The invention discloses a same-time same-frequency full duplex multi-tap radio frequency self-interference offset system and method. A wireless unit receiving end outputs self-interference signals, self-interference offset is not conducted at first, after being processed by a radio frequency receiving channel and an analog-digital converter, the self-interference signals are sent to a pattern recognition module to generate an adjustment value, multiple taps are controlled to interfere in a reconstruction filter to reconstruct sending end radio frequency signals in a radio frequency mode, radio frequency self-interference offset is conducted on output reconstruction signals through a summator, signals after the radio frequency self-interference offset are sent to an adjustment algorithm module again through the radio frequency receiving channel and the analog-digital converter to obtain digital signals which are sent to the adjustment algorithm module, an adjusting value needed for adjusting the time delay zero is obtained, radio frequency interference reconstruction is further controlled, controlling over the radio frequency interference reconstruction is carried out repeatedly according to the method, and self-interference offset is achieved. According to the same-time same-frequency full duplex multi-tap radio frequency self-interference offset system and method, joint control of the pattern recognition module and the adjustment algorithm module is used, same-time same-frequency-radio self-interference can be removed effectively, the frequency spectrum utilization rate is improved, the radio frequency self-interference offset performance is improved, and the working stability of communication equipment is guaranteed.