The invention belongs to the technical field of medicines, and particularly relates to a blood nourishing and nerve calming sleep gel composition based on a
plant exosome carrier, a microneedle, a patch and application. The composition comprises a
passiflora caerulea
exosome loaded with
sedative active ingredients, the
angelica sinensis exosome is loaded with blood nourishing and activating active ingredients; and a
gel matrix; the
sedative active component is selected from a
schisandra chinensis extract and / or a
passiflora caerulea extract, and the blood nourishing and activating
active component is selected from an
angelica sinensis extract and / or a
ligusticum wallichii extract. Through a
plant exosome nano-carrier technology, the
transdermal absorption efficiency and stability of
active components are remarkably improved, and three-target-point coordination of calming, blood nourishing and
circadian rhythm regulation is realized. The invention also provides two preparation forms of a microneedle patch and a
storage type sustained release patch, which respectively meet the requirements of quick effect and long-acting maintenance. The
traditional Chinese medicine theory of nourishing blood and tranquilizing mind is combined with the modern nano transdermal technology, and the
traditional Chinese medicine composition can be used for treating blood deficiency type
insomnia and improving
sleep quality, and is high in safety and convenient to use.