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Method for extraction preparation of astragaloside

A technology of astragaloside IV and ethanol, which is applied in the field of preparing astragaloside IV, can solve the problems of environmental pollution, high production cost, and low yield, and achieve the effects of reducing environmental pollution and low manufacturing cost

Active Publication Date: 2006-10-11
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that this method exists is that extract purity is low, yield is low
The problem with this type of process is that the production cost is high, and it can also cause certain environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The beneficial effect of astragaloside IV preparations in the treatment of cerebral infarction has been verified by the following experiments:

[0023] laboratory apparatus

[0024] Automatic biochemical analyzer (TBA-120FR, Japan), liquid scintillation counter (Wallac, Pharmacia).

[0025] Experimental Reagents and Drugs

[0026] Endothelin (ET), thromboxane B2 (TxB2), 6-keto-prostaglandin F1α (6-KetoPGF1α) radioimmunotherapy kit (Beijing Furui Bioengineering Company), red tetrazolium (Tianjin Lianxing Biotechnology Company). Superoxide dismutase (SOD), malondialdehyde (MDA) kit (Nanjing Jiancheng Biological Reagent Company).

[0027] Astragaloside IV injection: 10ml / bottle. Wherein the raw material of astragaloside IV is prepared by the method of the present invention, and the content of astragaloside IV is converted into the crude drug amount of astragalus is 40g

[0028] Compound Danshen injection: Shanghai Zhongxi Pharmaceutical Co., Ltd. (batch number: 0412105...

Embodiment 2

[0055] The beneficial effects of astragaloside IV preparations in the treatment of ischemic stroke have been verified by the following experiments:

[0056] laboratory apparatus

[0057] Automatic biochemical analyzer (TBA-120FR, Japan), liquid scintillation counter (Wallac, Pharmacia).

[0058] Experimental Reagents and Drugs

[0059] Endothelin (ET), thromboxane B2 (TxB2), 6-keto-prostaglandin F1α (6-KetoPGF1α) radioimmunotherapy kit (Beijing Furui Bioengineering Company), red tetrazolium (Tianjin Lianxing Biotechnology Company). Superoxide dismutase (SOD), malondialdehyde (MDA) kit (Nanjing Jiancheng Biological Reagent Company).

[0060] Astragaloside IV injection: 10ml / bottle. Wherein the raw material of astragaloside IV is prepared by the method of the present invention, and the content of astragaloside IV is converted into the crude drug amount of astragalus is 40g

[0061] Compound Danshen injection: Shanghai Zhongxi Pharmaceutical Co., Ltd. (batch number: 0412105)....

Embodiment 3

[0107] Example 3: Extraction and preparation of astragaloside IV

[0108] Take 10kg of astragalus thin slices, add water to decoct twice, the amount of water added each time should not exceed the surface of the medicine, combine the two decoctions, filter to obtain the filtrate 1, concentrate it into a thick extract with a specific gravity of 1.35, and add a concentration of 80%. The ethanol makes the alcohol precipitation concentration be 75%, take the supernatant, reclaim the ethanol to the volume of the original medicinal material, add 3% activated carbon of the original medicinal material, filter, then filter with 75% ethanol until the filtrate is nearly colorless, the filtrate is concentrated, add Adjust the pH value of the concentrated solution to 8 with NaOH solution, hydrolyze at 90°C for 0.5 hours, filter, wash the precipitate with 0.5% NaOH solution until it is colorless, wash it with water until neutral, take the precipitate and dry it at 80°C. Instantly. The purit...

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PUM

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Abstract

This invention publisizes an extraction procedure for Astragalus membranaceous as followings: a.The raw astragalus roots would be soaked in water, refluxing extracted. The extract is condensed to dense concrete; b. precipitates the dense concrete with ethanol, recover the supernatant and adjust PH value to no more than 7, hydrolyze at 60-120deg C for 0.5-3 hours; c. filter the hydrolysate, precipitate ,wash to colorless with alkali, then add water to PH 7; d. Dry the sediment. The purity of Astragalus membranaceous with this invention is up to 90-98%. The recovery ratio reaches to 1.13-0.18%. The manipulation time is reduced by 30-50%.

Description

technical field [0001] The invention relates to a method for extracting active ingredients of medicine from plants, in particular to a method for extracting and preparing astragaloside IV from astragalus. technical background [0002] Astragaloside IV is the main component of more than ten kinds of saponins in Astragalus membranaceus, which has the functions of anti-inflammation, anti-aging, anti-virus, and enhancing the body's immunity. Modern pharmacological studies have also shown that it has pharmacological effects such as improving the deformability of white blood cells, improving myocardial contraction and relaxation functions, promoting insulin secretion and scavenging free radicals. The content of astragaloside IV in Astragalus membranaceus is very low. At present, the method of extracting astragaloside IV mainly adopts decoction water extraction or decoction water extraction and alcohol precipitation method. The problem that this method exists is that extract puri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07J53/00
Inventor 李振江陈浩达黄怀鹏赵成安
Owner SHINEWAY PHARMA GRP LTD
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