Traditional Chinese medicine enema composition for treating pelvic inflammatory diseases and application thereof

Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine enema composition for treating pelvic inflammatory diseases and a preparation method and application thereof. The invention discloses a traditional Chinese medicine enema composition for treating pelvic inflammatory diseases. The traditional Chinese medicine enema composition is prepared from the following components: 27-33 parts of dandelion, 12-18 parts of rhizoma sparganii, 17-23 parts of spina gleditsiae, 12-18 parts of curcuma zedoary, 17-23 parts of salvia chinensis, 27-33 parts of raw salvia miltiorrhiza, 27-33 parts of dahurian patrinia herb, 17-23 parts of fried radix bupleuri, 12-18 parts of beautiful sweetgum fruit, 17-23 parts of red paeony root, 27-33 parts of sargentgloryvine stem, 7-13 parts of radix clematidis, 27-33 parts of raw bighead atractylodes rhizome, 17-23 parts of fried cowherb seed and 17-23 parts of vinegar-processed corydalis tuber. The traditional Chinese medicine enema composition for treating the pelvic inflammatory disease has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and relieving swelling and pain, and the purpose of treating the pelvic inflammatory disease is achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular, relates to a composition of traditional Chinese medicine enema for treating pelvic inflammatory disease and its use Background Art

[0002] Pelvic inflammatory disease (PID) refers to a group of infectious diseases of the female upper reproductive tract, mainly including endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis. Pelvic inflammatory disease often occurs in women of childbearing age. If it is not treated promptly and thoroughly, it can lead to infertility, tubal pregnancy, chronic pelvic pain, and repeated inflammation, which seriously affects women's reproductive health and increases the family and socioeconomic burden. At present, Western medicine mostly uses antibiotics to treat pelvic inflammatory disease, which has a significant effect on acute pelvic inflammatory disease, but has poor therapeutic effects on tissue adhesions and blood circulation disorders caused by chronic inflammation. In addition, patients have low tolerance, and long-term use of antibiotics is prone to drug resistance, which affects the clinical treatment effect. The treatment methods of traditional Chinese medicine have shown good results in the treatment of pelvic inflammatory disease, making up for the shortcomings of current Western medicine treatment methods. Summary of the invention

[0003] The purpose of the present invention is to provide a composition of Chinese medicine enema for treating pelvic inflammatory diseases. The Chinese medicine composition has significant effect in treating pelvic inflammatory diseases, has little toxic and side effects, and is well tolerated by patients.

[0004] The second object of the present invention is to provide a use of the traditional Chinese medicine enema composition in preparing a medicine for treating pelvic inflammatory disease.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0006] The first aspect of the present invention provides a composition of a Chinese medicine enema for treating pelvic inflammatory disease. The composition is prepared from the following components: 27-33 parts of dandelion, 12-18 parts of trifoliate lanceolate, 17-23 parts of thorny gleditsia, 12-18 parts of curcuma, 17-23 parts of lycopodiella ciliata, 27-33 parts of raw salvia miltiorrhiza, 27-33 parts of scutellaria baicalensis, 17-33 parts of stir-fried bupleurum, 12-18 parts of fennel, 17-23 parts of red peony root, 27-33 parts of spatholobi, 7-13 parts of clematis, 27-33 parts of raw atractylodes, 17-23 parts of stir-fried vetchling herb, and 17-23 parts of vinegar corydalis.

[0007] Preferably, the composition of the traditional Chinese medicine enema for treating pelvic inflammatory disease is made of the following components: 30 parts of dandelion, 15 parts of trifoliate radix, 20 parts of gleditsia spinosa, 15 parts of curcuma, 20 parts of lithospermum officinale, 30 parts of raw salvia miltiorrhiza, 30 parts of scutellaria baicalensis, 20 parts of stir-fried bupleurum, 15 parts of rhizoma liquidambar formosana, 20 parts of red peony root, 30 parts of saffron vine, 10 parts of clematis, 30 parts of raw atractylodes, 20 parts of stir-fried fenugreek, and 20 parts of vinegar corydalis.

[0008] Among the above raw material components, the pharmacological effects of each Chinese medicine raw material are as follows:

[0009] Taraxacum: clears away heat and detoxifies, reduces swelling and resolves knots, promotes diuresis and relieves stranguria. Used for carbuncle, breast abscess, scrofula, red eyes, sore throat, lung abscess, intestinal abscess, damp-heat jaundice, and painful stranguria caused by heat.

[0010] Trigonum multiflorum: promotes blood circulation and qi circulation, eliminates stagnation and relieves pain. Used for lumps and masses, dysmenorrhea, amenorrhea due to blood stasis, chest pain, and bloating and pain due to food stagnation.

[0011] Gleditsia sinensis: reduces swelling, removes toxins, discharges pus, kills insects. Used for carbuncle at the beginning or when pus forms but does not break out; external treatment for scabies, leprosy.

[0012] Curcuma: promotes qi and resolves blood, eliminates stagnation and relieves pain. Used for lumps and masses, blood stasis and amenorrhea, chest pain and heartache, and bloating and pain caused by food stagnation.

[0013] Lithospermum officinale: promote blood circulation and remove blood stasis, clear away heat and dampness, dissipate stagnation and reduce swelling. Used for irregular menstruation, dysmenorrhea, amenorrhea, metrorrhagia, bloody stool, damp-heat jaundice, heat-toxic bloody dysentery, painful stranguria, leucorrhea, rheumatic bone pain, scrofula, sores, and mastitis.

[0014] Raw Salvia miltiorrhiza: promotes blood circulation and removes blood stasis, relieves pain, clears the heart and relieves vexation, cools blood and eliminates carbuncle. Used for chest pain, abdominal pain, lumps and accumulation, heat pain, restlessness and insomnia, irregular menstruation, dysmenorrhea and amenorrhea, sores and swelling.

[0015] Subaijiang: clears the liver and improves eyesight, harmonizes the middle and eliminates dampness, detoxifies and reduces swelling. Used for red and swollen eyes, abdominal distension and pain, hypochondriac pain, intestinal carbuncle, edema, leucorrhea, sores, furuncles and carbuncle swelling.

[0016] Stir-fried Bupleurum: dispels heat, relieves liver qi and depression, and raises Yang Qi. Used for colds and fever, alternating cold and heat, chest and flank pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0017] Rhizoma Lulutong: dispel wind, activate collaterals, promote diuresis, and regulate menstruation. Used for joint pain, numbness, spasm, edema, oligolactosis, and amenorrhea.

[0018] Red peony root: clears heat and cools blood, dissipates blood stasis and relieves pain. Used for heat entering the blood, fever-induced rashes, hematemesis and epistaxis, red and swollen eyes, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, abdominal pain due to lumps and masses, injuries from falls, carbuncles, swellings and ulcers.

[0019] Sargentodendron chinense: clears away heat and detoxifies, promotes blood circulation, dispels wind and relieves pain. Used for abdominal pain caused by intestinal carbuncle, ulcers caused by heat toxins, amenorrhea, dysmenorrhea, swelling and pain caused by falls, and rheumatic pain.

[0020] Clematis: dispels rheumatism and dredges meridians. Used for rheumatic pain, numbness of limbs, cramps of tendons and veins, and difficulty in flexion and extension.

[0021] Raw Atractylodes: Strengthens the spleen and replenishes Qi, dries dampness and promotes diuresis, stops sweating, and stabilizes the fetus. It is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, spontaneous sweating, and restless fetus.

[0022] Stir-fried Vaccaria: promotes blood circulation and menstruation, promotes lactation and reduces swelling, promotes diuresis and relieves stranguria. Used for amenorrhea, dysmenorrhea, lack of milk, swelling and pain in breast abscess, and pain in stranguria.

[0023] Vinegar Corydalis: promotes blood circulation, promotes qi circulation, and relieves pain. Used for chest, flank, abdominal pain, chest obstruction, heart pain, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain due to falls.

[0024] The traditional Chinese medicine composition provided by the invention uses Sargentodoxae and Subaijiang as main ingredients for clearing away heat, detoxicating and reducing swelling, uses Taraxacum mongolicum, Gleditsia sinensis and Lithospermum officinale for reducing swelling and dispersing nodules, uses Trillium, Curcuma zedoaria, Salvia miltiorrhiza and Paeonia lactiflora for promoting blood circulation and removing blood stasis as auxiliary ingredients, uses Rhizoma Lulufen, Vaccaria segetalis, Radix Clematis and Corydalis for promoting menstruation and relieving pain, uses Radix Bupleuri and Atractylodes macrocephala for soothing the liver and strengthening the spleen, and guides all the medicines into the liver and spleen meridians to directly reach the diseased area, so that the whole formula has the effects of clearing away heat, detoxicating, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain.

[0025] The second aspect of the present invention provides an enema preparation, which is prepared from the traditional Chinese medicine enema composition.

[0026] The third aspect of the present invention provides a use of the traditional Chinese medicine enema composition in preparing a medicine for treating pelvic inflammatory disease.

[0027] The pelvic inflammatory disease refers to a group of infectious diseases of the female upper reproductive tract, mainly including endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis.

[0028] Due to the adoption of the above technical solution, the present invention has the following advantages and beneficial effects:

[0029] The Chinese medicine enema composition for treating pelvic inflammatory disease provided by the present invention has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and achieves the purpose of treating pelvic inflammatory disease. Compared with the treatment with western medicine alone, it is more effective, has less toxic and side effects, has better patient compliance, and is not prone to drug resistance. The Chinese medicine enema composition for treating pelvic inflammatory disease of the present invention has significant efficacy, less toxic and side effects, and good patient tolerance. DETAILED DESCRIPTION

[0030] In order to explain the present invention more clearly, the present invention is further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the following specific description is illustrative rather than restrictive, and should not be used to limit the scope of protection of the present invention.

[0031] Example 1

[0032] A Chinese medicine enema composition for treating pelvic inflammatory disease is prepared from the following components:

[0033] Weigh 30g of dandelion, 15g of trifoliate ginkgo, 20g of gleditsia spine, 15g of zedoaria, 20g of lithospermum officinale, 30g of raw salvia miltiorrhiza, 30g of subaijiang, 20g of stir-fried bupleurum, 15g of fennel, 20g of red peony root, 30g of spatholobi, 10g of clematis, 30g of raw atractylodes, 20g of stir-fried fenugreek, and 20g of vinegar corydalis.

[0034] Put the weighed herbs into a casserole, add 1000ml of water, stir well and soak for 1 hour, boil over high heat first, then simmer over low heat for about 1 hour, and filter out the liquid medicine. Add 1000ml of water to the residue and boil for the second time. After boiling, simmer over low heat for about 1 hour, and filter out the liquid medicine. Combine the two liquid medicines to get about 200ml of enema. If the liquid medicine is more than 200ml, it can be further boiled and concentrated. If it is less than 200ml, add boiling water to 200ml and stir evenly. Put the liquid medicine into a disposable enema bag. Perform enema once a day, and control the liquid medicine temperature at 39-41℃ during enema.

[0035] Precautions for enema: The time for enema during the contraceptive period is from the end of menstruation to the next menstruation, and the time for enema during the pregnancy preparation period is from the end of menstruation to the ovulation day. Before enema, empty your bowels and bladder, lie on your side in bed and bring your knees as close to your abdomen as possible, move your buttocks to the edge of the bed, and fully expose your anus. You or your family members slowly insert the top of the anal canal from the anus to the rectum 10-15cm. Turn on the enema switch, and after completing the Chinese medicine enema, try to stay in a side-lying position for 20-30 minutes to allow the medicine to be fully absorbed. If there is no obvious discomfort, you do not need to go to the toilet. If you have a strong urge to defecate, go to the toilet to empty the medicine.

[0036] To further illustrate the effect of this Chinese medicine enema in the treatment of pelvic inflammatory disease, a retrospective analysis was conducted on 142 patients diagnosed with pelvic inflammatory disease in 2021 who used this Chinese medicine enema to analyze its clinical efficacy and adverse reactions.

[0037] 1) Clinical Data

[0038] Inclusion criteria: Western medicine diagnosis is consistent with the diagnosis of pelvic inflammatory disease in "Obstetrics and Gynecology", and TCM syndrome differentiation is consistent with the blood stasis and dampness obstruction type in the "Guidelines for Clinical Research of New Chinese Medicines (Trial)". Age 18-55 years old.

[0039] Exclusion criteria: pregnant or lactating women; women with allergic constitution or allergies to multiple drugs; women with pelvic tuberculosis, endometriosis, etc.; women who have taken related drugs within 4 weeks of using this enema, making it difficult to judge the efficacy.

[0040] A retrospective analysis was conducted on 142 patients with pelvic inflammatory disease who used this Chinese medicine enema according to the above criteria from January to December 2021. This Chinese medicine enema was used once a day, with one month as a course of treatment, and was discontinued during menstruation.

[0041] 2) Criteria for determining efficacy

[0042] According to the criteria for determining the efficacy of pelvic inflammatory disease in the "Obstetrics and Gynecology of Integrated Traditional Chinese and Western Medicine":

[0043] Recovery: clinical symptoms disappear, and there is no pelvic effusion or mass;

[0044] Markedly effective: Clinical symptoms basically disappeared, gynecological examination showed that the mass was reduced, and adhesion and tenderness of the uterus and adnexa were alleviated;

[0045] Ineffective: The above criteria are not met and there is no improvement in symptoms and signs.

[0046] Total effective rate = [(number of cured cases + number of markedly effective cases) / total number of cases] × 100%

[0047] 3) The clinical treatment results are shown in the following table:

[0048] Table 1 Treatment effects of 142 patients

[0049]

[0050] The results of the investigation and research showed that among 142 patients treated with this Chinese medicine enema, 31 were clinically cured, 98 were significantly effective, and 13 were ineffective, with an overall effective rate of 90.85%.

[0051] Typical clinical cases

[0052] Case 1: Ms. Wu, 32 years old, had two artificial abortions within one year, after which her menstrual flow decreased significantly. She had occasional lower abdominal pain in the past year, which did not affect her normal life, so she did not pay attention to it or seek medical treatment. In the past two months, her lower abdominal pain worsened, so she came to our hospital for treatment. B-ultrasound showed uneven endometrium and pelvic effusion. Diagnosis: female pelvic inflammatory disease. The Chinese medicine enema prescription of the present invention is given, 30g of dandelion, 15g of trifoliate lanceolate, 20g of thorn of Gleditsia sinensis, 15g of zedoaria, 20g of lithospermum officinale, 30g of raw salvia miltiorrhiza, 30g of subaijiang, 20g of stir-fried bupleurum, 15g of liquidambar formosana, 20g of red peony root, 30g of sedum caulis, 10g of clematis, 30g of raw atractylodes, 20g of stir-fried vaccaria, 20g of vinegar corydalis, the above medicinal materials are put into a casserole, 1000ml of water is added, soaked for 1 hour, boiled over high heat and then decocted over low heat for 1 hour, and the medicinal liquid is filtered out. 1000ml of water is added to the filter residue and decocted for the second time, and the medicinal liquid is filtered out. Combine the two medicinal liquids into about 200ml of enema. The medicinal liquid is loaded into a disposable enema bag. The temperature of the medicinal liquid is controlled at 39-41°C during enema, and enema is performed once every night, with a total course of treatment of 28 days, during which 3 days are suspended due to menstruation. About 10 days after enema, the patient's abdominal pain was significantly relieved. One week after the 28-day treatment, the patient went to the doctor for a follow-up ultrasound, and no pelvic effusion was found. A telephone follow-up was conducted 3 months after the treatment, and the patient no longer had lower abdominal pain.

[0053] Case 2: Patient Ms. Du, 28 years old, had chronic pelvic pain three months ago, with a slight sore waist and pain in the lower abdomen on both sides. Menstruation was one week early, with normal flow and no dysmenorrhea. Now she is taking cefaclor orally and metronidazole vaginal suppositories vaginally, but there is no obvious relief of the symptoms. She went to the Department of Integrated Chinese and Western Medicine of our hospital for treatment and was given the Chinese medicine enema prescription of the present invention, including 30g of dandelion, 15g of trifoliate lanceolate, 20g of thorny thorns, 15g of curcuma, 20g of lithotripsy, 30g of raw salvia miltiorrhiza, 30g of Subaijiang, 20g of stir-fried bupleurum, 15g of tonglutong, 20g of red peony root, 30g of sedum seu ... The total course of treatment was 35 days. After using this enema prescription for 28 days, the patient's abdominal pain, back pain and other symptoms had improved significantly. At the patient's request and to further consolidate the treatment effect, the medication time was extended by 7 days.

[0054] The above is only a preferred embodiment of the present invention, and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment, it is not used to limit the present invention. Any technician familiar with this patent can make some changes or modify the technical contents suggested above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the solution of the present invention.

Claims

1. A Chinese medicine enema composition for treating pelvic inflammatory disease, characterized in that: Including dandelion, trifoliate, soapberry thorn, curcuma, lithotripsy, raw salvia miltiorrhiza, Su Baijiang, fried bupleurum, rhizoma alba, red peony root, saffron vine, clematis, raw atractylodes, fried fenugreek, and vinegar Corydalis yanhusuo.

2. The Chinese medicine enema composition for treating pelvic inflammatory disease according to claim 1, characterized in that: The invention is prepared from the following components: 27-33 parts of dandelion, 12-18 parts of trigonosciadium japonicum, 17-23 parts of gleditsia spinosa, 12-18 parts of curcuma zedoaria, 17-23 parts of lithospermum officinale, 27-33 parts of raw salvia miltiorrhiza, 27-33 parts of scutellaria baicalensis, 17-23 parts of stir-fried bupleurum, 12-18 parts of fructus liquidambar formosana, 17-23 parts of red peony root, 27-33 parts of spatholobi, 7-13 parts of clematis root, 27-33 parts of raw atractylodes, 17-23 parts of stir-fried vetchling herb, and 17-23 parts of vinegar-corydalis.

3. The Chinese medicine enema composition for treating pelvic inflammatory disease according to claim 1, characterized in that: The Chinese medicine enema composition for treating pelvic inflammatory disease is prepared from the following components: 30 parts of dandelion, 15 parts of trifoliate lanceolate, 20 parts of gleditsia thorn, 15 parts of curcuma, 20 parts of lithospermum officinale, 30 parts of raw salvia miltiorrhiza, 30 parts of scutellaria baicalensis, 20 parts of stir-fried bupleurum, 15 parts of rhizoma liquidambar formosana, 20 parts of red peony root, 30 parts of saffron vine, 10 parts of clematis, 30 parts of raw atractylodes, 20 parts of stir-fried fenugreek, and 20 parts of vinegar corydalis.

4. The Chinese medicine enema composition according to claim 2 and claim 3, characterized in that: The preparation method of the Chinese medicine enema composition comprises the following steps: weighing each raw material component by weight and putting it into a casserole, adding 1000 mL of water, stirring and soaking for 1 hour, boiling over high heat first and then decocting over low heat for 1 hour, filtering out the medicinal liquid; adding 1000 mL of water to the filter residue and decocting for the second time, boiling over high heat and then decocting over low heat for 1 hour, filtering out the medicinal liquid. The two decoctions are combined, allowed to stand and the precipitate is filtered out, and 200 mL of the medicinal liquid is taken and packaged to obtain a Chinese medicine enema composition for treating pelvic inflammatory diseases.

5. A pharmaceutical preparation comprising the Chinese medicine enema composition as claimed in any one of claims 1 to 4 as an active ingredient.

6. Use of the traditional Chinese medicine enema composition according to any one of claims 1 to 4 in the preparation of a medicine for treating pelvic inflammatory disease.

Images