309 results about "Tyrosinase activity" patented technology

The invention discloses an anti-aging composition containing ergothioneine, glutathione and fish collagen, relates to the technical field of anti-aging compositions, and aims to solve the technical problems that a traditional anti-aging composition lacks attention to the aspects of cell energy metabolism, barrier repair and the like, and the overall skin improvement effect is not obvious. The ergothioneine is used as a natural antioxidant, and the content of the ergothioneine is 0.01-5wt%; the ergothioneine participates in a synergistic effect of an intracellular antioxidant enzyme system, so that tyrosinase activity is effectively inhibited, melanogenesis is reduced, and DNA and protein are protected from oxidation damage; in a simulated strong ultraviolet environment, compared with skin cells not using the ergothioneine-containing product, the content of free radicals in the cells is reduced by 30% after the ergothioneine-containing product is used; the ergothioneine can also regulate a cell signal channel, promote cell metabolism and maintain normal growth of cells. The mask has the advantages of accelerating skin metabolism and improving the self-repairing ability of the skin.

The invention provides application of UBR5 in preparation of drugs for treating pigmented skin diseases, and further the pigmented skin diseases comprise various types of pigmented nevus (mainly congenital pigmented nevus and megalous with the risk of malignant transformation). Various pigmented spots (mainly chloasma, freckles, Taitian nevus, post-inflammation hyperpigmentation and the like) and hypopigmentation / depigmentation spots (mainly leucoderma, post-inflammation hypopigmentation and the like). Experimental results show that UBR5 is highly expressed in disease tissues such as pigmented nevus. The UBR5 expression level and the melanogenesis ability are in significant positive correlation, targeted knockout / knockdown of UBR5 in melanocytes can significantly inhibit the expression level of melanogenesis related genes such as MITF, TRP1, TRP2, TYR and other proteins, the melanin content of melanocytes and tyrosinase activity, vice versa, and the melanogenesis ability of melanocytes after overexpression of UBR5 is significantly increased.

The invention discloses a method for fermenting mulberry leaves through compound probiotics, a mulberry leaf fermentation product and application, and relates to the technical field of fermentation. The fermentation method comprises the following steps: carrying out compound fermentation on mulberry leaves by adopting staphylococcus xylosus and lactobacillus plantarum according to a volume ratio of (1-3): (1-3), wherein the total inoculum size is 2-10% of the volume of a fermentation culture medium; the mulberry leaf fermentation product is prepared by the method. The invention also provides application of the mulberry leaf fermentation product in preparation of whitening cosmetics and / or skin care products. The preparation method has the beneficial effects that the two probiotics including the lactobacillus plantarum and the staphylococcus xylosus are used for performing compound fermentation on the mulberry leaves, and the lactobacillus plantarum and the staphylococcus xylosus can achieve a synergistic effect during compound fermentation of the mulberry leaves, so that active substances for inhibiting tyrosinase in the mulberry leaves can be effectively released; active substances are all retained in the fermentation product, and the inhibition rate of the fermentation product on the tyrosinase activity is remarkably increased.

The invention relates to application of a tea exosome in preparation of a medicine for improving skin pigmentation, the tea exosome is creatively extracted and purified, and the tea exosome can effectively inhibit proliferation of melanoma cells and inhibit expression of melanin generation related protein by scavenging free radicals and inhibiting tyrosinase activity, so that the effect of improving skin pigmentation is achieved. The intracellular melanin removal is promoted. In a mouse in-vivo experiment, after the tea exosome is applied, it is observed that the skin epidermis thickness of a mouse is reduced, the dermis thickness is increased, collagen arrangement is tighter and more ordered, the content is increased, and meanwhile generation of inflammatory factors is reduced. The tea exosome can significantly increase the content of a melanin autophagy key factor LC3B and reduce the content of P62 to promote melanin autophagy, and has good percutaneous infiltration capacity, thereby playing a role in improving skin pigmentation.

The invention provides an application of N-trans-p-coumaroyl tyramine or a derivative thereof in preparation of a skin whitening product, and relates to the technical field of biology, and the application of the N-trans-p-coumaroyl tyramine or the derivative thereof in preparation of cosmetics for skin whitening or drugs for skin whitening is as follows: (I) the N-trans-p-coumaroyl tyramine or the derivative thereof is applied to preparation of cosmetics for skin whitening or drugs for skin whitening; (2) inhibiting melanogenesis in a non-diagnostic and therapeutic manner; (3) preparing a melanin inhibitor; (IV) inhibiting the tyrosinase activity of the subject in a non-diagnostic and therapeutic manner; or (V) preparing the tyrosinase inhibitor. According to the invention, a natural compound N-trans-p-coumaroyl tyramine which is derived from a traditional Chinese medicine and has a whitening effect is found, and a new functional component with a whitening effect is provided for the skin beautifying industry.

The invention relates to the technical field of daily chemicals, in particular to a white tomato whitening and repairing composition as well as a preparation method and application thereof. The composition comprises the following components in percentage by mass: 68-85% of jojoba oil, 10-25% of squalane and the balance of white tomato extract, wherein the total percentage is 100%. The white tomatoes are rich in colorless carotenoids (such as phytoene and tetrahydrolycopene), and have excellent antioxidant and whitening capabilities: melanin formation is inhibited, and the colorless carotenoids can inhibit tyrosinase activity, reduce melanin generation and fundamentally whiten the skin. Pigmentation caused by ultraviolet rays can be relieved through the anti-oxidation effect, and the color spots are prevented and faded. The skin color can be brightened after continuous use, so that the skin presents natural luster.

The invention relates to a tyrosinase antibody for inhibiting tyrosinase and application of the tyrosinase antibody, relates to the technical field of tyrosinase inhibition, and relates to an anti-tyrosinase antibody containing a heavy chain CDR and a light chain CDR with specific sequences or an antigen binding fragment of the antibody. The anti-tyrosinase antibody inhibits tyrosinase activity, and thus it is expected that the anti-tyrosinase antibody can be effectively applied to improvement of skin whitening or treatment of skin pigmentation diseases.

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.

The invention discloses a whitening composition containing PDRN and SOD (superoxide dismutase). The composition comprises a selaginella tamariscina extract, a mulberry root extract, a cystosella rubra extract and a nucleotide protein compound, and the nucleotide protein compound comprises the PDRN and the SOD. The composition obtained by scientific compatibility of the selaginella tamariscina extract, the mulberry root extract, the cystosella rubra extract and the nucleotide protein compound has a remarkable inhibition effect on tyrosinase activity, is safe and efficient, and can be widely applied to the field of cosmetics.

A group of polypeptides, which can be used as a tyrosinase inhibitor. The polypeptides have the effects of inhibiting tyrosinase activity, reducing melanin secretion, resisting oxidation, skin-whitening, spot-removing, etc. The polypeptides can be widely used in antioxidant drugs and in the preparation of skin-whitening cosmetics for resisting melanogenesis and lightening spots as a new raw material, and has good application scenarios.

The invention discloses a tyrosinase inhibitory peptide from kelp as well as a preparation method and application of the tyrosinase inhibitory peptide. The preparation method comprises the following steps: pretreating kelp, fermenting the kelp by using lactobacillus plantarum, carrying out centrifugation, ultrafiltration and component identification on the obtained fermentation liquor to obtain the composition of kelp polypeptide, screening the tyrosinase inhibitory peptide through molecular docking, and finally carrying out solid-phase synthesis to obtain the tyrosinase inhibitory peptide prepared by the invention. The lactobacillus plantarum fermentation technology is simple and feasible, the production cost is low, equipment is easy to obtain, active ingredients in kelp can be released to the maximum extent, and the prepared polypeptide has the effect of inhibiting the activity of tyrosinase and can be used for developing a tyrosinase inhibitor.

The invention discloses a polypeptide with a whitening effect and a preparation method and application thereof.The polypeptide is obtained from hydrolyzed protein of babylonia areolata, the amino acid sequence of the polypeptide is cysteine-arginine-proline-threonine-cysteine-serine-arginine-leucine-alanine-cysteine, and the amino acid sequence of the polypeptide is cysteine-arginine-proline-threonine-cysteine-serine-arginine-leucine-alanine. The compound can obviously inhibit the generation of melanin in cells and the activity of tyrosinase in vitro, has the characteristics of low toxicity, low irritation, good stability, safety and high efficiency, and can be applied to whitening cosmetics.

The invention relates to the technical field of cosmetics, in particular to a composition and application thereof in preparation of whitening skin care products. The composition provided by the invention comprises the kapok extract, the rose extract, the China rose extract and the lotus seed pot extract, and the formed composition has the effect of inhibiting tyrosinase activity. When the extract is added into cosmetics as a cosmetic additive, the generation of melanin is reduced, so that the whitening effect is achieved. Experiments show that the melanin can be remarkably reduced within 14 days after gel containing the composition is smeared.

The invention discloses a whitening active peptide with an effect of inhibiting melanin formation as well as a preparation method and application of the whitening active peptide. The amino acid sequence of the whitening active peptide is as follows: YYYDPWAGK. Whitening activity verification is carried out on the peptide, the relative tyrosinase activity in cells can be remarkably reduced to 164.26 + / -3.03% from 245.52 + / -1.55% by the peptide with the concentration of 200 mu g / mL, and meanwhile, the relative melanin content can be reduced to 130.05 + / -1.23% from 206.65 + / -4.33%. In addition, the peptide not only can significantly reduce the relative tyrosinase activity of zebrafish from 100 + / -0.36% to 60.42 + / -0.73%, but also can reduce the relative melanin content of zebrafish from 100 + / -2.01% to 63.74 + / -2.05%, and lays an important theoretical foundation for the research and application of zebrafish in the fields of functional food, health care products, cosmetics and medicines.

The application discloses a whitening and freckle-removing composition, conditioner, medicine and cosmetic. The whitening and freckle-removing composition comprises broccoli, ganoderma lucidum and inula japonica in the composition; the broccoli comprises broccoli raw materials and / or broccoli extract, the ganoderma lucidum comprises ganoderma lucidum raw materials and / or ganoderma lucidum extract, and the inula japonica comprises inula japonica raw materials and / or inula japonica extract. The application has significant synergistic activity by scientific compounding of the broccoli and the inula japonica, has significant inhibitory effect on tyrosinase activity, can inhibit the expression and function of the rate-limiting enzyme TYR in the melanin synthesis process, has significant whitening and freckle-removing activity, is safe and efficient, and can be applied to various conditioners, medicines and cosmetics.

The invention belongs to the technical field of medicine separation and preparation, and relates to a separation and preparation method and application of non-natural ginsenoside. The method comprises the following steps: extracting and concentrating a saccharomyces cerevisiae engineering bacterium fermentation product sample serving as a raw material to obtain a saponin crude extract I; enriching the saponin crude extract I by adopting macroporous adsorption resin to obtain a saponin crude extract II; and separating by adopting a high-speed counter-current chromatography to obtain a saponin extract III, namely the non-natural ginsenoside. The non-natural ginsenoside is a non-natural ginsenoside 3 [beta]-O-Glc-DM or a non-natural ginsenoside 20 [S]-O-Glc-DM, and the non-natural ginsenoside is a non-natural ginsenoside 3 [beta]-O- The method is simple, convenient and efficient, the prepared non-natural ginsenoside has the effects of reducing the activity of tyrosinase in cells and inhibiting melanogenesis, and a thought is provided for development and application of ginsenoside.

The invention discloses a cosmetic sodium DNA raw material and its whitening and sunscreen application and preparation method, and relates to the field of biotechnology. The invention provides a method for preparing sodium DNA, a cosmetic raw material, comprising using a lysate to lyse fish tissue, wherein the lysate comprises 1-10mol / L EDTA, 1-5mol / L NaCl, 0.1-3mmol / L urea, 0.01-2% sodium N-lauroyl sarcosinate by mass fraction, 0.1-2% Brij30 by mass fraction, 5-15mmol / L sodium citrate and 40-80mmol / L Tris-HCl, and the obtained sodium DNA has a high purity and yield. When sodium DNA is used to prepare cosmetics, it has a good effect of inhibiting tyrosinase activity and a sunscreen effect, and has a strong antioxidant capacity, and has broad application prospects in the field of cosmetics.

The invention relates to a composition with whitening and skin tendering effects, essence lotion and a preparation method and application of the essence lotion, in the composition with the whitening and skin tendering effects, the weight ratio of achillea millefolium extract to hydroxyethyl piperazine ethanesulfonic acid to ormosia henryi bark extract is (0.1-1): (0.5-8): (0.05-0.5). The essence lotion is prepared from the following components in percentage by weight: 0.75 to 6 percent of composition with skin whitening and tendering effects, 3 to 8 percent of emollient, 0.5 to 2 percent of emulsifier, 0.01 to 1 percent of filler, 0.5 to 2 percent of thickener, 0.8 to 1.5 percent of preservative, 0.02 to 0.2 percent of daily essence, 0.1 to 10 percent of skin conditioner, 0.1 to 10 percent of humectant and the balance of deionized water. The main components have a synergistic effect, can effectively regulate and control the information network effect of endothelin and reduce the differentiation, proliferation and the like of melanocytes in the first step of melanin generation by inhibiting the activity of tyrosinase, can promote cell autophagy and effectively metabolize melanin and lipofuscin generated in the skin, and achieves the effects of whitening, whitening, whitening and the like. The skin tendering effect is realized.

The invention discloses a whitening and freckle-removing composition, a conditioner, a medicine and a cosmetic. The whitening and freckle-removing composition is prepared from emblic leafflower fruit, passion fruit and Chinese ladiestresses root and leaf A; the phyllanthus emblica comprises a phyllanthus emblica raw material and / or a phyllanthus emblica extract, and the passion fruit comprises a passion fruit raw material and / or a passion fruit extract. Through scientific compatibility of the Chinese ladiestresses root-ginseng A and the second active component comprising one or more of the emblic leafflower fruit, the passion fruit and the salvia officinalis, the Chinese ladiestresses root-ginseng A has a remarkable inhibition effect on tyrosinase activity, can inhibit expression and functions of rate-limiting enzyme TYR in the melanin synthesis process, has a remarkable whitening and freckle-removing active effect, and has a remarkable whitening and freckle-removing effect. The composition is safe and efficient, and can be applied to various conditioners, medicines and cosmetics.

The invention belongs to the technical field of daily chemical industry, and discloses a carbon quantum dot with a whitening function and a preparation method and application thereof. The preparation method comprises the following steps: uniformly mixing a carbon-containing whitening component, a nitrogen source and water, carrying out hydrothermal reaction, cooling, filtering and dialyzing to obtain the carbon quantum dots with the whitening function. The carbon quantum dots are subjected to high-temperature treatment in the synthesis process, the obtained product has thermal stability and light stability, the problem that traditional whitening components are unstable is solved, and the application scene of whitening cosmetics under the illumination condition is expanded. The quantum dot not only retains the whitening disclosure of a carbon-containing whitening component, but also has the function of absorbing ultraviolet rays, can reduce the generation of skin melanin from two pathways of physically shielding ultraviolet rays and chemically inhibiting tyrosinase activity, and has dual effects; compared with common carbon quantum dots and whitening components which only have a single whitening pathway, melanin generation is more efficiently inhibited. Therefore, the carbon quantum dots can be used for preparing whitening skin care products.

The invention discloses an active peptide with a whitening effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines and cosmetics. The amino acid sequence of the active peptide is shown as SEQ ID No.1-26, the active peptide has a good inhibition effect on melanin synthesis and tyrosinase activity, and the active peptide has whitening activity and application potential as a whitening product, has the advantages of being safe, effective, free of toxic and side effects, good in biocompatibility and the like, and has a wide application prospect.

The invention discloses a tyrosinase inhibitor, a preparation method thereof and application of the tyrosinase inhibitor in preparation of a product for inhibiting tyrosinase activity. Based on the protein structure of the TYR, the TYR inhibitor which is novel in structure and higher in curative effect and selectivity is found by adopting reasonable drug design and structural modification strategies.

The present invention belongs to the field of fermentation engineering, and specifically relates to a yeast and its application in linseed oil fermentation and a linseed hydroponic oil product. The genetically recombinant yeast expresses phenylalanine deaminase, tyrosine deaminase, cinnamic acid hydroxylase, 4-coumaric acid CoA ligase, chalcone synthase, chalcone isomerase, flavonoid 3-hydroxylase and stilbene synthase. The linseed hydroponic oil obtained by fermenting genetically recombinant yeast and linseed oil in the present invention has enhanced stability and is not prone to mutation; and the linseed hydroponic oil has a higher total flavonoid content, better antioxidant activity and tyrosinase inhibition activity than linseed oil.

The application discloses application of a complex containing Dendrobium officinale leaf extract in preparation of a whitening and freckle-removing preparation, and the complex comprises the Dendrobium officinale leaf extract, a Rhizoma Polygonati extract and beta arbutin. After the components of the complex are mixed in a specific ratio and fully combined and synergized, the ability of inhibiting tyrosinase activity can be significantly improved by 300%, 175% and 87% respectively compared with the Dendrobium officinale leaf, the Rhizoma Polygonati and the beta arbutin, the melanin generation in zebra fish within 72 hours can be effectively inhibited, the melanin content can be obviously reduced, the melanin inhibition rate is increased by 394%, 532%, 24.14% and 37.39% respectively compared with the Dendrobium officinale leaf group, the Rhizoma Polygonati group, the beta arbutin group and the Dendrobium officinale leaf-Rhizoma Polygonati group, the Dendrobium officinale leaf-Rhizoma Polygonati complex can obviously improve the melanin inhibition rate in zebra fish, the combination of the two and the beta arbutin can make the melanin inhibition rate reach 98.70%, and the whitening and freckle-removing effect of skin can be greatly enhanced.

The invention provides lactobacillus reuteri Ligh-alpha with whitening and anti-aging activity and related application thereof, and relates to the technical field of microorganisms and application thereof. The Lactobacillus reuteri Ligh-alpha is preserved in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms on January 2, 2024, and the preservation number of the Lactobacillus reuteri Ligh-alpha is CGMCC No. 29488. The lactobacillus reuteri Ligh-alpha provided by the invention can be used for effectively inhibiting the activity of tyrosinase and reducing melanin synthesis; meanwhile, the Ligh-alpha strain also has excellent free radical scavenging ability and relatively high reducing power, shows very strong antioxidant ability, and can tolerate acid-base and cholate environments. Therefore, the Lactobacillus reuteri Ligh-alpha strain has a wide market application prospect in the aspect of preparing products for whitening, resisting oxidation, resisting aging and the like.

The invention discloses a nanometer emulsion based on a citrus extract and a preparation method of the nanometer emulsion. The nano-emulsion takes citrus pectin as a main chain, gallic acid, ascorbic acid-phosphate and oleic acid are sequentially grafted, the oleic acid is lipophilic, the rest is hydrophilic, and the amphiphilic pectin can form the whitening nano-emulsion which can be stably stored for a long time. The natural citrus extract is used for replacing traditional synthetic components, has the anti-oxidation, whitening and anti-inflammatory effects, can reduce the skin sensitivity risk, and conforms to the green beauty makeup trend; meanwhile, the oil phase is anchored by a hydrophobic block, steric hindrance is formed by a hydrophilic block, the stability of the emulsion is remarkably improved, and the shelf life is prolonged to 24 months; phenolic acid and ascorbic acid contained in the traditional Chinese medicine composition can effectively scavenge free radicals, inhibit tyrosinase activity, reduce melanogenesis and reduce release of a proinflammatory factor IL-6; the composition is low in cost, environment-friendly, suitable for the fields of cosmetics and medicines and wide in market prospect.

The present invention relates to a plant composition with whitening and freckle-removing effects and its application, belonging to the technical field of compositions. The plant composition comprises the following raw materials: sea fennel extract, osmanthus extract, barley extract, smooth fruit elm bark extract, black sesame extract, thyme extract, spinach extract and a solvent. The present invention combines sea fennel extract, osmanthus extract and barley extract, starting from a triple whitening mechanism of inhibiting tyrosinase activity, inhibiting melanin formation caused by α-MSH, and inhibiting melanocyte activity, to synergistically improve the whitening effect of the composition. In addition, three freckle-removing plant extracts are added to the formula of the present invention. The smooth fruit elm bark extract is used to reduce freckles, the black sesame extract is used to enhance the cell melanin metabolism ability, and the thyme extract is used to stimulate the growth of new cells. The three make the composition prepared by the present invention achieve a synergistic effect of freckle-removing from three perspectives.

The invention belongs to the technical field of chemical extraction, and particularly relates to a method for one-step extraction of litchi pulp polysaccharide and polyphenol based on a deep-eutectic solvent. A choline chloride-lactic acid system is used for extracting and preparing for a certain period of time through a deep-eutectic solvent, a supernatant obtained through centrifugation is lychee pulp polyphenol, a lychee pulp polysaccharide extracting solution can be obtained by washing precipitates with water for three times, and one-step efficient extraction of polyphenol and polysaccharide is achieved. The LPPP extracted by DES has strong antioxidant ability and tyrosinase activity inhibition ability, which is speculated that the LPPP can effectively inhibit the synthesis of melanin. Therefore, the litchi pulp polyphenol has high biological activity and can be used as a functional additive of food or cosmetics.

The invention discloses a preparation method of prune exosomes and application of the prune exosomes in regulation and control of pigment metabolism and skin cell inflammatory response, and the preparation method comprises the following steps: taking prune, washing, peeling, dicing, juicing, adding a compound enzyme preparation, centrifuging at 2,000 g for 20 min, carrying out trehalose-assisted ultracentrifugation, centrifuging at 12,000 g for 30 min, centrifuging at 40,000 g for 60 min, centrifuging at 120,000 g for 70 min, collecting precipitate PBS, re-suspending, and filtering to obtain the high-purity prune exosomes. It is proved for the first time that the prune exosome dose-dependently inhibits the melanin content and tyrosinase activity in B16F10 melanoma cells, the mRNA expression level of key inflammatory factors TNF-alpha, IL-1beta and IL-6 in TNF-alpha-induced Hacat cells is remarkably reduced, in addition, the inhibition effect of melanin can be amplified through an STAT3 channel by combining the prune exosome with luteolin, and the application of the prune exosome to the preparation of the anti-inflammatory drug is promoted. The polypeptide can be used for preparing a preparation for regulating pigment anabolism and skin-related inflammatory response, and a potential biological application value is exerted.

The invention relates to the technical field of whitening and freckle removing, in particular to light-sensitive whitening and freckle removing essence and a preparation method and application thereof.The light-sensitive whitening and freckle removing essence is prepared from, by mass, 72.07% of water, 6% of butanediol, 3%-5% of X-resveratrol, 3% of tranexamic acid, 2.5% of nicotinamide, 2% of a red removing factor, 1% of panthenol, 1% of an anti-inflammatory agent, 0.5% of an anti-allergy agent, 0.5% of carnosine, 0.5% of p-hydroxyacetophenone, 1% of 1, 2-propylene glycol and the balance 1, 2-propylene glycol. The mask comprises the following components in percentage by weight: 0.5% of 1, 2-hexanediol, 0.2% of carbomer, 0.18% of arginine, 0.05% of sodium hyaluronate, 0.1%-1% of a light stabilizer and 5% of bis-ethylhexyloxyphenol sulfonate. According to the invention, the resveratrol is esterified by methyl propiolate, so that the molecular structure of the resveratrol is optimized, the performance of the resveratrol in the aspect of light stability is enhanced, and the degradation under the illumination condition is reduced; the esterified resveratrol can effectively inhibit tyrosinase activity, regulate melanocyte signal transduction and realize whitening and spot fading effects.