80 results about "Female Reproductive Tract" patented technology

Provided is a pharmaceutical composition for permeabilizing fetal membranes including an active ingredient having a log K in the range of 2 to 4, where K is the octanol/water partition coefficient. The active ingredient may be, for example, bupivacaine, sodium lauryl sulfate or oleic acid. Further provided is a system for transfetal membrane transport. The system includes a probe unit adapted for insertion into a female reproductive tract and releasing a substance onto fetal membranes that permeabilizes the membranes. The system is also configured to apply ultrasound radiation to the fetal membranes to further increase the membrane permeability.

The invention belongs to the field of probiotics and relates to Lactobacillus crispatus SQ1505. The Lactobacillus crispatus SQ1505 has great performances of acid and hydrogen peroxide production and biofilm formation, has an adhesion effect on human vaginal epithelial cells and an antibacterial effect on vaginal pathogenic bacteria, can be used for prevention and treatment of vaginitis and is a new-generation probiotic capable of replacing antibiotics for preventing and treating female reproductive tract infections.

Instead of immersing human reproductive cells in a single culture medium throughout the various procedures used in IVF, a process is provided by which the reproductive cells may be moved through a sequence of distinct culture media as the various IVF procedures are carried out. In one implementation, the culture media specifically formulated to provide a physical environment similar to that found within the female reproductive tract and conducive to growth and development of human reproductive cells during the various stages of the IVF process. In this regard, specifically formulated culture media can be applied to support the reproductive cells in one or more of the following procedures: oocyte retrieval and handling; oocyte maturation; ordinary fertilization; oocyte, zygote and embryo examination and biopsy; embryonic development to the eight-cell stage; embryonic development to the blastocyst stage; embryo transfer; and cryopreservation.

The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post-menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor Modulator, and/or a recombinant commensal bacterium that expresses endogenous microbicides into the intestinal tract or reproductive tract of a subject. It also provides methods for boosting innate and adaptive immunity by providing a glucocorticoid. Methods for preventing sexually transmitted infections including HIV infection are also provided.

The present invention discloses a female reproductive tract microecology evaluation and detection system. The system includes a full-automatic intelligent stainer, a vaginitis automatic detection workstation, a morphology full-automatic microscopic detection platform, a computer, an input device and an output device. The full-automatic intelligent stainer is used for automatic staining on a sample of vaginal secretions; the vaginitis automatic detection workstation is used for biochemical detection on preformed enzymes and metabolites in the vaginal secretions to obtain the functional assessment result data; the morphology full-automatic microscopic detection platform is connected to the computer and used for the detection of a smear formed after staining by the full- automatic intelligent stainer, and the morphology full-automatic microscopic detection platform detects and analyzes the visible components in the vaginal secretions to obtain morphological pattern data; the computer is used for controlling the full-automatic intelligent stainer, the vaginitis automatic detection workstation, the morphology full-automatic microscopic detection platform, the input device and the output device; the computer is equipped with application software and pathological knowledge base; and the input device is connected to the computer.

Described herein are cell culture media, kits and methods for preparing cell culture media, and methods for culturing cells, for example, cells of the female reproductive tract, and tumor cells.

The invention discloses an application of polypeptide in preparing preparations for preventing and treating human papilloma virus infection, and belongs to the field of infectious disease treatment. Apolypeptide preparation for preventing and treating human papilloma virus infection is also provided; and the polypeptide preparation takes the polypeptide with effective dose as active ingredients and is prepared by adding pharmaceutically acceptable subsidiary materials or auxiliary components. The polypeptide can be used for the treatment and prevention of human papilloma virus infection, so that the polypeptide is significant in effect; and the polypeptide has no inhibition effects on the normal flora of female genital tracts, so that the polypeptide is good in safety.

The invention relates to a female genital tract pathogen identification method based on morphology and a YOLO algorithm. For the problems of pathogenic bacteria species identification, cell viabilityinspection and the like under a domestic microscope, the invention provides an accurate, rapid and intelligent diagnosis mode by taking out a suspected target through a darknet-53 network model and aYOLO algorithm and then matching with a traditional morphological algorithm for screening. The detection speed of the YOLO algorithm is hundreds of times higher than that of a traditional algorithm, the efficient requirement of medical diagnosis can be met, then a morphological algorithm is added to carry out shape fitting on a target, dimensions such as color values, contours and sizes are judged, and therefore the detection accuracy and the detection rate are further improved.

Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and extending the lifespan of sperm in the female reproductive tract, by adding PEG to the surface of the sperm are provided. Such methods may be used in artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates.

The invention discloses a subacid electrolyzed oxidizing water gynecological anti-infection treatment facility. The subacid electrolyzed oxidizing water gynecological anti-infection treatment facility comprises a controller, a treatment contact component, a subacid electrolyzed oxidizing water generation device and an atomization assembly; a water pressure reducing valve is additionally arranged on the subacid electrolyzed oxidizing water generation device on the basis of original oxidation reduction potential water so as to control the water inlet flow, a brine pump is additionally arranged so as to adjust the circulation stroke frequency, and therefore subacid water with the PH value ranging from 3.5 to 5.5, the oxidation reduction potential (ORP) ranging from +800 mV to +1000 mV and the available chlorine content ranging from 80 mg/L to 150 mg/L is generated; and then the atomization assembly and the treatment contact component are additionally arranged so as to meet the requirements of female genital tract anti-infection treatment. The application limit that a traditional subacid electrolyzed oxidizing water generation device is only used in the disinfection field is overcome, and a new gynecological anti-infection physical treatment scheme which is wide in antibacterial spectrum, rapid in sterilization, non-toxic and free of stimulation, is favorable for maintaining a genital tract acid environment, and is favorable for genital tract micro-ecological environment reconstruction is provided for clinic.

This invention relates to an intravaginal fertility plug, for use by both humans and animals, constructed from regions consisting of impermeable and permeable, polymeric film membrane covering, completely or partially, an elastically deformable and compressible interior, which, because of pressure from the vaginal walls on the unit (forming a seal), can be used to promote fertility by temporarily sealing in semen in the female reproductive tract. A lubricant can be used with the intravaginal fertility plug to facilitate insertion into and removal from the vagina; the lubricant would enhance the seal formed between the unit's surface and the vaginal wall and may contain medication itself. The intravaginal fertility plug, not intended for overly prolonged use in the vaginal should be one-time use, and can, upon removal, be discarded.

The invention discloses a female reproductive tract cell pathological intelligent classification method, which is implemented on the basis of a convolutional neural network, and which specifically comprises the following steps: constructing a female reproductive tract cell intelligent classification convolution neural network model; obtaining training samples, which are images of multiple kinds offemale reproductive tract cells; labeling the target cells in the images of all female reproductive tract cells; pre-processing the tagged image of female reproductive tract cells; inputting the pre-processed images of female reproductive tract cells into the intelligent classification and convolutional neural network model, inputting the images of female reproductive tract cells to be detected into the intelligent classification and the convolutional neural network model of female reproductive tract cells after training, and obtaining the classification and judgment results. The invention can realize the yin and yang judgment of various cells of female reproductive tract and the classification of specific pathological changes of positive female reproductive tract cells, realize automaticidentification and classification, and achieve the purpose of intelligent diagnosis.

The diagnosis of male infertility is based predominantly on the results of standard semen analysis for concentration, total motility, progressive motility, volume, pH, viscosity and/or morphology. When sperm enter the female reproductive tract, they must undergo a series of physiological changes, known as capacitation, in order to fertilize an egg. This process involves plasma membrane changes that occur in response to stimuli within the female tract. These changes include removal of sterols and redistribution of the ganglioside G_M1. Semen analysis identifies only half the cases of male infertility due to standard semen analysis providing little information on sperm functional competence. Previous data demonstrated that localization of the ganglioside, G_M1, identifies sub-populations of sperm capable of undergoing the functional maturation process known as capacitation and tracks strongly with fertility.

The invention discloses a compound essence oil genital care lotion for women. The lotion is characterized by comprising the following ingredients: 5-20 parts of camomile essence oil, 10-70 parts of eucalyptus essence oil and 10-70 parts of tea essence oil, and also comprising 10-60 parts of finger citron essence oil. The total parts of above ingredients are 100%. The function of each ingredient is exerted, and meanwhile, the ingredients have synergic effect, so that the effect of the lotion product is improved. The product is mild, has no irritation and good sterilizing effect, and is suitable for daily genital care. Besides, the product has refreshing smell and elegant fragrance, has pressure-relieving and tranquilizing effects, and is beneficial to maintaining acid-alkali balance in genital meatus.

The invention relates to the dominance evaluation of ecological communities at the community level and species level, and mainly invents a concept and a method capable of comprehensively evaluating the dominance at the community level and species level. The concept and the method are used to monitor endangered species in macro-ecological communities and to diagnose and predict the risk of human flora-related diseases in microbial communities. The inventor defines a dominance index at the community level, a species dominance distance at the species level and a species dominance index. The threeindexes are defined by a unified mathematical concept and method, and can be used to evaluate the dominance of various biological/ecological communities (including macro-ecological communities (suchas tropical rainforests) and human microbial communities) in various time and/or space scales. In the specification, the microbial flora (community) in the female reproductive tract is taken as an example, and the dominance index is used to study the dominance change of the community in the time scale and the dominance of each species in the community and identify the difference in dominance of the same species in different communities (in the space scale).

The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissue engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.

The invention discloses compound probiotic bacteria, a fungicide and application of the compound probiotic bacteria in preparation of the fungicide for preventing and treating candida albicans vaginitis. The compound probiotic bacteria contains Lactobacillus plantarum SD-H9, Lactobacillus reuteri WX-94 and Lactobacillus rhamnosus SD-L8 which are preserved in China General Microbiological Culture Collection Center (CGMCC) and respectively have the preservation numbers of CGMCC NO.16649, CGMCC NO.15062 and CGMCC NO.16650. The compound probiotic bacteria fungicide contains the following components in parts by mass: 80-90 parts of the compound probiotic bacteria, 6-8 parts of isomalto-oligosaccharide and 0.5-1 part of cyclodextrin. The compound probiotic bacteria and the compound probiotic bacteria fungicide provided by the invention are capable of effectively reducing inflammatory reaction and relieving and improving symptoms of the candida albicans vaginitis and have great application and development prospects in prevention and treatment of female reproductive tract infectious diseases such as the candida albicans vaginitis.

The invention discloses a micromanipulation dish and a sperm selection method for preferred sperms. The micromanipulation dish for the preferred sperms comprises a dish pan and a dish cover; concave sample pool and selection passageways are arranged on an upper surface of the dish pan, wherein the selection passageways comprise a first passageway, a second passageway and third passageways; the sample pool is connected with a midpoint of the second passageway via the first passageway; a plurality of induction chambers are separately arranged on the two sides of the midpoint of the second passageway; the upper surface of the dish pan is further divided into a sperm collection area, a sperm braking area and a micro-injection area; two ends of the second passageway are respectively connected with the sperm collection area via the third passageways which slope upwards; and the sperm braking area and the micro-injection area are arranged close to the micro-injection area. Being utilized, themicromanipulation dish for the preferred sperms is capable of simulating motion trajectory of sperm in female genital tracts, as well as adsorption of apoptotic sperms by connexin V and regulation ofprogesterone on sperm functions, so that, selected preferred sperms can be immediately used for intracytoplasmic sperm microinjection, thereby beneficially improving fertilization rate of in vitro fertilization.

The invention belongs to the field of human reproductive health, and relates to reproductive protective agent facilitating human fertilization. The reproductive protective agent is divided into three independent formulas, and is used sequentially before, during and after having sex. The three formulas of the reproductive protective agent have different functions, can not only protect the integrity of vaginal mucosa of women, reduce the friction resistance and the mechanical damage to the male genitalia and the female reproductive tract caused by friction when being used together, but also can significantly increase the number of the left female reproductive tract local sperms, prolong the survival time of the sperms, enhance the movement activity of the sperms and protect the activity of the sperms so that the sperms are not killed by various local reproductive tract harmful factors, so as to achieve the purpose of improving the success rate of single fertilization.

A device and method for the collection of sterile specimen samples from the uterus is presented. Also presented is a method of delivering nano-encapsulated drugs to the female reproductive tract to treat pelvic inflammatory disease. The device generally is comprised of an outer cannula over which a cover is provided. A sampler may be positioned within the cannula so that when the sampler is advanced through the cannula, the sampler exits an orifice at one end of the cannula and pierces the cover causing it to retract. In use, the device is positioned within the vagina and once correctly positioned, the sampler is advanced thus piercing the cover and allowing an uncontaminated sample to be taken from the uterus or a drug to be delivered directly into the uterus.

The invention provides female genital tract repair gel containing compound enzyme. The repair gel is prepared from raw materials in parts by mass as follows: antioxidant enzyme, lysozyme, chlorhexidine acetate, triethanolamine, glycerin and Carbopol. The invention further provides a preparation method of the repair gel. The preparation method comprises steps of material preparation, emulsificationand gel formation. The main components of the female genital tract repair gel comprise antioxidant enzyme, lysozyme, chlorhexidine acetate and the like, are pure bio-enzyme components, contain no hormones or antibiotics and are safe and free of side effects; the female genital tract repair gel is applicable to daily usual care of females, and has bacteriostatic and cleaning effects and functionsof removing odor, relieving itching and repairing damage and mucosal barriers; the female genital tract repair gel inhibits bacteria and fungi causing gynecological diseases, consolidates and strengthens resistance of the female reproductive system and is suitable for wide crowds such as infants, the aged, pregnant women and puerperae. The application method is simple, and washing is not needed.

The invention provides a superoxide dismutase-containing repairing gel for female genital tract. The repairing gel comprises the following raw materials in parts by mass: superoxide dismutase, lysozyme, chlorhexidine acetate, triethanolamine, jojoba oil, carbomer and oligopeptides-1. The invention also provides a preparation method thereof. The preparation method comprises the following steps: preparing raw materials; emulsifying; forming gel. Superoxide dismutase, lysozyme, chlorhexidine acetate, oligopeptides-1, and the like, are taken as the main components of the repairing gel; the components are pure biological enzymes, are free from hormone and antibiotics, are safe and have no side effect; the repairing gel is suitable for routine nursing of women, inhibiting bacteria and cleaning,removing odor and relieving itching, and repairing injury and mucosal barrier; the repairing gel is capable of inhibiting bacteria and fungi causing gynecological diseases and strengthening and enhancing resistance of a female reproductive system; the repairing gel is suitable for a wide range of people, including infants, the aged, pregnant women and puerpera; an use method is simple and no washing is required.

Formulations of praziquantel are used to locally treat female genital schistosomiasis. The formulations can be applied to the upper or lower female genital tract, depending on the location of the infection. Thick or viscous formulations can be used advantageously in the vagina. Solutions of active ingredient can be instilled in the uterus.