249results about How to "Avoid survival" patented technology

The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and / or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and / or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.

Methods and compositions for regulating immunity are disclosed. For enhancing an immune response, agents that inhibit OX-2 are administered. Such methods are useful in treating cancer. For suppressing an immune response, an OX-2 protein or a nucleic acid encoding an OX-2 protein is administered. Such methods are useful in preventing graft rejection, fetal loss, autoimmune disease, allergies and in inducing tumor cell growth.

This invention relates to methods for promoting neuronal survival and regeneration using LINGO-1 antagonists and TrkB agonists. Additionally, the invention relates to methods for treating pressure induced optic neuropathies using LINGO-1 antagonists. The invention also relates generally to methods for increasing TrkB activity and inhibiting JNK pathway signaling using a LINGO-1 antagonist.

The present invention generally offers a system and a method that allows a vessel to treat water while providing corrosion inhibition. A nitrogen source produces nitrogen gas that may be pumped directly to, preferably but optionally, a venturi injector, or may first be pumped into an empty tank and then delivered to the injector means. Water being pumped through the injector via a transfer piping means comes into contact with the nitrogen, and dissolved oxygen in the water transfers to micro-fine nitrogen bubbles generated by the injector. The water and the micro-fine bubbles are pumped from the injector and into the tank, where the micro-fine bubbles float to the surface, and the oxygen is released into the tank's headspace. The deoxygenated water may be re-circulated through the system for additional deoxygenation or released from the tank into the surrounding waterways.

The present invention relates to chimeric molecules comprising an oligonucleotide complementary to a region of the ribonucleotide component of telomerase attached to an activator of RNase L ("activator-antisense complex") which specifically cleaves the ribonucleotide portion of a telomerase enzyme. The present invention relates to methods of inhibiting telomerase enzymatic activity with activator-antisense complexes targeted to the RNA component of telomerase. The present invention further relates to methods of treating malignant neoplastic disease, wherein the malignant cells contain a telomerase activity that is necessary for the growth of the malignant cells.

As described below, the present invention provides methods and compositions for controlling a honey bee parasitic mite. In addition, the invention features compositions useful for the treatment or prevention of a parasitic mite infestation in a honey bee hive.

The invention discloses an antibiotic door and window section, which comprises the following parts: 100g polychloroethylene, 4-12g polyethylene chloride, 4-7g impact ACR, 0.8-2.4gmanufactured ACR, 2.8-6g organic tin stalizier, 4-6g titanium oxide, 15-30g lightweight calcium carbonate, 0.2-0.7g stearic acid, 0.1-0.g polyethylene wax oxide, 0.2-1g phthalate ester coupler, 0.3-0.7g benzophenone optical stabilizer, 0.01-0.05g bisphenol A anti-oxidant, 0.02-0.1g fluorescent brightener, 0.001-0.003g titanium blue and 1-2g silver ion antibacterial agent.

The present invention generally offers a system and a method that allows a vessel to treat water while providing corrosion inhibition. An oxygen stripping gas source produces oxygen stripping gas that may be pumped directly to, preferably but optional a venturi injector, or may first be pumped into an empty tank and then delivered to the injector means. Water being pumped through the injector via a transfer piping means comes into contact with the oxygen stripping gas, and dissolved oxygen in the water transfers to micro-fine stripping gas bubbles generated by the injector. The water and the micro-fine bubbles are pumped from the injector and into the tank, where the micro-fine bubbles float to the surface, and the oxygen is released into the tank's headspace. The deoxygenated water may be re-circulated through the system for additional deoxygenation or released from the tank into the surrounding waterways.

The invention relates to the technical field of agriculture, and provides an orchard grass intercropping method. The method comprises the following steps: zones are divided, wherein grass is planted between orchard lines, and straws are laid within a range of 0.5m from tree trunks; plowing is carried out, wherein an EM inoculant is spread to grass planting zone soil, and plowing is carried out after 20-30 days; seed soaking is carried out, wherein grass seeds are soaked with the EM inoculant for 4-12h, and are air-dried at a shaded and ventilated place; sowing is carried out, wherein a sprinkler irrigation treatment is carried out with a diluted composite bacterial fertilizer, and uniform sowing is carried out with a sowing amount of 12-15kg / Mu when the soil is moist; management is carried out, wherein watering is carried out after sowing, and sprinkler irrigation is carried out with a diluted EM inoculant when seedlings uniformly shoot; and maintenance is carried out, wherein a grass height is maintained at 10-20cm, and a mixture of trimmed-off grass and straws is laid within a range of a tree base. The method has water-retaining, fertilizer-retaining and drought-resisting functions. With the method, farm chemical is not applied, and the effect of green manure is good. Chemical fertilizer is saved, and disease degree can be reduced from the source. Soil salinization can be effectively ameliorated, and fruits can be green and organic.

As described below, the present invention provides methods and compositions for controlling a honey bee parasitic mite. In addition, the invention features compositions useful for the treatment or prevention of a parasitic mite infestation in a honey bee hive.

A compound Cu(DDC)2 with relatively high tumor-inhibiting activity can be used for treating cancers such as melanoma, breast cancer, lung cancer, liver cancer, and the like. The treatment effect is broad, and the compound has certain selective killing effect against tumor cells. The invention relates to an Cu(DDC)2 injection protein nano-particle preparation used for treating tumor, and a preparation method thereof. Therefore, problems of poor water-solubility and difficulty in intravenous administration of Cu(DDC)2 are solved. According to the invention, with an ultrasonic method, a high-pressure homogenization method, and a micro-jet method, the Cu(DDC)2 injection protein nano-particles are prepared. The Cu(DDC)2 protein nano-particles are prepared from the components that (Cu(DDC)2 + organic solvent) :(protein + water) = 1:2-1:30, wherein the specification of Cu(DDC)2 is 0.01-5mg / mL, the specification of protein is 0.05-25% (w / v), and a ratio of organic solvent to water is 1:2-1:30. Proteins such as human serum albumin (HSA), bovine serum albumin (BSA), hydrophobic protein, glycoprotein, and lipoprotein or polypeptide is adopted as a carrier and a stabilizer for coating medicine particles, such that the particles have good biocompatibility and high security. Cu(DDC)2 tumor-inhibiting treatment effect is improved, and adverse reaction is reduced.

The invention relates to a medicament in combination of a disulfiram preparation and copper, having an anti-tumor function. The combination of disulfiram and copper in the invention plays a role in treating tumor cells, belonging to the technical field of medicaments. The anti-tumor combination medicament comprises disulfiram or derivatives thereof and copper and any one or more optional medicinal vectors, which are used simultaneously, respectively or sequentially; the dosage of the disulfiram in each single medicament ranges from 2 to 200 mg / kg or equals to the equivalent dosage of disulfiram derivatives; and the copper comprises micro copper ions contained in the human body and other absorbable forms of copper irons, wherein the dosage of the copper in each single medicament is 0.1-5 mg per day. The combination medicament disclosed by the invention has remarkable effect in treating tumors and reduced toxic and side effects.

Described herein is the use of CDK inhibitors such as roscovitine for inducing apoptosis of granulocytes, for example neutrophils. Their use for treating inflammatory diseases is also provided.

The invention discloses plastic powder releasing negative ions. The powder contains the following components in parts by weight: 20-50 parts of polyester resin, 20-50 parts of epoxy resin, 15-45 parts of titanium dioxide, 5-15 parts of filler, 1-5 parts of auxiliaries and 0.5-10 parts of negative ion additive. A manufacturing method of the negative ion powder is performed according to the following steps of: a) adding 20-50 parts of polyester resin, 20-50 parts of epoxy resin, 15-45 parts of titanium dioxide, 5-15 parts of filler, 1-5 parts of auxiliaries and 0.5-10 parts of negative ion additive into a stirrer and uniformly mixing; b) placing the mixed raw materials which are uniformly stirred into an extrusion machine together, and performing hot extrusion at the temperature of 80-100 DEG C; and c) crushing a mixed negative ion material which is molded by extrusion, and screening by a 200-mesh screen. The plastic powder releasing the negative ions, disclosed by the invention, has the advantages of cleanness, full-automatic spray-coating, easiness in recovery and the like, can be used for quickly manufacturing negative ion household electrical appliances, automobiles and other devices, and can improve the housing and living environment and simultaneously realize the function of preventing the living of bacteria and mildew. The manufacturing method disclosed by the invention is simple, and the process is easy to operate.

The invention relates to a method for raising the insect resistance of plants. The invention provides target genes from insects, a construct is designed based on nucleic acid sequences of the target genes and interfering RNA molecules which interfere target gene expression are formed in the plants, after the plants are eaten by insects, the expression of related genes can be inhibited and is less or not affected by the digestive system in insects and other barriers. The method of the invention can raise the insect resistance of plants, reduce the usage of pesticides, reduce the agricultural production cost, and preserve the ecological environment.

The invention discloses a lubricating oil heating and stirring device capable of being automatically cleaned on the basis of large equipment, and relates to the technical field of automobile accessoryproduction. The device comprises a box, and a stirring bin and a machine bin are sequentially arranged in the box from top to bottom; a guide column is fixedly arranged on the left side of the stirring bin, and a screw rod is rotationally connected to the top of the right side of the stirring bin; the bottom of the screw rod penetrates through the bottom of the stirring bin and extends into the machine bin, and the bottom of the screw rod is rotationally connected with the bottom of the machine bin; a first bevel gear is fixedly arranged on the surface of the screw rod and located in the machine bin. According to the lubricating oil heating and stirring device capable of being automatically cleaned on the basis of the large equipment, a high-pressure pipe can be moved up and down throughthe screw rod, a high-pressure sprayer can spray out chemicals at a high speed, and the inner wall of the stirring bin and spiral stirring blades can be flushed; oil stains on the inner wall can be scraped by a scraping plate, the inner wall can be kept clean, and the situation that residual lubricating oil in the box is not cleaned up for a long time and goes bad and accordingly product next timeis affected is avoided; the device is easy to operate and saves time and labor..

The invention discloses a production method, a using method and production equipment of high-activity nonreactive feed. Raw materials of the feed comprise a concentrate feed raw material and a companion feed raw material. The feed is obtained through fermentation by adopting a reasonable raw material formula and a proportion thereof; the produced fermentation feed has low cost, is good for marketcirculation, also does not contain any harmful additive agent which affects the health of human beings, and has higher utilization ratio by adopting the specific proportion when the feed is used for raising pigs; harmful substances in intestinal canals of animals are absorbed and utilized by beneficial fungi, comprehensive nutritious substance can be provided for animals, and the balance of microbiota in the gastrointestinal tract of piglets is regulated, which plays roles of diarrhea prevention as well as harmful fungi inhibition and killing in the intestinal canal; the immunity of animals is strengthened; the occurrence of disease is reduced; and the cultivation cost is lowered, thus healthy and safe animal products are produced to protect the health of human beings.

The tensile stress applied to a hardening resin should be sufficiently small so that no disconnection is caused in a hardening resin formed in a spool by hardening of a molding material and sufficiently large so that the hardening resin formed in the spool can be separated from the internal surface of the spool by the reduction of the diameter of the cross sectional area. For this, a runner stripper plate holding the hardening resin is separated from a nozzle and a spool bush. This state is maintained for a predetermined time to separate the hardening resin from the internal circumferential surface of the spool.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of pancreatic cancer cells and be used as a pharmaceutical composition to inhibit the pancreatic tumor growth.

As described below, the present invention features methods and compositions for controlling a honey bee parasitic mite or for the treatment or prevention of a parasitic mite infestation in a honey bee hive. In particular embodiments, the invention provides a miticidal delivery device, wherein the device is a strip comprising at least about 15% potassium salts of hop beta acids, solvent and an emulsifier.

The invention relates to enterohaemorrhagic escherichia coli phage and an application thereof. The enterohaemorrhagic escherichia coli phage is characterized in that the preservation number of a phage strain is CCTCC NO:M 2016539, and the phage strain is preserved at the China Center for Type Culture Collection at Wuhan university in China on September 29, 2016, and is classified and named asenterohaemorrhagic coliphage vB-ECM-MIE, entero-haemorrhagic-Escherichia-coli-O157:H7 phage vB-ECM-MIE. The enterohaemorrhagic escherichia coli phage has efficient sterilization capacity on EHEC.

The invention relates to an organic and inorganic compound fertilizer, which is characterized by being prepared by the steps of: adding chemical fertilizer into an organic raw material, mixing and then granulating by adopting opposite roller extrusion at low temperature (60-65 DEG C), spraying slurry to encapsulate the granules by amino acid; and implanting a microbial agent to the encapsulation film according to 6-8 hundred million of bacteria per gram, wherein the microbial agent comprises plant growth promoting bacteria, bacilli and actinomycetes. The organic and inorganic compound fertilizer provided by the invention integrates organic fertilizer, the chemical fertilizer and microorganism into one and has advantages of strong fertility, durable fertilizer, high fertilizer utilization rate, capabilities of repairing and improving soil structure, enriching organic substances of soil, improving crop quality and increasing output and the like.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of gastric cancer cells and be used as a pharmaceutical composition to inhibit the gastric tumor growth.

The invention relates to a disulfiram lipid microsphere preparation for injection for treat tumor and a preparation method thereof, belonging to the field of pharmaceutical preparations. The disulfiram lipid microsphere preparation is prepared from the following components in mass percent: 0.1-4% of disulfiram or derivatives thereof, 5-30% of vegetable oil, 0.6-3% of lecithin, 0-4% of polyethylene glycol phospholipid or derivatives thereof, 0-4% of amino acid block copolymer, 0-0.6% of oleic acid or oleate, 0-1% of antioxidant, 0-0.4% of complexing agent, 1-3% of glycerol and balance of water for injection. According to the invention, due to the introduction of the polyethylene glycol phospholipid or derivatives thereof and the amino acid block copolymer, a fat emulsion can be kept in the blood for a longer time, an additional passive target function on tumor is provided for the medicament, the stability of the fat emulsion preparation is improved, and the effect of disulfiram on treating tumor is enhanced.

The invention discloses a separated escherichia coli bacteriophage and the application of the escherichia coli bacteriophage in food and anti-infection as a biocide. The separated bacteriophage monomer (escherichia coli phage, the Latin name is escherichia coli bacteriophage) is named as BPH-EC-5 and has broad-spectrum bactericidal effect to escherichia coli. The bacteriophage BPH-EC-5 is preserved in China general microbiological culture collection center (CGMCC) (the address is: Institute of microbiology, Chinese academy of sciences, Datun Road, Chaoyang District, Beijing), the collection date is November 13, 2007 and the collection number is 2253.

The invention discloses a water-based epoxy terrace coating capable of releasing negative ions and a preparation method for the water-based epoxy terrace coating. The coating is a double-component emulsion coating and consists of a component A and a component B, wherein the component A comprises water-based epoxy resin emulsion, deionized water, a wetting dispersing agent, a defoaming agent, titanium white, a negative ion additive, quartz powder, precipitated barium sulphate, a thickening agent, a substrate wetting agent and water-based color paste; and the component B comprises a water-based epoxy hardener and the deionized water. Besides the advantages of the ordinary water-based epoxy terrace coating, the prepared water-based epoxy terrace coating has the functions of releasing the negative ions and emitting far infrared, can decompose and remove harmful gases such as methyl aldehyde and the like in air quickly and inhibit the survival of mycetes, and is long in valid period of construction and convenient to construct.

The present invention relates to treating a hematologic cancer using a Hypoxia- Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.