Scald and burn dressing prepared by coaxial electrostatic spinning method and preparation method thereof

A coaxial electrospinning, silk fibroin technology, applied in textiles and papermaking, medical science, non-woven fabrics, etc., can solve the problems of low drug loading, obvious drug burst release, etc. The effect of good performance, good biocompatibility and biodegradability

Active Publication Date: 2014-07-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nanoparticles with polymers as carriers, including nanocapsules, nanospheres, liposomes, micelles, vesicles, etc., have been widely studied and applied in the field of drug delivery as new drug preparations, but these dosage forms basically have The problem of low dosage and obvious drug burst release is also a problem that needs to be solved urgently in the field of preparations

Method used

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  • Scald and burn dressing prepared by coaxial electrostatic spinning method and preparation method thereof
  • Scald and burn dressing prepared by coaxial electrostatic spinning method and preparation method thereof
  • Scald and burn dressing prepared by coaxial electrostatic spinning method and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 1) Dissolve 10mg of astragaloside IV and 100mg of polyvinylpyrrolidone (K30, China Pharmaceutical (Group) Shanghai Chemical Reagent Company) in 3ml of solvent (composed of 1.5ml of ethanol and 1.5ml of DMF), and stir at 1000rpm After 30 minutes, the inner tube solution was formed. The preparation process was carried out at room temperature, using a 25mL ground-mouth Erlenmeyer flask as the container, and the electromagnetic rotor stirred the solution. After the solute is completely dissolved, the solution is left to stand to remove air bubbles before use.

[0055] 2) Dissolve 100mg of silk fibroin in 6ml of hexafluoroisopropanol and stir at 1000rpm for 30min to form an outer tube solution. The solution was stirred. After the solute is completely dissolved, the solution is left to stand to remove air bubbles before use.

[0056] 3) Use the inner tube solution and outer tube solution system obtained in step 1) and step 2) respectively to carry out systematic coaxial ele...

Embodiment 2

[0058] The content of astragaloside IV in step 1) was replaced by 5 mg, and the others were the same as in Example 1.

Embodiment 3

[0060] The inner tube solution is astragaloside IV and PVP solution (DMF / absolute ethanol=50 / 50), and the flow rate is 0.6mL / h; the outer tube solution is silk fibroin solution (hexafluoroisopropanol), and the flow rate is 0.3mL / h. h; Others are the same as in Example 1.

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Abstract

The invention discloses scald and burn dressing prepared by a coaxial electrostatic spinning method. The scald and burn dressing is a nanofiber membrane with a core/shell structure, wherein the shell is made of a natural biological high molecular material and the core is a degradable synthetic high molecular material loaded with astragaloside. The mass ratio of astragaloside to the degradable synthetic high molecular material is 1:(2-50). The invention further discloses a preparation method of the scald and burn dressing. The raw materials are easy to get and cheap, and the preparation process is simple, easy to operate and control and can be easily put into large-scale industrial production. The prepared scald and burn dressing has good flexibility and high mechanical strength, and can form a protective fiber felt on the surface of the wound to promote growth of normal skin tissues and reduce formation of scar tissues, thereby curing skin injury.

Description

technical field [0001] The invention relates to the field of dressing preparation, in particular to a scald and burn dressing prepared by a coaxial electrospinning method and a preparation method thereof. Background technique [0002] The skin is the largest organ in the human body and has a high-level tissue structure. Its functions are to prevent bacterial erosion and infection, protect the human body, regulate body temperature, and excrete body fluids. In daily life and work, skin damage is inevitable. Among the various injuries of the skin, wounds, burns, scalds, etc. are more common. The main problems to be solved in the treatment of skin injuries are: gas (including water vapor) permeability; prevention of loss of tissue fluid and body fluid and loss of electrolyte (fluid) and protein; mechanical properties and contact rejection with tissue, etc. In addition to the destruction of skin and tissue, large-scale skin damage may also cause a series of complex pathological...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/44D04H1/4382D04H1/728
Inventor 高建青单颖慧
Owner ZHEJIANG UNIV
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