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37 results about "Optical fluorescence" patented technology

Optical fluorescence occurs when a molecule absorbs light at wavelengths within its absorption band, and then nearly instantaneously emits light at longer wavelengths within its emission band.

Ingestible device platform for the colon

An ingestible pill platform for colon imaging is provided, designed to recognize its entry to the colon and expand in the colon, for improved imaging of the colon walls. On approaching the external anal sphincter muscle, the ingestible pill may contract or deform, for elimination. Colon recognition may be based on a structural image, based on the differences in diameters between the small intestine and the colon, and particularly, based on the semilunar fold structure, which is unique to the colon. Additionally or alternatively, colon recognition may be based on a functional image, based on the generally inflammatory state of the vermiform appendix. Additionally or alternatively, pH, flora, enzymes and (or) chemical analyses may be used to recognize the colon. The imaging of the colon walls may be functional, by nuclear-radiation imaging of radionuclide-labeled antibodies, or by optical-fluorescence-spectroscopy imaging of fluorescence-labeled antibodies. Additionally or alternatively, it may be structural, for example, by visual, ultrasound or MRI means. Due to the proximity to the colon walls, the imaging in accordance with the present invention is advantageous to colonoscopy or virtual colonoscopy, as it is designed to distinguish malignant from benign tumors and detect tumors even at their incipient stage, and overcome blood-pool background radioactivity.
Owner:SPECTRUM DYNAMICS MEDICAL LTD

Endoscope

The invention provides an endoscope which comprises a connecting optical fiber, a self-focusing lens, a slant reflection mirror and a motor. The connecting optical fiber is connected with the tail portion of the self-focusing lens, the slant reflection mirror is opposite to the self-focusing lens, the rear end of the slant reflection mirror is fixed with one end of a rotary shaft, the other end of the rotary shaft is fixed with one end of a column magnet, a supporting sleeve is arranged outside of the rotary shaft, the column magnet, the rotary shaft, the slant reflection mirror and the self-focusing lens are coaxial, and a transparent sleeve is arranged outside the column magnet, the rotary shaft, the slant reflection mirror and the self-focusing lens, and the supporting sleeve and the self-focusing lens are both fixed with the transparent sleeve. A pair of plate magnets with opposite S poles and N poles is arranged on the power output end of the motor in the circumferential direction, a power output shaft of the motor is coaxial with the rotary shaft, and the plate magnets are adjacent to the column magnet. The endoscope is high in flexibility, the outer diameter of the transparent sleeve can be less than 1mm and even can reach micron dimension, and a use range is wide. The endoscope is applicable to an OCT system and imaging systems of optical scanning imaging, scanning fluorence imaging, B ultrasonic imaging and the like.
Owner:SHANGHAI JIAO TONG UNIV

Device for improving performance in STED and RESOLFT microscopy using a single phase mask

The present invention refers to a method for high spatial resolution imaging comprising a phase plate or a spatial light modulator (SLM) device for STimulated Emission Depletion (STED) microscopy and Reversible Saturable OpticaL Fluorescence Transitions (RESOLFT) microscopy, where a bivortex pattern is imprinted on the said phase plate or SLM to generate a beam. The bivortex pattern allows some freedom in shaping the STED beam to improve the microscope's axial performance and optical sectioning capacity.The present invention further refers to a method for STED and RESOLFT microscopy comprising the step of modulating the optical phase of a laser using a phase plate or a spatial light modulator device with a phase mask comprising a bivortex with a tunable radius.The disclosed phase masks and methods of STED and RESOLFT microscopy may advantageously be applied to provide a hybrid 2D / 3D STED regime but one with a significant reduction in the degrees of freedom for alignment relative to what is found in incoherent beam superpositions, thus providing an improvement in beam quality, namely a minimized central intensity and lower sensitivity to aberrations, resulting in an increased signal level and axial performance.
Owner:INST DE BIOLOGIA MOLECULAR E CELULAR IBMC
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