106 results about "Anti ageing" patented technology

The invention belongs to the field of skin care products, and particularly relates to an anti-wrinkle and anti-aging composition as well as a preparation method and application thereof, and the anti-wrinkle and anti-aging composition comprises neurotransmitter inhibition peptide, signal peptide, madecassoside, inositol and glycosylglycerol. The neurotransmitter inhibition type peptide is at least three of acetyl hexapeptide-8, arginine / lysine polypeptide, dipeptide diaminobutyrylbenzylamide diacetate and acetyl octapeptide-3, and the signal type peptide is at least two of palmitoyl pentapeptide-4, decapeptide-4 and acetyl tetrapeptide-9. Compared with the prior art, all the components of the anti-wrinkle and anti-aging composition act on different anti-aging pathways and can be matched with one another from multiple aspects of oxidation resistance, inflammation resistance, moisturizing, cell viability enhancement, wrinkle reduction and the like, a more comprehensive and better anti-aging effect is provided, skin aging is comprehensively resisted, the skin is in a more young state, and the anti-wrinkle and anti-aging composition has the advantages that the anti-wrinkle and anti-aging effects are achieved. And the anti-wrinkle and anti-aging composition is small in irritation and good in stability.

The invention discloses a polypeptide with anti-aging and anti-inflammatory activity and application thereof, and belongs to the field of biological medicine. In the prior art, anti-aging components are large in side effect, single in action target, unreasonable in polypeptide substance sequence design, insufficient in stability and difficult to give consideration to anti-aging and anti-inflammatory synergistic effects. The sequence provided by the invention comprises a polypeptide as shown in SEQ ID No.1 and a polypeptide with the homology not lower than 85%, and the polypeptide can be prepared into cosmetics or health care products. The polypeptide provided by the invention can promote collagen synthesis, inhibit inflammatory factors, improve skin aging and inflammation, and also can improve bone quality.

The invention relates to a whitening and anti-aging composition which is characterized by comprising a solvent, a vitamin C derivative and an active agent, and the vitamin C derivative comprises 3-o-ethyl ascorbic acid, ascorbyl glucoside, magnesium ascorbyl phosphate, sodium ascorbyl phosphate and ascorbic acid polypeptide. By the adoption of the technical scheme, the whitening and anti-aging composition and the cosmetic containing the composition are high in stability, good in transdermal absorbability, lasting in effect, mild and capable of whitening skin and resisting aging in a synergistic mode.

The invention discloses cubilose peptide with an anti-aging function and application of the cubilose peptide. The amino acid sequence of the cubilose peptide is TFSLCEICETMVK. The cubilose peptide disclosed by the invention can resist aging, prevent diseases, beautify and protect skin, and improve the immunity of the organism, and has important significance in developing the efficacy of cubilose, improving the economic value of cubilose and expanding the application of the cubilose peptide.

The present application provides a kind of application of the steroid compound in preparation prevention or treatment skin pigmentation related condition or anti-aging related product, the steroid compound is as shown in formula I, and has treatment, lightening and / or alleviating effect on senile plaques, freckles, chloasma and the like caused by pigmentation on the skin of mammal.(I).

Compositions comprising specific tetrapeptides, for use in methods for treating, preventing, minimizing, diminishing or reversing various signs of aging of the skin are provided. The compositions are useful in improving the firmness or elasticity of skin, smoothing of fine-lines or wrinkles, reducing skin pores and hyperpigmentation, and increasing skin thickness, radiance and / or softness.

This invention relates to the field of cosmetics, and more particularly to active oligopeptides and their application in the preparation of anti-aging products. This invention provides an active oligopeptide with anti-aging activity, the amino acid sequence of which is shown in SEQ ID NO:1 and / or SEQ ID NO:4. This invention also provides an active oligopeptide (β1 and β1c) designed based on computational structural biology, targeting the β-Klotho FGF19 / / FGF21 and receptor-binding arm (RBA) region, and optimized for physicochemical properties, for use in skin anti-aging.

The invention belongs to the technical field of cosmetics, and particularly relates to collagen peptide with an anti-aging effect as well as a preparation method and application of the collagen peptide. The amino acid sequence of the collagen peptide is as shown in SEQ ID NO.1, and the nucleotide sequence of the collagen peptide is as shown in SEQ ID NO.2. According to the invention, effective sequences of human III type and XVII type collagen are recombined to construct and express the collagen peptide Sa1, and the collagen peptide Sa1 has obvious antioxidant effect, no cytotoxicity and good safety. The skin care product added with the collagen peptide Sa1 can promote skin collagen absorption and effectively exert the anti-oxidation effect, so that the effects of improving skin elasticity and delaying skin aging are achieved.

The invention discloses an anti-aging composition as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 10 to 50 parts of ergothioneine; 5 to 25 parts of coenzyme Q10; 50 to 150 parts of 3-SL; 50 to 150 parts of collagen tripeptide; 100 to 500 parts of NAD (nicotinamide adenine dinucleotide); and 50 to 150 parts of glutathione. According to the anti-aging composition disclosed by the invention, various functional components such as the ergothioneine, the coenzyme Q10, the 3SL, the collagen tripeptide, the NAD < + > and the glutathione are reasonably proportioned, so that the anti-aging composition shows a remarkable synergistic anti-aging effect in in-vitro and in-vivo experiments. The anti-aging composition can enhance the cell antioxidant capacity, reduce the active oxygen level and promote the expression of collagen I and SIRT1, and compared with a single component or a non-optimized combination, the anti-aging effect is remarkably improved.

This invention provides the application of substances targeting the CYTB-187AA gene and / or protein in the preparation of drugs for delaying aging and / or prolonging lifespan. The research results of this invention indicate that by reducing the expression of CYTB-187AA protein and / or inhibiting its activity, the aging process can be effectively delayed, thereby achieving the goal of extending healthy lifespan or lifespan. The research results of this invention are of great significance for scientific research on aging mechanisms and the development of anti-aging intervention strategies.

The invention provides an anti-aging composition and a skin care product. The anti-aging composition is prepared from components in percentage by mass as follows: 5%-40% of hydroxypropyl tetrahydropyrantriol, 5%-40% of a skin feeling / rheology regulator and 2%-12% of a ternary compound, the ternary complex is prepared from the following raw materials: organic acid, amino acid and saccharides. The anti-aging composition provided by the embodiment of the invention can be used for improving the skin penetration of the hydroxypropyl tetrahydropyrantriol.

This invention belongs to the field of cosmetic technology, specifically relating to a collagen peptide with anti-aging effects, its preparation method, and its application. The amino acid sequence of the collagen peptide is shown in SEQ ID NO.1, and the nucleotide sequence is shown in SEQ ID NO.2. This invention constructs and expresses a collagen peptide Sa1 by recombining the effective sequences of human type III and XVII collagen. This collagen peptide Sa1 exhibits significant antioxidant effects, is non-cytotoxic, and has good safety. Skincare products containing collagen peptide Sa1 can promote the absorption of collagen in the skin, effectively exert antioxidant effects, thereby improving skin elasticity and delaying skin aging.

Cosmetic composition, e.g. an anti-ageing composition, comprising retinyl palmitate (pref. 0.25-0.5 wt.%), Silybum marianum seed oil (pref. 1-3 per cent by weight), betaine (pref. 2-4 weight per cent)

This invention discloses a layered anti-aging composition and its application. It comprises 4-10 parts of *Vigna angularis* fruit extract, 0.01-0.2 parts of soluble collagen, and 10-20 parts of *Fucus vesiculosus* extract, all parts by weight. The composition of this invention employs a layered anti-aging skincare strategy ("layered" generally refers to different skin areas, i.e., "cellular layer-dermis-epidermal layer"). This composition can promote the expression of LOR (lower retinal occlusion) and the relative expression level of TGM5 (epidermis), increase the content of type I procollagen C-terminal peptide and elastin (dermis), enhance mitochondrial activity, and increase ATP content (cellular layer). That is, it works progressively from the epidermis to the dermis to the cellular layer, having a relevant effect on each layer of skin, and possessing the functions of enhancing skin elasticity, firming, anti-aging, and repairing the skin barrier.

The present invention relates to a composition comprising an anti-aging peptide and, more specifically, to an anti-aging cosmetic, food, and pharmaceutical composition comprising the anti-aging peptide. The anti-aging peptide according to the present invention not only exhibits excellent skin permeability, but also demonstrates remarkable antioxidant activity, wrinkle reduction, skin elasticity enhancement, collagenase inhibition, or hyaluronidase inhibition effects, as confirmed experimentally. These findings indicate that the anti-aging peptide of the present invention possesses excellent anti-aging activity and thus can be variously used as a functional material in pharmaceutical, medicinal, cosmetic, and food fields.

The invention relates to an anti-aging composition, and belongs to the field of medicines and health-care product preparations. The composition is a microcapsule assembled by a water-soluble wall material, a first core material, a fat-soluble wall material and a second core material which are sequentially coated from outside to inside, and the first core material comprises beta-nicotinamide mononucleotide (NMN), nicotinamide ribose (NR), ergothioneine and trimethylglycine (TMG); the second core material comprises resveratrol, curcumin, pyrroloquinoline quinone (PQQ) and spermidine, and is dissolved in medium chain triglyceride (MCT oil) containing an antioxidant tocopherol. According to the dosage form, physical isolation and differentiated release of water-soluble and fat-soluble components are realized, and the problems of incompatibility among the components, poor stability, low bioavailability and the like are solved. Through the multi-target synergistic effect, the composition can effectively improve the NAD + level and enhance the mitochondrial function so as to improve the skin state and delay senescence.

The invention belongs to the technical field of anti-aging, and particularly discloses a composition and a preparation method and application thereof in preparation of a product with an anti-aging effect, and the composition comprises the following components in parts by mass: 10-50 parts of SOD yeast powder, 5-30 parts of epigallocatechin gallate, 10-60 parts of pleurotus citrinopileatus concentrated powder and 10-40 parts of emblic leafflower fruit extract. The composition provided by the invention plays a role in anti-aging core pathways such as oxidative stress removal, cell damage repair, metabolism regulation, immune enhancement and the like, and realizes anti-aging synergistic interaction in ways of pathway complementation, target point coordination and function amplification, so that the anti-aging effect is effectively improved.

The application discloses an anti-photoaging skin care product, an oxidation-resistant anti-aging compound and application, and can solve the anti-aging problem of skin. The oxidation-resistant anti-aging compound has a structure shown in formula (1): wherein R is a C1-C18 alkyl chain.

The invention discloses application of an A2aR-GZMK inhibitor in preparation of an anti-aging product, and belongs to the technical field of biological medicines. The invention provides a treatment scheme for delaying brain senescence by targeting GZMK and adenosine-A2aR signal channels so as to improve body senescence for the first time. According to the present invention, the activity of GZMK is specifically inhibited by using a GZMK inhibitor (such as PPACK), and / or the immunosuppression signal of adenosine is blocked by using an adenosine A2a receptor inhibitor (such as Istradex), such that the accumulation and the activation of Gzmk + CD8 T cells in the brain can be effectively reduced, and the senescence-related neuroinflammation can be reduced so as to improve the neuronal function and delay the brain senescence process. And no matter whether the activity of the GZMK is directly inhibited or the expression of the GZMK is indirectly regulated and controlled by targeting an upstream A2a receptor, a solid biological basis and a clinical safety basis are provided.

A peptide complex of the present invention promotes the expression of an SIRT1 gene, which is known as a longevity gene, promotes the expression of an FGF21 gene and increases the phosphorylation of AMPK. In addition, a peptide complex of the present invention exhibits an anti-inflammatory effect. Therefore, the peptide complex of the present invention inhibits aging, promotes the expression of SIRT1 gene, which is a longevity gene, and can be used for treating or preventing SIRT1-related diseases.

The invention provides an application of a lipid peroxidation inhibitor in preparation of an anti-premature senescence syndrome drug or an anti-aging drug. Experiments prove that by adding the lipid peroxidation inhibitor, the cell nucleus morphology of cells can be effectively maintained, the expression of intracellular senescence-related beta-galactosidase is reduced, the senescence characteristic of the cells is delayed, and nuclear membranes and nuclear fiber layers damaged due to Progyrin accumulation are repaired, so that the normal functions of the cell nucleuses are recovered, the activity and functions of the cells are improved, and the anti-aging effect is achieved. Powerful cellular level support is provided for relieving and treating the early senescence syndrome and senescence.

The invention relates to the field of biological medicine, in particular to application of a small molecule compound in preparation of an anti-aging preparation. The invention provides an application of a small molecule compound in preparation of a preparation for treating and / or preventing senescence of a subject, and is characterized in that the small molecule compound comprises quinacrine and / or rimonaban. According to the present invention, both the quinacrine and the rimonabant can provide the anti-aging effect by adjusting the insulin / insulin-like growth factor (ILS) signal channel, such that the quinacrine and the rimonabant can be adopted as the novel insulin / insulin-like growth factor signal channel regulator so as to provide the life prolonging effect on the subject.

The application provides anti-aging use of cromolyn and derivatives thereof. Specifically, the application provides use of cromolyn or a kind of cromolyn N-ethyl-N-phenyl acrylamide derivative in preparation of an anti-aging composition or preparation. The cromolyn and derivatives thereof of the application can prolong the lifespan of nematodes; the derivative JM03 can also significantly prolong the antioxidant stress resistance and osmotic stress resistance of nematodes. Therefore, the cromolyn and derivatives thereof of the application have application prospects in the aspect of anti-aging.

The present invention relates to an anti-aging composition comprising a Polygonum cuspidatum extract, or polydatin and 2-methoxystypandrone compounds, having cellular senescence and metabolic function recovery effects. The extract or compounds restore mitochondrial function in senescent cells, improve energy metabolism, activate the autophagy system, and reduce inflammatory factors while improving wrinkles and enhancing skin elasticity factors, thereby restoring senescent cells to a young cellular state. The extract or compounds can be applied as a senomorphic composition and can be readily used as a multifunctional cosmetic composition, pharmaceutical composition, or nutraceutical for anti-aging purposes.

The invention discloses an anti-aging composition containing ergothioneine and a preparation method of the anti-aging composition, and relates to the technical field of biological medicines and health-care products, the anti-aging composition containing ergothioneine comprises the following components by weight: 0.01-1% of ergothioneine, 0.01-1% of an anti-aging agent, 0.01-1% of an anti-aging agent, 0.01-1% of an anti-aging agent, and the balance of water. 0.09%-4% of a molecular chaperone mediated autophagy (CMA) activating agent; and the balance of pharmaceutically, cosmetically or food acceptable carriers and / or excipients. According to the invention, the frontier problem of mitochondrial autophagy and CMA collaborative decline in cytobiology is taken as a technical breakthrough for the first time, and the designed product mechanism is deeper and is different from mainstream products in the market; according to the invention, mitochondrial autophagy and CMA, which are two key pathways which are correlated with each other and cooperatively decline in an aging process, are targeted at the same time. 2 '' 1 + 1gt, 2 '' synergistic effect is generated by enhancing mitochondrial autophagy through ergothioneine and enhancing CMA compounding through CMA activator specificity, so that vicious circle between the ergothioneine and the CMA activator is broken, and anti-aging is realized from a more essential level of'cell waste '.

The invention belongs to the technical field of bioengineering, and particularly relates to recombinant collagen with an anti-aging effect as well as a preparation method and application of the recombinant collagen. The amino acid sequence of the recombinant collagen is as shown in SEQ ID NO.1, and the nucleotide sequence of the recombinant collagen is as shown in SEQ ID NO.2. According to the present invention, the effective sequences of the human-derived I type collagen, the human-derived III type collagen and the human-derived XVII type collagen are subjected to effective recombination to construct and express the recombinant collagen col1 having the anti-aging effect, and the recombinant collagen col1 has characteristics of significant antioxidant effect and good safety. The skin care product added with the recombinant collagen peptide col1 can promote skin collagen absorption and effectively exert the anti-oxidation effect, so that the effects of improving skin elasticity and delaying skin aging are achieved, and the skin care product has wide application prospects.

The present application relates to an anti-aging composition. Specifically, the present application provides a composition comprising a Paris extract and / or a Panax notoginseng extract. The Paris extract and the Panax notoginseng extract of the present application have excellent anti-aging effects, and the Paris extract and the Panax notoginseng extract have a synergistic effect in terms of anti-aging.

The present invention relates to a novel anti-aging peptide. It has been experimentally identified that the anti-aging peptide according to the present invention has high skin permeability and has remarkable antioxidant activity, reduces skin wrinkles, improves skin elasticity, and inhibits collagenase or hyaluronidase. Therefore, the anti-aging peptide of the present invention has excellent anti-aging activity, and thus can be variously used as a functional material in the fields of pharmaceuticals, medicinal products, cosmetics and food.

The present invention addresses the problem of providing a composition that exhibits the effect of improving skin texture, the effect of promoting skin elasticity, the effect of improving wrinkles, or an anti-aging effect, and a composition exhibiting the effect of promoting collagen expression, the effect of promoting elastin expression, the effect of inhibiting hyaluronidase expression, the effect of promoting hyaluronic acid production, or the effect of inhibiting MMP-1 expression.　The present invention for solving the above problem is a composition for promoting skin elasticity, for improving wrinkles, or for anti-aging, and contains at least one compound selected from the group consisting of compounds represented by formula (I) below and salts thereof. In formula (I), R1, R2, R3, R4, R5, and R6 each independently represent a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a cycloalkyl group, an aryl group, an acyl group, a heteroarylcarbonyl group, an alkoxycarbonyl group, –CHO, –COOH, or –OH.

The invention discloses a skin cell anti-aging composition based on regulation and control of KLF4 / UCP2 multiple pathways and application of the skin cell anti-aging composition. The skin cell anti-aging composition comprises quercetin and L-serine in a specific proportion. The application of the composition comprises various cosmetic or dermatologically acceptable dosage forms. The combination of quercetin and L-serine produces a remarkable synergistic effect, and particularly, the effect of the composition is remarkably superior to that of a single component in the aspects of inhibiting KLF4 expression so as to up-regulate UCP2 expression and eliminating ROS (reactive oxygen species). By inhibiting the expression of KLF4, the expression of UCP2 is efficiently up-regulated, and the mechanism simultaneously intervenes from the two aspects of upstream regulation of signal transduction and material basis of metabolic reaction, so that the effect is more fundamental, and the synergistic effect is remarkable. The generation of mitochondrial ROS is reduced from the source; meanwhile, by supplementing the GSH to synthesize the precursor L-serine, an endogenous anti-oxidation defense network taking the GSH as a core is enhanced, and systematic improvement of the cell anti-oxidation capability is realized.