12 results about "Atractylenolide I" patented technology

The invention provides a composite antibiotic-replacing microcapsule preparation as well as a preparation method and application thereof. The composite antibiotic-replacing microcapsule preparation comprises a core material as well as an inner-layer wall material and an outer-layer wall material which are sequentially coated outside the core material, wherein the core material comprises a Chinese herbal medicine extract, plant essential oil and probiotics, the Chinese herbal medicine extract comprises forsythin, astragalus polysaccharide and atractylenolide III, the plant essential oil comprises origanum oil and cinnamyl aldehyde, and the probiotics comprise bacillus subtilis; the inner-layer wall material is prepared by crosslinking sodium alginate and calcium chloride, and the outer-layer wall material comprises chitosan. The traditional Chinese medicine composition has the characteristics of synergistic interaction, high stability and good intestinal tract targeting property, and can improve the resistance replacement effect.

The application discloses a sesquiterpene derivative, a preparation method and application thereof. The application provides a novel sesquiterpene derivative which is obtained by modifying atractylodin III. Activity research shows that the sesquiterpene derivative has stronger inhibiting effect on IgE or histamine secretion than atractylodin III. It is known to those skilled in the art that allergy is mediated by IgE, and histamine secretion under the stimulation of IgE is an important cause of various allergic symptoms. Therefore, the sesquiterpene derivative provided by the application has the prospect of being developed into a medicine for preventing and / or treating diseases which are prevented and / or treated by inhibiting IgE or histamine secretion, such as allergic diseases like food allergy.

The invention discloses a multi-index content determination method of hovenia acerba and rhizoma atractylodis bowel-relaxing granules, and belongs to the technical field of traditional Chinese medicine detection. The invention establishes a high performance liquid chromatography method for simultaneously determining nine components including caffeic acid, chicoric acid, naringin, naringin, hesperidin, neohesperidin, chrysophanol, aurantio-obtusin and atractylenolide I in a preparation, and the content of the components is calculated through a relative correction factor by taking caffeic acid as an internal reference by adopting a quantitative analysis of multi-components by single marker. According to the method, effective detection of the immature bitter orange medicinal material and the immature bitter orange base source is realized, and the immature bitter orange and the sweet orange base source of the traditional Chinese medicine immature bitter orange can be accurately distinguished, so that more comprehensive and accurate quality control of the traditional Chinese medicine is realized, and the stability and consistency of clinical efficacy of the traditional Chinese medicine are guaranteed.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a pharmaceutical composition containing atractylenolide, a preparation method and application, the pharmaceutical composition takes lipidosome as a carrier, and comprises lipidosome carrier components such as atractylenolide, oxaliplatin, phospholipid, cholesterol and the like and specific auxiliary components. The pharmaceutical composition is prepared by adopting a film dispersion-ultrasonic homogenization method, the water solubility of the atractylenolide is effectively improved, the bioavailability of the medicine and the stability of the preparation are improved, through the synergistic effect of the atractylenolide and the oxaliplatin, the chemotherapy-related toxic and side effects are reduced while the anti-tumor curative effect is enhanced, and the pharmaceutical composition is suitable for clinical application. The compound can be used for preparing anti-tumor drugs, and a novel efficient and low-toxicity drug scheme is provided for tumor treatment.

The application provides a method for screening active ingredients capable of activating TAS1R3 receptors, and belongs to the technical field of screening of active ingredients of traditional Chinese medicines. The application establishes a biosensor, and the biosensor detects the current signal after each concentration of compound solution reacts with the TAS1R3 receptor; the dissociation constant K D of the interaction between the compound and the TAS1R3 receptor is calculated according to the linear fitting equation between the common logarithm of the concentration of the compound and the current change, and the compound with the K D value in the range of 10 ‑13 -10 ‑8 M is screened as the active ingredient capable of activating the TAS1R3 receptor. In the application, the interaction dissociation constant K D of the Atractylodes lactone II and the glycyrrhizic acid with the TAS1R3 protein is 3.759*10 ‑8 M and 4.435*10 ‑9 M respectively, and the binding force with the TAS1R3 protein is very strong. Moreover, the Atractylodes lactone II and the glycyrrhizic acid have the function of improving anemia within a certain concentration, and provide a new idea for the screening of candidate compounds with the sweet characteristic and the treatment of anemia or blood deficiency syndrome in traditional Chinese medicines and the research and development of new drugs.

The invention discloses a atractylenolide synthesis intermediate and a synthesis method of atractylenolide and a derivative thereof, and the method comprises the following steps: oxidizing methyl in a compound 17 to prepare a compound 18; preparing a compound 19 from the compound 18 under the action of a Grubbs catalyst; carrying out hydrogenation reduction on the compound 19 to prepare a compound 20; dehydrating and eliminating the compound 20 to obtain a compound 21; hydrolyzing the compound 21 to obtain a compound 22; according to the invention, asymmetric total synthesis of atractylone, 13 kinds of eudecane atractylenolides and lactam natural products is finally realized, the technical bottleneck of chiral control of the compounds is broken through for the first time, the convergent design has both step economy and derivative universality, and especially, the type of a nucleophilic reagent is changed by a system, so that the method is suitable for industrial production. And derivative libraries with various structures are successfully constructed.

The invention discloses a traditional Chinese medicine grease oral cream for repairing gastric mucosa and a preparation method thereof, optimizes a traditional heating extraction process into direct compatibility of traditional Chinese medicine extracts, and belongs to the technical field of traditional Chinese medicine preparations. The emulsifiable paste is prepared from a fixed-proportion grease base (20% of emu oil, 40% of olive oil, 20% of coconut oil and 20% of castor oil), six traditional Chinese medicine extract effective components (1-2% of astragaloside, 1-2% of atractylenolide, 1-2% of atractylenone, 1-2% of berberine, 1-2% of scutellaria baicalensis extract and 1-2% of obakunone), 3% of vitamin E, 20-25% of sea buckthorn seed oil and 10% of excipient beewax. According to the preparation process, heating extraction is abandoned, the problems that the extract is difficult to dissolve and easy to agglomerate in grease are solved through infiltrating the extract with a small amount of grease, homogenizing at the low temperature of 60 DEG C and shaping and fixing beewax, and uniform dispersion and stable dispersion of the extract are realized.

This invention discloses a pharmaceutical composition with preventive or therapeutic effects on liver injury. The pharmaceutical composition consists of turmeric dione and atractylodes lactone II. Through the synergistic effect of turmeric dione and atractylodes lactone II, it is used to treat liver injury caused by various reasons. Cell experiments show that this invention can effectively inhibit the proliferation activity of hepatic stellate cells (LX-2 cells) and inhibit the phosphorylation activation of the PI3K / AKT / mTOR pathway. Animal experiments show that this invention can improve liver function indicators and liver tissue pathological damage in animals with liver injury, regulate blood rheological indicators and related factor levels, and has broad application prospects. The preparation method and application of this invention are also disclosed.

The invention provides a method for preparing microcapsules by combining graded extraction of rhizoma atractylodis macrocephalae essential oil with three-layer coaxial electrofluid spraying, and aims to solve the technical problem of non-uniform drug loading caused by polarity difference of main effective components atractylone and atractylenolide in the rhizoma atractylodis macrocephalae essential oil. According to the method, supercritical CO2 fractional extraction is adopted to obtain an essential oil component rich in atractylone and an essential oil component rich in atractylenolide. And then forming the microcapsule with a core-composite shell-canopy three-layer structure under the action of a high-voltage electrostatic field by adopting a three-layer coaxial electronic injection process. The method is mild in preparation process, loss of volatile components and degradation of active components can be effectively avoided, drug loading uniformity and targeted slow release performance are remarkably improved, and the method is suitable for the fields of gastrointestinal conditioning, gastrointestinal mucosa repair and inflammation resistance and the like.

The invention discloses an application of atractylenolide III in preparation of a serratia liquefaciens quorum sensing quenching agent. Belongs to the technical field of medicine. The invention aims to provide the medicine for inhibiting the bacterial quorum sensing system of serratia liquefaciens, so that the toxicity of pathogenic bacteria is weakened on the premise of not inhibiting the growth of the pathogenic bacteria. The invention provides an application of atractylenolide III in a quenching agent for inhibiting a serratia liquefaciens quorum sensing system. A brand new solution is provided for developing an efficient and safe food biological preservative.

The invention discloses discovery of an anti-heart-failure traditional Chinese medicine monomer composition based on a Zhenwu decoction. The discovery comprises the following steps: 1, preparing the Zhenwu decoction; 2, collecting and analyzing a serum sample; 3, determination of heart failure resistant endogenous metabolites and determination of peak intensity; 4, determination of components absorbed into blood and determination of peak intensity; 5, carrying out correlation analysis on peak intensity; the traditional Chinese medicine monomer composition is obtained by dissolving songlin, atractylenolide II, pachymic acid, paeoniflorin and 6-gingerol in a sodium carboxymethyl cellulose solution, and plays a role in preparing the heart failure resisting medicine. According to the method disclosed by the invention, the heart-failure-resistant endogenous metabolite and absorbed blood-entering component information of the true Wu decoction are simultaneously obtained through one-time liquid chromatography-mass spectrometry analysis, so that the heart-failure-resistant active component of the true Wu decoction is further obtained, the time is saved, and the result accuracy is improved; the traditional Chinese medicine monomer composition disclosed by the invention is stable and controllable in quality, has an effective heart failure resisting effect and is suitable for preparing heart failure resisting medicines.

This invention provides a novel use of Atractylodes macrocephala essential oil for the prevention and treatment of hair loss and alopecia areata. The characteristic components of the Atractylodes macrocephala essential oil include: atractylenolide I, atractylenolide II, atractylenolide III, atractylone, β-elemene, hesperidin, and isohesperidin. The invention also provides a method for preparing essential oil compositions, pharmaceutical formulations, and uses for the prevention and treatment of hair loss and alopecia areata. This method reduces bitterness and the first-pass effect in the liver, resulting in more stable blood drug concentrations and improved patient compliance. Compared to existing methods, it has advantages such as better efficacy and no toxic side effects. Developing health products and pharmaceuticals for the prevention and treatment of hair loss and alopecia areata based on this method has great potential.