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Preparation method for astragaloside

A technology of astragaloside IV and Astragalus membranaceus, applied in the field of preparing high-yield and high-purity astragaloside IV, which can solve the problems of low yield and achieve the effects of low production cost, high purity, and high yield

Inactive Publication Date: 2009-01-14
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese Patent Application No. 200610012687.6 discloses a preparation method of astragaloside IV, which uses extraction, ethanol decolorization, alkali hydrolysis and other steps to obtain astragaloside IV, which simplifies the intermediate steps, but the yield is not high

Method used

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  • Preparation method for astragaloside
  • Preparation method for astragaloside
  • Preparation method for astragaloside

Examples

Experimental program
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Effect test

Embodiment 1

[0040] After crushing 1 kg of Astragalus root, heat and reflux with water to extract 3 times, add 10 times of water to reflux for 1 hour for the first time, and add 8 times of water to reflux for 0.5 hours for the second and third times. Combine the extracts, add Ca(OH) 2 Appropriate amount of solid powder to make Ca(OH) 2Saturated solution, placed at room temperature for 16 hours, centrifuged, the supernatant adjusted to pH 8 with dilute hydrochloric acid solution, added to HPD100 macroporous adsorption resin, washed with 10 liters of deionized distilled water to remove sugars and salts, and then washed with 5 liters of 40% alcohol washes away impurities. Then, astragaloside IV was eluted with 3 liters of 80% alcohol, and the eluate was concentrated to a small volume, centrifuged to obtain astragaloside IV, and recrystallized with dilute ethanol to obtain 1.9 g of astragaloside IV, with a content of 98%.

Embodiment 2

[0042] After crushing 1 kg of Astragalus root, heat and reflux extraction with water for 3 times, add 12 times of water for reflux for 1.5 hours for the first time, and add 10 times of water for 1 hour for the second and third times. Combine the extracts, add Ca(OH) 2 Appropriate amount of solid powder to make Ca(OH) 2 Saturated solution, placed at room temperature for 20 hours, centrifuged, the supernatant adjusted to pH 8 with dilute hydrochloric acid solution, added to D101 macroporous adsorption resin, washed with 14 liters of deionized distilled water to remove sugars and salts, and then washed with 5 liters of 40% alcohol washes away impurities. Then, astragaloside IV was eluted with 3 liters of 80% alcohol, and the eluate was concentrated to a small volume, centrifuged to obtain astragaloside IV, and recrystallized with dilute ethanol to obtain 2.1 g of astragaloside IV, with a content of 95%.

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Abstract

The invention aims to provide an Astragaloside IV preparation method with simple operation, high yield and high purity. In order to achieve the purposes of the method, the method adopts the specific technical proposal as follows: the preparation method of Astragaloside IV takes a traditional Chinese medicine of astragalus root as a raw material, and comprises the steps of water extraction, alkali treatment, adsorption by macroporous adsorptive resin, washing, rinsing by diluted alcohol liquid, elution of Astragaloside IV by alcohol liquid with rather high concentration, concentration and crystallization. The Astragaloside IV prepared by the method has the advantages of light color and high purity, and the preparation method has the advantages of high yield, low production cost, and simple, convenient and standard process.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a method for preparing high-yield and high-purity astragaloside IV by using the traditional Chinese medicine astragalus as a raw material. Background technique [0002] Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. is the dry root of the leguminous plant Astragalus membranaceus (Fisch.) Bge. The effect of diuresis, detoxification, healing sores and promoting muscle growth was first recorded in "Shen Nong's Herbal Classic". It is a very common Chinese medicine in Chinese medicine prescriptions, and it is also used frequently in Chinese patent medicines. [0003] Astragalus extract is yellow powder. It has the effects of enhancing immunity, anti-fatigue, anti-mutation, protecting the liver and inhibiting osteoclasts. [0004] A large number of pharmacological studies have reported that Astragalus saponins are the main...

Claims

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Application Information

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IPC IPC(8): C07J53/00C07J17/00A61K36/481
Inventor 叶晓平宋纯清茅仁刚张华
Owner SHANGHAI NORMAL UNIVERSITY
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