The invention provides a preparation method for high-activity 
lepidium meyenii extract. The preparation method is characterized by comprising the following steps of: crushing fresh or dry 
lepidium meyenii roots, and performing primary ultrasonic reinforced extraction, primary 
solid-liquid separation and primary low-temperature supernatant concentration under the conditions of certain liquid / 
solid ratio and 20 to 50 DEG C by taking water as a 
solvent; performing secondary ultrasonic reinforced extraction, secondary 
solid-liquid separation and secondary low-temperature supernatant concentration on filter residues under the conditions of certain liquid / solid ratio and 20 to 50 DEG C by using an 
ethanol-water solution; and mixing the two concentrated solutions, and 
drying the mixture at low temperature or quickly to obtain powdery 
lepidium meyenii extract. The preparation method has the characteristics of high speed, high efficiency, completeness of functional component extraction, capability of preventing the damage of heat-sensitive functional components of 
lepidium meyenii, high bioactivity of the extract, low 
energy consumption, low cost and the like. The 
lepidium meyenii extract prepared by the preparation method provided by the invention has the effects of eliminating fatigue, resisting pressure, improving 
immunity, alleviating 
climacteric syndromes, resisting prostatic 
hyperplasia, enhancing 
sexual function, and the like.