101 results about "Quinone Compound" patented technology

The invention relates to an enzyme reagent, glucose electrochemical test paper and a preparation method thereof, and belongs to the technical field of electrochemical detection. The glucose electrochemical test paper comprises an electrode substrate and an enzyme reagent arranged on the electrode substrate, the enzyme reagent is prepared from the following components in parts by mass: 5 to 7 parts of buffer solution, 0.01 to 0.2 part of hexamine ruthenium trichloride, 0.01 to 0.1 part of quinone compound, 0.1 to 1.2 parts of metal organic framework immobilized glucose dehydrogenase and 0.2 to 0.8 part of film-forming agent. According to the glucose electrochemical test paper, the detection accuracy of glucose can be improved, and the problems of large interference, small linear range, insensitive detection and the like in the prior art are improved or solved.

The invention discloses a synthetic method for preparing corresponding hydroquinone through normal-pressure hydrogenation of quinone. Hydroquinone is an important compound, widely exists in natural products with biological activity, and is an important precursor for synthesizing various medicines, agricultural chemicals, polymers and functional materials. The method for reducing the quinone compound into hydroquinone is a simple and direct method. Although many reducing agents, such as SnCl2, Zn, Fe, Na2S2O4, NaBH4, polymethylhydrosiloxane (PMHS), have been used for this conversion, these processes are often affected by the use of stoichiometric or excess reagents, violent reaction conditions, and the formation of large amounts of waste. The hydrogenation reaction of quinone with H2 is obviously the most ideal way to achieve this conversion because it has high atomic efficiency and environmental friendliness. However, hydrogenation often needs high-pressure equipment or high temperature, so that the application potential is greatly limited. Accordingly, we we wish to exhibit a process for the hydrogenation of quinone to hydroquinone under atmospheric pressure.

The invention provides application of naphthoquinone compounds in preparation of insecticides for preventing and / or treating parasitic diseases in aquatic animals, and belongs to the technical field of aquaculture. The naphthoquinone compound disclosed by the invention is 2-chloro-1, 4-naphthoquinone, and can be used for killing or preventing pyramidal bodies in aquatic animals. The invention also provides an insecticide for killing or preventing pyramidal worms in aquatic animals by using the naphthoquinone compound, and the insecticide comprises the following raw materials in percentage by weight: 20-30% of the naphthoquinone compound, 5-10% of a surfactant, 5-10% of a dissolving agent and the balance of water. An in-vitro insecticidal experiment and an in-vivo insecticidal experiment prove that the 2-chloro-1, 4-naphthoquinone can be used for efficiently killing insects; and the 2-chloro-1, 4-naphthoquinone has no obvious toxic or side effect on the fish body, and does not influence the growth and physiological functions of the fish body.

The present invention aims to provide a vehicle composition for inorganic fine particle dispersion which has excellent decomposability at low temperature and enables degreasing in a short time, an inorganic fine particle-dispersed slurry composition containing the vehicle composition for inorganic fine particle dispersion, and a method for producing an inorganic fine particle-dispersed sheet with the inorganic fine particle-dispersed slurry composition. The present invention relates to a vehicle composition for inorganic fine particle dispersion, containing a binder resin, an organic solvent, and an organic compound having a boiling point at normal pressure of 200° C. or higher and lower than 400° C., the binder resin containing a (meth)acrylic resin, the organic compound containing at least one selected from a phenol compound, an aromatic amine compound, a quinone compound, and a nitro compound, the amount of the organic compound being 1 to 100 parts by weight relative to 100 parts by weight of the binder resin.

The invention relates to application of anthraquinone compounds and pharmaceutically acceptable salts thereof in preparation of drugs for treating anemia, the anthraquinone compounds have a structure as shown in formula I. In the formula I, R1-R5 are independently selected from hydrogen, hydroxyl, unsubstituted or hydroxyl-substituted C1-C6 linear or branched alkyl, C1-C6 alkoxy, C1-C6 acyl or-(CH2) n1O (CH2) n2CH3, n1 is selected from 1, 2 or 3, and n2 is selected from 0, 1, 2 or 3. The anthraquinone compound provided by the invention can significantly up-regulate the transcriptional levels of HAMP, EPO and HBG1 genes, has a good treatment effect on thalassemia and beta-sickle anemia, has no significant influence on cell viability and mouse weight, and has medication safety.

The invention relates to the use of a compound of Formula (I) as described herein and its effective dose in the prevention and / or treatment of fibrosis diseases. The compound can effectively prevent and / or treat a fibrosis disease without cytotoxicity or genotoxicity.

The invention provides a preparation method of multifunctional anhydride, and belongs to the field of organic synthesis. The preparation method of the multifunctional anhydride provided by the invention comprises the following step: in the presence of a phenolic compound or a quinone compound, reacting a compound shown as a formula I with maleic anhydride to obtain a compound shown as a formula II. The phenolic compound or the quinone compound is added into the reaction system, so that the side reaction can be effectively inhibited, and the reaction yield is increased. # imgabs0 #

The invention is applicable to the technical field of colorimetric detection, and provides a bisphenol A colorimetric detection method based on copper-based nano enzyme. The copper-based nano-enzyme with laccase-like activity is prepared in an alkaline water phase system through a one-step method by taking low-price natural plant protein-zein as a ligand, divalent soluble copper salt as a metal precursor and hydroxylamine and the like as a reducing agent. The copper-based nano enzyme is superior to natural laccase in the aspects of catalytic activity, substrate affinity and stability, and bisphenol A can be catalyzed to be oxidized to generate quinone compounds; the quinone compound is further subjected to a coupling reaction with 4-aminoantipyrine, and a red product with a remarkable characteristic absorption peak at the wavelength of 510 nm is generated. The quantitative analysis of bisphenol A can be realized by measuring the absorbance of the system at 510nm. The method has the advantages of high sensitivity, low detection cost, simplicity and convenience in operation and the like, and is suitable for rapid detection of bisphenol A in drinking water and environmental water.

This invention discloses a method for iron-catalyzed methylation of quinone compounds, comprising the following steps: in a solvent, using 2-aryl-2-propanols as methylating agents, peroxides as oxidants, iron as catalysts, and amino acids or their derivatives as ligands, oxidizing the C(sp) group of aromatic compounds. 2 The H-bond undergoes methylation to generate methyl-substituted quinone compounds. This invention offers advantages such as readily available, inexpensive, and environmentally friendly catalysts; readily available, inexpensive oxidants that do not generate hazardous waste; mild, stable, and inexpensive methylating agents; mild reaction conditions with high selectivity and high yield; widely available and stable substrates; good compatibility of substrate functional groups and a wide range of substrate applications; compatibility with complex molecules and natural products, enabling effective methylation of quinone compounds. Under optimized reaction conditions, the yield of the target product after separation can reach 80%.

The invention relates to a compound having antibacterial and antifungal properties and the chemical structure of Formula X, and to the synthesis method of said compound. Said compound is a piperazine-substituted quinone compound, and the position and orientation of the molecule within DNA and E. coli DNA gyrase B have been determined by means of molecular simulation.

The present invention provides a method for preparing 1,4-naphthoquinone compounds by selective oxidation of aromatic ketones, which is a new method for catalytic oxidation of aromatic ketones to prepare 1,4-naphthoquinone compounds using copper-based and vanadium-based heterogeneous catalytic materials, belonging to the technical field of fine chemicals. This method uses molecular oxygen as the oxidant, and a heterogeneous copper-based and vanadium-based catalytic material to prepare 1,4-naphthoquinone compounds by liquid-phase selective oxidation of aromatic ketones under mild conditions. The Cu-N-C and V-N-C composite materials used therein are obtained by mixing inorganic metal salts with organic nitrogen-containing compounds to obtain a precursor, and calcining in an inert atmosphere at a temperature of 300-800 °C for 0.5-10 h. The method provided by the present invention uses aromatic ketones as raw materials and molecular oxygen as the oxidant, and the catalytic reaction conditions are mild with few pollutants. It is a new route for preparing 1,4-naphthoquinone compounds, with strong practicability and broad application prospects.

The invention discloses a preparation method of sulfoalkyl (methyl) acrylate, which is characterized in that (methyl) acrylic acid and hydroxyalkyl sulfonic acid are used as raw materials, an acidic resin catalyst is adopted, and the sulfoalkyl (methyl) acrylate is prepared by reaction in the presence of a solvent and a compound polymerization inhibitor, the compound polymerization inhibitor is a combination of a phenolic compound and at least one of the following compounds (A)-(D): (A) a quinone compound; (B) a nitroxide radical compound; (C) an inorganic salt compound; and (D) copper N, N-di-n-butyl dithiocarbamate. By using the method, the polymerization side reaction in the reaction process can be effectively inhibited, and the method has the advantages of short reaction time, simple post-treatment and low content of the hydroxyalkyl sulfonic acid dimer in the product.

The invention relates to the technical field of organic synthesis, in particular to an imidazole epoxy resin curing agent as well as a preparation method and application thereof. The imidazole epoxy resin curing agent is prepared from the following components in parts by weight: 82 to 144 parts of alkyl imidazole, 108 to 198 parts of quinone compound and 229 to 342 parts of solvent. A phenolic compound is connected to an imidazole ring, that is, alkyl imidazole and a quinone compound are subjected to a Michael addition reaction, and alkyl imidazole connected with the phenolic compound is generated. The phenolic hydroxyl group-containing alkyl imidazole curing agent fundamentally solves the problem of separation of an imidazole curing agent and a phenolic polymerization inhibitor.

The invention provides protected ortho-quinone compounds comprising a group represented by:where —Ar— is optionally substituted phenylene,—X is selected from —NH2, —OH and —SH, and the protected forms of each,—W— is optionally substituted methylene, such as methylene, andd is a double or single bond, and the salts and solvates thereof

The invention provides a preparation method of a chiral benzyl borate compound, and belongs to the technical field of preparation of organic compounds, and the preparation method comprises the following steps: mixing a p-methylene benzoquinone compound, bis (pinacolato) diboron, a Bolm chiral ligand, a PS-CS-SiO2 (at) Cu catalytic material and a reaction solvent, stirring, reacting for set time, carrying out reduced pressure suction filtration after the reaction is completed, and drying to obtain the chiral benzyl borate compound. Filtering to obtain filtrate and filter residues; sequentially extracting the filtrate by using ethyl acetate and a saturated saline solution, then drying an organic phase by using anhydrous Na2SO4, carrying out reduced-pressure suction filtration, and carrying out rotary drying to obtain a crude product; and carrying out thin layer chromatography purification on the crude product to obtain the 1, 6-chiral benzyl borate compound. The raw materials used in the invention are cheap and easily available, the synthesis operation steps are simple, the reaction conditions are mild, the obtained 1, 6-chiral benzyl borate compound has high yield and enantioselectivity, and the catalytic material can be biologically degraded and recycled.

The invention discloses a traditional Chinese medicine component content regulation gene of Tabebuia rubra and an identification method thereof. The medicinal component is a flavonoid compound or a quinone compound; wherein the genes for regulating and controlling the content of the flavonoid compounds comprise CDL1206902, CDL1211941, CDL1201396 and nove l.4709, and the genes for regulating and controlling the content of the flavonoid compounds comprise CDL1206902, CDL1211941, CDL1201396 and The gene for regulating and controlling the content of the quinone compounds comprises a CDL1225459 gene, a CDL1208649 gene, a CDL1208581 gene and a CDL1216197 gene. The invention also discloses an identification method of the traditional Chinese medicinal component content regulation gene of the Tabebuia rubra. The gene related to the contents of the flavonoid compounds and the quinones compounds in the Tabebuia chrysantha provided by the invention provides a scientific basis for metabolic regulation and molecular breeding of medicinal components.

The invention belongs to the technical field of deep sea microbial materials, and discloses a perylenequinone compound of Alternaria sp. Xiao20, a derivative of the perylenequinone compound, or a pharmaceutically acceptable salt of the perylenequinone compound, a preparation method of the perylenequinone compound, and an application of the perylenequinone compound and the derivative or the pharmaceutically acceptable salt of the perylenequinone compound in preparation of medicines for preventing and / or treating neuroinflammation diseases. The invention provides a perylenequinone compound or a derivative thereof separated from a fermentation product of alternaria alternata, and the perylenequinone compound or the derivative thereof has important significance on development of marine drugs; the perylenequinone compound or the derivative or the pharmaceutically acceptable salt of the perylenequinone compound disclosed by the invention can be used for inhibiting the release of a neuromicroglia inflammatory factor NO; according to the present invention, the release level of the LPS-induced nerve microglial cell inflammatory factor NO is significantly reduced, the technical effect of neuroinflammation disease treatment is achieved, and the LPS-induced nerve microglial cell inflammatory factor NO can be prepared, such that the LPS-induced nerve microglial cell inflammatory factor NO can be used for preparing the neuroinflammation disease prevention and / or treatment drug, and has important significance on neuroinflammation disease treatment and new drug development.

Provided herein is a method of treating, preventing, or alleviating one or more symptoms of Chagas disease in a subject, comprising administering to the subject: (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof; and (iii) an antiparasitic agent.

The invention relates to the technical field of batteries, in particular to a battery, a battery liquid leakage detection method and a power utilization device. The battery provided by the invention comprises an electrolyte and a shell for packaging the electrolyte, a first reagent is added into the electrolyte, the first reagent comprises a boron compound, the outer surface of the shell is provided with the first reagent, the first reagent comprises an anthraquinone compound, and the chemical general formula of the anthraquinone compound is shown as a formula I in the specification. Based on the fact that an anthraquinone compound can be in contact with a boron compound in an electrolyte and is subjected to a coupling reaction with the boron compound, o-diphenolic hydroxyl of the anthraquinone compound is complexed with boron to generate a fluorescent complex, if liquid leakage exists in the battery, a fluorescent color development peak of the fluorescent complex can be detected through photosensitive detection equipment, and the fluorescent color development peak of the fluorescent complex can be detected through detection equipment. Therefore, whether electrolyte leakage exists or not can be conveniently and sensitively detected.

The invention relates to the technical field of food processing, and discloses a method and a device for quickly oxidizing and coloring star anise. The method comprises the following steps: drying star anise, and performing intermittent irradiation treatment under the conditions of controlled power, temperature and humidity by adopting ultraviolet rays with a specific composite wave band to catalyze phenolic compounds in the star anise to oxidize to generate reddish brown quinone compounds so as to realize coloring. The device comprises a support, an ultraviolet irradiation module, an environment control module and an automatic control module which are arranged in a cabinet body. Through the specific ultraviolet band and process parameters, the reddish brown effect of natural oxidation for 3 months is achieved within 1 month, the conversion efficiency is remarkably improved, the storage period is shortened by 66% or above, and the storage problem that the red conversion period is long after star anise is dried is effectively solved. The method is simple and convenient in process operation and suitable for large-scale processing, and has a positive promotion effect on upgrading of the star anise industry technology.

The present application relates to naphthyl methylene quinone compounds, and preparation method and application thereof, the naphthyl methylene quinone compound has the structural formula of formula I, wherein R1 and R2 are each independently H, C 1‑18 Alkyl or C 1‑18 Cycloalkyl; R3 is H, C 1‑3 Alkyl, C 1‑3 Alkoxy, hydroxyl, nitro or carboxyl.The naphthyl methylene quinone compound of the present application has extended electronic delocalization, which is beneficial to disperse free radicals, makes the structure stable, and plays a role in the termination of free radical reaction chain.The polymerization inhibitor composition containing the naphthyl methylene quinone compound provided by the present application has excellent polymerization inhibition performance, and can be used in the industrial device for inhibiting the polymerization of double bond polymerization monomers.

A cyanobacterial quinone electrolyte preparation method and application. The present application belongs to the technical field of electrolyte preparation. The quinone compound extracted from cyanobacteria is used as the core, the electrolyte has good redox reversibility, can efficiently mediate electron transfer, significantly improves the electrochemical performance of the electrolyte, and the cyanobacterial quinone compound is derived from natural algae, has the advantages of environmental friendliness, good biocompatibility, easy availability of raw materials and low cost, compared with artificial synthetic quinone materials or other natural quinone extracts, the dispersion stability and electrochemical cycle stability in the electrolyte are more outstanding, thereby the working efficiency and service life of the electrolyte adapter device can be greatly improved.

The invention discloses a pharmaceutical composition for resisting NQO1 high-expression malignant tumors and application of the pharmaceutical composition, and relates to the technical field of medicines. When the vitamin K3, the vitamin K4 or the pharmaceutically acceptable salts thereof are combined with the quinone compounds for use, the killing sensitivity of NQO1 high-expression malignant tumor cells to the quinone compounds is obviously enhanced, and an explosive synergistic or synergistic anti-tumor effect is initiated; the killing effect of various quinone compounds on NQO1 high-expression malignant tumor cells is remarkably improved, so that the application dosage of the quinone compounds is reduced to reduce side effects, and the effect of killing NQO1 high-expression tumor cells with low dosage and high efficiency is achieved.

The invention discloses an aluminum ion battery organic positive electrode material and an aluminum ion battery, and the aluminum ion battery organic positive electrode material comprises the following components: an organic active substance which is a covalent organic framework material synthesized by 1, 3, 5-tri (4-formylphenyl) benzene (TFP) and a quinone compound with carbonyl active sites through a solvothermal method, the covalent organic framework material has a porous structure and a pi-pi conjugated skeleton. The covalent organic framework material is used as an organic active substance, the covalent organic framework material has rich carbonyl active sites, carbonyl can be disconnected and coordinated with AlCl2 < + > in the electrolyte in the discharging process, the previous state can be reversibly recovered in the charging process, and therefore the reversible capacity per gram is high. AlCl2 < + > can be rapidly diffused in the positive electrode due to a strong pi-pi conjugated skeleton and a porous structure, so that the positive electrode has rapid charging and discharging capability. The framework structure has low solubility and a more stable structure, so that the material has excellent cycling stability and excellent temperature adaptability.

The invention discloses an anthraquinone compound as well as a preparation method and application thereof in resisting prostatic cancer. The structure of the anthraquinone compound 1 is shown as a formula (I). According to the present invention, the solid fermentation extract product of Aspergillus versicola SCSIO 41323 is subjected to separation and purification so as to obtain the compound Nidurufin (1), wherein the compound Nidurufin (1) is obtained from the solid fermentation extract product of Aspergillus versicola SCSIO 41323; prostate cancer cell activity evaluation finds that the compound 1 can significantly inhibit the activity of prostate cancer cells and inhibit cell proliferation, protein expression of AR, KLK3, MBOAT2 and the like can be significantly inhibited by increasing ROS activity and inducing ferroptosis of prostate cancer cells, and the Nidurfin (1) can inhibit growth of prostate cancer cells in vitro and in vivo, and can inhibit growth of prostate cancer cells in vitro and in vivo. The method is of great significance to development and utilization of deep sea abyssal and other extreme environment source microbial resources.

The present application relates to a kind of methyltransferase that can catalyze anthraquinone compound methylation, amino acid sequence is as shown in SEQ ID NO:2, also provide the application of this methyltransferase in the production of emodin-3-methyl ether and other methylated anthraquinone compounds.The present application digs a new methyltransferase, which can methylate anthraquinone compound, and can convert emodin into emodin-3-methyl ether.The present application constructs the engineering bacteria that can produce emodin-3-methyl ether using the coding gene of the enzyme, widens the methyltransferase library that can be used for emodin methylation, provides new way for emodin-3-methyl ether cell factory construction.

The invention discloses a preparation method of 9,10-phenanthrenequinone compounds, comprising the following steps: using an enaminone compound as shown in a chemical structure formula (I) as a raw material, under a protective gas environment, in the presence of a small molecule catalyst and an oxidant, reacting for 2 to 12 hours at 30 to 90 ° C in an organic solvent to obtain a reaction product, and then purifying the resulting reaction product to obtain a chemical structure formula (II) as shown in 9,10-phenanthrenequinone compounds. The present invention uses an enaminone compound as a raw material, which is a raw material with simple synthesis and high conversion rate, a wide range of substrate applications, low raw material and catalyst costs, low pollution, few reaction byproducts, and has the characteristics of green environmental protection; in addition, the reaction conditions required for the inventive method are very mild, the number of reactions is small, the operation is simple, and the yield is high.

The present disclosure describes fused quinone compounds, and compositions and methods thereof. Such compounds can be useful in treating mitochondrial diseases in a subject, such as a human.

The invention belongs to the technical field of mass spectrometry, and provides a quinone compound online mass spectrometry method based on micro-droplet derivatization. The mass spectrometry method comprises the following steps: introducing a derivatization reagent solution into an ion source I to form micro-droplets I; introducing a quinone compound solution into an ion source II to form micro-droplets II; after the micro-droplet I and the micro-droplet II are fused, a derivatization reagent and a quinone compound are subjected to a conjugate addition reaction to obtain a zwitterionic product; and carrying out mass spectrometry on the zwitterionic product. According to the method, a derivatization reagent triphenylphosphine is adopted, rapid and online derivatization of quinone compounds is achieved through micro-droplet fusion, zwitterionic products are rapidly generated within the time scale of milliseconds, analysis steps are simplified, and derivatization time is shortened; the detection sensitivity of the quinone compounds is remarkably improved by 2-3 orders of magnitude, and a complicated pretreatment step is not needed; the method has universality and is also suitable for detection of low-concentration quinone compounds, and RSD is 3.3-7.3%.