind of polycyclic polyketone compounds and its preparation method, pharmaceutical composition and application, the chemical structure type of the polycyclic polyketone compound is different from existing anti-osteosarcoma chemotherapy drug, it is compound with brand-new structure, while inventor finds that the polycyclic polyketone compound has significant anti-osteosarcoma cell 143B and U2OS activity by experiment, the anti-osteosarcoma activity of part compound is better than positive control drug, the result further indicates that the polycyclic polyketone compound of the present application can significantly inhibit the growth of osteosarcoma, and it is expected to develop into a new type of anti-osteosarcoma drug, can be used for treating osteosarcoma and the disease caused by bone and joint pain and lung disease.Further, the synthesis route of the polycyclic polyketone compound used in the present application is efficient and simple, and has good raw material economy.

A multi-purpose medicinal cream comprising shea butter, wild opium lettus powder, Orange Blood, Frankincense, Lavender, Rosemary, Copaiba Balsam, Birch Sweet, Lemon Grass, Marjoram, Basil, Eucalyptus, Peppermint, Cinnamon, Cedarwood, Thyme, Clove, Vetiver, Geranium, Cinnamon Leaf, and Ylang Ylang. The multi-purpose cream is an aid in pain management of disorders including lupus, arthritis, rheumatoid arthritis, knee and joint pain, neck pain, inflammation, migraines, and neuropathic disorders, as well the treatment of skin conditions including eczema, dry skin, psoriasis, swelling, heat rash, rashes, and rashes of dogs.

The invention discloses a sodium hyaluronate composition and application of the sodium hyaluronate composition in preparation of medicines for preventing and treating knee osteoarthritis, and belongs to the field of medicines. The composition is an oral preparation, and the oral preparation is prepared from sodium hyaluronate, cortex acanthopanacis, caulis polygoni multiflori, radix achyranthis bidentatae, pawpaw, radix astragali and pharmaceutically acceptable auxiliary materials. Sodium hyaluronate is combined with'arthralgia-removing powder 'to treat knee osteoarthritis, and results of clinical tests show that by combining the two medicines, knee joint pain can be effectively relieved for a long time, knee joint activity can be improved, swelling can be eliminated, comprehensive functions of knee joints can be improved, patients do not relapse after drug withdrawal, and existing treatment effects can still be maintained.

The present application relates to the medical technology field, especially to a kind of traditional Chinese medicine composition for osteoarthritis and preparation method thereof, and the inventor combines the characteristics of TCM syndrome differentiation and treatment and holistic concept, and summarizes a traditional Chinese medicine composition for treating knee osteoarthritis, which is prepared from the following components in parts by mass: angelica 10-14 parts, safflower 8-12 parts, frankincense 4-6 parts, myrrh 4-6 parts, redwood 8-10 parts, borneol 0.2-0.4 parts, and linseed oil 22-30 parts.The traditional Chinese medicine composition can be directly used externally according to the use method of traditional Chinese medicine prescription, and has good efficacy and patient adaptability according to the clinical trials of the inventor, can effectively treat joint pain problems of patients with osteoarthritis, and has no toxic side effects.The process of the present application is simple, and has good operability and wide application prospect.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating gouty arthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components: 5g to 15g of pseudobulbus cremastrae seu pleiones, 10g to 20g of rhizoma polygoni cuspidati, 15g to 30g of semen coicis, 15g to 30g of rhizoma smilacis glabrae, 15g to 30g of bulbus lilii, 10g to 20g of rhizoma dioscoreae septemlobae, 10g to 25g of rhizoma corydalis, 10g to 20g of radix paeoniae rubra, 15g to 30g of rhizoma dioscoreae, 10g to 20g of radix The preparation method of the traditional Chinese medicine composition comprises the following steps: mixing the components according to the formula ratio, decocting with water twice, combining filtrate, continuously decocting and concentrating to 400mL. The traditional Chinese medicine composition disclosed by the invention can relieve arthralgia caused by damp-heat toxin stasis in the acute attack period of gouty arthritis, effectively controls the acute attack of gout, reduces adverse reaction and is good in safety.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for promoting menstruation and removing stasis, an external preparation and application. The traditional Chinese medicine composition consists of teasel root, lycopodium clavatum, frankincense, myrrh, divaricate saposhnikovia root, pseudo-ginseng, turmeric, cinnamon, litsea cubeba, ligusticum wallichii, gardenia, mulberry twig, lotus leaf, rheum officinale, dragon's blood, salvia miltiorrhiza, safflower, folium artemisiae argyi and mint. The traditional Chinese medicine composition for promoting menstruation and removing stasis is reasonable in compatibility, has an excellent treatment effect on wind-cold-dampness arthralgia, and is suitable for patients with symptoms such as scapulohumeral periarthritis, cervical spondylosis, lumbocrural pain, muscle and joint pain, rheumatic arthritis, rheumatoid arthritis and gouty arthritis. A specific natural penetrant composition and a traditional Chinese medicine composition are selected to be prepared into an external dosage form, the medicine can be promoted to enter a target organ or tissue through a physiological barrier, the medicine can directly act on a focus, the effect is quick, the efficacy is lasting, the use is convenient, the patient compliance is good, no toxic or side effect exists, and a new choice of an external transdermal agent is provided for clinical treatment of chronic pain.

The present application relates to a kind of gout paste set and preparation method thereof, the gout paste includes: paste A and paste B;Paste A is for the umbilical paste of gout remission period;Paste B is used for the paste of the painful joint of attack period;The drug efficacy component of paste A is made of the first traditional Chinese medicine composition comprising the following components: atractylodes, huangjiu, willow bark, yiyiren, wulingzhi, cansha, baizhu, gancao, tougucao, sandalwood, chishao, chuanqiong, dog spine, fuling, zhuling, dilon, chenpi, huoxiang, wangbuliuxing and suhe xiang;The drug efficacy component of paste B is made of the second traditional Chinese medicine composition comprising the following components: jinyinhua, huangbai, yanhuosuo, wulingzhi, cansha, zihuoding, da xueteng, luoshiteng, jixieteng, tougucao, tuobie worm, oyster, laohu, mody, turmeric, danneling, tianzhu huang and ice. The present application effectively reduces the level of patient's blood uric acid, C-reactive protein and cell sedimentation rate and TCM syndrome score, drug safety is high, and recurrence rate is low.

The present disclosure relates generally to joint health supplement compositions derived from a xenogeneic cartilaginous tissue source, methods of making such compositions, as well as methods of using such compositions, for example, to treat joint pain or other joint ailments due to arthritis in human and animal populations both at risk and actively presenting with such joint pain or other joint ailments. One aspect of the present disclosure can include a nutritional joint health supplement composition including a cartilaginous tissue material harvested from a xenogeneic tissue source and at least a trace amount of a detergent, wherein the nutritional joint health supplement composition has a beneficial component profile and reduced cellular and DNA content.

The present invention relates to GLP-1 receptor agonist compounds having an additional agonist activity over the GIP receptor and / or an agonist activity over the glucagon receptor and / or an antagonist activity over the GIP receptor for use in the treatment of joint diseases and / or joint pain and selected from the group comprising retatrutide, tirzepatide, orforglipron, mazdutide, efinopegdutide, froniglutide, maridebart cafraglutide, survodutide, efpeglenatide, ecnoglutide, efocipegtrutide and UBT251. The invention also relates to a pharmaceutical composition comprising at least one of the above mentioned GLP-1 receptor agonist compound, and a pharmaceutically acceptable excipient, for use in the treatment of joint diseases and / or joint pain.

The present disclosure relates to compositions containing natural plant extracts that inhibit Hyaluronidase 1 and their use in effectively treating conditions such as dryness of skin and lips, skin damage due to UV radiation, chronic inflammatory conditions affecting the skin, the urinary bladder or prostate, osteoarthritis and joint pain, and also promoting wound healing.

The application discloses a compound Fengshi Ning capsule and a preparation method thereof, and belongs to the field of traditional Chinese medicine preparations. The capsule is composed of Notopterygium incisum, Angelica pubescens, Saposhnikovia divaricata, Corydalis, Ligusticum chuanxiong, Pheretima, Radix Paeoniae Alba, Dictyophora, and Glycyrrhiza, and is prepared through volatile oil extraction and inclusion, ethanol or water extraction, concentration, granulation, and capsule filling processes. The preparation has high bioavailability and good stability. Experiments show that the dissolution rate of effective components of the preparation is effectively improved compared with traditional preparations, the preparation can enhance the effects of dispelling wind and dampness, promoting blood circulation and relieving pain, and is suitable for treating rheumatoid arthritis, joint pain and other diseases.

The invention belongs to the field of biological medicine or health food, and particularly relates to a composition for improving bone joint health and application thereof. Through wide research, the combination of the chondroitin sulfate sodium with small molecular weight and N-acetylglucosamine achieves unexpected synergistic effects in the aspects of inhibiting inflammatory factor level, improving arthralgia / stiffness, reducing joint swelling, maintaining articular cartilage health and the like; and a foundation is laid for developing products capable of effectively maintaining the health of bone joints.

The use of low dose naltrexone as an adjuvant therapy to the use of biologic and / or immune modulator therapies is disclosed for the treatment of bowel and gastrointestinal disease, as well as for the treatment of abdominal and joint pain associated therewith.

The use of low dose naltrexone as an adjuvant therapy to the use of biologic and / or immune modulator therapies is disclosed for the treatment of bowel and gastrointestinal disease, as well as for the treatment of abdominal and joint pain associated therewith.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for improving rheumatoid arthritis and bone metabolism abnormality-sarcopenia bone and muscle metabolism. The traditional Chinese medicine composition of the present application comprises eucommia ulmoides, rhizoma dispersae, semen euryales, astragalus, schisandra chinensis, poria cocos, angelica sinensis, huai niu xi, cornu cervi, persicae semen, drynaria, radix rehmanniae preparata, and can be used for improving rheumatoid arthritis and bone metabolism abnormality-sarcopenia bone and muscle metabolism, specifically, can effectively improve muscle mass and muscle strength, improve joint pain symptoms, effectively improve patient inflammatory chemotactic factor, limb skeletal muscle mass and bone metabolism index, reduce the risk of fracture, prevent falling, reduce the risk of fracture, effectively improve the metabolic network of rheumatoid arthritis and bone metabolism abnormality patients, help osteoblast growth, improve bone metabolism, and prevent and treat osteoporosis. The present application provides a new way for developing effective traditional Chinese medicine compound for treating rheumatoid arthritis and bone metabolism abnormality-sarcopenia.

WEARABLE MEDICAL DEVICE FOR MONITORING OF JOINT PAIN IN RHEUMATOID ARTHRITIS

The invention relates to the field of biological medicine, and discloses external cream capable of relieving post-traumatic bone joint degeneration pain symptoms and a preparation method of the external cream. By constructing a posttraumatic osteoarthritis rat model, it is found that experimental rats applying the atractylenolide I ointment group are superior to a control group in the aspects of behavioral analysis, bone mineral content, pain conduction and the like. According to the research, the suspension latex preparation containing atractylenolide particles is prepared from the Chinese herbal medicine extract atractylenolide I through an advanced medicine preparation process for the first time and is used for epidermis joints of lower limbs and the like. The composition can be used for improving arthralgia symptoms caused by joint degeneration after trauma, and an experimental foundation is laid for follow-up research of related drugs.

The invention belongs to the technical field of pet nutrition and health care, and discloses an enzyme-containing composition for relieving arthralgia of dogs and cats, the composition is composed of a compound enzyme component, a joint repair nutrition component and a carrier, the compound enzyme component comprises bromelain, papain and hyaluronidase, the nutritional components comprise chondroitin sulfate, glucosamine, a curcumin extract and type II collagen. All the components have a synergistic effect, so that the composition has multiple effects of quickly relieving inflammation, relieving arthralgia and promoting cartilage repair. In order to improve the enzyme activity, a low-temperature vacuum drying technology is adopted for enzyme treatment, and meanwhile, liposome embedding is utilized for realizing targeted delivery, so that the bioavailability of the joint part is improved. The composition disclosed by the invention is good in stability, high in bioavailability and suitable for auxiliary nutrition intervention of arthritis and degenerative joint diseases of dogs and cats.

The invention relates to the technical field of pain-relieving plasters, in particular to a traditional Chinese medicine transdermal slow-release pain-relieving plaster as well as a preparation method and an application method of the traditional Chinese medicine transdermal slow-release pain-relieving plaster. Comprising the following raw materials in parts by weight: 80 to 150 parts of frankincense, 80 to 150 parts of myrrh, 80 to 150 parts of unprocessed radix aconiti, 80 to 150 parts of processed semen strychni, 80 to 150 parts of flos caryophylli, 120 to 200 parts of cortex acanthopanacis, 120 to 200 parts of cortex cinnamomi, 120 to 200 parts of centella asiatica, 120 to 200 parts of herba schizonepetae, 120 to 200 parts of radix saposhnikoviae and 120 to 200 parts of fresh ginger. Boswellia carteri and myrrh have the effects of promoting blood circulation to remove blood stasis and relieving swelling and pain, and can improve local blood circulation, relieve inflammatory response and relieve pain; unprocessed radix aconiti is hot in nature, has the effects of eliminating cold to stop pain, dispelling wind and eliminating dampness, and has a very good treatment effect on arthralgia caused by wind-cold damp pathogen of a patient suffering from rheumatoid arthritis.

The invention discloses a traditional Chinese medicine plaster for treating pain and a use method thereof, and belongs to the technical field of traditional Chinese medicine external preparations. The plaster is composed of 10 g of unprocessed radix aconiti lateralis, 10 g of unprocessed rhizoma pinelliae, 10 g of semen brassicae, 10 g of fructus evodiae, 10 g of sulfur and 5 g of borneol, the total weight is 55 g, the plaster can be divided into 55 parts, the raw materials form the unique formula, no other components are added, all the raw materials are natural raw materials in specific production places and specific harvesting time, and the quality and purity are strictly guaranteed. The plaster is in an external application dosage form, and is uniform in texture, firm in application, small in irritation and long in shelf life. During use, after the skin of a painful part is cleaned up, 1 part of the plaster is smeared on sterile gauze and applied to the painful part once a day, seven days are taken as a course of treatment, and the number of courses of treatment is adjusted according to the degree of pains. The plaster can be used for effectively treating various pains such as muscular soreness, arthralgia, traumatic injury pains, rheumatic arthralgia and neuralgia, and is exact in treatment effect and safe and convenient to use.

The invention discloses a plant essential oil liniment for treating wind-cold-dampness arthralgia type osteoarthralgia and a preparation method of the plant essential oil liniment. The liniment takes cassia twig, notopterygium root, radix angelicae pubescentis, ginger, frankincense, myrrh, clove and other plant essential oil as active ingredients, takes grape seed oil and camellia seed oil as carrier substrates, and is added with azone as a penetration enhancer. Based on the theory of expelling wind, removing cold, removing dampness and dredging collaterals in traditional Chinese medicine, all the components have a synergistic effect through scientific proportioning and a special preparation process, and the transdermal absorption rate and bioavailability of the medicine are remarkably improved. The product has the advantages of quick response, exact curative effect, safety and convenience in use and the like, and is suitable for treating wind-cold-dampness arthralgia syndromes such as rheumatic arthritis, osteoarthritis and the like.

The invention belongs to the technical field of medicines, and particularly relates to a pericarpium citri reticulatae-containing traditional Chinese medicine patch for relieving arthralgia and a preparation method thereof. The joint pain relieving traditional Chinese medicine patch containing the pericarpium citri reticulatae comprises traditional Chinese medicine components and a medicine carrying layer, the traditional Chinese medicine component is prepared from the following raw materials in parts by mass: 15 to 35 parts of pericarpium citri reticulatae, 10 to 25 parts of radix et rhizoma rhei, 10 to 30 parts of radix angelicae pubescentis, 1 to 15 parts of liquorice root, 10 to 25 parts of ramulus cinnamomi, 10 to 30 parts of radix gentianae macrophyllae, 25 to 40 parts of herba plantaginis, 5 to 15 parts of cortex erythrinae, 5 to 20 parts of earthworm, 1 to 10 parts of rhizoma arisaematis and 10 to 25 parts of caulis lonicerae. According to the patch disclosed by the invention, the patch with good transdermal absorption is prepared from carefully selected raw materials through a modern process, and the patch has the advantages of convenience in use, quick response, lasting relief of arthralgia and the like, and is suitable for adjuvant therapy of diseases such as rheumatoid arthritis, rheumatic arthritis, osteoarthritis and the like.

This invention discloses a traditional Chinese medicine composition and its preparation for rheumatic arthralgia. The composition consists of nine herbs: *Hedyotis diffusa*, earthworm, *Eupolyphaga sinensis*, centipede, silkworm, scorpion, dung beetle, *Sinomenium acutum*, and *Zaocys dhumnades*. The composition exerts its efficacy through specific weight ratios, and is particularly suitable for treating joint pain and deformities caused by rheumatoid arthritis and osteoarthritis. The key to this invention lies in the heavy use of multiple insect-derived medicinal materials, which can penetrate deep into the meridians and collaterals, exerting a powerful effect of dispelling wind, clearing the meridians, relieving dampness and pain, and breaking up blood stasis and dissipating nodules in stubborn rheumatic arthralgia. Simultaneously, specific processing techniques are specified for the key insect-derived medicinal materials, such as wine-processing, salt-processing, roasting, and wheat bran-frying, to reduce toxicity, enhance efficacy, and ensure medication safety. The traditional Chinese medicine composition of this invention can be further prepared into various modern dosage forms such as powders, granules, and capsules, facilitating patient administration and clinical application.

The invention provides an application of a secreting type curl-related protein in preparation of a medicine for treating arthritis and the medicine for treating the arthritis, and belongs to the technical field of biology. According to the present invention, the research results show that the secreting type curling-related protein has good arthritis treatment effect, can significantly up-regulate the expression level of the II type collagen marker COL2A1 and the SOX family transcription factor SOX5 in the damaged cartilage cells, and can promote the expression of the cell cycle-related protein Ki67 to achieve the enhancement of the cartilage cell proliferation ability. Meanwhile, the SFRP can regulate the polarization phenotype of human synovial macrophages in a targeted manner and remarkably inhibit expression of a proinflammatory M1 macrophage marker iNOS, so that release of inflammatory factors in a synovial tissue inflammatory microenvironment is reduced, synovial inflammation is regulated in a targeted manner, and arthralgia is remarkably relieved.

There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint. Methods of treatment or prevention are described for a disease or condition selected from degenerative disc disease, disc injury, pain, arthritis, or suspected arthritis.

The present disclosure relates to chemical compositions and methods for treating pain, including osteoarthritis pain. The composition comprises a group of TRPV1 ion channel modulator derivatives, including capsaicin derivatives, which can be covalently linked to a polymer. The disclosed TRPV1 ion channel modulator derivatives are covalently linked to a polymer, and alternatively or additionally, the ion channel modulator derivatives are mixed with a polymer. Also disclosed are methods of treating pain using the disclosed compounds via injection into or near a pain site. The disclosed compositions and methods are advantageous in that they exhibit sustained release of TRPV1 ion channel modulators, mitigate initial acute pain associated with TRPV1 modulators, and can be used at high concentrations, thereby effectively treating pain, including osteoarthritis knee joint pain.