22 results about "Pachymic acid" patented technology

The invention provides a nerve soothing and mind stabilizing pill and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: cleaning, infiltrating, cutting, drying, performing high-pressure steam sterilization on genuine medicinal materials such as poria cocos, poria with hostwood, ginseng, polygala tenuifolia, rhizoma acori graminei and the like in a formula of the mind-tranquilizing and mind-tranquilizing pill, mixing and crushing at low temperature to obtain fine powder, adding refined honey to prepare pills, and finally coating with cinnabar powder to obtain the mind-tranquilizing and mind-tranquilizing pill. The contents of polygala-ketone III, 3, 6 '-dimustard acyl sucrose, ginsenoside Rb1, beta-asarone, dehydrotumoic acid, pachymic acid and calcium salt in the prepared nerve-soothing and mind-stabilizing pill are high, the loss of index components in the pelleting process is small, and the dissolution time limit and microbial limit of the pill meet the requirements of Chinese Pharmacopoeia of 2025 edition. The preparation process of the mind-tranquilizing and mind-stabilizing pill is stable, and the prepared mind-tranquilizing and mind-stabilizing pill can effectively improve cognitive impairment, inflammation and oxidative stress injury caused by insomnia.

The invention discloses a quality detection control method of poria cocos new acid in a poria cocos extract, which comprises the following steps: S1, integrated sample pretreatment: putting poria cocos medicinal material powder, a buffer solution and immobilized compound enzyme into a reaction device integrated with ultrasonic and microwave assistance and membrane filtration functions, and carrying out one-stop enzymolysis and extraction, the primarily purified extracting solution is directly obtained; s2, efficient solid-phase extraction and purification: purifying the extracting solution through a solid-phase extraction column filled with a metal and organic framework composite material to obtain a to-be-detected solution; and in the enzymolysis process, real-time feedback regulation is carried out by combining near infrared spectrum online monitoring data. According to the quality detection control method for the poria cocos neoacid in the poria cocos extract, enzymolysis, extraction and filtration are integrated through the integrated device, and the ultrasonic and microwave synergistic effect is matched, so that the dissolution efficiency of a target object is improved while the enzymatic activity is guaranteed.

The application discloses application of pachymic acid B in preparation of a medicine for preventing peritoneal metastasis of gastric cancer and a medicine composition thereof. The pachymic acid B is chemically named as 3-O-acetyl-16alpha-hydroxydehydrotrametenolic acid. The in-situ transplantation peritoneal metastasis model of the gastric cancer proves that intraperitoneal injection of the pachymic acid B can significantly reduce the number of peritoneal metastasis nodules and tumor load, the prevention effect is equivalent to that of oxaliplatin, and there is no obvious organ toxicity. Further experiments prove that the pachymic acid B can up-regulate the mRNA and protein expression levels of SPRED2 genes in peritoneal tissues of the gastric cancer, and plays a role in a time-dose dependent manner. The pachymic acid B provided by the application is administered by intraperitoneal injection, can be prepared into a suspension containing sodium carboxymethyl cellulose, and is especially suitable for perioperative administration of gastric cancer primary focus resection. Compared with the prior art, the application has the advantages of clear composition, novel action mechanism, high safety, simple operation, strong accessibility and the like.

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for simultaneously determining the contents of various components in Shuanling antidiarrheal granules based on a UPLC-QQQ-MS / MS. The contents of 18 components in the Shuanling antidiarrheal granules are simultaneously determined by using an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. The 18 components comprise adenosine, gallic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, liquiritin, ellagic acid, kaempferitrin, narirutin, hesperidin, baicalin, oroxylin A-7-O-beta-D-glucuronide, wogonin, baicalein, wogonin, pachymic acid B and pachymic acid A. The invention further discloses a preparation method of the pharmaceutical composition. Through the UPLC-QTRAP-MS / MS combined technology, the technical prejudice that single component depends on in quality control of the traditional Chinese medicine compound preparation is broken through, the key problems that multiple components in a complex matrix are difficult to separate, low-content components are difficult to detect and the like are solved, efficient, accurate and synchronous determination of 18 components is achieved, and the method is suitable for large-scale popularization and application. A new reference path is opened up for modernized quality control of the traditional Chinese medicine compound preparation.

The invention discloses a plant composition capable of improving sleep. The plant composition is prepared from the following components in percentage by weight: 45-55% of hippophae rhamnoides, 30-40% of schisandra chinensis, 20-30% of poria cocos and 10-20% of spina date seeds. The invention also discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicines used in the invention are safe and effective and have synergistic interaction after mutual compatibility, and the preparation method of the composition effectively extracts effective components and removes non-effective components, so that the product has very remarkable functions of improving sleep and enhancing immunity. The composition is safe, economical, exact in curative effect, simple in production process, stable in condition and suitable for large-scale industrial production.

The invention provides a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of hypoglycemic products, and relates to the technical field of traditional Chinese medicines. The invention discloses a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: 4-8 parts of ginseng stem and leaf saponin, 8-16 parts of astragalus polysaccharide, 6-12 parts of astragaloside, 8-16 parts of catalpol, 6-12 parts of rehmannia D, 8-16 parts of verbascoside, 3-5 parts of raspberry polysaccharide, 4-8 parts of ellagic acid, 4-8 parts of pachymaran, 5-10 parts of pachymic acid, 8-16 parts of lycium barbarum polysaccharide, 40-62 parts of schisandra chinensis, 20-40 parts of Chinese yam, 40-62 parts of radix ophiopogonis, 40-62 parts of radix trichosanthis and 40-62 parts of rhizoma alismatis. The traditional Chinese medicine raw materials are pretreated by using the high-voltage pulsed electric field, and then ethanol extraction treatment is performed twice, so that the yield of the traditional Chinese medicine extract is high, and the traditional Chinese medicine composition obtained by mixing the traditional Chinese medicine extract with other active ingredients has an excellent effect of treating type II diabetes mellitus.

A whitening and spot-fading composition based on molecular docking technology and a preparation method therefor. The composition comprises atractylenolide I, pachymic acid, paeoniflorin and glabridin, wherein the mass ratio of the atractylenolide I, pachymic acid, paeoniflorin and glabridin is 50-600:100-700:600-2000:10-200. On the basis of the docking binding energy of active ingredients in four plants Atractylodes macrocephala, Paeonia lactiflora, poria cocos and licorice to a key target molecule of a disease, it is found by screening that compounding the atractylenolide I, pachymic acid, paeoniflorin and glabridin as active ingredients can obtain the composition having a remarkable whitening and spot-fading effect, the melanin synthesis inhibition rate of the composition reaches 69.4%-83.6%, and the tyrosinase activity inhibition rate of the composition reaches 76.8%-91.3%.

This application provides a strain of *Bifidobacterium pseudolongum* capable of converting *Poria cocos* oligosaccharides into prebiotics and its applications, belonging to the field of microbial technology. The *Bifidobacterium pseudolongum* strain provided in this application (… Bifidobacterium pseudolongum subsp. globosum L10, deposited at the Guangdong Provincial Center for Microbial Culture Collection (GDMCC No. 67277) on November 12, 2025, is a bacterium that can utilize poria cocos oligosaccharides derived from poria cocos acidic polysaccharides for proliferation and decompose and transform the poria cocos oligosaccharides. The resulting substances can be utilized and proliferated by probiotics in the human gut, thereby regulating the balance of the human gut microbiota and improving the body's immunity. It also provides a new way of utilizing poria cocos acidic polysaccharides and improves their availability.

This invention discloses the application of dermal ethylsin in the preparation of antibacterial and repairing cosmetics or pharmaceuticals, and compositions containing it. Dermal ethylsin can inhibit Propionibacterium acnes, Staphylococcus aureus, and / or Staphylococcus epidermidis, and can promote keratinocyte migration and / or upregulate the expression of repair-related genes. Cytotoxicity tests show that dermal ethylsin has good safety. Human efficacy evaluation shows that serums containing dermal ethylsin can significantly reduce inflammatory papules, improve skin redness, and improve barrier function. Therefore, dermal ethylsin can be used as a dual-action antibacterial and repairing active agent in cosmetics or pharmaceuticals for acne skin care, sensitive skin repair, and / or post-medical aesthetic repair. Dermal ethylsin is derived from *Gnaphalium affine*, has good safety, and is non-irritating to the skin.

This invention discloses a traditional Chinese medicine composition for regulating calcium ion homeostasis in the stomach, belonging to the field of traditional Chinese medicine technology. It is made from calcined oyster shell, calcined abalone shell, dried plum, poria cocos, and jujube seed in a specific weight ratio. This invention selects highly efficient calcium sources, calcined oyster shell and calcined abalone shell, in equal proportions, avoiding the deficiency of insufficient calcium content in traditional calcined dragon bone. It targets and supplements local calcium ions in the stomach, enhances the stabilizing effect of calcium ions on potassium ion channels, inhibits abnormal potassium ion leakage, and improves gastrointestinal smooth muscle tone. At the same time, it eliminates unsuitable medicinal materials such as Codonopsis pilosula, Astragalus membranaceus, Eucommia ulmoides, and Lycium barbarum. It uses Prunus mume to inhibit the proliferation of harmful bacteria in the small intestine and reduce fermentation and gas production, Poria cocos to supplement gastrointestinal trace elements, and Ziziphus jujuba var. spinosa to stabilize potassium ion channels, restore the calcium-potassium ion balance in the stomach, improve gastrointestinal motility rhythm, and alleviate problems such as small intestinal bacterial overgrowth, insufficient gastrointestinal motility, and abdominal distension. This composition does not contain sucrose, maltodextrin, chemical additives, or irritating excipients. It is fully decocted and suitable for people with fragile gastrointestinal barriers and immune sensitivity. The raw materials are safe and readily available, the preparation method is simple, and it has broad application prospects in gastrointestinal conditioning.

The present application belongs to the technical field of detection, and relates to a detection method for multiple active ingredients of Shishi Tonglin capsules, comprising simultaneously determining the contents of salvianolic acid B, protodioscin, dioscin, hederagenin and tanshinone II A in Shishi Tonglin capsules based on UPLC-QAMS method, or / and simultaneously determining the contents of salvianolic acid B, verbascoside, berberine hydrochloride, pachymic acid A and tanshinone II A in Shishi Tonglin capsules based on HPLC-QAMS method. The present application utilizes the method of combining liquid chromatography with one measurement multiple evaluation, determines one stable, easily obtained and low-priced active ingredient, calculates the contents of other ingredients by using the relative correction factor method, realizes the simultaneous determination of multiple ingredients in Shishi Tonglin capsules, and has the advantages of simple determination method, good accuracy of detection results and reduced detection cost.

The invention relates to the technical field of biological medicine, and particularly discloses a traditional Chinese medicine compound based on iPSC exosomes and a preparation method and application of the traditional Chinese medicine compound. The invention discloses a traditional Chinese medicine compound based on an iPSC exosome. The traditional Chinese medicine compound is prepared by loading a fat-soluble component and a hydrophilic component on the iPSC exosome, the diameter of the iPSC exosome is 30-150 nm, and the total drug loading capacity of the iPSC exosome is 40-60 [mu] g / mg protein; the fat-soluble component is selected from pachymic acid and curcumin; and the hydrophilic component is selected from ginsenoside Rg1 and baicalin. The traditional Chinese medicine compound provided by the invention realizes synchronous delivery of traditional Chinese medicine micromolecules of fat-soluble components and hydrophilic components on the basis of the iPSC exosome; the problem that the exosome is single in drug loading variety is solved, the drug loading rate and the encapsulation rate are improved, and the application prospect in depression treatment drugs is wide.

The invention relates to the technical field of traditional Chinese medicine fermentation preparation, in particular to a preparation method and application of yellow bud soup based on multi-bacterium synergistic fermentation. According to the method, ginseng, poria cocos, rhizoma zingiberis and liquorice are subjected to differential pretreatment, and a composite functional flora containing ganoderma lucidum, thermophilic lactic acid bacteria and saccharomycopsis fibuligera is constructed; solid-state fermentation is carried out under the conditions of temperature gradient, segmented stirring, gradient ventilation and dynamic material supplementing, so that the contents of key active ingredients such as ginsenoside Rg3, pachymic acid and 6-gingerol are remarkably increased. The fermentation product can be used for preparing a preparation for warming yang, tonifying spleen, clearing damp, reducing phlegm and protecting gastrointestinal tracts. Through multi-bacterium synergistic fermentation and dynamic regulation, the content of ginsenoside Rg3 is increased by 3.2 times or more compared with that of a traditional water decoction method, the content of symbolic components such as pachymic acid and 6-gingerol is increased by 2 times or more, and the drug effect is greatly enhanced; and macromolecular components can be converted into micromolecular active substances through microbial metabolism, so that the digestion burden of gastrointestinal tracts is reduced.

The invention discloses discovery of an anti-heart-failure traditional Chinese medicine monomer composition based on a Zhenwu decoction. The discovery comprises the following steps: 1, preparing the Zhenwu decoction; 2, collecting and analyzing a serum sample; 3, determination of heart failure resistant endogenous metabolites and determination of peak intensity; 4, determination of components absorbed into blood and determination of peak intensity; 5, carrying out correlation analysis on peak intensity; the traditional Chinese medicine monomer composition is obtained by dissolving songlin, atractylenolide II, pachymic acid, paeoniflorin and 6-gingerol in a sodium carboxymethyl cellulose solution, and plays a role in preparing the heart failure resisting medicine. According to the method disclosed by the invention, the heart-failure-resistant endogenous metabolite and absorbed blood-entering component information of the true Wu decoction are simultaneously obtained through one-time liquid chromatography-mass spectrometry analysis, so that the heart-failure-resistant active component of the true Wu decoction is further obtained, the time is saved, and the result accuracy is improved; the traditional Chinese medicine monomer composition disclosed by the invention is stable and controllable in quality, has an effective heart failure resisting effect and is suitable for preparing heart failure resisting medicines.

The invention provides application of tramelic acid to prevention and control of beet armyworms, and relates to the technical field of pest prevention and control. The tramelic acid can generate a remarkable antifeedant effect on beet armyworms under a certain concentration, can inhibit growth of beet armyworm larvae to a certain extent and even cause death of the beet armyworm larvae, and can be used as a novel beet armyworm control agent. According to the invention, the defects in the prior art are overcome, the plant source extracted component of tramelic acid can effectively prevent and treat beet armyworms, and the component is green and safe, reduces environmental pollution, and has a good prospect in development of a novel agent for preventing and treating beet armyworms.

The invention discloses a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of pancreatic cancer treatment medicines, and belongs to the technical field of biological medicines. Indissolvable drugs atractylenolide I and pachymic acid are compatible according to a specific ratio and prepared into the nano preparation, the solubility and bioavailability of the atractylenolide I and the pachymic acid are improved, the atractylenolide I and the pachymic acid can be jointly delivered into tumor tissues and gradually disintegrated in a tumor hypoxic environment, so that synergistic release of the atractylenolide I and the pachymic acid is triggered, and the bioavailability of the atractylenolide I and the pachymic acid is improved. The inhibition effect on pancreatic cancer cells and the regulation and control capability on a tumor microenvironment are enhanced.

The invention belongs to the field of biological medicines, and particularly relates to application of astragaloside in preparation of a medicine for treating myocardial remodeling after myocardial infarction. In-vivo and in-vitro experiments prove that the astragaloside can up-regulate the expression of Acox1, Cd36, Pgc1a and Cpt1a lipid metabolism related factors and improve lipid metabolism disorder after myocardial infarction; meanwhile, Acta2, Col1a1, Col3a1, Postn fibrosis factors and alpha-SMA expression are inhibited, and myocardial fibrosis after myocardial infarction is relieved; the left ventricular ejection fraction and the left ventricular short axis shortening rate can be remarkably increased, the left ventricular end diastolic inner diameter and the left ventricular end systolic inner diameter are reduced, and cardiac dysfunction caused by myocardial infarction is improved. The composition can block pathological circulation of lipid metabolism disorder, myocardial fibrosis and cardiac function decline in a targeted manner, the curative effect is dose-dependent, the safety is good, and a brand new effective drug choice is provided for clinical treatment of myocardial remodeling after myocardial infarction.

The invention discloses a pachymaric acid targeted release pellet preparation. The pellet preparation consists of a pellet core and a targeted coating layer coating the surface of the pellet core, the pellet core comprises the following components in parts by weight: 10-30 parts of pachymic acid, 40-80 parts of an excipient and 2-10 parts of an adhesive; the targeted coating layer is a pH active oxygen double-sensitive coating material, and the weight of the targeted coating layer accounts for 5-15% of the total weight of the pellet preparation. According to the pachymic acid targeted release pellet preparation and the application of the pachymic acid targeted release pellet preparation in treatment of ulcerative colitis, local inflammation of colon can be relieved, the condition of damaged intestinal mucosa can be improved in an auxiliary mode, meanwhile, exposure of drugs to non-target parts of the whole body can be reduced, and related side effect risks can be reduced; the preparation is convenient to take, has small stimulation to gastrointestinal tracts, and is suitable for long-term medication of patients to maintain the curative effect, so that the ulcerative colitis symptom is assisted to be controlled, the disease recurrence risk is reduced, and a practical medication choice is provided for ulcerative colitis treatment.

The present application relates to a kind of triterpenoid acid compound content determination method and application in Poria cocos, belong to the field of traditional Chinese medicine quality analysis and control.The determination method includes using liquid chromatography (high performance liquid chromatography, HPLC) to detect Poria cocos test solution;Wherein, triterpenoid acid compound includes 6 alpha-hydroxy poria acid C, Poria cocos new acid B, dehydrogenated tuma acid, tuma acid, Poria cocos new acid A, 3-epidehydrogen tuma acid, poria acid C, 3-epidehydrogen tuma acid, dehydrogenated tuma acid, Poria cocos acid, Songling new acid, dehydrogenated zishikuan acid, zishikuan acid.The present application establishes suitable HPLC analysis method of Poria cocos triterpenoid acid compound, selects Poria cocos acid as internal reference, establishes one measurement multiple evaluation method for simultaneously determining the content of 13 kinds of Poria cocos triterpenoid acid in Poria cocos, saves detection cost and time, and provides reference for the quality control of Poria cocos.

The application discloses a fingerprint spectrum construction method of a traditional Chinese medicine composition containing polygala and ginseng, and comprises the following steps: traditional Chinese medicine composition test sample solution preparation; first control sample solution preparation; second control sample solution preparation; obtaining the traditional Chinese medicine composition fingerprint spectrum according to the results of high performance liquid chromatography detection of the traditional Chinese medicine composition test sample solution, the first control sample solution and the second control sample solution; wherein the control samples are polygalaxanthone III, 3,6'-di-glucosinolate sucrose, beta-asarone and pachymic acid. The application comprehensively and systematically analyzes the chemical components of the traditional Chinese medicine composition containing polygala and ginseng, and provides a theoretical basis for quality control and in-depth research on the pharmacodynamic material basis.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating pancreatic cancer as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following raw materials in percentage by weight: atractylol, eugenol, safflower red and pachymic acid, and can be prepared into various clinical common oral preparations. The pharmaceutical composition disclosed by the invention has the effects of reducing tumor cell proliferation, reducing toxicity and enhancing efficacy, and also has the effects of enhancing the immunity of a patient, prolonging the lifetime of the patient and improving the life quality of the patient, so that the pharmaceutical composition disclosed by the invention has a relatively good development and utilization prospect.

The invention discloses a pachymic acid efficient synthesis heterologous expression vector and application, and relates to the technical field of gene engineering, the expression vector comprises a pachymic acid expression gene CYP5035 and a transmembrane domain excision cytochrome P450 enzyme sequence trCPR; the nucleotide sequence of the CYP5035 is as shown in SEQ ID NO. 1; 1, and the nucleotide sequence of the trCPR is as shown in SEQ ID NO. 2. The yield of pachymic acid produced by the engineering strain is remarkably improved.