62 results about "Astragaloside" patented technology

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention belongs to the technical field of disease treatment medicine preparation, and particularly relates to a composition for relieving oxidative stress, nano-particles and application of the composition and the nano-particles. The protopanoxadiol type saponin component (protopanoxadiol PPD or ginsenoside CK) and astragaloside are combined for use, so that a synergistic interaction effect is achieved, and the drug effect of the composition is greater than that of single use of the protopanoxadiol type saponin component (protopanoxadiol PPD or ginsenoside CK) and astragaloside; in addition, the supramolecular nanoparticles prepared by taking the chitosan as a raw material in a self-assembly mode are uniform in particle size and good in stability and dispersity, and oxidative stress of a body can be relieved.

The invention belongs to the technical field of biomedical materials, and particularly relates to astragaloside-loaded conductive hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: uniformly mixing a methylacrylic anhydride gelatin aqueous solution with an organic solvent solution of astragaloside, and carrying out ultraviolet light cross-linking curing to form methylacrylic anhydride gelatin / astragaloside hydrogel; soaking the obtained hydrogel in hydrochloric acid containing a free radical initiator; then soaking and polymerizing in an aniline ethanol solution; and soaking and purifying to obtain the methylacrylic anhydride gelatin-polyaniline conductive hydrogel loaded with astragaloside. In-vitro experiments prove that the compound has a certain anti-inflammatory effect, can induce neural stem cells to be directionally differentiated into neurons and oligodendrocytes, and is beneficial to promoting nerve regeneration and myelin sheath formation; finally, in-vivo experiments prove that the composition can improve the athletic ability and tissue function recovery of SCI rats, and has a good application prospect.

The invention discloses a preparation for improving the anti-stress capacity of primates as well as a preparation method and application of the preparation. The preparation is prepared from the following raw materials in parts by weight: 5 to 15 parts of semen ziziphi spinosae extract, 3 to 8 parts of ganoderma lucidum polysaccharide, 1 to 3 parts of gamma-aminobutyric acid, 2 to 5 parts of vitamin C, 1 to 3 parts of vitamin E, 10 to 20 parts of glucose, 2 to 6 parts of astragaloside and 3 to 7 parts of chamomile extract. The preparation method comprises the steps of extracting, mixing and granulating. Through feed addition, drinking water addition and environment spraying application, the multi-component synergistic stress relieving effect can be achieved, safety and low toxicity are achieved, preparation is easy and convenient, application is flexible, and animal health and catching safety are effectively guaranteed.

The invention provides lactobacillus reuteri GY-18 and application thereof in increasing the content of astragaloside, and belongs to the technical field of microorganisms, fermentation and natural product biotransformation. The lactobacillus reuteri GY-18 capable of improving the content of astragaloside in a fermented astragalus membranaceus product is obtained through screening, the lactobacillus reuteri GY-18 is preserved in the China Center for Type Culture Collection (CCTCC), the preservation number is CCTCC M 20252796, and the lactobacillus reuteri GY-18 can be used for improving the content of astragaloside in the fermented astragalus membranaceus product. The lactobacillus reuteri GY-18 can secrete acetylxylan esterase for promoting conversion of astragaloside into astragaloside IV, has efficient specificity on conversion of astragaloside into astragaloside IV, and is high in conversion capacity; according to the method, the content of astragaloside IV is remarkably increased within 24 hours in a semi-solid state fermentation mode, and the method has good practicability.

The invention belongs to the technical field of biomedical materials. The invention provides a composite nano preparation for treating diabetic ulcer and promoting wound healing and a preparation method thereof. The preparation method comprises the following steps: mixing tetra (4-carboxyl phenyl) porphyrin and FeCl3. 6H2O for reaction, then adding a mixed solution composed of benzoic acid and 3, 5-dicarboxyphenylboronic acid for reaction, and then performing centrifugal drying; dispersing in water, adding a chloroplatinic acid solution, stirring, adding a sodium borohydride solution, continuously stirring, and centrifugally drying; stirring with a mixture of curcumin, flavonoid glycoside and astragaloside in ethanol, and carrying out centrifugal drying; and finally, stirring with glucose oxidase in water, and centrifugally drying. The composite nano preparation provided by the invention has an excellent antibacterial effect on multi-drug-resistant bacteria, can effectively destroy a biological membrane, can well treat diabetic ulcer and promote wound healing, and has a relatively good application prospect.

The invention discloses a method for extracting astragaloside IV from astragalus membranaceus, and relates to the technical field of traditional Chinese medicine extraction.The method comprises the following steps that firstly, astragalus membranaceus powder is pretreated and then put into an extraction kettle of a supercritical CO2 extraction device; in the first stage, an entrainer a is used for extraction for 15-20 min under the conditions that the pressure is 30-35 MPa, the temperature is 50-54 DEG C and the CO2 flow speed is 0.8-0.9 L / min; in the second stage, an entrainer b is used for extraction for 75-85 min under the conditions that the pressure is 28-33 MPa, the temperature is 52-56 DEG C and the CO2 flow rate is 0.6-0.7 L / min; in the third stage, an entrainer c is used for extraction for 15-20 min under the conditions that the pressure is 20-25 MPa, the temperature is 42-46 DEG C and the CO2 flow rate is 0.4-0.5 L / min; and finally collecting the extract and purifying to obtain a pure product of astragaloside. The method for extracting astragaloside IV from astragalus membranaceus, provided by the invention, has relatively high extraction rate and purity.

The invention discloses an intestinal tract hemostatic composition as well as a preparation method and application thereof, and relates to the field of hemostatic drugs. Wherein the catechin, the hyperoside, the isoquercitrin, the quercetin-3-O-glucuronide, the gallocatechin, the myricetin-3-O-galactoside, the proanthocyanidin B1, the proanthocyanidin B3, the syringe-3-O-glucoside and the astragalus smicus glycoside are flavonoid compounds; nuciferine, higenamine, N-methyl-higenamine and N-trans-feruloyl tyramine are taken as alkaloid compounds, and the compound is selected from the group consisting of higenamine, nuciferine, higenamine The composition has the advantages of simple preparation process, good hemostatic effect and the like, and provides a new raw material choice for the development of intestinal bleeding treatment medicines.

The invention discloses a method for determining chemical components in a medicine for treating vitiligo, which relates to the technical field of medicine analysis, and is characterized in that ultra-high performance liquid chromatography-mass spectrometry is adopted to determine the content of chemical components in a Bailing tablet: psoralen, isopsoralen, astragaloside, quercetin, polysaccharide and amino acid. The determination method comprises the following steps: respectively injecting a reference solution and a test solution into a liquid chromatograph for determination to obtain a chromatogram, and calculating the content of paeoniflorin in a test sample by adopting an external standard method, chromatographic conditions of a chromatogram obtained by adopting a liquid chromatograph are as follows: octadecylsilane chemically bonded silica is taken as a filling agent. According to the method for determining the chemical components in the medicine for treating leucoderma, the established detection method is verified, and the result shows that the detection method is easy and convenient to operate, accurate in result, high in specificity and good in reproducibility.

The invention relates to glycyrrhizic acid astragaloside composite hydrogel, and belongs to the technical field of medical materials. The invention aims to solve the problems that astragaloside is poor in water solubility, and hydrogel prepared by a traditional method is uneven in drug entrapment and insufficient in healing promoting performance. According to the technical scheme, the preparation method is characterized in that glycyrrhizic acid is subjected to ultrasonic pretreatment to form nano-micelles, astragaloside is entrapped forcibly through high-pressure homogenization, and finally the composite hydrogel with a compact structure is obtained through programmed cooling. The glycyrrhizic acid astragaloside composite hydrogel prepared by the invention is mainly used for preparing dressings or medicines for promoting skin wound healing, and is particularly suitable for treating diabetic wounds.

The invention provides a mesenchymal stem cell cryopreservation solution and a preparation method thereof, and belongs to the technical field of cell engineering. According to the cryopreservation liquid, diluted DMEM is used as a basic culture medium, and trehalose, L-proline, polyethylene glycol, sodium carboxymethyl cellulose, sodium glycinate, sericin, glycerin, resveratrol and other components are introduced as additives on the basis of the basic culture medium. The formula of the cryopreservation liquid adopts a DMSO-free and serum-free scheme, sodium glycinate, sericin and glycerol are used as composite protective agents, ice crystal damage can be effectively relieved, osmotic pressure balance can be maintained, cell membrane and protein structures can be protected, the effect is better than that of DMSO and glycerol, and cytotoxicity is avoided. In addition, resveratrol, coryne, astragaloside and other components are used as growth factors, so that the activity of the mesenchymal stem cells in a cryopreservation state is maintained. The survival rate of the umbilical cord mesenchymal stem cells cryopreserved for 2 years can reach 99.83% at most, the cell viability OD value reaches 0.96, and the cell adherence and growth conditions are good when the cells are observed under a microscope.

The invention discloses an application of a compound composition containing astragaloside IV in preparation of a medicine for resisting plateau fatigue, and the compound composition containing astragaloside IV is prepared from the following raw materials in parts by weight: 500 to 2000 parts of astragaloside IV, 5000 to 20000 parts of ginsenoside Rg1, 2 to 5 parts of vitamin D3 and 30000 to 150000 parts of puerarin. Animal experiments prove that the compound composition can relieve plateau exercise fatigue, improve the hypoxia tolerance, exercise fatigue resistance and oxidative stress resistance of a body and improve the comprehensive exercise performance of the body. According to the invention, the defect of single-component efficacy is overcome, a compound preparation is designed in a targeted manner, an innovative and feasible compound combination is provided, and a new scheme is provided for promoting athletic performance under plateau hypoxia.

The invention discloses a preparation method of a radix astragali extracting solution with high antioxidant activity and the extracting solution, and aims to solve the problems of low extraction rate of active substances and inaccurate detection of antioxidant activity in the prior art. According to the method, five factors including ethanol content, extracting solution multiple and the like are taken as key variables, U10 * (108) uniform test design is adopted, the DPPH free radical scavenging rate is accurately determined by combining an electron paramagnetic resonance technology, and the contents of astragaloside, general flavone and polysaccharide are synchronously detected. A quantitative model is established through multivariate linear regression analysis, and the optimal process parameters are determined: the ethanol content is 80%, the extracting solution multiple is 4, the temperature is 85 DEG C, the time is 1.5 h, and the extraction time is 1 time. The DPPH free radical scavenging rate of the extracting solution prepared through the technology is larger than or equal to 92.75%, polysaccharide is larger than or equal to 12520 mg / L, total flavone is larger than or equal to 323.77 mg / L, astragaloside is larger than or equal to 257 mg / L, synergistic efficient extraction of multiple components is achieved, and the extracting solution is suitable for industrial production.

The invention discloses a natural anti-diabetic medicine and a preparation method and application thereof, and the preparation method of the natural anti-diabetic medicine is specifically implemented according to the following steps: step 1, carrying out cold soaking extraction by using 75% industrial ethanol, and respectively extracting by using petroleum ether and ethyl acetate to prepare a notopterygium root extract; 2, separating and purifying the notopterygium root extract obtained in the step 1 by utilizing silica gel column chromatography in combination with high performance liquid chromatography (HPLC) to obtain a single-component compound; the compound is identified as astragalin through nuclear magnetic spectrum and mass spectrum; the natural anti-diabetic drug prepared by the invention can effectively inhibit the increase of the weight, food intake and water intake of diabetic gene mice, and the effect of the natural anti-diabetic drug is superior to that of a first-line drug rosiglitazone for diabetes; the invention can provide a new method for research and development of preparation and application of novel natural anti-diabetic drugs, and also provides a reliable scientific basis for deep development and utilization of the folk drug notopterygium root in China.

The invention belongs to the technical field of pharmaceutical compositions, and particularly relates to an antibacterial and hemostatic pharmaceutical composition for skin healing and a preparation method thereof. The pharmaceutical composition is double gel and is composed of oleogel and hydrogel according to the mass ratio of (3-5): (5-7), the oleogel takes medium-chain triglyceride and Xiawei wax as matrixes and loads astragaloside, and the hydrogel takes chitosan and sodium alginate as matrixes and loads antibacterial peptide GL13K. The preparation method comprises the following steps: preparing the CS-SA-GL13K hydrogel and the medium-chain triglyceride small single-tree wax-astragaloside oil gel, mixing the CS-SA-GL13K hydrogel and the medium-chain triglyceride small single-tree wax-astragaloside oil gel in proportion, homogenizing and emulsifying, and quickly cooling to obtain the double gel. Tests show that the sterilization rates of the pharmaceutical composition on staphylococcus aureus and escherichia coli are both greater than 95%, the hemostatic effect is good, skin wound healing can be promoted, and the stability is good.

The application relates to application of astragaloside B to preparation of a medicine for treating oligoasthenospermia and the medicine, and belongs to the field of traditional Chinese medicine. Through animal experiments, it is shown that the astragaloside B significantly improves the quantity and quality of rat sperms, and no obvious side effects are observed during the treatment. The astragaloside B has the effects of inhibiting oxidation stress, promoting secretion of testosterone, regulating secretion of follicle stimulating hormone and luteinizing hormone, promoting growth and maturation of sperms, effectively improving sperm function, and enhancing the repair capacity of the body to testicular injury. Moreover, no obvious side effects are observed during the treatment of the astragaloside B on oligoasthenospermia.

The application provides a preparation method of cycloastragenol and relates to the technical field of biology.The preparation method of the cycloastragenol comprises the following steps: preparing a mixed solution of astragaloside, xylosidase and GSM microbial agent, and preparing the cycloastragenol through a conversion reaction.The preparation method can realize 100% conversion of the astragaloside through the synergistic effect of the GSM microbial agent and the xylosidase, and the preparation method is simple and efficient, and the prepared cycloastragenol has high yield and high purity.

The embodiment of the invention discloses an automatic mixing, filling and detecting method and device for medicine capsules containing earthworms and astragalus membranaceus, and the method comprises the steps that when the medicine capsules containing the earthworms and the astragalus membranaceus are filled, medicine powder for mixing the earthworms and the astragalus membranaceus is filled into all the medicine capsules; detecting the component content of the lumbrukinase in each medicine capsule, and screening out a first medicine capsule meeting the requirement of the lumbrukinase content; detecting the content of the astragaloside in the first medicine capsule, and screening out a second medicine capsule meeting the content requirement of the astragaloside; performing granularity analysis on the medicine powder in the second medicine capsule to obtain a granularity analysis result; and based on an analysis result of the granularity, screening out a third medicine capsule of which the granularity accords with a preset threshold value from the second medicine capsules so as to complete automatic mixing and filling detection of the medicine capsules.

The invention relates to a preparation method of a standard astragalus extract, and belongs to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: taking radix astragali decoction pieces, adding alkaline water with the pH value of 12.0-13.0, carrying out reflux extraction for 3-5 times, filtering, merging filtrate, drying the merged filtrate under reduced pressure, freezing, carrying out vacuum drying, and crushing to obtain the standard radix astragali extract. According to the method, key parameters such as pH value, extraction temperature, extraction times and time of alkaline water extraction are controlled, so that efficient extraction and stable preparation of astragaloside and polysaccharide are realized, and a technical basis is provided for fully developing and utilizing an astragalus membranaceus medicinal material and promoting modern application of the astragalus membranaceus medicinal material.

The invention relates to a dietary therapy formula for repairing ear hearing nerve cells and a preparation method thereof. Components with homology of medicine and food are optimally selected, the salvia miltiorrhiza and the radix puerariae can increase blood flow of inner ears, promote nutrition delivery, inhibit vasospasm of the inner ears and reduce ischemic injury of hair cells, alpha-linolenic acid is provided for a human body by utilizing the flaxseeds and the walnuts and converted into DHA, the DHA directly participates in nerve myelin sheath reconstruction, auditory nerve signal conduction is enhanced, and the health care effect is achieved. Chinese yam and astragalus membranaceus can provide Chinese yam polysaccharide and astragaloside, the mitochondrial function is improved, and cell apoptosis is delayed. The whole component is low in sugar content, is suitable for diabetics, expands the application crowd and non-medicine products, can reduce the psychological burden of eaters taking medicines for a long time, and is beneficial to popularization and application.

This invention discloses a methane inhibitor based on plant functional components and its application. The inhibitor, by mass fraction (100%), comprises the following raw materials: 1.5-6% p-hydroxybenzoic acid, 0.4-2.4% astragaloside, 5-40% polyethylene glycol 4000, and 81.6-99.999% bentonite. The methane inhibitor provided by this invention uses p-hydroxybenzoic acid and astragaloside as active ingredients. Through their synergistic effect, it effectively inhibits the activity of methanogenic bacteria and the methane production pathway in the rumen of ruminants, while simultaneously improving the rumen fermentation pattern. The above-mentioned methane inhibitor uses natural plant-derived active ingredients, is safe, non-toxic, environmentally friendly, and has a simple preparation process suitable for large-scale production.

The invention relates to an anti-cancer composition based on natural active ingredients and a medicine thereof, and belongs to the technical field of medicine compositions. The anticancer composition based on the natural active ingredients is prepared from the following components in percentage by mass: 1 to 10 percent of ginsenoside Rg3, 5 to 20 percent of dihydroquercetin, 20 to 40 percent of lucid ganoderma extract, 15 to 30 percent of astragalus extract and 15 to 30 percent of coix seed extract. In the anti-cancer composition based on the natural active ingredients, ginsenoside Rg3 has the effect of inhibiting tumor angiogenesis; the dihydroquercetin has remarkable antioxidant and anti-inflammatory activity; ganoderma lucidum polysaccharide can enhance the immune function of the body. Astragaloside has an immunoregulation effect; coix seed ester has the anti-tumor metastasis activity, the anti-cancer effect is remarkably enhanced through the synergistic effect of multiple components, toxic and side effects are low, the composition is suitable for long-term taking, and the product quality is stable.

The application provides a mesenchymal stem cell cryopreservation solution and a preparation method thereof, and belongs to the technical field of cell engineering. The cryopreservation solution takes diluted DMEM as a basic culture medium, and introduces trehalose, L-proline, polyethylene glycol, sodium carboxymethyl cellulose, sodium glycine, sericin, glycerol, resveratrol and other components as additives. The cryopreservation solution formula adopts a DMSO-free and serum-free scheme, uses sodium glycine, sericin and glycerol as a composite protective agent, can effectively alleviate ice crystal damage, maintain osmotic pressure balance and protect cell membranes and protein structures, and has an effect superior to DMSO and glycerol and no cytotoxicity. In addition, the application uses resveratrol, coenzyme and astragaloside and other components as growth factors to maintain the activity of mesenchymal stem cells in a frozen state. After umbilical cord mesenchymal stem cells are cryopreserved for 2 years according to the application, the survival rate of the umbilical cord mesenchymal stem cells can reach 99.83% at most, the cell viability OD value reaches 0.96, and the cells are observed to have good adhesion and growth conditions under a microscope. △ The survival rate of the umbilical cord mesenchymal stem cells can reach 99.83% at most, the cell viability OD value reaches 0.96, and the cells are observed to have good adhesion and growth conditions under a microscope.

The invention discloses an astragaloside nano preparation as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving astragaloside in an organic solvent to prepare an astragaloside solution as an organic phase; dissolving a stabilizer in water to prepare a stabilizer solution as a water phase; s2, the astragaloside solution and the stabilizer solution are pumped into a micro-fluidic chip from different channel inlets according to the set total flow velocity and flow velocity ratio, micro mixing is conducted, and an astragaloside nano suspension is prepared; s3, the astragaloside nano suspension is dried, and the astragaloside nano preparation is prepared.

The invention provides a method for extracting astragaloside and quercetin from astragalus mongholicus. The method comprises the following steps: crushing the astragalus mongholicus, performing alcohol extraction and water extraction, filtering, concentrating, performing alcohol precipitation, performing chromatography, crystallizing and recrystallizing to obtain pure products of the quercetin and the astragaloside. Through the steps of water extraction and alcohol precipitation, the interference of astragalus polysaccharide on the separation and purification of astragaloside and quercetin is reduced, the separation and purification steps are effectively shortened, the production efficiency is greatly improved, and the investment of production equipment is reduced; according to the method, an alcohol solution is subjected to alcohol recovery, astragaloside and quercetin can be separated through ethyl acetate extraction, degradation of quercetin caused by acid and alkali treatment is completely avoided, high-content astragaloside and quercetin are obtained through chromatography, crystallization and recrystallization, and the purification cost is also saved.

The invention discloses a composition containing dapagliflozin and fenerenone and a preparation method thereof, and relates to the technical field of medicines, the composition is composed of dapagliflozin, fenerenone, a traditional Chinese medicine synergistic component, a bioactive substance, probiotic freeze-dried powder, a slow-release carrier and functional auxiliary materials; through the elaborately designed composition proportion, the treatment effect of the medicine and the patient experience are remarkably improved, the composition fuses the two effective components of dapagliflozin and fenerenone, and traditional Chinese medicine synergistic components of astragaloside and berberine are matched, so that the blood glucose reducing effect of the medicine is enhanced, and through the adjusting effect of traditional Chinese medicine, the blood glucose reducing effect of the medicine is improved. The traditional Chinese medicine composition effectively relieves possible adverse reactions of patients, and meanwhile, due to the addition of bioactive substances coenzyme and vitamin D, the overall efficacy of the medicine is further improved, the body function and metabolic level of the patients can be improved, and the traditional Chinese medicine composition has remarkable advantages in treatment effect compared with a traditional single-component medicine and is worthy of popularization and application. And the treatment requirements of patients can be better met.

The invention discloses a process for preparing astragaloside through multi-strain fermentation. Through segmented biotransformation, by utilizing a segmented process that in-situ enzyme production of trichoderma reesei, aspergillus oryzae deacetylation and aspergillus niger step-by-step desugaring are carried out to directionally transform upstream saponin, and bacillus subtilis and candida are used for terminal modification, astragaloside is not subjected to continuous desugaring or ring opening to obtain cycloastragenol after being formed, and the yield of astragaloside is remarkably improved.

The invention discloses a culture method and application of high-secretion IFN-gamma CD4 + T cells, and relates to the technical field of immune cell culture. The cell culture medium disclosed by the invention is prepared from the following components: IL-2, IL-7, IL-15, IL-18, AB plasma, ConA, OKT3, CD28, an STING agonist, astragaloside, ginsenoside Rh2 and astragalus polysaccharide. The CD4 + T cells cultured by the culture medium disclosed by the invention are cultured in vitro for 15 days, the content of the CD4 + T cells is greater than 70%, and the CD4 + T cells secrete IFN-gamma at a higher level compared with the CD4 + T cells cultured by a common CD4 + T cell culture medium, and in addition, the in-vitro killing rate of the CD4 + T cells to HCT116 intestinal cancer cells reaches 95% or above due to the added STING agonist, astragaloside, ginsenoside Rh2 and astragalus polysaccharide.

The invention discloses a traditional Chinese medicine grease oral cream for repairing gastric mucosa and a preparation method thereof, optimizes a traditional heating extraction process into direct compatibility of traditional Chinese medicine extracts, and belongs to the technical field of traditional Chinese medicine preparations. The emulsifiable paste is prepared from a fixed-proportion grease base (20% of emu oil, 40% of olive oil, 20% of coconut oil and 20% of castor oil), six traditional Chinese medicine extract effective components (1-2% of astragaloside, 1-2% of atractylenolide, 1-2% of atractylenone, 1-2% of berberine, 1-2% of scutellaria baicalensis extract and 1-2% of obakunone), 3% of vitamin E, 20-25% of sea buckthorn seed oil and 10% of excipient beewax. According to the preparation process, heating extraction is abandoned, the problems that the extract is difficult to dissolve and easy to agglomerate in grease are solved through infiltrating the extract with a small amount of grease, homogenizing at the low temperature of 60 DEG C and shaping and fixing beewax, and uniform dispersion and stable dispersion of the extract are realized.

The invention relates to the technical field of feed preparation, in particular to an artemisia apiacea chicken feed and a preparation method thereof.According to the artemisia apiacea chicken feed and the preparation method thereof, artemisia apiacea dried and smashed materials with the specific particle size and the artemisinin content being not lower than 0.5% are scientifically compounded with astragalus membranaceus powder with the immunity enhancing function and the astragaloside content being not lower than 0.8%, and dual guarantees of antibiosis, anti-inflammation and immunoregulation are formed; meanwhile, the accurate proportion of trace elements in the premix ensures the metabolic balance of the body, and the various active components have a synergistic effect, so that the premix not only has excellent performance in the aspects of promoting the growth and development of the chickens and improving the feed conversion rate, but also enhances the immune function of the body and optimizes the intestinal health, realizes the comprehensive improvement of the growth performance, disease resistance and intestinal microecology, and improves the immunity of the chickens. In this way, the technical problems that in the prior art, a chicken feed formula is usually single, the function focus point is narrow, and growth, immunity enhancement and intestinal tract improvement are difficult to achieve are solved.