The invention discloses a multifunctional gypsum painting ready mixed mortar as well as a preparation method and application thereof. The multifunctional gypsum painting ready mixed mortar comprises the following components: beta-semi-hydrated gypsum, heavy calcium carbonate, calcium hydroxide, quartz sand, methyl cellulose ether, adhesive, a phase-change material, modified starch, a dispersant, a gypsum shrinking resistant agent, lightweight calcium carbonate, barite powder, talcum powder, tourmaline powder and kieselguhr. The materials, such as kieselguhr, tourmaline, the barite powder, thephase-change material, and the like, are reaonsbaly used in the multifunctional gypsum painting ready mixed mortar; and it is proved that the multifunctional gypsum painting ready mixed mortar has various functions of automatic adjustment of indoor temperature and humidity, radiation resistance, bacterium resistance, air purification, and the like. In addition, the gypsum painting ready mixed mortar has higher anion generating amount and far infrared emissivity, can rapidly exhaust odor generated by products, such as paint, colloid, and the like and can exhaust smoke for a long term.