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Astragaloside injection preparation and its preparing process

A technology of glycoside injection and astragaloside IV, applied in the field of medicine, can solve the problems of poor solubility of astragaloside IV and the like

Inactive Publication Date: 2004-11-10
上海博泰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention studies the solubility of astragaloside IV and solves the problem of poor solubility of astragaloside IV

Method used

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  • Astragaloside injection preparation and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 (small injection);

[0018] Component Quantity (g / bottle)

[0019] Astragaloside IV 0.005

[0020] Ethanol 0.50

[0021] Propylene glycol 0.50

[0022] Glycerin 0.10

[0023] The preparation process is:

[0024] Take astragaloside IV, add ethanol, glycerin and propylene glycol to dissolve, filter and sterilize, subpackage and seal, and sterilize to obtain the product. The content of astragaloside IV in the astragaloside IV raw material is 97% of the labeled amount.

Embodiment 2

[0025] Embodiment 2 (powder injection);

[0026] Component Quantity (g / bottle)

[0027] Astragaloside IV 0.01

[0028] Mannitol 0.03

[0029] The preparation process is:

[0030] Take astragaloside IV, add mannitol, add 20ml of water, heat to dissolve, weigh hot filter to sterilize, sub-package, and freeze-dry to obtain. The content of astragaloside IV in the astragaloside IV raw material is 95% of the labeled amount.

Embodiment 3

[0031] Embodiment 3 (powder injection)

[0032] Component Quantity (g / bottle)

[0033] Astragaloside IV 0.03

[0034] Lactose 0.05

[0035] The preparation process is:

[0036] Take astragaloside IV and lactose, add 10ml of ethanol, dissolve, filter and sterilize, spray dry, aseptically subpackage, and press the cap to get it. The content of astragaloside IV in the astragaloside IV raw material is 100% of the labeled amount.

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Abstract

The invention discloses an astragaloside IV injection preparation (small injection, powder injection, glucose fluid infusion and sodium chloride fluid infusion), and the process for its preparation, wherein the auxiliary solvent and solvent assisting deflocculating agent are screened, which has proved that propylene glycol, ethanol, glycerin, polyethylene glycol, benzyl benzoate and acetic acid dimethylamide has solubilization function for astragaloside IV.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a pharmaceutical preparation of astragaloside IV, more specifically to an injection of astragaloside IV (including small injections, powder injections, glucose infusion and sodium chloride infusion). It relates to a preparation method of the preparation. Background technique [0002] Astragalus is a traditional traditional Chinese medicine that invigorates qi and strengthens the surface, diuretics and toxins, drains pus, and suppresses sores and promotes granulation. A large number of studies have shown that the main active ingredient of astragalus with cardiovascular activity is astragaloside IV. Traditional Chinese medicine believes that qi stagnation and blood stasis are a major cause of cardiovascular and cerebrovascular diseases, and astragaloside IV is effective in treating qi stagnation and blood stasis cardiovascular and cerebrovascular diseases. [0003] At present, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61P9/00
Inventor 张卫东张川苏娟李慧梁
Owner 上海博泰医药科技有限公司
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