11 results about "Pachymic acid" patented technology

The invention discloses a plant composition capable of improving sleep. The plant composition is prepared from the following components in percentage by weight: 45-55% of hippophae rhamnoides, 30-40% of schisandra chinensis, 20-30% of poria cocos and 10-20% of spina date seeds. The invention also discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicines used in the invention are safe and effective and have synergistic interaction after mutual compatibility, and the preparation method of the composition effectively extracts effective components and removes non-effective components, so that the product has very remarkable functions of improving sleep and enhancing immunity. The composition is safe, economical, exact in curative effect, simple in production process, stable in condition and suitable for large-scale industrial production.

The invention provides a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of hypoglycemic products, and relates to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: 4-8 parts of ginseng stem and leaf saponin, 8-16 parts of astragalus polysaccharide, 6-12 parts of astragaloside, 8-16 parts of catalpol, 6-12 parts of rehmannia D, 8-16 parts of verbascoside, 3-5 parts of raspberry polysaccharide, 4-8 parts of ellagic acid, 4-8 parts of pachymaran, 5-10 parts of pachymic acid, 8-16 parts of lycium barbarum polysaccharide, 40-62 parts of schisandra chinensis, 20-40 parts of Chinese yam, 40-62 parts of radix ophiopogonis, 40-62 parts of radix trichosanthis and 40-62 parts of rhizoma alismatis. The traditional Chinese medicine raw materials are pretreated by using the high-voltage pulsed electric field, and then ethanol extraction treatment is performed twice, so that the yield of the traditional Chinese medicine extract is high, and the traditional Chinese medicine composition obtained by mixing the traditional Chinese medicine extract with other active ingredients has an excellent effect of treating type II diabetes mellitus.

This application provides a strain of *Bifidobacterium pseudolongum* capable of converting *Poria cocos* oligosaccharides into prebiotics and its applications, belonging to the field of microbial technology. The *Bifidobacterium pseudolongum* strain provided in this application (… Bifidobacterium pseudolongum subsp. globosum L10, deposited at the Guangdong Provincial Center for Microbial Culture Collection (GDMCC No. 67277) on November 12, 2025, is a bacterium that can utilize poria cocos oligosaccharides derived from poria cocos acidic polysaccharides for proliferation and decompose and transform the poria cocos oligosaccharides. The resulting substances can be utilized and proliferated by probiotics in the human gut, thereby regulating the balance of the human gut microbiota and improving the body's immunity. It also provides a new way of utilizing poria cocos acidic polysaccharides and improves their availability.

This invention discloses the application of dermal ethylsin in the preparation of antibacterial and repairing cosmetics or pharmaceuticals, and compositions containing it. Dermal ethylsin can inhibit Propionibacterium acnes, Staphylococcus aureus, and / or Staphylococcus epidermidis, and can promote keratinocyte migration and / or upregulate the expression of repair-related genes. Cytotoxicity tests show that dermal ethylsin has good safety. Human efficacy evaluation shows that serums containing dermal ethylsin can significantly reduce inflammatory papules, improve skin redness, and improve barrier function. Therefore, dermal ethylsin can be used as a dual-action antibacterial and repairing active agent in cosmetics or pharmaceuticals for acne skin care, sensitive skin repair, and / or post-medical aesthetic repair. Dermal ethylsin is derived from *Gnaphalium affine*, has good safety, and is non-irritating to the skin.

This invention discloses a traditional Chinese medicine composition for regulating calcium ion homeostasis in the stomach, belonging to the field of traditional Chinese medicine technology. It is made from calcined oyster shell, calcined abalone shell, dried plum, poria cocos, and jujube seed in a specific weight ratio. This invention selects highly efficient calcium sources, calcined oyster shell and calcined abalone shell, in equal proportions, avoiding the deficiency of insufficient calcium content in traditional calcined dragon bone. It targets and supplements local calcium ions in the stomach, enhances the stabilizing effect of calcium ions on potassium ion channels, inhibits abnormal potassium ion leakage, and improves gastrointestinal smooth muscle tone. At the same time, it eliminates unsuitable medicinal materials such as Codonopsis pilosula, Astragalus membranaceus, Eucommia ulmoides, and Lycium barbarum. It uses Prunus mume to inhibit the proliferation of harmful bacteria in the small intestine and reduce fermentation and gas production, Poria cocos to supplement gastrointestinal trace elements, and Ziziphus jujuba var. spinosa to stabilize potassium ion channels, restore the calcium-potassium ion balance in the stomach, improve gastrointestinal motility rhythm, and alleviate problems such as small intestinal bacterial overgrowth, insufficient gastrointestinal motility, and abdominal distension. This composition does not contain sucrose, maltodextrin, chemical additives, or irritating excipients. It is fully decocted and suitable for people with fragile gastrointestinal barriers and immune sensitivity. The raw materials are safe and readily available, the preparation method is simple, and it has broad application prospects in gastrointestinal conditioning.

The present application belongs to the technical field of detection, and relates to a detection method for multiple active ingredients of Shishi Tonglin capsules, comprising simultaneously determining the contents of salvianolic acid B, protodioscin, dioscin, hederagenin and tanshinone II A in Shishi Tonglin capsules based on UPLC-QAMS method, or / and simultaneously determining the contents of salvianolic acid B, verbascoside, berberine hydrochloride, pachymic acid A and tanshinone II A in Shishi Tonglin capsules based on HPLC-QAMS method. The present application utilizes the method of combining liquid chromatography with one measurement multiple evaluation, determines one stable, easily obtained and low-priced active ingredient, calculates the contents of other ingredients by using the relative correction factor method, realizes the simultaneous determination of multiple ingredients in Shishi Tonglin capsules, and has the advantages of simple determination method, good accuracy of detection results and reduced detection cost.

The invention relates to the technical field of biological medicine, and particularly discloses a traditional Chinese medicine compound based on iPSC exosomes and a preparation method and application of the traditional Chinese medicine compound. The invention discloses a traditional Chinese medicine compound based on an iPSC exosome. The traditional Chinese medicine compound is prepared by loading a fat-soluble component and a hydrophilic component on the iPSC exosome, the diameter of the iPSC exosome is 30-150 nm, and the total drug loading capacity of the iPSC exosome is 40-60 [mu] g / mg protein; the fat-soluble component is selected from pachymic acid and curcumin; and the hydrophilic component is selected from ginsenoside Rg1 and baicalin. The traditional Chinese medicine compound provided by the invention realizes synchronous delivery of traditional Chinese medicine micromolecules of fat-soluble components and hydrophilic components on the basis of the iPSC exosome; the problem that the exosome is single in drug loading variety is solved, the drug loading rate and the encapsulation rate are improved, and the application prospect in depression treatment drugs is wide.

The invention discloses discovery of an anti-heart-failure traditional Chinese medicine monomer composition based on a Zhenwu decoction. The discovery comprises the following steps: 1, preparing the Zhenwu decoction; 2, collecting and analyzing a serum sample; 3, determination of heart failure resistant endogenous metabolites and determination of peak intensity; 4, determination of components absorbed into blood and determination of peak intensity; 5, carrying out correlation analysis on peak intensity; the traditional Chinese medicine monomer composition is obtained by dissolving songlin, atractylenolide II, pachymic acid, paeoniflorin and 6-gingerol in a sodium carboxymethyl cellulose solution, and plays a role in preparing the heart failure resisting medicine. According to the method disclosed by the invention, the heart-failure-resistant endogenous metabolite and absorbed blood-entering component information of the true Wu decoction are simultaneously obtained through one-time liquid chromatography-mass spectrometry analysis, so that the heart-failure-resistant active component of the true Wu decoction is further obtained, the time is saved, and the result accuracy is improved; the traditional Chinese medicine monomer composition disclosed by the invention is stable and controllable in quality, has an effective heart failure resisting effect and is suitable for preparing heart failure resisting medicines.

The invention provides application of tramelic acid to prevention and control of beet armyworms, and relates to the technical field of pest prevention and control. The tramelic acid can generate a remarkable antifeedant effect on beet armyworms under a certain concentration, can inhibit growth of beet armyworm larvae to a certain extent and even cause death of the beet armyworm larvae, and can be used as a novel beet armyworm control agent. According to the invention, the defects in the prior art are overcome, the plant source extracted component of tramelic acid can effectively prevent and treat beet armyworms, and the component is green and safe, reduces environmental pollution, and has a good prospect in development of a novel agent for preventing and treating beet armyworms.

The invention discloses a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of pancreatic cancer treatment medicines, and belongs to the technical field of biological medicines. Indissolvable drugs atractylenolide I and pachymic acid are compatible according to a specific ratio and prepared into the nano preparation, the solubility and bioavailability of the atractylenolide I and the pachymic acid are improved, the atractylenolide I and the pachymic acid can be jointly delivered into tumor tissues and gradually disintegrated in a tumor hypoxic environment, so that synergistic release of the atractylenolide I and the pachymic acid is triggered, and the bioavailability of the atractylenolide I and the pachymic acid is improved. The inhibition effect on pancreatic cancer cells and the regulation and control capability on a tumor microenvironment are enhanced.

The invention belongs to the field of biological medicines, and particularly relates to application of astragaloside in preparation of a medicine for treating myocardial remodeling after myocardial infarction. In-vivo and in-vitro experiments prove that the astragaloside can up-regulate the expression of Acox1, Cd36, Pgc1a and Cpt1a lipid metabolism related factors and improve lipid metabolism disorder after myocardial infarction; meanwhile, Acta2, Col1a1, Col3a1, Postn fibrosis factors and alpha-SMA expression are inhibited, and myocardial fibrosis after myocardial infarction is relieved; the left ventricular ejection fraction and the left ventricular short axis shortening rate can be remarkably increased, the left ventricular end diastolic inner diameter and the left ventricular end systolic inner diameter are reduced, and cardiac dysfunction caused by myocardial infarction is improved. The composition can block pathological circulation of lipid metabolism disorder, myocardial fibrosis and cardiac function decline in a targeted manner, the curative effect is dose-dependent, the safety is good, and a brand new effective drug choice is provided for clinical treatment of myocardial remodeling after myocardial infarction.