36 results about "Pachymic acid" patented technology

The invention discloses a natural-source FFA4 receptor agonist and application thereof, relates to the technical field of medicines, and in particular relates to discovery of a natural compound action target spot which is a G protein coupled receptor FFA4. The FFA4 receptor agonist is medolamic acid, oleanolic acid and hederagenin and / or corresponding pharmaceutically acceptable salts, solvates or polymorphs and pharmaceutical compositions thereof, and the FFA4 receptor agonist is one of medolamic acid, oleanolic acid and hederagenin and / or pharmaceutically acceptable salts, solvates or polymorphs and pharmaceutical compositions thereof. An in-vitro cell target experiment shows that the pachymic acid, the oleanolic acid and the hederagenin are FFA4 agonists. Researches show that the FFA4 receptor is related to non-alcoholic fatty liver disease, stomach injury induced by non-steroidal anti-inflammatory drugs, osteoporosis, inflammatory bowel disease and other diseases, so that the agonist has potential medicinal application.

The application discloses a pachymic acid medicine composition for preventing and treating ulcerative colitis and application thereof, and relates to the technical field of medical application. The composition is prepared from the following components in parts: pachymic acid 100-500 parts, carboxymethyl cellulose solution 10-100 parts, medicinal adjuvant 10-120 parts, synergistic adjuvant 10-100 parts, solvent 10-50 parts, and purified water 100-120 parts. The pachymic acid is used as a clear monomer active ingredient to prepare a medicine for preventing and treating ulcerative colitis. Compared with the existing compound, extract or multi-component combination technical scheme, the application has the characteristics of clear active ingredient, relatively clear efficacy basis, convenient quality control and subsequent development. It is clear that the ulcerative colitis can be prevented and treated by inhibiting the cGAS-STING and NF-κB signal pathways, reducing the damage of the colon epithelial cells, inhibiting the release of pro-inflammatory factors, repairing the damaged intestinal mucus barrier and intestinal epithelial barrier, regulating the apoptosis balance of intestinal cells, and enhancing the antioxidant activity of the intestinal tract. The application plays a role in preventing and treating ulcerative colitis from multiple targets such as inflammation inhibition, barrier repair and antioxidant.

The invention discloses a quality detection method of an infantile poria cocos and coix seed paste, the detection method sequentially comprises the steps of preparation of the infantile poria cocos and coix seed paste, thin-layer identification, finished product inspection and content determination, and according to inspection items (general rule 0183) under oral thick paste items of four parts of Chinese Pharmacopoeia of 2020 edition, inspection items of characters, relative density, insoluble substances and water content are studied; identifying poria cocos, semen euryales and semen coicis in the root-benefiting conditioning paste by adopting a thin layer chromatography (TLC); according to the method, the content of pachymic acid serving as an effective component in the poria cocos and coix seed paste for children is measured and researched by adopting an HPLC (High Performance Liquid Chromatography) method, so that a basis is provided for quality control of the product, and the method is good in reproducibility, good in durability, simple and convenient, and capable of effectively controlling the quality of the poria cocos and coix seed paste for children.

The invention provides a nerve soothing and mind stabilizing pill and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: cleaning, infiltrating, cutting, drying, performing high-pressure steam sterilization on genuine medicinal materials such as poria cocos, poria with hostwood, ginseng, polygala tenuifolia, rhizoma acori graminei and the like in a formula of the mind-tranquilizing and mind-tranquilizing pill, mixing and crushing at low temperature to obtain fine powder, adding refined honey to prepare pills, and finally coating with cinnabar powder to obtain the mind-tranquilizing and mind-tranquilizing pill. The contents of polygala-ketone III, 3, 6 '-dimustard acyl sucrose, ginsenoside Rb1, beta-asarone, dehydrotumoic acid, pachymic acid and calcium salt in the prepared nerve-soothing and mind-stabilizing pill are high, the loss of index components in the pelleting process is small, and the dissolution time limit and microbial limit of the pill meet the requirements of Chinese Pharmacopoeia of 2025 edition. The preparation process of the mind-tranquilizing and mind-stabilizing pill is stable, and the prepared mind-tranquilizing and mind-stabilizing pill can effectively improve cognitive impairment, inflammation and oxidative stress injury caused by insomnia.

The invention discloses a quality detection control method of poria cocos new acid in a poria cocos extract, which comprises the following steps: S1, integrated sample pretreatment: putting poria cocos medicinal material powder, a buffer solution and immobilized compound enzyme into a reaction device integrated with ultrasonic and microwave assistance and membrane filtration functions, and carrying out one-stop enzymolysis and extraction, the primarily purified extracting solution is directly obtained; s2, efficient solid-phase extraction and purification: purifying the extracting solution through a solid-phase extraction column filled with a metal and organic framework composite material to obtain a to-be-detected solution; and in the enzymolysis process, real-time feedback regulation is carried out by combining near infrared spectrum online monitoring data. According to the quality detection control method for the poria cocos neoacid in the poria cocos extract, enzymolysis, extraction and filtration are integrated through the integrated device, and the ultrasonic and microwave synergistic effect is matched, so that the dissolution efficiency of a target object is improved while the enzymatic activity is guaranteed.

The application discloses application of pachymic acid B in preparation of a medicine for preventing peritoneal metastasis of gastric cancer and a medicine composition thereof. The pachymic acid B is chemically named as 3-O-acetyl-16alpha-hydroxydehydrotrametenolic acid. The in-situ transplantation peritoneal metastasis model of the gastric cancer proves that intraperitoneal injection of the pachymic acid B can significantly reduce the number of peritoneal metastasis nodules and tumor load, the prevention effect is equivalent to that of oxaliplatin, and there is no obvious organ toxicity. Further experiments prove that the pachymic acid B can up-regulate the mRNA and protein expression levels of SPRED2 genes in peritoneal tissues of the gastric cancer, and plays a role in a time-dose dependent manner. The pachymic acid B provided by the application is administered by intraperitoneal injection, can be prepared into a suspension containing sodium carboxymethyl cellulose, and is especially suitable for perioperative administration of gastric cancer primary focus resection. Compared with the prior art, the application has the advantages of clear composition, novel action mechanism, high safety, simple operation, strong accessibility and the like.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for simultaneously determining the contents of various components in Shuanling antidiarrheal granules based on a UPLC-QQQ-MS / MS. The contents of 18 components in the Shuanling antidiarrheal granules are simultaneously determined by using an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. The 18 components comprise adenosine, gallic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, liquiritin, ellagic acid, kaempferitrin, narirutin, hesperidin, baicalin, oroxylin A-7-O-beta-D-glucuronide, wogonin, baicalein, wogonin, pachymic acid B and pachymic acid A. The invention further discloses a preparation method of the pharmaceutical composition. Through the UPLC-QTRAP-MS / MS combined technology, the technical prejudice that single component depends on in quality control of the traditional Chinese medicine compound preparation is broken through, the key problems that multiple components in a complex matrix are difficult to separate, low-content components are difficult to detect and the like are solved, efficient, accurate and synchronous determination of 18 components is achieved, and the method is suitable for large-scale popularization and application. A new reference path is opened up for modernized quality control of the traditional Chinese medicine compound preparation.

The present invention discloses a composition for improving sleep, preventing and treating anxiety, delaying aging and its preparation method. The composition includes lily, lemon balm, liquorice, mulberry, Poria, spinach seed, sea buckthorn, lotus seed core, roxburghii, alpinia oxyphylla, valerian root, acanthopanax senticosus, red rose, light bamboo leaf, snow lotus, gastrodia elata, passion flower, ergothioneine, dihydroquercetin, gamma-aminobutyric acid, casein peptide, royal jelly, pea peptide, tea theanine, fish collagen peptide and Haematococcus pluvialis powder. The composition of the present invention rationally proportions each component, and patient takes and is easy to carry, and is effective. In addition, the preparation method process of the composition is simple, stable and reliable in performance, high in production efficiency, low in production cost, and has broad application prospects.

The invention discloses a plant composition capable of improving sleep. The plant composition is prepared from the following components in percentage by weight: 45-55% of hippophae rhamnoides, 30-40% of schisandra chinensis, 20-30% of poria cocos and 10-20% of spina date seeds. The invention also discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicines used in the invention are safe and effective and have synergistic interaction after mutual compatibility, and the preparation method of the composition effectively extracts effective components and removes non-effective components, so that the product has very remarkable functions of improving sleep and enhancing immunity. The composition is safe, economical, exact in curative effect, simple in production process, stable in condition and suitable for large-scale industrial production.

The invention provides a composition for improving sleep and resisting anxiety and depression, a pharmaceutical preparation and application, and relates to the technical field of traditional Chinese medicines. The composition comprises the following components: poria cocos, spina date seeds, lily bulbs, mulberries, fingered citron, wheat, Chinese dates, lucid ganoderma, gastrodia elata powder, licorice roots and donkey-hide gelatin. Under the specific components and proportions, the prepared composition has better effects of improving sleep and resisting anxiety and depression; the raw materials are simple, easy to obtain, safe, toxic and free of side effects; the preparation method is simple and suitable for industrial popularization.

The invention discloses a method for determining the content of multi-index components of a nerve-soothing and mind-tranquilizing pill, and belongs to the technical field of traditional Chinese medicine component analysis. By optimizing a high performance liquid chromatography gradient elution procedure, strictly controlling an initial mobile phase ratio of the gradient elution procedure and matching with selection of a chromatographic column and a mobile phase, the method can be used for simultaneously, rapidly and comprehensively determining the content of the index components polygala # imgabs0 # ketone III, 3, 4-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5- The content of six index components, namely 6, 6 '-dimustard acyl sucrose, ginsenoside Rb1, beta-asarone, dehydrotumuloic acid and pachymic acid, is increased. The whole detection process is single-wavelength detection, the detection efficiency is high, the analysis time is short, the detection limits of the six components are all lower than 0.008 microgram / mL, and the method is high in sensitivity, good in specificity, accurate in result and good in reproducibility.

The invention provides a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of hypoglycemic products, and relates to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: 4-8 parts of ginseng stem and leaf saponin, 8-16 parts of astragalus polysaccharide, 6-12 parts of astragaloside, 8-16 parts of catalpol, 6-12 parts of rehmannia D, 8-16 parts of verbascoside, 3-5 parts of raspberry polysaccharide, 4-8 parts of ellagic acid, 4-8 parts of pachymaran, 5-10 parts of pachymic acid, 8-16 parts of lycium barbarum polysaccharide, 40-62 parts of schisandra chinensis, 20-40 parts of Chinese yam, 40-62 parts of radix ophiopogonis, 40-62 parts of radix trichosanthis and 40-62 parts of rhizoma alismatis. The traditional Chinese medicine raw materials are pretreated by using the high-voltage pulsed electric field, and then ethanol extraction treatment is performed twice, so that the yield of the traditional Chinese medicine extract is high, and the traditional Chinese medicine composition obtained by mixing the traditional Chinese medicine extract with other active ingredients has an excellent effect of treating type II diabetes mellitus.

A whitening and spot-fading composition based on molecular docking technology and a preparation method therefor. The composition comprises atractylenolide I, pachymic acid, paeoniflorin and glabridin, wherein the mass ratio of the atractylenolide I, pachymic acid, paeoniflorin and glabridin is 50-600:100-700:600-2000:10-200. On the basis of the docking binding energy of active ingredients in four plants Atractylodes macrocephala, Paeonia lactiflora, poria cocos and licorice to a key target molecule of a disease, it is found by screening that compounding the atractylenolide I, pachymic acid, paeoniflorin and glabridin as active ingredients can obtain the composition having a remarkable whitening and spot-fading effect, the melanin synthesis inhibition rate of the composition reaches 69.4%-83.6%, and the tyrosinase activity inhibition rate of the composition reaches 76.8%-91.3%.

This application provides a strain of *Bifidobacterium pseudolongum* capable of converting *Poria cocos* oligosaccharides into prebiotics and its applications, belonging to the field of microbial technology. The *Bifidobacterium pseudolongum* strain provided in this application (… Bifidobacterium pseudolongum subsp. globosum L10, deposited at the Guangdong Provincial Center for Microbial Culture Collection (GDMCC No. 67277) on November 12, 2025, is a bacterium that can utilize poria cocos oligosaccharides derived from poria cocos acidic polysaccharides for proliferation and decompose and transform the poria cocos oligosaccharides. The resulting substances can be utilized and proliferated by probiotics in the human gut, thereby regulating the balance of the human gut microbiota and improving the body's immunity. It also provides a new way of utilizing poria cocos acidic polysaccharides and improves their availability.

This invention discloses the application of dermal ethylsin in the preparation of antibacterial and repairing cosmetics or pharmaceuticals, and compositions containing it. Dermal ethylsin can inhibit Propionibacterium acnes, Staphylococcus aureus, and / or Staphylococcus epidermidis, and can promote keratinocyte migration and / or upregulate the expression of repair-related genes. Cytotoxicity tests show that dermal ethylsin has good safety. Human efficacy evaluation shows that serums containing dermal ethylsin can significantly reduce inflammatory papules, improve skin redness, and improve barrier function. Therefore, dermal ethylsin can be used as a dual-action antibacterial and repairing active agent in cosmetics or pharmaceuticals for acne skin care, sensitive skin repair, and / or post-medical aesthetic repair. Dermal ethylsin is derived from *Gnaphalium affine*, has good safety, and is non-irritating to the skin.

This invention discloses a traditional Chinese medicine composition for regulating calcium ion homeostasis in the stomach, belonging to the field of traditional Chinese medicine technology. It is made from calcined oyster shell, calcined abalone shell, dried plum, poria cocos, and jujube seed in a specific weight ratio. This invention selects highly efficient calcium sources, calcined oyster shell and calcined abalone shell, in equal proportions, avoiding the deficiency of insufficient calcium content in traditional calcined dragon bone. It targets and supplements local calcium ions in the stomach, enhances the stabilizing effect of calcium ions on potassium ion channels, inhibits abnormal potassium ion leakage, and improves gastrointestinal smooth muscle tone. At the same time, it eliminates unsuitable medicinal materials such as Codonopsis pilosula, Astragalus membranaceus, Eucommia ulmoides, and Lycium barbarum. It uses Prunus mume to inhibit the proliferation of harmful bacteria in the small intestine and reduce fermentation and gas production, Poria cocos to supplement gastrointestinal trace elements, and Ziziphus jujuba var. spinosa to stabilize potassium ion channels, restore the calcium-potassium ion balance in the stomach, improve gastrointestinal motility rhythm, and alleviate problems such as small intestinal bacterial overgrowth, insufficient gastrointestinal motility, and abdominal distension. This composition does not contain sucrose, maltodextrin, chemical additives, or irritating excipients. It is fully decocted and suitable for people with fragile gastrointestinal barriers and immune sensitivity. The raw materials are safe and readily available, the preparation method is simple, and it has broad application prospects in gastrointestinal conditioning.

The present application belongs to the technical field of detection, and relates to a detection method for multiple active ingredients of Shishi Tonglin capsules, comprising simultaneously determining the contents of salvianolic acid B, protodioscin, dioscin, hederagenin and tanshinone II A in Shishi Tonglin capsules based on UPLC-QAMS method, or / and simultaneously determining the contents of salvianolic acid B, verbascoside, berberine hydrochloride, pachymic acid A and tanshinone II A in Shishi Tonglin capsules based on HPLC-QAMS method. The present application utilizes the method of combining liquid chromatography with one measurement multiple evaluation, determines one stable, easily obtained and low-priced active ingredient, calculates the contents of other ingredients by using the relative correction factor method, realizes the simultaneous determination of multiple ingredients in Shishi Tonglin capsules, and has the advantages of simple determination method, good accuracy of detection results and reduced detection cost.

The present invention provides an analytical detection method for Ling Gui Zhu Gan Decoction. The method uses ultra-high performance liquid chromatography (UPLC) for detection and can be used for fingerprint detection of 14 components in Ling Gui Zhu Gan Decoction, including apiosyl liquiritin, liquiritin, apiosyl isoliquiritin, isoliquiritin, glycyrrhizin, cinnamic acid, cinnamaldehyde, o-methoxycinnamic acid, glycyrrhizic acid, atractylodes lactone III, atractylodes lactone II, pachymosin B, policocoric acid C and dehydropachymosic acid. The method can also be used for content control of liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizic acid. The method has strong applicability and is of great significance for comprehensive and objective evaluation of Ling Gui Zhu Gan Decoction.

The invention discloses a composition for improving sleep, preventing and treating anxiety and delaying senescence and a preparation method thereof. The composition comprises lily, balm, liquorice, mulberry, poria cocos, spina date seed, sea-buckthorn, lotus plumule, roxburgh rose, fructus alpiniae oxyphyllae, valerian root, acanthopanax, red rose, lophatherum gracile, saussurea involucrata, gastrodia elata, passion flower, ergothioneine, dihydroquercetin, gamma-aminobutyric acid, casein peptide, royal jelly, pea peptide, tea theanine, fish collagen peptide and haematococcus pluvialis powder. The composition disclosed by the invention is reasonable in component ratio, convenient to take and carry by a patient and good in effect. In addition, the preparation method of the composition is simple in process, stable and reliable in performance, high in production efficiency, low in production cost and wide in application prospect.

The invention belongs to the technical field of pulmonary arterial hypertension treatment medicines, and particularly relates to a composition for treating pulmonary arterial hypertension and application thereof. The composition comprises the following raw materials: pachymic acid B, cinnamic acid, atractylenolide I and glycyrrhizic acid. Experiments prove that for pulmonary arterial hypertension rats, the composition can obviously reverse decrease of the PAT / PET ratio, obviously relieve increase of right ventricular systolic pressure and average pulmonary arterial pressure, obviously relieve right ventricular hypertrophy index and obviously relieve PA myelization and pulmonary fibrosis of the pulmonary arterial hypertension rats. Therefore, the composition can be used for preparing medicines for treating pulmonary arterial hypertension.

The invention relates to the technical field of biological medicine, and particularly discloses a traditional Chinese medicine compound based on iPSC exosomes and a preparation method and application of the traditional Chinese medicine compound. The invention discloses a traditional Chinese medicine compound based on an iPSC exosome. The traditional Chinese medicine compound is prepared by loading a fat-soluble component and a hydrophilic component on the iPSC exosome, the diameter of the iPSC exosome is 30-150 nm, and the total drug loading capacity of the iPSC exosome is 40-60 [mu] g / mg protein; the fat-soluble component is selected from pachymic acid and curcumin; and the hydrophilic component is selected from ginsenoside Rg1 and baicalin. The traditional Chinese medicine compound provided by the invention realizes synchronous delivery of traditional Chinese medicine micromolecules of fat-soluble components and hydrophilic components on the basis of the iPSC exosome; the problem that the exosome is single in drug loading variety is solved, the drug loading rate and the encapsulation rate are improved, and the application prospect in depression treatment drugs is wide.

The invention relates to an application of pachymic acid, and discloses an application of pachymic acid in a medicine for treating lymphedema. Pachymic acid can relieve lymphatic fibrosis and promote lymphatic formation by adjusting the level of cycloeicosatrienoic acid EETs, so that related symptoms of lymphedema are relieved, and a new molecular target is provided for treatment of lymphedema. The potential of traditional Chinese medicine in modern treatment application is highlighted, and pachymic acid is expected to become a candidate medicine for treating lymphedema.

The invention relates to a method for determining the content of triterpenic acid compounds in poria cocos and application, and belongs to the field of quality analysis and control of traditional Chinese medicines. The determination method comprises the following steps: detecting a poria cocos test sample solution by adopting a high performance liquid chromatography (HPLC) method, and detecting the poria cocos test sample solution by adopting a high performance liquid chromatography (HPLC) method, wherein the triterpenic acid compounds comprise 6 alpha-hydroxy polyporus acid C, poria cocos neoic acid B, dehydrotumuloic acid, tumuloic acid, poria cocos neoic acid A, 3-epidehydrotumuloic acid, polyporus acid C, 3-epidehydrotumuloic acid, dehydrotumuloic acid, pachymic acid, Songling neoic acid, dehydroorifice acid and orifice acid. According to the present invention, the appropriate HPLC analysis method of the poria cocos triterpenic acid compound is established, the pachymic acid is selected as the internal reference substance, and the quantitative analysis of multiple components by single marker for simultaneously determining the content of 13 poria cocos triterpenic acids in the poria cocos is established, such that the detection cost and the detection time are saved, and the reference is provided for the quality control of the poria cocos.

The invention relates to the technical field of traditional Chinese medicine fermentation preparation, in particular to a preparation method and application of yellow bud soup based on multi-bacterium synergistic fermentation. According to the method, ginseng, poria cocos, rhizoma zingiberis and liquorice are subjected to differential pretreatment, and a composite functional flora containing ganoderma lucidum, thermophilic lactic acid bacteria and saccharomycopsis fibuligera is constructed; solid-state fermentation is carried out under the conditions of temperature gradient, segmented stirring, gradient ventilation and dynamic material supplementing, so that the contents of key active ingredients such as ginsenoside Rg3, pachymic acid and 6-gingerol are remarkably increased. The fermentation product can be used for preparing a preparation for warming yang, tonifying spleen, clearing damp, reducing phlegm and protecting gastrointestinal tracts. Through multi-bacterium synergistic fermentation and dynamic regulation, the content of ginsenoside Rg3 is increased by 3.2 times or more compared with that of a traditional water decoction method, the content of symbolic components such as pachymic acid and 6-gingerol is increased by 2 times or more, and the drug effect is greatly enhanced; and macromolecular components can be converted into micromolecular active substances through microbial metabolism, so that the digestion burden of gastrointestinal tracts is reduced.

The invention discloses discovery of an anti-heart-failure traditional Chinese medicine monomer composition based on a Zhenwu decoction. The discovery comprises the following steps: 1, preparing the Zhenwu decoction; 2, collecting and analyzing a serum sample; 3, determination of heart failure resistant endogenous metabolites and determination of peak intensity; 4, determination of components absorbed into blood and determination of peak intensity; 5, carrying out correlation analysis on peak intensity; the traditional Chinese medicine monomer composition is obtained by dissolving songlin, atractylenolide II, pachymic acid, paeoniflorin and 6-gingerol in a sodium carboxymethyl cellulose solution, and plays a role in preparing the heart failure resisting medicine. According to the method disclosed by the invention, the heart-failure-resistant endogenous metabolite and absorbed blood-entering component information of the true Wu decoction are simultaneously obtained through one-time liquid chromatography-mass spectrometry analysis, so that the heart-failure-resistant active component of the true Wu decoction is further obtained, the time is saved, and the result accuracy is improved; the traditional Chinese medicine monomer composition disclosed by the invention is stable and controllable in quality, has an effective heart failure resisting effect and is suitable for preparing heart failure resisting medicines.

The invention provides application of tramelic acid to prevention and control of beet armyworms, and relates to the technical field of pest prevention and control. The tramelic acid can generate a remarkable antifeedant effect on beet armyworms under a certain concentration, can inhibit growth of beet armyworm larvae to a certain extent and even cause death of the beet armyworm larvae, and can be used as a novel beet armyworm control agent. According to the invention, the defects in the prior art are overcome, the plant source extracted component of tramelic acid can effectively prevent and treat beet armyworms, and the component is green and safe, reduces environmental pollution, and has a good prospect in development of a novel agent for preventing and treating beet armyworms.

The invention discloses a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of pancreatic cancer treatment medicines, and belongs to the technical field of biological medicines. Indissolvable drugs atractylenolide I and pachymic acid are compatible according to a specific ratio and prepared into the nano preparation, the solubility and bioavailability of the atractylenolide I and the pachymic acid are improved, the atractylenolide I and the pachymic acid can be jointly delivered into tumor tissues and gradually disintegrated in a tumor hypoxic environment, so that synergistic release of the atractylenolide I and the pachymic acid is triggered, and the bioavailability of the atractylenolide I and the pachymic acid is improved. The inhibition effect on pancreatic cancer cells and the regulation and control capability on a tumor microenvironment are enhanced.

The invention provides a preparation method and application of poria cocos acidic polysaccharide acidolysis molecules for promoting proliferation of lactic acid bacteria, and belongs to the technical field of preparation of medical raw materials. The method comprises the step of treating the water-insoluble poria cocos acidic polysaccharide by using gluconic acid. According to the method provided by the invention, the conditions in the preparation process are mild, an organic solvent and traditional industrial acid are not used, the water solubility of the treated poria cocos acidic polysaccharide is remarkably improved, meanwhile, the treated poria cocos acidic polysaccharide shows good biological activity for promoting proliferation of intestinal flora, further development and utilization of the poria cocos acidic polysaccharide are facilitated, and the application prospect of a product prepared from the poria cocos acidic polysaccharide is improved.

The invention belongs to the field of biological medicines, and particularly relates to application of astragaloside in preparation of a medicine for treating myocardial remodeling after myocardial infarction. In-vivo and in-vitro experiments prove that the astragaloside can up-regulate the expression of Acox1, Cd36, Pgc1a and Cpt1a lipid metabolism related factors and improve lipid metabolism disorder after myocardial infarction; meanwhile, Acta2, Col1a1, Col3a1, Postn fibrosis factors and alpha-SMA expression are inhibited, and myocardial fibrosis after myocardial infarction is relieved; the left ventricular ejection fraction and the left ventricular short axis shortening rate can be remarkably increased, the left ventricular end diastolic inner diameter and the left ventricular end systolic inner diameter are reduced, and cardiac dysfunction caused by myocardial infarction is improved. The composition can block pathological circulation of lipid metabolism disorder, myocardial fibrosis and cardiac function decline in a targeted manner, the curative effect is dose-dependent, the safety is good, and a brand new effective drug choice is provided for clinical treatment of myocardial remodeling after myocardial infarction.

The invention belongs to the technical field of medicines, and particularly relates to a stable and safe tirofiban injection and a preparation process thereof, and the injection contains tirofiban hydrochloride, tocopheryl acetate, pachymic acid, meglumine, sorbitol, a pH regulator, ethanol and water. Acceleration tests show that the influence of illumination is avoided to the maximum extent, the content of related substances is low, the transparency, insoluble particles and content uniformity of the injection meet the requirements of Chinese Pharmacopoeia 2020 edition, pharmacological experiments are clear, and acceleration tests prove that the stability of the injection is superior to that of the prior art.