19 results about "Pelvic inflammatory disease" patented technology

The invention discloses a traditional Chinese medicine composition for treating chronic pelvic inflammation, which is prepared from the following raw materials: 8-16 parts of fried radix bupleuri, 8-16 parts of white peony root, 20-40 parts of astragalus membranaceus, 20-40 parts of radix pseudostellariae, 10-20 parts of poria cocos, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of angelica sinensis, 8-16 parts of ligusticum wallichii, 8-16 parts of mint, 8-16 parts of rhizoma cyperi, 8-16 parts of corydalis tuber, 8-16 parts of fried endothelium corneum gigeriae galli, 8-16 parts of salvia miltiorrhiza, 8-16 parts of sargentgloryvine stem, 8-16 parts of patrinia and 4-8 parts of liquorice. The traditional Chinese medicine is especially suitable for treating qi deficiency and blood stasis type chronic pelvic inflammation.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

Disclosed herein are new salts and polymorphs of cethromycin for the treatment of diseases due to infection by bacteria and certain protozoans, including, for example, malaria, Babesosis, Toxoplasmosis, diarrheal disease, respiratory disease, sexually transmitted bacterial infections, and some bioterror bacteria, including, for example, plague, tularemia and post-inhalation anthrax. Also disclosed herein are new salts and polymorphs of cethromycin for the treatment of inflammatory diseases, including, for example, pelvic inflammatory disease, and peptic ulcer disease.

To provide a bifunctional degrading agent for interleukin-1 receptor-related kinases and its therapeutic use. [Solution] This disclosure provides a bifunctional compound as an IRAK4 degradation agent via the ubiquitin-proteasome pathway, and a method for treating diseases modulated by IRAK4. The compounds of this disclosure or their pharmaceutical compositions are useful as therapeutic agents for treating inflammatory disorders such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis, necrotizing enterocolitis, gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammation associated with gastrointestinal infections including C. difficile, viral myocarditis, acute and chronic tissue injury, non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, and renal diseases including chronic kidney disease and diabetic kidney disease.

The invention discloses a method for analyzing treatment of chronic pelvic inflammation by motherwort based on network pharmacology, and relates to the technical field of medical treatment, which comprises the following steps: firstly, screening active components of motherwort from TCMSP and BATMAN-TCM databases through multi-dimensional data mining and interaction network modeling, and then predicting potential action targets of the active components by using SwisTargetPredictions and CTD databases; the method comprises the following steps: searching a target gene related to the CPID by utilizing two databases, namely a GeneCards database and an OMIM database; the method comprises the following steps: identifying common genes of active components such as quercetin of motherwort and a CPID target gene through a motherwort-target gene-CPID interaction network, and constructing a regulatory network by using Cytoscape software; according to the method, protein interaction network analysis is carried out by adopting an STRING database, in-depth analysis is carried out on network topology characteristics by applying Cytoscape, and function enrichment analysis (GO and KEGG) is carried out on key genes by adopting a cluster Profiler packet of an R language. A research result shows that the motherwort regulates and controls a plurality of key biological pathways and molecular processes through a multi-component and multi-target synergistic effect, so that the treatment effect of the motherwort on CPID is exerted.

The invention belongs to the technical field of pharmaceutical compositions, and particularly provides a traditional Chinese medicine composition for treating chronic pelvic inflammation as well as a preparation method and a detection method thereof. The traditional Chinese medicine composition comprises 400-450 g of folium artemisiae argyi, 10-50 g of angelica sinensis, 300-400 g of sargentgloryvine stem, 10-50 g of wine-processed teasel root, 10-50 g of obscured homalomena rhizome, 10-50 g of vinegar-processed myrrh, 10-50 g of radix angelicae pubescentis, 10-50 g of radix paeoniae rubra, 10-50 g of dragon's blood, 10-50 g of cortex periplocae, 10-50 g of radix angelicae, 10-50 g of radix saposhnikoviae, 10-50 g of safflower carthamus, 10-50 g of mistletoe, 10-50 g of fried pepper, 10-50 g of vinegar-processed frankincense and 10- The traditional Chinese medicine has the characteristics of reinforcing qi, nourishing blood, nourishing liver and tonifying kidney; the traditional Chinese medicine composition has the effects of promoting qi and blood circulation, tonifying liver and kidney, strengthening vital qi, eliminating the pathogenic factors and recovering the pathogenic factors.

The application provides a pharmaceutical composition for treating gynecological inflammation and a preparation method thereof, and belongs to the technical field of medicines. After being subjected to water extraction and alcohol extraction, Sophora flavescens, Phellodendri chinensis, Forsythia suspensa and Ligustrum lucidum are used to obtain traditional Chinese medicine water extracts and traditional Chinese medicine alcohol extracts; the traditional Chinese medicine water extracts are reacted with silver salt and copper salt to obtain traditional Chinese medicine water extract-metal ion complex; the traditional Chinese medicine water extract-metal ion complex is mixed with the traditional Chinese medicine alcohol extracts, sodium taurodeoxycholate, laurocapram and berberine to prepare nanometer drug delivery micelles; and the nanometer drug delivery micelles are added into a hydrogel of chitosan, poloxamer P407 and poloxamer P188 to prepare the pharmaceutical composition for treating gynecological inflammation. The prepared composition has excellent treatment effect and low toxicity, thereby reducing the cost and improving the treatment effect of gynecological diseases such as chronic pelvic inflammatory disease, chronic cervicitis, vaginitis and artificial abortion complications, and has a wide application prospect.

The pelvic inflammation therapeutic apparatus comprises a machine frame and a fixing frame, the fixing frame is fixedly connected to one side of the machine frame, a heating box is fixedly connected to the interior of the fixing frame, a medicine tank is placed in the heating box, and a control panel is fixed to one side of the machine frame. The first liquid pipe, the second liquid pipe, the third liquid pipe and the fourth liquid pipe are designed to be of a combined structure, when the liquid pipes need to be deeply cleaned in the using process, a rotary knob is rotated to drive a second threaded rod to rotate, and a movable sleeve is driven to move under the threaded connection effect; the clamping plates are synchronously driven to move to cancel limiting and fixing of the second connecting discs, so that rapid separation between the adjacent connecting discs and the liquid pipes can be facilitated, operation is easy, use is convenient and fast, and the interiors of the sectional liquid pipes can be conveniently and deeply cleaned through the design of the sectional liquid pipes, so that follow-up use is facilitated.

This invention discloses a traditional Chinese medicine composition for the treatment of pelvic inflammatory disease, along with its thermosensitive gel and drug delivery device, belonging to the fields of traditional Chinese medicine and medical device technology. The traditional Chinese medicine composition is composed of Sichuan pepper, vinegar-processed corydalis, luffa cylindrica, cinnamon twig, angelica sinensis, red peony root, poria cocos, and earthworm in a specific ratio, with the core treatment principle of soothing the liver and regulating qi, promoting blood circulation and unblocking collaterals, targeting the syndrome of qi stagnation and blood stasis, and obstructed meridians. This composition can be formulated into a thermosensitive vaginal gel, using poloxamer as a matrix, exhibiting room temperature flow and body temperature solidification characteristics, which can prolong the local drug retention time. The accompanying drug delivery device has four interchangeable delivery heads: a single-point delivery head (No. 1) for deep targeted therapy, an umbrella-shaped delivery head for easy drug emptying, an array delivery head for uniform coverage of the vaginal wall, and a directional delivery head that can be adjusted at an angle to act on lesions on the lateral wall. This invention provides a more efficient and personalized solution for the treatment of chronic pelvic inflammatory disease.

The invention provides a traditional Chinese medicine composition with antibacterial and antiviral effects and application, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine composition is composed of fourteen traditional Chinese medicines: artemisia capillaris, radix clematidis, glabrous sarcandra herb, yam rhizome, shrubalthea flower, spina gleditsiae, ramuli euonymi, pogostemon cablin, oldenlandia diffusa, sculellaria barbata, eclipta, fennel, fingered citron and tribulus terrestris; in-vitro experiments show that the traditional Chinese medicine composition has broad-spectrum antiviral activity, and the inhibition rate of the traditional Chinese medicine composition to various viruses reaches 60% or above; in-vivo experiments prove that the traditional Chinese medicine composition disclosed by the invention has remarkable antibacterial activity: the serum inflammatory factor level of a rat with chronic pelvic inflammation caused by bacteria can be effectively regulated and controlled, and the uterus swelling rate is reduced; the traditional Chinese medicine composition can obviously relieve fungal infection mouse skin injury, reduces PASI score, slows down pathological process by regulating and controlling serum inflammatory factor level, and provides a safe and effective scheme for treatment of infectious diseases.

The traditional Chinese medicine composition of charred astragalus root, herba lycopi, fried atractylodes, poria, radix cyathulae, radix cyathulae, semen cuscutae, radix puerariae, fried white peony root, albizia flower, and charred licorice can be used for treating gynecological diseases or symptoms such as intrauterine adhesion, thin endometrium, oligomenorrhea, postmenstrual error, dysmenorrhea, endometritis, pelvic inflammatory disease, decreased ovarian reserve, repeated implantation failure, and infertility, or preparing drugs for treating gynecological diseases or symptoms.

The invention relates to the technical field of gynecological medicines, and particularly discloses a traditional Chinese medicine composition for treating gynecological inflammation and a preparation method thereof. The invention discloses a traditional Chinese medicine composition for treating gynecological inflammation. The traditional Chinese medicine composition comprises croton, liquorice, frankincense, myrrh, realgar, stiff silkworm, rheum officinale, rhizoma cyperi, pericarpium citri reticulatae, safflower carthamus, pinellia ternate, almond and cinnamon. The preparation method comprises the following steps: S1, pretreating the raw materials; s2, mixing the raw materials treated in the step S1, performing coarse crushing and fine grinding, and then performing sieving to obtain traditional Chinese medicine mixed fine powder; s3, pelleting: adding honey accounting for 20-40% of the total weight of the traditional Chinese medicine mixed fine powder into the traditional Chinese medicine mixed fine powder obtained in the step S2, and uniformly stirring and mixing to obtain a soft material; rubbing the soft material into strips, and pelleting to obtain traditional Chinese medicine pills; and S4, drying and packaging. The traditional Chinese medicine composition for treating gynecologic inflammation can be used for treating leukorrheal diseases, chronic pelvic inflammation and other gynecologic inflammatory diseases caused by damp-heat stasis, and has the advantages of taking effect at multiple targets, treating both symptoms and root causes and being small in side effect.

The invention provides a traditional Chinese medicine compound with a pelvic inflammation treatment function, a pharmaceutical preparation and a preparation method. The traditional Chinese medicine compound with the pelvic inflammation treatment function comprises at least one of ligusticum wallichii, radix bupleuri, fennel, salvia miltiorrhiza and cassia twig, peach kernel, safflower and red paeony root. Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention can be used for safely and effectively relieving the inflammation symptoms of pelvic inflammation without obvious side effects by virtue of mutual cooperation of multiple traditional Chinese medicines.

This disclosure relates, in general, to a process for preparing compounds that are inhibitors of the kinase IRAK4, and to synthetic intermediates prepared thereby. IRAK4 inhibitors may be useful in the treatment of inflammatory and fibrous disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammation associated with gastrointestinal infections including C. difficile, viral myocarditis, acute and chronic tissue injury, non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, and renal diseases, including chronic kidney disease and diabetic kidney disease.

The invention discloses a female bacteriostatic traditional Chinese medicine composition and application thereof. The traditional Chinese medicine composition comprises ginseng, saffron crocus, pseudo-ginseng, centipede, goldthread root, snow lotus herb, myrrh, frankincense, lithospermum, curcuma zedoary, stiff silkworm, peach kernel, motherwort, dragon's blood, radix sophorae flavescentis, fructus cnidii, golden cypress, artificial musk, borneol and hexane ammonium acetate. The traditional Chinese medicine composition adopts multiple rare traditional Chinese medicinal materials such as ginseng, saffron crocus and pseudo-ginseng, has the effects of improving immunity, tonifying qi and yin, promoting blood circulation to remove blood stasis, dissipating blood stasis, inhibiting bacteria and relieving itching, cooling and refreshing, cleaning and protecting vagina, and can prevent HPV, hysteromyoma, cervix rotten adnexitis and pelvic inflammation, trichomonas vaginitis, colpitis mycotica, irregular menstruation, dysmenorrhea and amenorrhea, urine leakage and the like to a certain extent; the device can be used for daily hygiene and health care of female pudendum discomfort.

This invention discloses a Yao bath composition for promoting blood circulation and dispelling wind, its preparation method, and its application, belonging to the field of Yao medicine technology. The Yao bath composition of this invention uses *Polygonum cuspidatum*, *Uncaria rhynchophylla*, and *Symplocos buergeriana* as the principal herbs, serving as the main anti-inflammatory and analgesic agents; *Clematis chinensis*, *Cinnamomum cassia*, *Angelica pubescens*, *Commiphora myrrha*, and *Artemisia argyi* as the assistant herbs, promoting blood circulation, dispelling cold, and relieving pain; *Polygonum multiflorum*, *Eucommia ulmoides*, and *Achyranthes bidentata* as adjuvant herbs, strengthening the body's resistance and guiding the medicine downwards; and *Glycyrrhiza uralensis* as the guiding herb, harmonizing the effects of all the herbs. It can be seen that the composition follows the traditional Chinese medicine theory of "promoting blood circulation, removing blood stasis, dispelling wind, clearing heat, and promoting diuresis." The combined effects of these herbs are anti-inflammatory, analgesic, and improve pelvic microcirculation, exerting therapeutic effects through multiple components, targets, and pathways. The pharmacological targets are clearly defined, effectively improving symptoms such as pain and inflammation caused by pelvic inflammatory disease, and showing significant therapeutic effects on pelvic inflammatory disease and other gynecological inflammations. Furthermore, through process optimization, the extraction of active ingredients can be promoted, thereby significantly improving the efficacy of the Yao bath composition.

1. Name of the product in this design: Magnetic Resonance Thermal Therapy Device. 2. Application of this design: for use in medical devices in rehabilitation, orthopedics, internal medicine, surgery and gynecology, to treat soft tissue injuries, neck, shoulder, back and leg pain, arthritis, bronchitis and pelvic inflammatory disease, promote wound healing and enhance the body's immunity. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

This invention relates to a drug delivery rotating magnetic field therapy head for gynecological pelvic inflammatory disease. It effectively solves the problems of not being able to coordinate drug treatment during magnetic therapy and not being able to support the magnetic field therapy head. The head includes a shell and a sleeve. A rotating shaft is rotatably connected inside the shell, and a first pulley is fixedly connected to the outside of the rotating shaft. A spring is located in the middle of the rotating shaft, with one end fixedly connected to the rotating shaft and the other end fixedly connected to the shell. An auxiliary mechanism is located outside the first gear, and a first bevel gear is fixedly connected to the outside of the rotating shaft. A pressing mechanism is located at the left end of the first bevel gear. This invention has a novel structure, ingenious design, and is simple and convenient to operate.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating pelvic inflammatory diseases and enema granules and application thereof. The invention discloses a traditional Chinese medicine composition for treating pelvic inflammatory diseases and enema granules thereof. The traditional Chinese medicine composition is prepared from the following components: 25-35 parts of dandelion, 10-20 parts of rhizoma sparganii, 15-25 parts of spina gleditsiae, 10-20 parts of curcuma zedoary, 25-35 parts of salvia chinensis, 25-35 parts of raw salvia miltiorrhiza, 15-25 parts of herba patriniae, 15-25 parts of radix bupleuri, 15-25 parts of beautiful sweetgum fruit, 15-25 parts of red paeony root, 25-35 parts of sargentgloryvine stem, 10-20 parts of radix clematidis, 15-25 parts of honey and bran fried bighead atractylodes rhizome, 15-25 parts of fried cowherb seed and 15-25 parts of vinegar corydalis tuber. The traditional Chinese medicine composition for treating the pelvic inflammatory disease and the enema granules thereof have the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and relieving swelling and pain, and the purpose of treating the pelvic inflammatory disease is achieved.