185 results about "Prenatal development" patented technology

The present invention relates to prevention of congenital deformations The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events gene expression during prenatal development, post-natal development and during development in the adult organism.

A method of processing a series of images of an embryo to determine estimated timings of developmental events for the embryo, wherein the method comprises: determining feature information for each image, the feature information for each image representing the content of the image; establishing machine learned classifiers for associating each image with a respective likelihood of the image being associated with one or more developmental events based on the feature information for the image; applying the machine learned classifiers to the feature information for each image to determine a respective likelihood of the image being associated with one or more developmental events, and determining estimated timings for the plurality of developmental events for the embryo from the respective likelihoods of the respective images being associated with respective ones of the plurality of developmental events. The method may further comprise determining an indication of a confidence estimate for the timings.

At present, when the poultry egg embryo grows in an incubator, embryos die in batch during growth due to environment factor mutation because the incubator does not have a monitoring system for the growth process so as to cause huge economic loss. The invention designs a set of measuring system for obtaining the fetal movement signal of a living body poultry egg embryo in the incubation period and provides a new method for measuring the fetal movement of the poultry egg embryo with a semi-intrusion method. On the basis of the flow equation of continuity of flow medium hydraulic transmission, the method utilizes a displacement sensor to extract the fetal movement signal of a living body poultry egg embryo in the incubation period (shown in figure one); under the condition that the poultry egg growth is not affected, the invention realizes the monitoring of the whole process of the poultry egg embryo growth in the incubation period. If the heartbeat signal of the living body embryo weakens or is abnormal in the incubation and growth process, the control system of the incubator immediately checks the incubator and correspondingly adjusts the working parameter so as to realize quick hidden danger and fault treatment to enable the incubator to work normally, thus avoiding serious economic loss. The invention of the monitoring system plays an important role in researching hatching egg growth process, increasing poultry hatching rate, sorting and improving the product quality of poultry egg in the biological pharmacy production and has great development prospect.

The invention discloses an embryo division process analysis and pregnancy rate intelligent prediction method and system. The method comprises the following steps: collecting embryo images within D1 toD6 periods; inputting the embryo image into a prokaryotic number prediction network model, a blastomere number prediction network model, a fragment proportion prediction network model, a blastocyst cavity and inner cell mass grade prediction network model and a trophoblast grade prediction network model; calculating and outputting a predicted prokaryotic number, a predicted blastomere number, a predicted fragment proportion, a predicted blastocyst cavity proportion, a predicted intracellular mass grade and a predicted trophoblast grade of the embryo image; and inputting the same into an embryo pregnancy rate state prediction machine learning model to calculate and output an embryo pregnancy rate prediction result. According to the intelligent prediction method and system, the whole embryodevelopment process is monitored, the embryo pregnancy rate is obtained through calculation by means of the comprehensive scoring function, manual intervention is not needed in the prediction process, and doctors can be helped to quickly and accurately judge embryo scores.

A theory has been presented that provides a simplified explanation of a cohesive mechanism of embryological development, hemostasis, coagulation, wound repair and tissue maintenance that operates continuously in the animal body to oppose the effects of stress. The theory endeavors to fit all known facts, and is based on the hypothesis that coagulation Factors VII and VIII are respectively local and systemic stress agents that regulate thrombin activity and synergize each other's effects. Stress Theory may explain the etiologies of several hitherto mysterious disease syndromes, and the stress mechanism lo and may play a more pervasive role in disease than is generally appreciated. The theory offers fresh avenues for research and clinical strategy.

The invention belongs to the technical field of biomedicine, and discloses a deep learning-based chromosome uploidy prediction system and method, terminal and medium, and the method comprises the steps: selecting a part of embryo images in the whole process of embryo development, combining the images into a video as a training data set according to the time sequence, building a video sequence feature network model, training the embryo video, extracting morphological characteristics and dynamic characteristics in the embryo development process; and fusing the embryo video features and the clinical data features of the patient, and training a network according to the fused features to obtain a prediction result. According to the method, a video sequence feature network framework is creatively used, the space-time characteristics in the embryo development process are well obtained, and the extraction of the dynamic characteristics and the morphological characteristics of the embryo cells is effectively completed; the prediction model provided by the invention can automatically complete the prediction of the chromosome uploidy, and no manual intervention exists in the prediction process.

The invention relates to detection and reorganization of a hatching living bird embryo. At present, testing methods of the hatching living bird embryo comprise apexcardiogram (ACG), ballistocardiogram (BCG), electrocardiograph (ECG) and impedance cardiogram (ICG). Because the methods have a variety of defects, a testing system of a weak acoustic signal of the living bird embryo is designed by using the weak acoustic signal sent by the hatching living bird embryo and combining the acoustic theory with the characteristics of a rotational ellipsoid, therefore, the invention solves the problem of recognizing the mode of the living bird embryo. Tests on the weak acoustic signal of the living chick embryo show that: the detection system has the advantages of novel design, simple operation, strong practicability, low cost and remarkable effect, and can not cause any adverse effects on the living chick embryonic development. The invention is also suitable for the mode reorganization and the weak acoustic signal detection of other living bird embryos.

The invention discloses Zuogui pill serum containing active ingredients of Zuogui pill serum metabolic substance groups and a preparation method and application of the Zuogui pill serum. The preparation method includes the steps of (1), mixing medicinal materials for preparing Zuogui pills according to a formulation dosage for preparing the Zuogui pills and performing water extraction so as to obtain water extract; (2), administrating the water extract in animals at a dosage of 10-20 g kg<-1> d<-1> for 7-10 days continuously, once to twice per day, collecting blood after administration, and collecting serum after blood centrifugation so as to obtain the Zuogui pill serum. The Zuogui pill serum is highly rich in glycoside active ingredients and is capable of remarkably increasing an inhibited embryo development rate under intervention of high glucose to promote embryo development.

The present invention relates to a method and system for selecting embryos for in vitro fertilization based on the observed timing and duration of cell cleavage and associated cell morphology, and more particularly to a method for determining embryo quality, the The method includes monitoring an embryo for a period of time, and determining one or more quality criteria for the embryo, wherein the one or more quality criteria are based on when the embryo develops from four blastomeres to eight blastomeres The degree of irregularity in the timing of cell division, and / or based on the determination of the time to cleavage into five blastomere embryos (t5) where t5 is between 48.7 hours and 55.6 hours, and / or based on two time intervals ratio, each of the two time intervals being determined as the duration of the time period between two morphological events in embryonic development from fertilization to eight blastomeres, and based on the one or more mass Standards determine embryo quality.