6 results about "Pelvic inflammatory disease" patented technology

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating sequelae of a damp-heat stasis type pelvic inflammatory disease and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from traditional Chinese medicinal materials such as hairyvein agrimony, angelica sinensis, rhizoma smilacis glabrae, cortex phellodendri, zaocys dhumnade, salvia miltiorrhiza, herba lycopi and vinegar-processed bupleurum yunnanense according to a certain weight ratio, wherein the hairyvein agrimony serves as a monarch The traditional Chinese medicine composition can synergistically regulate inflammatory response, reduce the level of proinflammatory factors, improve the expression of anti-inflammatory factors, improve the immune state of a body, remarkably improve local blood perfusion of pelvic cavity and promote repair of a uterus tissue structure. Compared with antibiotic drugs, the traditional Chinese medicine composition disclosed by the invention has more outstanding technical effects in the aspects of improving pelvic blood flow and repairing tissues, and also has a good protection effect on uterine epithelial cells in an inflammatory state. The invention further provides enema liquid prepared from the traditional Chinese medicine composition, a rectal administration preparation and application of the enema liquid and the rectal administration preparation. The traditional Chinese medicine composition provided by the invention is good in safety and clear in action mechanism, can be used for preparing related medicines for preventing and treating damp-heat stasis type pelvic inflammatory disease sequelae, and has a good application prospect.

To provide a bifunctional degrading agent for interleukin-1 receptor-related kinases and its therapeutic use. [Solution] This disclosure provides a bifunctional compound as an IRAK4 degradation agent via the ubiquitin-proteasome pathway, and a method for treating diseases modulated by IRAK4. The compounds of this disclosure or their pharmaceutical compositions are useful as therapeutic agents for treating inflammatory disorders such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis, necrotizing enterocolitis, gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammation associated with gastrointestinal infections including C. difficile, viral myocarditis, acute and chronic tissue injury, non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, and renal diseases including chronic kidney disease and diabetic kidney disease.

The invention belongs to the technical field of pharmaceutical compositions, and particularly provides a traditional Chinese medicine composition for treating chronic pelvic inflammation as well as a preparation method and a detection method thereof. The traditional Chinese medicine composition comprises 400-450 g of folium artemisiae argyi, 10-50 g of angelica sinensis, 300-400 g of sargentgloryvine stem, 10-50 g of wine-processed teasel root, 10-50 g of obscured homalomena rhizome, 10-50 g of vinegar-processed myrrh, 10-50 g of radix angelicae pubescentis, 10-50 g of radix paeoniae rubra, 10-50 g of dragon's blood, 10-50 g of cortex periplocae, 10-50 g of radix angelicae, 10-50 g of radix saposhnikoviae, 10-50 g of safflower carthamus, 10-50 g of mistletoe, 10-50 g of fried pepper, 10-50 g of vinegar-processed frankincense and 10- The traditional Chinese medicine has the characteristics of reinforcing qi, nourishing blood, nourishing liver and tonifying kidney; the traditional Chinese medicine composition has the effects of promoting qi and blood circulation, tonifying liver and kidney, strengthening vital qi, eliminating the pathogenic factors and recovering the pathogenic factors.

This invention discloses a traditional Chinese medicine composition for the treatment of pelvic inflammatory disease, along with its thermosensitive gel and drug delivery device, belonging to the fields of traditional Chinese medicine and medical device technology. The traditional Chinese medicine composition is composed of Sichuan pepper, vinegar-processed corydalis, luffa cylindrica, cinnamon twig, angelica sinensis, red peony root, poria cocos, and earthworm in a specific ratio, with the core treatment principle of soothing the liver and regulating qi, promoting blood circulation and unblocking collaterals, targeting the syndrome of qi stagnation and blood stasis, and obstructed meridians. This composition can be formulated into a thermosensitive vaginal gel, using poloxamer as a matrix, exhibiting room temperature flow and body temperature solidification characteristics, which can prolong the local drug retention time. The accompanying drug delivery device has four interchangeable delivery heads: a single-point delivery head (No. 1) for deep targeted therapy, an umbrella-shaped delivery head for easy drug emptying, an array delivery head for uniform coverage of the vaginal wall, and a directional delivery head that can be adjusted at an angle to act on lesions on the lateral wall. This invention provides a more efficient and personalized solution for the treatment of chronic pelvic inflammatory disease.

This disclosure relates, in general, to a process for preparing compounds that are inhibitors of the kinase IRAK4, and to synthetic intermediates prepared thereby. IRAK4 inhibitors may be useful in the treatment of inflammatory and fibrous disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammation associated with gastrointestinal infections including C. difficile, viral myocarditis, acute and chronic tissue injury, non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, and renal diseases, including chronic kidney disease and diabetic kidney disease.

This invention discloses a Yao bath composition for promoting blood circulation and dispelling wind, its preparation method, and its application, belonging to the field of Yao medicine technology. The Yao bath composition of this invention uses *Polygonum cuspidatum*, *Uncaria rhynchophylla*, and *Symplocos buergeriana* as the principal herbs, serving as the main anti-inflammatory and analgesic agents; *Clematis chinensis*, *Cinnamomum cassia*, *Angelica pubescens*, *Commiphora myrrha*, and *Artemisia argyi* as the assistant herbs, promoting blood circulation, dispelling cold, and relieving pain; *Polygonum multiflorum*, *Eucommia ulmoides*, and *Achyranthes bidentata* as adjuvant herbs, strengthening the body's resistance and guiding the medicine downwards; and *Glycyrrhiza uralensis* as the guiding herb, harmonizing the effects of all the herbs. It can be seen that the composition follows the traditional Chinese medicine theory of "promoting blood circulation, removing blood stasis, dispelling wind, clearing heat, and promoting diuresis." The combined effects of these herbs are anti-inflammatory, analgesic, and improve pelvic microcirculation, exerting therapeutic effects through multiple components, targets, and pathways. The pharmacological targets are clearly defined, effectively improving symptoms such as pain and inflammation caused by pelvic inflammatory disease, and showing significant therapeutic effects on pelvic inflammatory disease and other gynecological inflammations. Furthermore, through process optimization, the extraction of active ingredients can be promoted, thereby significantly improving the efficacy of the Yao bath composition.