The invention discloses a long-acting synergistic controlled release fertilizer, which mainly comprises a nitrogen fertilizer, a phosphate fertilizer, a potash fertilizer, a biological inoculant, a urease inhibitor, a nitrification inhibitor and poly(aspartic acid). Specifically, in terms of weight percentage, the nitrogen fertilizer accounts for 10-60, the phosphate fertilizer accounts for 10-60, the potash fertilizer accounts for 10-60, an organic biological multielement compound agent accounts for 5-50, wherein the biological inoculant accounts for 6-8, a liquid binder accounts for 3-5, a filling material accounts for 10-20, livestock and poultry manure or humic acid accounts for 50-80, the urease inhibitor accounts for 0.1-0.15, the nitrification inhibitor accounts for 0.15-0.2, and the poly(aspartic acid) accounts for 6-20. The invention aims to overcome the defects in the prior art, ordinary fertilizers have the disadvantages of short effective period, unreasonable nutrient proportion, unscientific and unbalanced nutrient supply, especially the nitrogen fertilizer conflict is more prominent. The long-acting synergistic controlled release fertilizer is released along with the absorption rate of crops, fertilizer loss can be effectively reduced, and saving, yield increase, synergia, convenience, environmental protection and multiple objectives can be achieved, and agricultural sustainable development can be realized. The long-acting synergistic controlled release fertilizer is simple and feasible in application, and is suitable for China's actual conditions, thus being an inevitable course for the world fertilizer development in the 21st century.