This invention discloses the application of β,β-dimethylacrylshikonin in the prevention and control of nonbacterial
enteritis in carnivorous fish. Through experiments, the applicant discovered that, under the condition of replacing 50% of fishmeal
protein in the feed with
soybean meal protein, the addition of shikonin compounds, shikonin
alcohol extract, or shikonin ultrafine
powder can effectively improve the symptoms of
enteritis in pearl
grouper, increase the average
weight gain rate of pearl
grouper, improve the
antioxidant capacity of pearl
grouper, improve intestinal tissue structure, reduce the transcription levels of pro-
inflammatory factors IL1β and IL8 in the intestine, and simultaneously upregulate the transcription level of anti-inflammatory factor IL10. Therefore, shikonin compounds, shikonin
alcohol extract, or shikonin ultrafine
powder have significant effects on
soybean meal-induced
enteritis in fish and can be used to prepare drugs or feed additives for the treatment or prevention of
soybean meal-induced enteritis in fish.