185 results about "Amidogen" patented technology

The invention relates to the field of water treatment, in particular to a composite material with polyfunctional groups and a preparation method and application thereof.The composite material with the polyfunctional groups contains at least two groups including carboxyl, amino, amido and hydroxyl and at least one group including sulfo and nitro; the composite material contains a cross-linked compound of a polymer I and a polymer II, and the polymer I is a carbon chain polymer and contains at least one group including a sulfonic acid group and a nitro group; and the polymer II is at least one of chitosan and a derivative thereof, and chitin and a derivative thereof. The composite material with multiple functional groups is preferably a composite fiber, has a synergistic adsorption effect of multiple functional groups, can effectively adsorb a complex heavy metal ion system in a water body, and is a heavy metal ion adsorbent which is high in adsorption efficiency, large in adsorption quantity and wide in applicable temperature range.

The invention discloses a preparation method, an intermediate and application of menochromone. The preparation method comprises the following steps: reacting 4-bromopyrrole-2-carboxylic acid with propargylamine to generate 4-bromo-N-propynyl pyrrole-2-formamide; the preparation method comprises the following steps: reacting 4-bromo-N-propinyl pyrrole-2-formamide with pinacol borane to generate a mixture; reacting the mixture with 2-(t-butyloxycarboryl amino)-5-iodo-1H-imidazole to generate (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate, and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with the tert-butyl carbamate; and reacting the (E)-(5-(3-(4-bromo-1H-pyrrole-2-formamido) prop-1-ene-1-yl)-1H-imidazole-2-yl) tert-butyl carbamate with a dioxane hydrochloride solution, so as to generate the menochromone. The invention provides a preparation method of menosin, which is short in synthetic route, simple and convenient to operate, high in product yield and suitable for industrial production.

The invention discloses amino-terminated hyperbranched polyamide acid as well as a preparation method and application thereof. The amino-terminated hyperbranched polyamide acid is formed by polymerizing an aromatic anhydride monomer, an aromatic triamine monomer and an aromatic diamine monomer; the mole numbers of the aromatic anhydride monomer, the aromatic triamine monomer and the aromatic diamine monomer are a, b and c respectively, a: (b + c) = 1: 1-1: 1.5, and the proportion of b to c is any proportion. The amino-terminated hyperbranched polyamide acid disclosed by the invention not only has abundant terminal amino groups, but also contains a large number of polar groups such as ether bonds, imidazole rings, amide groups and carboxyl groups in molecular chains. Therefore, a stable water-based colloid emulsion can be formed in the presence of water and a small amount of organic solvent, other auxiliaries are not needed, and the interface performance and the mechanical performance of the composite material can be greatly improved.

The invention discloses polyhedral oligomeric silsesquioxane containing an amido bond and a hindered phenol functional group as well as a preparation method and application of the polyhedral oligomeric silsesquioxane. The structural formula of the polyhedral oligomeric silsesquioxane is one or more of the following formulas I-III, r1 and R2 are independently selected from at least one of hydrogen, alkyl, alkoxy, hydroxyalkyl, cycloalkyl, cycloalkyl alkyl, aryl, aralkyl, heterocyclic radical, heterocyclic radical alkyl, carboxyl, ester group, acylamino, amino, amido, halogen, nitro, cyano, oxycarbonyl and aminocarbonyl; and R3 and R4 are independently selected from alkylene with 0 to 20 carbons. The polyhedral oligomeric silsesquioxane containing the amido bond and the hindered phenol functional group prepared by the preparation method disclosed by the invention is high in hindered phenol functional group content and small in size, long-term and efficient protection can be realized under a low addition amount, and the thermo-oxidative aging resistance of a polymer is effectively improved.

An amido group-containing monomer composition contains 80.00 to 99.99 mass % of an amido group-containing monomer (a) of the following formula (1) and 0.01 to 20.00 mass % of a metal chelate complex (b) having carbonyl group as a ligand:wherein R1 represents a hydrogen atom or a methyl group, R2 represents a hydrocarbon group having a carbon number of 1 to 6, R3 represents a hydrocarbon group having a carbon number of 1 to 23, and R4 represents hydrogen or a methyl group.

The invention deals with a composition comprising a liquid carrier, which is liquid at a temperature of 23 °C, a block co-polymer comprising at least one block (A) wherein block (A) comprises at least one amide group and at least one block (B) having no amide groups, dissolved in the liquid carrier, wherein block (A) does not contain aromatic groups, and an ionic compound, wherein the ionic compound comprises at least one of CaCl2, MgCl2, SrCl2, ZnCl2, carbamimidoylazanium chloride, NaSCN, NaBr, dissolved in the liquid carrier.

One embodiment of the nonlinear light-absorbing material disclosed herein comprises a compound represented by the following formula (1) as its main component. In formula (1), R 1 ~R 10 Each group can be a hydrogen atom, halogen atom, saturated hydrocarbon group, haloalkyl group, unsaturated hydrocarbon group, hydroxyl group, carboxyl group, alkoxycarbonyl group, aldehyde group, acyl group, amide group, nitrile group, alkoxy group, acyloxy group, thiol group, alkylthio group, sulfonic acid group, acylthio group, alkylsulfonyl group, sulfonamide group, primary amino group, secondary amino group, tertiary amino group, or nitro group.

The application discloses a kind of high selectivity nanofiltration composite membrane and preparation method thereof, belong to nanofiltration membrane related technical field.The application is in the form of in-situ polymerization with anhydride, ester group, amide group on membrane surface, the degree of hydrolysis of polyamide membrane is controlled by the cleaning of post-processing solution, to control the charge density of membrane surface, to improve or reduce the permeability of monovalent ion;By controlling the ratio of trimesoyl chloride and diacyl chloride monomer, the size of pore structure can be adjusted, further improving the permeability of monovalent salt;By adjusting the amount of hydrophilic pore-forming agent to improve the hydrophilic performance of ultrafiltration base film, the flux and monovalent salt permeability of nanofiltration composite membrane are improved.The high selectivity nanofiltration composite membrane prepared by the application has excellent divalent salt ion removal rate, lower monovalent salt removal rate, and higher water flux, suitable for industrial production.

The invention discloses a method for preparing a chiral benzhydrol compound through asymmetric hydrogenation of o-amido benzophenone under catalysis of rhodium. The chiral rhodium catalyst is generated in situ from a metal rhodium salt and a chiral phosphine-phosphoramidite ligand in various solvents. Compared with other methods for synthesizing chiral benzhydrol, the method has the characteristics of cheap catalyst, easiness in preparation of chiral ligand, mild reaction conditions, simplicity and convenience in operation, high yield, high enantioselectivity and the like, and can be applied to large-scale preparation of chiral benzhydrol compounds. The method is also suitable for efficient preparation of the rice plant growth regulation inhibitor (S)-Inabenide, the yield can reach 92%, the enantioselectivity can reach 96%, and the method has good industrial application prospects.

The invention discloses an adsorbent resin and a preparation method thereof, and belongs to the technical field of wastewater adsorption treatment. The preparation method comprises the following process steps: S1, taking p-chloromethyl styrene, styrene and n, n '-(4, 4'-methylene diphenyl) bismaleimide as monomers, mixing the monomers, a cross-linking agent and a pore-foaming agent to obtain an oil phase, and carrying out suspension polymerization in the presence of a dispersion phase, an additive and an initiator to obtain a polymerization product; s2, carrying out Soxhlet extraction and other treatments on the polymerization product to obtain chloromethylated amide group modified polystyrene; s3, carrying out amination treatment on the chloromethylated amido group modified polystyrene to obtain an amination product; and S4, washing and vacuum drying the amination product obtained in the step S3 to obtain the adsorption resin. The adsorbent resin obtained by the method can effectively enrich long-chain alkyl carboxylic acid in a water body, and has the advantages of low cost, high adsorption capacity, strong selectivity and excellent cyclic regeneration stability.

This invention relates to a thickening and water-retaining agent with a branched network structure and its preparation method. The raw materials, by weight, include: 10 parts of unsaturated acid monomer; 5-40 parts of acrylamide; 1-5 parts of unsaturated amide monomer; 3-10 parts of unsaturated sulfonate monomer; 2-5 parts of workability-modifying monomer; 0.5-2 parts of oxidant; 0.5-6 parts of polymerizable reducing agent; and water. The thickening and water-retaining agent with a branched network structure prepared by this invention, during the hydration process of cement, continuously adds branched structure through the hydrolysis effect of amide groups, and continuously and slowly releases free water to replenish the free water consumed during hydration. This meets the flowability requirements of concrete after hydration, solving the problems of existing thickening and water-retaining agents that cannot simultaneously meet the initial and post-hydration thickening and water-retaining properties and flowability requirements of concrete, and also addressing the issue of storage stability.

The invention relates to a drug-loading material containing modified sodium alginate and application of the drug-loading material in pesticide preparations, and belongs to the technical field of pesticide pharmacy, the drug-loading material containing modified sodium alginate contains an N-vinyl caprolactam chain segment, the volume phase transition temperature of the drug-loading material can be regulated and controlled through the concentration of metal ions, and the temperature-sensitive chain segment collapses at high temperature, so that the drug-loading material containing modified sodium alginate has good stability. At low temperature, the network is loose to promote release, at low temperature, the network is compact, ineffective release is inhibited, temperature fluctuation in the field is adapted, metal ions, carboxyl of modified sodium alginate, carboxyl of dehydroabietic acid and acylamino of N-vinylcaprolactam form a dynamic coordination network, accurate gradient release is presented in weak-acid, neutral and alkaline environments, and the metal ion-modified hydrogel has good biocompatibility. Amino and carboxyl of the chitosan quaternary ammonium salt form an acid-base buffer pair, the pH response interval is further refined, release disorder caused by small fluctuation of soil acidity and alkalinity is avoided, the drug-loading material has a temperature and pH dual response function, and targeted release in a pest and disease damage high-incidence environment (high temperature and specific pH) is achieved.

The invention provides a preparation method of a novel chiral thiourea / phosphine bifunctional organic catalyst with a cis-cyclic 1, 2-phosphinamine skeleton and application of the novel chiral thiourea / phosphine bifunctional organic catalyst in an asymmetric catalytic reaction. The chiral organic catalyst is prepared by taking cis chiral 2-(diphenylphosphine)-1, 2, 3, 4-tetrahydro-1-naphthylamine and an isothiocyanate compound as raw materials through a one-step reaction under a mild condition. The chiral thiourea / phosphine bifunctional organic catalyst is simple to prepare and stable in property, and shows excellent catalytic activity and stereoselectivity in an asymmetric hydrosilylation reaction of o-amido benzophenone.

The application belongs to the technical field of compound preparation, and discloses a kind of 3-amido quinoline structure containing compound, its chemical structural formula is as follows: wherein, R1 is halogen;R2 is N-substituted five or six-membered nitrogen heterocyclic primary amine group or 3-substituted six-membered nitrogen heterocyclic primary amine group;R3 is 4-methylphenyl or 4-benzyl morpholinyl.The 4-methylphenyl or 4-benzyl morpholinyl substituted terminal alkyne ketone, 2-amino-5-halogen benzaldehyde is used as raw material to synthesize intermediate product, and the intermediate product is reacted with N-substituted five or six-membered nitrogen heterocyclic primary amine or 3-substituted six-membered nitrogen heterocyclic primary amine, to obtain a variety of 3-amido quinoline structure containing compounds, the raw material is widely sourced, low in price, green and environmentally friendly, and easy to operate, simple in condition, fast in reaction time, convenient in post-treatment, high in product yield, suitable for large-scale preparation, and has wide application prospect.

The present invention relates to a process for stereoselective polyene cyclization to produce tricyclic compounds of formula (I), wherein X is CH2or C=O, comprising reacting a compound of formula (II), wherein X is CH2or C=O and wherein the curved line indicates the E- or Z-configuration, in the presence of a catalytic amount of a Bronsted acid having an acidic sulfonamide moiety.(I)(II)

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of furosemide. The preparation method of furosemide comprises the following steps: chlorosulfonation: reacting chlorosulfonic acid and 2,4-dichlorobenzoic acid, hydrolyzing, filtering, and obtaining 2,4-dichloro-5-sulfonyl chlorobenzoic acid; amination: adding 2,4-dichloro-5-sulfonyl chlorobenzoic acid into ammonia water, reacting, neutralizing, filtering, purifying, and obtaining 2,4-dichloro-5-sulfonamidobenzoic acid; condensation: reacting 2-furfurylamine and 2,4-dichloro-5-sulfonamidobenzoic acid, and obtaining furosemide crude product; decolorization: adding the furosemide crude product into a saturated sodium bicarbonate solution, adding activated carbon for decolorization, neutralizing, and crystallizing, and thus furosemide product is obtained. The raw material used in the application is easy to obtain and low in price, the comprehensive reaction period is short, the amount of hazardous waste generated is small, the prepared furosemide is high in purity and high in total yield, the comprehensive cost of the whole preparation process is low, and the application is suitable for industrial production.

The invention discloses amido polylactic acid as well as a preparation method, application and an application method thereof. The amido polylactic acid is prepared from polylactic acid, an oxidizing agent, a dicarboxyl amine compound, a hydroxyl-containing acyl chloride monomer and a catalyst. The preparation method comprises the following steps: firstly, respectively preparing a dihydroxy amide monomer and polylactic acid with carboxyl at two ends, then esterifying the dihydroxy amide monomer and the polylactic acid to obtain an amido polylactic acid fiber with an amido group, and blending the amido polylactic acid fiber with a polyethylene fiber to prepare the amido polylactic acid degradation film material. According to the invention, amide groups are introduced into polylactic acid molecules through a chemical method, so that the polylactic acid is endowed with new performance, the heat resistance, chemical stability, biocompatibility and the like of the polylactic acid can be improved, and the formed amido polylactic acid degradable film material has the characteristics of degradability and antibacterial property, is relatively high in heat resistance and mechanical property, and can be widely applied to the field of degradable film materials. The method can be widely applied to the biomedical field.

The application discloses solid spherical silicon micro-powder and a preparation method thereof. The preparation method comprises the following steps: providing a silicon compound system, wherein the silicon compound system comprises a silica sol and a thickening agent, the thickening agent contains carboxyl and or amide groups, and does not contain alkali metal ions; performing spray drying on the silicon compound system to obtain a silicon micro-powder precursor; and performing heat treatment on the silicon micro-powder precursor to remove organic phase substances and solvents in the silicon micro-powder precursor, thereby obtaining solid spherical silicon micro-powder. The preparation method provided by the application adds the thickening agent into the silica sol to form the silicon compound system, and then performs spray drying. After the solvents and the organic phase are removed through heat treatment, the solid spherical silicon micro-powder with high compactness and high sphericity is obtained. The preparation process is simple and easy to implement, the energy consumption is low, and the cost is low.

The present application relates to the technical field of hydrolysis of hydroxy fatty acid ester, and discloses a hydrolysis filler, a preparation method and application thereof. The hydrolysis filler comprises a silane layer and an active layer which are successively coated on the outer surface of the filler; the active layer comprises amido, pyrrolyl, and sulfhydryl and / or thioether, phosphoric acid group and sulfonic acid group. When the hydrolysis filler is used for hydrolysis of hydroxy fatty acid ester to prepare hydroxy glycolate aqueous solution, the water-ester ratio in the hydrolysis process and the oligomer content in the target product can be effectively reduced.

The invention provides an application of a 3-substituted-5-acylamino benzoate derivative shown in a formula (1) in preparation of drugs for treating acute lung injury and resisting inflammation. The invention discovers that the 3-substituted-5-acylamino benzoate derivative has the function of a P2Y14R antagonist for the first time, has an obvious antagonistic effect on P2Y14R related inflammation, and can be used for preparing the P2Y14R related anti-inflammatory drugs.

The application discloses a method for simultaneously detecting 18 kinds of amino acids in Daqu based on high-resolution liquid chromatography-mass spectrometry, and belongs to the technical field of liquor detection. Chromatographic conditions of the method include that an ethylene bridge hybrid particle with surface-bonded amide groups is used as a filler, ammonium acetate-formic acid aqueous solution is used as mobile phase A, and acetonitrile is used as mobile phase B for gradient elution; mass spectrometry conditions include that an H-ESI ion source is used, the spray voltage in the positive ion mode is 3000-4000 V, and the spray voltage in the negative ion mode is 2000-3000 V; qualitative analysis is performed according to mass-to-charge ratios of the 18 kinds of amino acids, and quantitative analysis is performed by using a standard curve method. The method has the characteristics of simple pretreatment operation, easy-to-obtain reagents, high extraction efficiency and good stability, can realize synchronous and accurate qualitative and quantitative analysis of the 18 kinds of amino acids, and provides reliable data support for flavor substance research of Daqu.

The invention belongs to the technical field of organic matter preparation, and provides an isoxazoline compound containing benzamide as well as a preparation method and application thereof.Chemical modification and molecular design are performed on a compound with an isoxazoline structure, a substituent group is introduced to N of an amide group, and the benzamide-containing isoxazoline compound is prepared. A series of high-efficiency compounds which can be used for killing insects or mites in agriculture or forestry and have excellent activity are obtained, and particularly, the compounds have very good biological activity on pests of lepidoptera, hemiptera and the like. When being used at an extremely low concentration, the compound disclosed by the invention also shows an excellent control effect on various pests or pest mites, has insecticidal or acaricidal activity in each stage (such as eggs, larvae (nymphs), pupae and adults) of the life cycle of the pests or pest mites, and has an excellent control effect on the pests or pest mites which have drug resistance to traditional insecticides or acaricides. And the composition also shows excellent control activity.

The invention relates to the technical field of semiconductor packaging, in particular to a reversible crosslinking reaction resin derivative, a self-healing SiC chip molding compound and application thereof. The reversible crosslinking reaction resin derivative comprises at least one aromatic compound containing an amido furan functional group, wherein the aromatic compound has any one or a combination of at least two of structural formulas shown in formulas (1)-(4); and a bismaleimide compound having a structure represented by formula (5). According to the reversible cross-linking reaction resin derivative, a reversible DA system is constructed by an aromatic compound containing an amido furan functional group and a bismaleimide compound, the DA reaction temperature is precisely regulated and controlled to 155-170 DEG C through amido so as to adapt to the junction temperature of 175-200 DEG C of a SiC chip, and the problem that cracks cannot be repaired through the reverse DA reaction of an existing material is solved.

The present disclosure relates to a salt and a crystal form of a picolinamide compound, and a preparation method therefor. Specifically, the present disclosure relates to a salt and a crystal form of 4-((2R,3S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-5-methyl-5-(trifluoromethyl)tetrahydrothiophene-2-carboxamido)pyridine-2-carboxamide, and a preparation method therefor. The crystal form in the present disclosure has high crystallinity, high purity, no hygroscopicity and good thermal stability; moreover, the process has high levels of safety, and is simple to operate and suitable for industrial production.

The invention belongs to the technical field of biological medicines, and relates to phenyl naphthalene derivatives and application thereof in preparation of medicines for preventing and treating tumors or medicines for neuroprotection. The compound is a compound shown in a formula I or a formula II or a pharmaceutically acceptable salt thereof. In the formula I, A is not present or is carbonyl, A'is carbonyl, sulfuryl, oximido and imino, R1 is amino, nitryl, acylamino, sulfonamide, aryl methoxy, aryl ethyoxyl, fluorine atom, trifluoromethyl, ureido, amidoxime, amidino and N-methyl sulfonamide, and R2 is hydrogen atom, methoxy, amino, nitryl, acylamino, amidoxime, amidino or fluorine atom; r2 and H2N-A'are located at the adjacent position of a benzene ring, R2 or H2N-A 'is located at the para-position of phenyl, and X1 and X2 are independently selected from CH or N. The phenyl naphthalene derivative provided by the invention has relatively high NQO2 inhibitory activity, and can be used as a chemical drug for tumor treatment and a neuroprotective agent for neurological diseases.

The invention deals with a composition comprising a cyclic amide comprising at least one amide NH group, a solvent, which is different from the cyclic amide comprising at least one amide NH group and wherein the solvent comprises at least one of an amide group, wherein the amide nitrogen of the amide group has two substituents, wherein the substituents are selected from aliphatic and aromatic groups, a sulfoxide group, and a urea compound, having a number average molecular weight of at least 350 g / mol.

The invention provides a targeted broad-spectrum corrosion and scale inhibitor for oilfield produced water as well as a preparation method and application of the targeted broad-spectrum corrosion and scale inhibitor. The targeted broad-spectrum corrosion and scale inhibitor is prepared from the following components in parts by weight: 30 to 40 parts of thioureido imidazoline grafted multipolymer mixed solution, 5 to 10 parts of diethyl triamine pentaacetic acid, 1 to 2 parts of NaOH, 2 to 4 parts of sodium ethylene diamine tetra (methylene phosphonate), 2 to 3 parts of oxalic acid, 1 to 2 parts of salicylic acid, 2 to 5 parts of cinnamic acid, 1 to 4 parts of citric acid and 40 to 50 parts of water. The corrosion and scale inhibitor has amide groups and a large number of N and O groups with high polarity, and the adsorption capacity of the corrosion inhibitor is remarkably improved; by designing the molecular structure of the multipolymer scale inhibitor, the content of carboxylate ions is increased, a sodium allysulfonate monomer is introduced, a scale inhibitor group containing multiple ligands is synthesized, the calcium tolerance of the components of the copolymer scale inhibitor under high salinity is improved, and a solubilizer and a synergist are compounded, so that the scale inhibitor has a good scale inhibition effect on calcium, barium and strontium.

The invention discloses a cancer cell membrane coated STING agonist loaded MXene compound and a preparation method and application thereof, and belongs to the technical field of biomedical materials.The preparation method comprises the steps that Ti3AlC2 and LiF are mixed, a concentrated hydrochloric acid solution is added, a reaction is conducted for 24-72 h at the temperature of 25-50 DEG C, and then centrifugal washing is conducted to obtain a black precipitate; adding the black precipitate into water, carrying out ultrasonic treatment under the protection of nitrogen to obtain a colloidal solution, and then centrifugally collecting supernate to obtain a d-MXene solution; the preparation method comprises the following steps: mixing a d-MXene solution and an STING agonist solution, stirring at room temperature, reacting in a dark place, adding a micromolecule enhancer containing an amide group into the mixture during the reaction to obtain an STING agonist-loaded MXene compound, and further coating by using a liver cancer cell membrane to obtain a cancer cell membrane-coated STING agonist-loaded MXene compound. The compound has a wide application prospect in the aspect of hepatocellular carcinoma treatment.

A pure composition comprises a monoalkyltin trialkoxide compound represented by the chemical formula RSn(OR′)3 or a monoalkyl tin triamide compound represented by the chemical formula RSn(NR′2)3 and no more than 4 mole % dialkyltin compounds relative to the total tin amount, where R is a hydrocarbyl group with 1-31 carbon atoms, and wherein R′ is a hydrocarbyl group with 1-10 carbon atoms. Methods are described for the formation of the pure compositions. A solid composition comprises a monoalkyl triamido tin compound represented by the chemical formula RSn—(NR′COR″)3, where R is a hydrocarbyl group with 1-31 carbon atoms, and where R′ and R″ are independently a hydrocarbyl group with 1-10 carbon atoms. The compositions are suitable for the formation of resist compositions suitable for EUV patterning in which the compositions have a high EUV absorption.

The invention discloses an antibacterial agent, a nylon composite material and a preparation method thereof, and the preparation method comprises the following steps: mixing a carboxylic acid compound, absolute ethyl alcohol, deionized water and N-isopropylacrylamide at 50-70 DEG C, stirring and reacting for 8-12 hours to obtain a solution A; mixing the solution A with hypochlorite ions, deionized water and absolute ethyl alcohol under the condition of 60-70 DEG C, and stirring and reacting for 10-12 hours to obtain a solution B; and filtering, washing and drying the solution B to obtain the antibacterial agent. The halamine antibacterial agent synthesized by the invention has a structure similar to an amide group, has good compatibility with nylon, and also has good mechanical properties.