836 results about "Amidogen" patented technology

4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

The invention provides nitrogen mixed grapheme hydrogel of which the water content is 90 to 99.5 percent, the electric conductivity is 10-3-100 S/m, and the molar ratio of N and C is 1 to 25 percent. The invention further provides nitrogen mixed aerogel of which the molar ratio of N and C is 2 to 20 percent, the molar ratio of C and O is 15 to 5, nitrogen atoms existing in the form of amidogen nitrogen accounts for 40 to 70 percent, pyridine type nitrogen accounts for 10 to 40 percent, graphite type nitrogen accounts for 10 to 30 percent, the specific area is 300 to 1500 m<2>/g, the apertures which are micropore account for 10 to 20 percent, the apertures which are mesoporous 20 to 50 percent, the apertures which are macropore 30 to 70 percent, the apparent density is 0.01 to 0.2 g/cm<3>, the pore volume is 5 to 20 cm<3>/g, and the electric conductivity is 1 to 1000 S/m. The nitrogen mixed grapheme hydrogel or aerogel and preparation method thereof provided by the invention has the characteristics that the operation is simple, the equipment requirement is low, the production efficiency is high, the scale-up of the technology is easy, the nitrogen mixed content is controllable and the compounding with other functional substances is simple.

A nanoparticle including an inorganic core comprising at least one metal and/or at least one semi-conductor compound comprising at least one metal includes a coating or shell disposed over at least a portion of a surface of the core. The coating can include one or more layers. Each layer of the coating can comprise a metal and/or at least one semiconductor compound. The nanoparticle further includes a ligand attached to a surface of the coating. The ligand is represented by the formula: X-Sp-Z, wherein X represents, e.g., a primary amine group, a secondary amine group, a urea, a thiourea, an imidizole group, an amide group, a phosphonic or arsonic acid group, a phosphinic or arsinic acid group, a phosphate or arsenate group, a phosphine or arsine oxide group; Sp represents a spacer group, such as a group capable of allowing a transfer of charge or an insulating group; and Z represents: (i) reactive group capable of communicating specific chemical properties to the nanocrystal as well as provide specific chemical reactivity to the surface of the nanocrystal, and/or (ii) a group that is cyclic, halogenated, or polar a-protic. In certain embodiments, at least two chemically distinct ligands are attached to an surface of the coating, wherein the at least two ligands (I and II) are represented by the formula: X-Sp-Z. In ligand (I) X represents a phosphonic, phosphinic, or phosphategroup and in ligand (II) X represents a primary or secondary amine, or an imidizole, or an amide; In both ligands (I) and (II) Sp, which can be the same or different in the two compounds, represents a spacer group, such as a group capable of allowing a transfer of charge or an insulating group; Z, which can be the same or different in the two compounds, is a group chosen from among groups capable of communicating specific chemical properties to the nanoparticle as well as provide specific chemical reactivity to the surface of the nanoparticle. In preferred embodiments, the nanoparticle includes a core comprising a semiconductor material.

The invention belongs to the field of nano particle or polymer composite material preparation and particularly relates to a dopamine compound modified or coated nano particle modified polymer composite material and a preparation method thereof. The composite material is composed of nano particles with surfaces modified or coated by dopamine compound and a high molecular polymer matrix. The nano particles with the surfaces modified or coated by the dopamine compound are uniformly scattered in the high molecular polymer matrix. According to the dopamine compound modified or coated nano particle modified polymer composite material, the dopamine compound modified or coated nano particles are utilized, the dopamine compound can aggregate spontaneously on the surface of a nano particle material to form a thin film to enable the surfaces of the nano particles to be connected with a function group such as hydroxyl and amidogen with strong activity, the compatibility of the nano particles in the high molecular polymer can be increased, and the dopamine compound is favorable for causing the nano particles and the high molecular polymer matrix to further generate secondary reaction. The dispersibility of the nano particles is good, and the stability is good in the dopamine compound modified or coated nano particle modified polymer composite material, and the comprehensive performance of the composite material can be improved remarkably.

The invention relates to polyurethaneurea hydrogel and preparation methods therefor. The preparation methods comprise two preparation methods. The first preparation methods is as follows: diisocyanate and catalysts are added in a polyethylene glycol (PEG) organic solution for reaction, then diamine chain extender is added, and products are obtained in the organic solvent after precipitation, wherein, the molar ratio of PEG, diisocyanate and diamine is 1:2:1. The second preparation method is as follows: N,N'-dicarbonyl diimidazole is added in a PEG organic solution for reaction, then excess diamine chain extender is added, macromolecules with amidogens at two ends are obtained, finally, diisocyanate is added, and products are obtained in the organic solvent after precipitation, wherein, the molar ratio of PEG and diisocyanate is 1:2. The polyurethaneurea hydrogel has advantages of large elongation and high tensile strength, and has shape memory functions. The polyurethaneurea hydrogel has application prospects at aspects of biomedical hydrogel, tissue engineering, hydrogel support materials, biomedical devices with shape memory functions and the like.

The invention discloses a method for preparing a perdurable hydrophilic polyether modified amino-polysiloxane softener. The method is characterized by comprising the following steps: octamethylcy-clotetrasiloxane and amino silane coupling agents with different structures are used as raw materials; with a bulk polymerization method, under the analysis of an alkali catalyst, firstly, an amino organic polysiloxane softener with high ammonia value is generated through ring-opening polymerization; and secondly, on the basis of the amino organic polysiloxane softener, amidogen is subjected to etherifying modification, thereby synthesizing the hydrophilic polyether modified amino-polysiloxane softener with good hand feeling and hydrophilic property. The prepared softener keeps the hydrophilic property and simultaneously improves the softness of hydrophilic silicon oil so that the hand feeling of textile can reach the hand feeling of the prior linearity amino silicon oil after the textile is treated by the softener and the treated textile can keep the hydrophilic property permanently.

The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:

where R, L, X¹, X², X³, X⁴, Y¹, Y², Y³, and Y⁴ are described herein.

The invention discloses a photo-curing monomer with ortho-phenolic hydroxyl strucutre, a preparation method and bond thereof. In the formula I monomer, the compound which has crylic acid at two ends or crylic acid double bond at one end and methylacrylic acid double bond at the other end is added to the amidogen of dopamine and derivant thereof through a Michael addition method to form corresponding secondary amine or tertiary amine. In the formula II monomer, the double bond is introduced by (methyl) acrylic anhydride, (methyl) crylic acid and (methyl) acryloyl chloride. The photopolymerization bond comprises the following components by weight percent: 20 to 99.9 percent of the compound with the ortho-phenolic hydroxyl structure, 0 to 70 percent of activated thinner and/or solvent, 0.1 to 10 percent of evocating agent and 0 to 60 percent of natural macromolecule or modified outcome thereof. The bond can be bonded in dry state and wet state, is a quick and long lasting bond, realizes the organic bond of biological bond and photopolymerization, has the advantages of low manufacture cost, simple and convenient operation and high productivity and has extensive application foreground in the biological bond field.

Disclosed is a surfacely modified hydrophobic Chitosan oligosaccharide polymer drug-loaded colloidal cluster, obtained by grafting chitosan with a average molecular weight of 1.5kD-51kD and aliphatic acid of C10-C22, comprising based on hydrophobic modified Chitosan oligosaccharide polimer colloidal clusters, modifying amidogens or hydroxy groups of Chitosan oligosaccharide molecules on polimer surface with bi-functional small organic moleculers, forming chemical bond bridges between molecules on the surfaces of polymer colloidal clusters,to improve the instability of polymer colloidal cluster diluted, and to imorove the original loose structure of polimer colloidal cluster surfece to form a fine and close net-shaped structure, to decrease a sudden release of drugs, and to control drugs with slow release. The drug-loaded colloidal cluster provided is a nano-carrier with excellent organelle targeting, is applicated in life science field and pharmacy field.

The invention relates to a fluorescent ion probe (I) with high selectivity and high sensitivity in detection and the application of the fluorescent ion probe in identifying and detecting heavy metal ion and transition metal ion, wherein, the Y is an organic conjugate group with fluorescence transmitting function such as pyrene, naphthalene, 4-amidogen-1, 8-naphthyl imide, Dan sulfonamide, anthracene, carbazole, benzimidazoins, benzoxazoles, boron fluoride bipyrrole (BODIPY), fluorescein, 3, 4, 9, 10-perylenetetracarboxylic diimide or rhodamine B; the X is acylamino group, sulfoamino group or ester group. The fluorescent ion probe uses the fluorescence peak of fluorescence chromophore aggregate as the response signal to identify metal ion, thereby effectively avoiding the quenching effect of transition metal ion and heavy metal ion on fluorophore; moreover, the fluorescent ion probe realizes selective identification of heavy metal ion and transition metal ion in various solvents and aqueous solution in particular.

A structural formula of a 6-aliphatic hydrocarbon amido hexyl hydroximic acid collecting agent is represented by a formula (I), wherein R represents C2-C18 aliphatic hydrocarbon group. The preparation method comprises the steps as follows: caprolactam and hydroxylamine hydrochloride or hydroxylamine sulphate are taken as raw materials, methylbenzene is taken as a solvent, the reaction temperature ranges from 80 DEG C to 110 DEG C, the reaction lasts for 1-4 hours, and 6-amino hexyl hydroximic acid is generated; 6-amino hexyl hydroximic acid reacts with C2-C18 fat carboxylic acid at the reaction temperature ranging from 100 DEG C to 160 DEG C for 1-4 hours to generate 6-aliphatic hydrocarbon amido hexyl hydroximic acid, and the product yield can be higher than 91%; and 6-aliphatic hydrocarbon amido hexyl hydroximic acid used in flotation of scheelite, wolframite, tombarthite ore, tin ore, bauxite, titanic iron ore or fluorite ore is taken as the collecting agent, so that the flotation recovery rate can be increased by 3%-10%.

The present invention relates to a method of producing a biodegradable resin composition, which includes step (1) of mixing a biodegradable resin, a plasticizer and a crystal nucleating agent with one another at the melting point (Tm) of the biodegradable resin or more, wherein the crystal nucleating agent is an aliphatic compound having, in its molecule, two or more of at least one group selected from an ester group a hydroxyl group and an amide group, and step (2) of thermally treating the resulting biodegradable resin composition at a temperature of from the glass transition temperature (Tg) to less than Tm of the composition, as well as a biodegradable resin composition, which contains a biodegradable resin, a plasticizer, and the above crystal nucleating agent, and which satisfies the following conditions: the haze thereof with a thickness of 0.5 mm after thermal treatment at 60° C. for 36 or 60 hours is 20% or less; the storage elastic modulus (E′) at a temperature of 25° C. and a frequency of 50 Hz is 1×10⁸ to 2×10⁹ Pa; and the storage elastic modulus (E′) at a temperature of 60° C. and a frequency of 50 Hz is 1×10⁷ to 1×10⁹ Pa.

A lubricative composition for industrial machinery and equipment which comprises a base oil selected from among mineral oils, fats and oils, synthetic oils and mixture of two or more of them, and at least one additive selected from among the following components (A) to (D): component (A): (A-1) a phosphorus-containing carboxylic acid and/or (A-2) a thiophosphoric ester, component (B): a dispersant viscosity index improver, component (C): (C-1) a specific amidocarboxylic acid compound and/or (C-2) a specific carboxylic acid compound, and component (D): an ester oiliness improver. The composition is favorable as a lubricating oil composition and useful as a gear oil composition, a lubricating oil composition for paper machines or a lubricating oil composition for slide guides, a hydraulic oil, or the like.

The invention relates to a 5-site or 6-site substituent naphthalimide compound and antitumor applications thereof, which belongs to the fine chemical field. The compound is characterized in that various aliphatic amidogen, heterocyclic amidogen, aryl and Ar aryl are respectively introduced into the 5-site or 6-site of the naphthalimide by a nucleophilic substitution reaction to obtain small molecule compound similar to a lead compound amonafide structure. The small molecule compound has obvious inhibiting activity in vitro test on Hela and P388D1, and wherein, some compounds have stronger cytotoxicity than the amonafide under the same test conditions. In addition, the structures of the compounds take on diversity; the compounds without acetylation sites can be prevented from having the side effect similar to the amonafide; the other compounds with the acetylation sites can be prevented from having the side effect by personalized administration, therefore, the compound has medical application prospect in curing diseases related to tumors.

The invention belongs to the technical field of nano materials, and in particular relates to a method for preparing a hybrid composite material of carbon fibers/carbon nanotubes/bismaleimide resin. The method comprises the following steps: after carboxylating, acylating and chlorinating the surfaces of purified carbon nanotubes and dried carbon fibers, introducing diamine or polyamine with a feature structure thereon, wherein a large amount of the diamine or the polyamine are jointed on the surfaces of the carbon nanotubes and the carbon fibers; performing an addition reaction on the carbon nanotubes jointed with the amidogen and the bismaleimide resin to obtain a carbon nanotubes-containing bismaleimide resin linear block polymer serving as a substrate; and compositing the substrate and the carbon fibers in a certain mode to form a multi-dimensional hybrid composite material structure linked by covalent bonds finally. The method has the advantages of strengthening and toughening bismaleimide by using the strength and the toughness of the carbon nanotubes, improving the bonding strength between the bismaleimide and the carbon fiber substrate surface, improving overall performance of the multi-dimensional hybrid composite material of the carbon fibers/the carbon nanotubes/ the bismaleimide resin, and widening the application of the carbon fibers, the carbon nanotubes and the bismaleimide resin.

A polyhydroxyalkanoate containing in a molecule at least one unit represented by the chemical formula (1). The polyhydroxyalkanoate is a biodegradable plastic with enhanced melt-processability and exhibits excellent charging stability, high chargeability, and enhanced dispersibility when used as a charge control agent of a toner in an electrophotographic process.

• (R denotes -A₁(—SO₂R₁)_x. R₁ is selected from OH, a halogen atom, ONa, OK, and OR_1a. R_1a and A₁ are selected from a substituted or unsubstituted aliphatic hydrocarbon structure, a substituted or unsubstituted aromatic ring structure, and a substituted or unsubstituted heterocyclic structure. Further, m and x are integers selected from 1 to 8, and when two or more units exist, each of R, R₁ R_1a, A₁, m, and x is defined as above independently for each of the units.)

The invention relates to a functionalized carbon nanotube which can be used as epoxy resin curing agent and the preparation method, which belongs to the technical field of the nano-material. After a purified carbon nanotube is treated with strong oxidative acid, a carboxylated carbon nanotube is obtained; the carboxylated carbon nanotube is chlorided by thionyl chloride, and the obtained product is reacted with polyhydric alcohol or polybasic amine to obtain a modified carbon nanotube with hydroxyl or amidogen; then the hydroxyl is utilized to react with aromatic polybasic acid anhydride compound to obtain the functionalized carbon nanotube with anhydride group and carboxyl group, which can be further used as curing agent to ensure carbon nanotube well dispersed in epoxy resin, thus to improve the compatibility between the carbon nanotube and the epoxy resin, both the mechanical property and the thermal stability of the epoxy resin can be improved, thereby the advantage of the carbon nanotube can be exerted to the maximum, and the functional design and the application of the carbon nanotube can be achieved.

The invention discloses a preparation method of a porous inorganic filling materials-fixed quinone compound, belonging to the technical field of water treatment in environmental engineering. The method comprises the following steps of: selecting porous inorganic filling materials such as ceramsites, volcanics and the like; plating gamma-aluminum oxide on the surface of the materials; aminating, so that the surfaces of the porous inorganic filling materials contain a certain quantity of primary amidogen; putting the aminated materials into hydrochloric solution to have reaction for protecting the primary amidogen; and putting the reacted porous inorganic filling materials into sodium hydroxide solution, adding sulfonyl chloride group-containing anthraquinone compound which is dissolved in dichloromethane, and reacting for 6-10h under the room temperature to fix the water-soluble quinone compound. The quinone compound-containing macroporous polymer is applied to an anaerobic reactor to be capable of improving the biotransformation speed of an organic matter which is hardly degraded. The method covalently fixes the quinone compound on the macroporous polymer of a biologic carrier, so that the redox medium is easily contacted with the microbe, thereby overcoming the problem of the secondary pollution since the water-soluble quinone compound flows out with the water.

The invention discloses a nitrogen-containing heterogeneous ring compound, a preparation method thereof and an application of the nitrogen-containing heterogeneous ring compound in inhibition of kinase activity. The general formula of the nitrogen-containing heterogeneous ring compound is represented as a formula I or a formula I', wherein R1, R2, R3 and R4 in the formula I or the formula I' are selected from any one of hydrogen, halogen, cyanogroup, hydroxyl, amidogen and substituted or unsubstituted C1-C6 alkyl groups independently, and a 3-10-membered ring system can be formed by any two groups in R1, R2, R3 and R4; M1, M2 and M3 are selected from CRa or N independently, and at least one of M1, M2 and M3 is N; W is selected from substituted or unsubstituted C1-C6 alkyl groups, substituted or unsubstituted C2-C6 alkenyl, unsubstituted or halogenated 4-8-membered alkine groups, substituted or unsubstituted C3-C8 naphthenic base, substituted or unsubstituted 4-8-membered heterocyclic groups, 5-10-membered aromatic or heteroaryl groups, substituted carbonyl, substituted sulfonyl and substituted or unsubstituted amidogen. The nitrogen-containing heterogeneous ring compound can inhibit EGFR (epidermal growth factor receptor) mutant kinase activity or ALK (anaplastic lymphoma kinase) activity and is a multi-target tumor therapeutic drug with a brand-new action mechanism.

The invention discloses a chrysin nitrogen-containing derivative. Nitrogen-containing groups are introduced to a chrysin structure to synthesize the chrysin nitrogen-containing derivative with a novel structure. The molecular structure of the chrysin nitrogen-containing derivative is shown as (I), wherein R represents fatty amidogens of C1-C20, aromatic amidogens of C6-C20, heterocycle-containing amidogens of C1-C20 and alcohol amidogens or benzyl amidogens of C1-C20, and n represents the carbon chains of C2-C20. The derivative can have the biological activities of some similar alkaloids and simultaneously enlarge polarities, and the synthesized derivative presents a certain alkalinity, which is convenient to achieve the purpose of improving the water solubility with inorganic acid or organic acid finished salts.

The invention discloses a method for preparing hemostatic cotton through hyaluronic acid crosslinked gelatin and belongs to the field of biomedical materials. The method includes the steps that firstly, a novel hydroformylation hyaluronic acid crosslinking agent is prepared; then, the hydroformylation hyaluronic acid crosslinking agent is mixed with gelatin for foaming, refrigerating and drying are conducted, and the gelatin hemostatic cotton can be obtained after sterilization. According to the method, strong oxidant sodium periodate is utilized to oxidize a carbon-carbon bond of cis diol in the hyaluronic acid so that the hyaluronic acid can react with amidogen for formylation; the hyaluronic acid obtained after formylation serves as a macromolecular crosslinking agent and reacts with the gelatin containing an amino functional group, and the gelatin is made to form a cross-linked structure, so that mechanical performance is enhanced, and the sponge function is given to the gelatin. The gelatin is good in biocompatibility, has the hemostatic and anti-microbial functions and serves as a sponge base material, the hydroformylation hyaluronic acid serves as the crosslinking agent, the prepared hemostatic cotton is good in mechanical performance, safe and non-toxic, the hemostatic property is remarkably improved, a good pain relieving function is achieved, and the effect of promoting healing of injured tissues is achieved.

The present invention relates to the field of well drilling, and discloses a primary emulsifier and a preparation method therefor, an emulsifier composition and an application thereof, and oil-based drilling fluid. The primary emulsifier comprises an amide compound and a fatty acid compound; the amide compound comprises at least one amide group, at least one unsaturated double bond, and at least one alkyl containing 14-30 carbon atoms; and the fatty acid compound comprises 20-80 carbon atoms. When the primary emulsifier is used for drilling fluid base mud, the primary emulsifier has a good emulsifying effect and excellent temperature resistance. In addition, the synthetic materials of the primary emulsifier provided by the present invention are widely available and inexpensive, non-fluorescent, and environmentally friendly, and thus the primary emulsifier has great prospects for industrial applications.